Uridine (BioDeep_00000000256)

 

Secondary id: BioDeep_00000229622, BioDeep_00000398753

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

化学式: C9H12N2O6 (244.0695332)
中文名称: 尿苷
谱图信息: 最多检出来源 Homo sapiens(blood) 0.01%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Uridine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/uridine (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000256). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)

描述信息

Uridine, also known as beta-uridine or 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione, is a member of the class of compounds known as pyrimidine nucleosides. Pyrimidine nucleosides are compounds comprising a pyrimidine base attached to a ribosyl or deoxyribosyl moiety. More specifically, uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. Uridine is soluble (in water) and a very weakly acidic compound (based on its pKa). Uridine can be synthesized from uracil. It is one of the five standard nucleosides which make up nucleic acids, the others being adenosine, thymidine, cytidine and guanosine. The five nucleosides are commonly abbreviated to their one-letter codes U, A, T, C and G respectively. Uridine is also a parent compound for other transformation products, including but not limited to, nikkomycin Z, 3-(enolpyruvyl)uridine 5-monophosphate, and 5-aminomethyl-2-thiouridine. Uridine can be found in most biofluids, including urine, breast milk, cerebrospinal fluid (CSF), and blood. Within the cell, uridine is primarily located in the mitochondria, in the nucleus and the lysosome. It can also be found in the extracellular space. As an essential nucleoside, uridine exists in all living species, ranging from bacteria to humans. In humans, uridine is involved in several metabolic disorders, some of which include dhydropyrimidinase deficiency, MNGIE (mitochondrial neurogastrointestinal encephalopathy), and beta-ureidopropionase deficiency. Moreover, uridine is found to be associated with Lesch-Nyhan syndrome, which is an inborn error of metabolism. Uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. Uridine plays a role in the glycolysis pathway of galactose. In humans there is no catabolic process to metabolize galactose. Therefore, galactose is converted to glucose and metabolized via the normal glucose metabolism pathways. More specifically, consumed galactose is converted into galactose 1-phosphate (Gal-1-P). This molecule is a substrate for the enzyme galactose-1-phosphate uridyl transferase which transfers a UDP molecule to the galactose molecule. The end result is UDP-galactose and glucose-1-phosphate. This process is continued to allow the proper glycolysis of galactose. Uridine is found in many foods (anything containing RNA) but is destroyed in the liver and gastrointestinal tract, and so no food, when consumed, has ever been reliably shown to elevate blood uridine levels. On the other hand, consumption of RNA-rich foods may lead to high levels of purines (adenine and guanosine) in blood. High levels of purines are known to increase uric acid production and may aggravate or lead to conditions such as gout.
Uridine is a ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N(1)-glycosidic bond. It has a role as a human metabolite, a fundamental metabolite and a drug metabolite. It is functionally related to a uracil.
Uridine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Uridine is a Pyrimidine Analog. The chemical classification of uridine is Pyrimidines, and Analogs/Derivatives.
Uridine is a natural product found in Ulva australis, Synechocystis, and other organisms with data available.
Uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. Uridine has been studied as a rescue agent to reduce the toxicities associated with 5-fluorouracil (5-FU), thereby allowing the administration of higher doses of 5-FU in chemotherapy regimens. (NCI04)
Uridine is a metabolite found in or produced by Saccharomyces cerevisiae.
A ribonucleoside in which RIBOSE is linked to URACIL.
Uridine is a molecule (known as a nucleoside) that is formed when uracil is attached to a ribose ring (also known as a ribofuranose) via a b-N1-glycosidic bond. ; Uridine is a molecule (known as a nucleoside) that is formed when uracil is attached to a ribose ring (also known as a ribofuranose) via a ?-N1-glycosidic bond. Uridine is found in many foods, some of which are celery leaves, canola, common hazelnut, and hickory nut.
A ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N(1)-glycosidic bond.

[Spectral] Uridine (exact mass = 244.06954) and Adenosine (exact mass = 267.09675) and Glutathione (exact mass = 307.08381) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
[Spectral] Uridine (exact mass = 244.06954) and Glutathione (exact mass = 307.08381) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.

Uridine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=58-96-8 (retrieved 2024-06-29) (CAS RN: 58-96-8). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.
Uridine (β-Uridine) is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.

同义名列表

70 个代谢物同义名

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1-((2R,3R,4S,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-dihydropyrimi dine-2,4-dione; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; Uridine, United States Pharmacopeia (USP) Reference Standard; 1-beta-D-Ribofuranosyluracil, Uracil-1-beta-D-ribofuranoside; 1-beta-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione (Uridine); Uridine, powder, BioReagent, suitable for cell culture; beta-delta-Ribofuranoside 2,4(1H,3H)-pyrimidinedione-1; 1-beta-delta-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione; .beta.-D-Ribofuranoside, 2,4(1H,3H)-pyrimidinedione-1; 1-.beta.-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione; 1-.BETA.-D-RIBOFURANOSYLPYRIMIDINE-2,4(1H,3H)-DIONE; 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione; b-D-Ribofuranoside 2,4(1H,3H)-pyrimidinedione-1; 1-b-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione; 1-Β-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione; 1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione; Uridine, Vetec(TM) reagent grade, 99\\%; 6B6FA3F8-70A2-44EA-B99C-D35D0A9237AA; ADENOSINE IMPURITY F (EP IMPURITY); ADENOSINE IMPURITY F [EP IMPURITY]; Uracil-1-.beta.-d-ribofuranoside; 1-beta-delta-Ribofuranosyluracil; Uracil, 1-beta-D-ribofuranosyl-; 1-.beta.-D-Ribofuranosyluracil; 1-beta-D-Ribofuranosyluracil; beta-D-ribofuranosyl-uridine; Uracil-1-A-D-ribofuranoside; Uridine, BioUltra, >=99\\%; 1-Β-D-ribofuranosyluracil; 1-A-D-Ribofuranosyluracil; 1-b-D-Ribofuranosyluracil; URIDINE [USP IMPURITY]; URIDINE (USP IMPURITY); URIDINE (USP-RS); URIDINE [USP-RS]; URIDINE [WHO-DD]; d-Ribosyl uracil; Uracil riboside; URIDINE [MART.]; URIDINE (MART.); UNII-WHI7HQ7H85; Uridine, >=99\\%; .beta.-Uridine; URIDINE [INCI]; URIDINE [MI]; Allo-Uridine; beta-Uridine; Allo Uridine; SMP1_000029; Uridine,(S); Allouridine; WHI7HQ7H85; b-Uridine; Β-uridine; AI3-52690; C9H12N2O6; d-uridine; Uridine; Uridin; 4jx9; 4pd6; 1af2; araU; Urd; u; Uridine



数据库引用编号

57 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(17)

PlantCyc(5)

代谢反应

733 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(104)

WikiPathways(3)

Plant Reactome(0)

INOH(2)

PlantCyc(603)

COVID-19 Disease Map(2)

PathBank(19)

PharmGKB(0)

171 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Felipe Almeida Moreira, Jhon Fernando Berrío Escobar, Cristiano Giordani, Luciano Caseli. Exploring the physicochemical properties of the integration of Tristearoyl uridine in Langmuir monolayers: An approach to cell membrane modeling for prodrugs. Biophysical chemistry. 2024 Jul; 310(?):107256. doi: 10.1016/j.bpc.2024.107256. [PMID: 38728807]
  • Xiaoyue Yu, Jinqiu Sun, Yongjie Yang, Jianping Zhang, Yongliang Lu, Wei Tang. Enhanced Herbicide Metabolism and Target Site Mutation Enabled the Multiple Resistance to Cyhalofop-butyl, Florpyrauxifen-benzyl, and Penoxsulam in Echinochloa crus-galli. Journal of agricultural and food chemistry. 2024 May; 72(20):11405-11414. doi: 10.1021/acs.jafc.4c02450. [PMID: 38717990]
  • Kjell Sergeant, Simon Goertz, Salma Halime, Hanna Tietgen, Hanna Heidt, Martina Minestrini, Cédric Jacquard, Stephanie Zimmer, Jenny Renaut. Exploration of the Diversity of Vicine and Convicine Derivatives in Faba Bean (Vicia faba L.) Cultivars: Insights from LC-MS/MS Spectra. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051065. [PMID: 38474577]
  • Yi-Sheng Miao, Jia-Yue Wang, Rui-Rui Zhuang, Xiao-Kui Huo, Zi-Chang Yi, Xiao-Nan Sun, Zhen-Long Yu, Xiang-Ge Tian, Jing Ning, Lei Feng, Xiao-Chi Ma, Xia Lv. A high-affinity fluorescent probe for human uridine-disphosphate glucuronosyltransferase 1A9 function monitoring under environmental pollutant exposure. Journal of hazardous materials. 2024 Jan; 465(?):133439. doi: 10.1016/j.jhazmat.2024.133439. [PMID: 38218035]
  • Yingshan Ji, Jianqiang Sun, Jingxuan Xie, Wei Wu, Stella C Shuai, Qi Zhao, Wei Chen. m5UMCB: Prediction of RNA 5-methyluridine sites using multi-scale convolutional neural network with BiLSTM. Computers in biology and medicine. 2024 01; 168(?):107793. doi: 10.1016/j.compbiomed.2023.107793. [PMID: 38048661]
  • Natalia V Belosludtseva, Lubov L Pavlik, Irina B Mikheeva, Eugeny Yu Talanov, Dmitriy A Serov, Dmitriy A Khurtin, Konstantin N Belosludtsev, Galina D Mironova. Protective Effect of Uridine on Structural and Functional Rearrangements in Heart Mitochondria after a High-Dose Isoprenaline Exposure Modelling Stress-Induced Cardiomyopathy in Rats. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417300. [PMID: 38139129]
  • Eva Ľuptáková, Armelle Vigouroux, Radka Končitíková, Martina Kopečná, David Zalabák, Ondřej Novák, Sara Salcedo Sarmiento, Sanja Ćavar Zeljković, David Jaroslav Kopečný, Klaus von Schwartzenberg, Miroslav Strnad, Lukáš Spíchal, Nuria De Diego, David Kopečný, Solange Moréra. Plant nucleoside N-ribohydrolases: riboside binding and role in nitrogen storage mobilization. The Plant journal : for cell and molecular biology. 2023 Dec; ?(?):. doi: 10.1111/tpj.16572. [PMID: 38044809]
  • Li Liu, Xue Feng, Jia-Lu Wang, Jia-Lei Chen, Meng-Meng Hou, Xiang-Yu Zhang, Kai-Yang Li, Xi-Wen Li, Shi-Lin Chen. [Comprehensive evaluation of Pinellia ternata germplasm resources based on phenotypic trait classification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Dec; 48(24):6613-6623. doi: 10.19540/j.cnki.cjcmm.20230811.101. [PMID: 38212021]
  • Elena Lesch, Maike Simone Stempel, Vanessa Dressnandt, Bastian Oldenkott, Volker Knoop, Mareike Schallenberg-Rüdinger. Conservation of the moss RNA editing factor PPR78 despite the loss of its known C-to-U editing sites is explained by a hidden extra target. The Plant cell. 2023 Nov; ?(?):. doi: 10.1093/plcell/koad292. [PMID: 38000897]
  • Hee-Jin Song, Ji-Eun Kim, You-Jeong Jin, Yu-Jeong Roh, Ayun Seol, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Beum-Soo An, Seung-Yun Yang, Sungbaek Seo, Seong-Min Jo, Young-Suk Jung, Dae-Youn Hwang. Complement C3-Deficiency-Induced Constipation in FVB/N-C3em1Hlee/Korl Knockout Mice Was Significantly Relieved by Uridine and Liriope platyphylla L. Extracts. International journal of molecular sciences. 2023 Oct; 24(21):. doi: 10.3390/ijms242115757. [PMID: 37958740]
  • Yang Chen, Yanchen Guo, Hao Chang, Zebu Song, Zhi Wei, Zhao Huang, Zezhong Zheng, Guihong Zhang, Yankuo Sun. Brequinar inhibits African swine fever virus replication in vitro by activating ferroptosis. Virology journal. 2023 10; 20(1):242. doi: 10.1186/s12985-023-02204-x. [PMID: 37875895]
  • Nina I Uspalenko, Alexei A Mosentsov, Natalia V Khmil, Lyubov L Pavlik, Natalia V Belosludtseva, Natalia V Khunderyakova, Maria I Shigaeva, Vasilisa P Medvedeva, Anton E Malkov, Valentina F Kitchigina, Galina D Mironova. Uridine as a Regulator of Functional and Ultrastructural Changes in the Brain of Rats in a Model of 6-OHDA-Induced Parkinson's Disease. International journal of molecular sciences. 2023 Sep; 24(18):. doi: 10.3390/ijms241814304. [PMID: 37762607]
  • Matthew H Ward, Zeribe C Nwosu, Costas A Lyssiotis. Uridine: as sweet as sugar for some cells?. Cell research. 2023 Aug; ?(?):. doi: 10.1038/s41422-023-00860-w. [PMID: 37567975]
  • Zhefeng Wang, Yumei Zhang, Tiantian Zhou, Xin Wu. N-carbamoyl aspartate reduced body weight by stimulating the thermogenesis of iBAT. Biochemical and biophysical research communications. 2023 Jul; 665(?):152-158. doi: 10.1016/j.bbrc.2023.04.094. [PMID: 37163935]
  • Shangyu Gao, Yu Sun, Xiaoguang Chen, Changhua Zhu, Xiaoye Liu, Wenlei Wang, Lijun Gan, Yanwu Lu, Frank Schaarschmidt, Marco Herde, Claus-Peter Witte, Mingjia Chen. Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA. Nucleic acids research. 2023 Jun; ?(?):. doi: 10.1093/nar/gkad529. [PMID: 37334828]
  • Anne Caroline Joly, Shahinez Garcia, Jean-Michel Hily, Sandrine Koechler, Gérard Demangeat, Damien Garcia, Emmanuelle Vigne, Olivier Lemaire, Hélène Zuber, Dominique Gagliardi. An extensive survey of phytoviral RNA 3' uridylation identifies extreme variations and virus-specific patterns. Plant physiology. 2023 May; ?(?):. doi: 10.1093/plphys/kiad278. [PMID: 37177985]
  • Qing Yang, Yinchao Zhang, Xiaoling Qu, Fengyan Wu, Xiuchun Li, Min Ren, Ying Tong, Xiuming Wu, Aiguo Yang, Yong Chen, Shuai Chen. Genome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in abiotic stress and flavonol biosynthesis in Nicotiana tabacum. BMC plant biology. 2023 Apr; 23(1):204. doi: 10.1186/s12870-023-04208-9. [PMID: 37076827]
  • Volker Knoop. C-to-U and U-to-C: RNA editing in plant organelles and beyond. Journal of experimental botany. 2023 04; 74(7):2273-2294. doi: 10.1093/jxb/erac488. [PMID: 36527364]
  • Kaixia Niu, Pengpeng Bai, Junyang Zhang, Xinchi Feng, Feng Qiu. Cytidine Alleviates Dyslipidemia and Modulates the Gut Microbiota Composition in ob/ob Mice. Nutrients. 2023 Feb; 15(5):. doi: 10.3390/nu15051147. [PMID: 36904146]
  • Zhiyong Zhang, Xi Wang, Xiaoyang Zhang, Jiaheng Wu, Junhui Chen, Wenlong Li. Integrated LC-MS and network pharmacology methods to screen quantitative indicators in the Hippocampus histrix Kaup and method transfer. Journal of pharmaceutical and biomedical analysis. 2023 Feb; 228(?):115294. doi: 10.1016/j.jpba.2023.115294. [PMID: 36827860]
  • Rafael Itzhakov, Dmitry Tworowski, Noy Sadot, Tali Sayas, Elazar Fallik, Maya Kleiman, Elena Poverenov. Nucleoside-Based Cross-Linkers for Hydrogels with Tunable Properties. ACS applied materials & interfaces. 2023 Feb; 15(5):7359-7370. doi: 10.1021/acsami.2c19525. [PMID: 36701767]
  • Xiaoguang Chen, Sang-Hoon Kim, Sangkee Rhee, Claus-Peter Witte. A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis. The Plant cell. 2023 Jan; 35(1):510-528. doi: 10.1093/plcell/koac320. [PMID: 36342213]
  • Martina Dvořáčková, Jiří Fajkus. Visualization of the Nucleolus Using 5' Ethynyl Uridine. Methods in molecular biology (Clifton, N.J.). 2023; 2672(?):377-385. doi: 10.1007/978-1-0716-3226-0_24. [PMID: 37335490]
  • Lianyu Zhou, Lu Jiao, Jiasheng Ju, Xuelan Ma. Effect of Sodium Selenite on the Metabolite Profile of Epichloë sp. Mycelia from Festuca sinensis in Solid Culture. Biological trace element research. 2022 Nov; 200(11):4865-4879. doi: 10.1007/s12011-021-03054-w. [PMID: 34973128]
  • Chuanlin Shi, Jie Zhang, Bingjin Wu, Rachel Jouni, Changxiu Yu, Blake C Meyers, Wanqi Liang, Qili Fei. Temperature-sensitive male sterility in rice determined by the roles of AGO1d in reproductive phasiRNA biogenesis and function. The New phytologist. 2022 11; 236(4):1529-1544. doi: 10.1111/nph.18446. [PMID: 36031742]
  • Dengtan Li, Jingwen Zhang, Chao Cheng, Kaixuan Hou, Xiaole Wang, Lusheng Zhu, Bing Li, Zhongkun Du, Jinhua Wang, Jun Wang. Effects of ecotoxicity of penoxsulam single and co-exposure with AgNPs on Eisenia fetida. Chemosphere. 2022 Nov; 307(Pt 4):136134. doi: 10.1016/j.chemosphere.2022.136134. [PMID: 36028129]
  • Tangqi Feng, Qian Peng, Lei Wang, Yuanli Xie, Kang Ouyang, Feile Li, Huazhong Zhou, Hongju Ma. Multiple resistance mechanisms to penoxsulam in Echinochloa crus-galli from China. Pesticide biochemistry and physiology. 2022 Oct; 187(?):105211. doi: 10.1016/j.pestbp.2022.105211. [PMID: 36127055]
  • Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen, Wen-Xiong Chen. Assessing the causal association between human blood metabolites and the risk of epilepsy. Journal of translational medicine. 2022 09; 20(1):437. doi: 10.1186/s12967-022-03648-5. [PMID: 36180952]
  • Elena Lesch, Maximilian T Schilling, Sarah Brenner, Yingying Yang, Oliver J Gruss, Volker Knoop, Mareike Schallenberg-Rüdinger. Plant mitochondrial RNA editing factors can perform targeted C-to-U editing of nuclear transcripts in human cells. Nucleic acids research. 2022 09; 50(17):9966-9983. doi: 10.1093/nar/gkac752. [PMID: 36107771]
  • Xiaoyan Wang, Wenwen Kong, Yuan Wang, Jinhui Wang, Luyao Zhong, Kangwen Lao, Xianxin Dong, Dingyu Zhang, He Huang, Beixin Mo, Yu Yu, Guodong Ren. Uridylation and the SKI complex orchestrate the Calvin cycle of photosynthesis through RNA surveillance of TKL1 in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. 2022 09; 119(38):e2205842119. doi: 10.1073/pnas.2205842119. [PMID: 36095196]
  • Ruijia He, Jing Qiao, Xiaoxia Wang, Wenlian Chen, Tong Yin. A new quantitative method for pseudouridine and uridine in human serum and its clinical application in acute myeloid leukemia. Journal of pharmaceutical and biomedical analysis. 2022 Sep; 219(?):114934. doi: 10.1016/j.jpba.2022.114934. [PMID: 35839582]
  • Mizuho Ichinose, Masuyo Kawabata, Yumi Akaiwa, Yasuka Shimajiri, Izumi Nakamura, Takayuki Tamai, Takahiro Nakamura, Yusuke Yagi, Bernard Gutmann. U-to-C RNA editing by synthetic PPR-DYW proteins in bacteria and human culture cells. Communications biology. 2022 09; 5(1):968. doi: 10.1038/s42003-022-03927-3. [PMID: 36109586]
  • Natalia V Belosludtseva, Vlada S Starinets, Irina B Mikheeva, Maxim N Belosludtsev, Mikhail V Dubinin, Galina D Mironova, Konstantin N Belosludtsev. Effect of Chronic Treatment with Uridine on Cardiac Mitochondrial Dysfunction in the C57BL/6 Mouse Model of High-Fat Diet-Streptozotocin-Induced Diabetes. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810633. [PMID: 36142532]
  • Surabhi Bangarbale, Blythe D Shepard, Shivani Bansal, Meth M Jayatilake, Ryan Kurtz, Moshe Levi, Carolyn M Ecelbarger. Renal Metabolome in Obese Mice Treated with Empagliflozin Suggests a Reduction in Cellular Respiration. Biomolecules. 2022 08; 12(9):. doi: 10.3390/biom12091176. [PMID: 36139016]
  • Petja Rosenqvist, Janne J Mäkinen, Kaisa Palmu, Johanna Jokinen, Ranjit K Prajapati, Heidi J Korhonen, Pasi Virta, Georgiy A Belogurov, Mikko Metsä-Ketelä. The role of the maleimide ring system on the structure-activity relationship of showdomycin. European journal of medicinal chemistry. 2022 Jul; 237(?):114342. doi: 10.1016/j.ejmech.2022.114342. [PMID: 35439612]
  • Pengmian Feng, Wei Chen. iRNA-m5U: A sequence based predictor for identifying 5-methyluridine modification sites in Saccharomyces cerevisiae. Methods (San Diego, Calif.). 2022 07; 203(?):28-31. doi: 10.1016/j.ymeth.2021.04.013. [PMID: 33882361]
  • Jiapeng Fang, Dongchen Yang, Zerui Zhao, Jinyi Chen, Liyao Dong. A novel Phe-206-Leu mutation in acetolactate synthase confers resistance to penoxsulam in barnyardgrass (Echinochloa crus-galli (L.) P. Beauv). Pest management science. 2022 Jun; 78(6):2560-2570. doi: 10.1002/ps.6887. [PMID: 35334143]
  • Jihyun Kang, Andrew HyoungJin Kim, Inseung Jeon, Jaeseong Oh, In-Jin Jang, SeungHwan Lee, Joo-Youn Cho. Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase. Clinical and translational science. 2022 05; 15(5):1104-1111. doi: 10.1111/cts.13203. [PMID: 34863048]
  • A A Maslova, E C Matyugina, E Yu Shustova, V P Volok, L I Kozlovskaya, S N Kochetkov, A L Khandazhinskaya. [New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2]. Molekuliarnaia biologiia. 2022 May; 56(3):510-515. doi: 10.31857/s0026898422030107. [PMID: 35621108]
  • Mohammed Mahbubul Matin, Monir Uzzaman, Shagir Ahammad Chowdhury, Md Mosharef Hossain Bhuiyan. In vitro antimicrobial, physicochemical, pharmacokinetics and molecular docking studies of benzoyl uridine esters against SARS-CoV-2 main protease. Journal of biomolecular structure & dynamics. 2022 05; 40(8):3668-3680. doi: 10.1080/07391102.2020.1850358. [PMID: 33297848]
  • Shumin Li, Siying Liu, Rui Ai Chen, Mei Huang, To Sing Fung, Ding Xiang Liu. Activation of the MKK3-p38-MK2-ZFP36 Axis by Coronavirus Infection Restricts the Upregulation of AU-Rich Element-Containing Transcripts in Proinflammatory Responses. Journal of virology. 2022 03; 96(5):e0208621. doi: 10.1128/jvi.02086-21. [PMID: 34985993]
  • Ashleigh J Burke, William R Birmingham, Ying Zhuo, Thomas W Thorpe, Bruna Zucoloto da Costa, Rebecca Crawshaw, Ian Rowles, James D Finnigan, Carl Young, Gregory M Holgate, Mark P Muldowney, Simon J Charnock, Sarah L Lovelock, Nicholas J Turner, Anthony P Green. An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir. Journal of the American Chemical Society. 2022 03; 144(9):3761-3765. doi: 10.1021/jacs.1c11048. [PMID: 35224970]
  • Wei V Zheng, Yaqin Li, Xianyi Cheng, Yanwei Xu, Tao Zhou, Dezhi Li, Yu Xiong, Shaobin Wang, Zaizhong Chen. Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells. Journal of cellular and molecular medicine. 2022 02; 26(3):840-854. doi: 10.1111/jcmm.17131. [PMID: 34970843]
  • Sean J Hoehn, Sarah E Krul, Brandon J Skory, Carlos E Crespo-Hernández. Increased Photostability of the Integral mRNA Vaccine Component N1 -Methylpseudouridine Compared to Uridine. Chemistry (Weinheim an der Bergstrasse, Germany). 2022 Jan; 28(6):e202103667. doi: 10.1002/chem.202103667. [PMID: 34875113]
  • Yikelamu Alimu, Yoko Kusuya, Takako Yamamoto, Kana Arita, Naofumi Shigemune, Hiroki Takahashi, Takashi Yaguchi. Mechanism of Polyhexamethylene Biguanide Resistance in Purpureocillium lilacinum Strains. Biocontrol science. 2022; 27(3):117-130. doi: 10.4265/bio.27.117. [PMID: 36216563]
  • Zihao Wu, Xiao Zhang, Guimei Chang, Jun Yang, Jinpeng Wan, Feijun Wang, Dayun Tao, Jiawu Zhou, Lianguang Shang, Peng Xu, Diqiu Yu. Natural alleles of a uridine 5'-diphospho-glucosyltransferase gene responsible for differential endosperm development between upland rice and paddy rice. Journal of integrative plant biology. 2022 Jan; 64(1):135-148. doi: 10.1111/jipb.13184. [PMID: 34742166]
  • Lubing Li, Xiahatai Ayiding, Ran Han. miRNA-Gene Interaction Network Construction Strategy to Discern Promising Traditional Chinese Medicine against Osteoporosis. BioMed research international. 2022; 2022(?):9093614. doi: 10.1155/2022/9093614. [PMID: 35757478]
  • Jiayin Hu, Tingting Hu, Zhe Guo, Yonggui Song, Lina Shan, Xianbao Shi. Species Difference in the Metabolism of Mulberrin in Vitro and Its Inhibitory Effect on Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes. Chemical & pharmaceutical bulletin. 2022; 70(10):669-678. doi: 10.1248/cpb.c22-00093. [PMID: 36184449]
  • Chutamath Sittplangkoon, Mohamad-Gabriel Alameh, Drew Weissman, Paulo J C Lin, Ying K Tam, Eakachai Prompetchara, Tanapat Palaga. mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model. Frontiers in immunology. 2022; 13(?):983000. doi: 10.3389/fimmu.2022.983000. [PMID: 36311701]
  • Ke Feng, Wenjie Dai, Ling Liu, Shengming Li, Yi Gou, Zhongwei Chen, Guodong Chen, Xufeng Fu. Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics. Frontiers in public health. 2022; 10(?):923170. doi: 10.3389/fpubh.2022.923170. [PMID: 35991069]
  • Amin Osman Elzupir. Molecular Docking and Dynamics Investigations for Identifying Potential Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2: Repurposing of Approved Pyrimidonic Pharmaceuticals for COVID-19 Treatment. Molecules (Basel, Switzerland). 2021 Dec; 26(24):. doi: 10.3390/molecules26247458. [PMID: 34946540]
  • Su-Nyeong Jang, So-Young Park, Hyunyoung Lee, Hyojin Jeong, Ji-Hyeon Jeon, Im-Sook Song, Mi Jeong Kwon, Kwang-Hyeon Liu. In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5'-diphospho-glucuronosyltransferase activity and expression. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Oct; 51(10):1087-1094. doi: 10.1080/00498254.2021.1963503. [PMID: 34338601]
  • Dahae Lee, Ji-Young Kim, Yutong Qi, Sangsu Park, Hye Lim Lee, Noriko Yamabe, Hocheol Kim, Dae Sik Jang, Ki Sung Kang. Phytochemicals from the flowers of Prunus persica (L.) Batsch: Anti-adipogenic effect of mandelamide on 3T3-L1 preadipocytes. Bioorganic & medicinal chemistry letters. 2021 10; 49(?):128326. doi: 10.1016/j.bmcl.2021.128326. [PMID: 34403725]
  • Meredith N Frazier, Lucas B Dillard, Juno M Krahn, Lalith Perera, Jason G Williams, Isha M Wilson, Zachary D Stewart, Monica C Pillon, Leesa J Deterding, Mario J Borgnia, Robin E Stanley. Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. Nucleic acids research. 2021 09; 49(17):10136-10149. doi: 10.1093/nar/gkab719. [PMID: 34403466]
  • Yajie Yu, Jane Ding, Shunqin Zhu, Ahmet Alptekin, Zheng Dong, Chunhong Yan, Yunhong Zha, Han-Fei Ding. Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma. Cell death & disease. 2021 08; 12(9):821. doi: 10.1038/s41419-021-04120-w. [PMID: 34462431]
  • Irina B Krylova, Elena N Selina, Valentina V Bulion, Olga M Rodionova, Natalia R Evdokimova, Natalia V Belosludtseva, Maria I Shigaeva, Galina D Mironova. Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel. Scientific reports. 2021 08; 11(1):16999. doi: 10.1038/s41598-021-96562-7. [PMID: 34417540]
  • Michelle R Denburg, Yunwen Xu, Alison G Abraham, Josef Coresh, Jingsha Chen, Morgan E Grams, Harold I Feldman, Paul L Kimmel, Casey M Rebholz, Eugene P Rhee, Ramachandran S Vasan, Bradley A Warady, Susan L Furth. Metabolite Biomarkers of CKD Progression in Children. Clinical journal of the American Society of Nephrology : CJASN. 2021 08; 16(8):1178-1189. doi: 10.2215/cjn.00220121. [PMID: 34362785]
  • Chu Thanh Binh, Hanh-Dung Thai, Bui Thi Viet Ha, Van-Tuan Tran. Establishment of a new and efficient Agrobacterium-mediated transformation system in the nematicidal fungus Purpureocillium lilacinum. Microbiological research. 2021 Aug; 249(?):126773. doi: 10.1016/j.micres.2021.126773. [PMID: 33940365]
  • Peter Simmonds, M Azim Ansari. Extensive C->U transition biases in the genomes of a wide range of mammalian RNA viruses; potential associations with transcriptional mutations, damage- or host-mediated editing of viral RNA. PLoS pathogens. 2021 06; 17(6):e1009596. doi: 10.1371/journal.ppat.1009596. [PMID: 34061905]
  • Christopher F Bennett, Katherine E O'Malley, Elizabeth A Perry, Eduardo Balsa, Pedro Latorre-Muro, Christopher L Riley, Chi Luo, Mark Jedrychowski, Steven P Gygi, Pere Puigserver. Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly. Nature chemical biology. 2021 06; 17(6):703-710. doi: 10.1038/s41589-021-00772-z. [PMID: 33723432]
  • Guiyue Tang, Bingran Xie, Xiangna Hong, Hang Qin, Jingfang Wang, Hai Huang, Pei Hao, Xuan Li. Creating RNA Specific C-to-U Editase from APOBEC3A by Separation of Its Activities on DNA and RNA Substrates. ACS synthetic biology. 2021 05; 10(5):1106-1115. doi: 10.1021/acssynbio.0c00627. [PMID: 33938211]
  • Yilin Liu, Chunyan Xie, Zhenya Zhai, Ze-Yuan Deng, Hugo R De Jonge, Xin Wu, Zheng Ruan. Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet. Food & function. 2021 Mar; 12(4):1829-1840. doi: 10.1039/d0fo02533j. [PMID: 33527946]
  • Yao Li, Li Yi, Sipeng Cheng, Yongshan Wang, Jiongjiong Wang, Jing Sun, Quan Zhang, Xiulong Xu. Inhibition of canine distemper virus replication by blocking pyrimidine nucleotide synthesis with A77 1726, the active metabolite of the anti-inflammatory drug leflunomide. The Journal of general virology. 2021 03; 102(3):. doi: 10.1099/jgv.0.001534. [PMID: 33416466]
  • Hélène Scheer, Caroline de Almeida, Emilie Ferrier, Quentin Simonnot, Laure Poirier, David Pflieger, François M Sement, Sandrine Koechler, Christina Piermaria, Paweł Krawczyk, Seweryn Mroczek, Johana Chicher, Lauriane Kuhn, Andrzej Dziembowski, Philippe Hammann, Hélène Zuber, Dominique Gagliardi. The TUTase URT1 connects decapping activators and prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis. Nature communications. 2021 02; 12(1):1298. doi: 10.1038/s41467-021-21382-2. [PMID: 33637717]
  • Youngchang Kim, Jacek Wower, Natalia Maltseva, Changsoo Chang, Robert Jedrzejczak, Mateusz Wilamowski, Soowon Kang, Vlad Nicolaescu, Glenn Randall, Karolina Michalska, Andrzej Joachimiak. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Communications biology. 2021 02; 4(1):193. doi: 10.1038/s42003-021-01735-9. [PMID: 33564093]
  • Ernesto Callegari, Jian Lin, Susanna Tse, Theunis C Goosen, Vaishali Sahasrabudhe. Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid. CPT: pharmacometrics & systems pharmacology. 2021 02; 10(2):127-136. doi: 10.1002/psp4.12581. [PMID: 33314761]
  • A A Mosentsov, E V Rozova, N V Belosludtseva, I N Mankovskaya, Yu V Putiy, I N Karaban, I B Mikheeva, G D Mironova. Does the Operation of Mitochondrial ATP-Dependent Potassium Channels Affect the Structural Component of Mitochondrial and Endothelial Dysfunctions in Experimental Parkinsonism?. Bulletin of experimental biology and medicine. 2021 Feb; 170(4):431-435. doi: 10.1007/s10517-021-05081-y. [PMID: 33725242]
  • Amarnath Bollu, Md Khurshidul Hassan, Manjusha Dixit, Nagendra K Sharma. The 2'-caged-tethered-siRNA shows light-dependent temporal controlled RNAi activity for GFP gene into HEK293T cells. Bioorganic & medicinal chemistry. 2021 01; 30(?):115932. doi: 10.1016/j.bmc.2020.115932. [PMID: 33316720]
  • Feng Yin, Yonghua Ling, Jason Martin, Rohini Narayanaswamy, Lisa McIntosh, Fumin Li, Guowen Liu. Quantitation of uridine and L-dihydroorotic acid in human plasma by LC-MS/MS using a surrogate matrix approach. Journal of pharmaceutical and biomedical analysis. 2021 Jan; 192(?):113669. doi: 10.1016/j.jpba.2020.113669. [PMID: 33120310]
  • Taga Lerner, Mitchell Kluesner, Rafail Nikolaos Tasakis, Branden S Moriarity, F Nina Papavasiliou, Riccardo Pecori. C-to-U RNA Editing: From Computational Detection to Experimental Validation. Methods in molecular biology (Clifton, N.J.). 2021; 2181(?):51-67. doi: 10.1007/978-1-0716-0787-9_4. [PMID: 32729074]
  • Usman A Tahir, Daniel H Katz, Tianyi Zhao, Debby Ngo, Daniel E Cruz, Jeremy M Robbins, Zsu-Zsu Chen, Bennet Peterson, Mark D Benson, Xu Shi, Lucas Dailey, Charlotte Andersson, Ramachandran S Vasan, Yan Gao, Changyu Shen, Adolfo Correa, Michael E Hall, Thomas J Wang, Clary B Clish, James G Wilson, Robert E Gerszten. Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study. Circulation. Heart failure. 2021 01; 14(1):e007275. doi: 10.1161/circheartfailure.120.007275. [PMID: 33464957]
  • Alejandro A Edera, M Virginia Sanchez-Puerta. Computational Detection of Plant RNA Editing Events. Methods in molecular biology (Clifton, N.J.). 2021; 2181(?):13-34. doi: 10.1007/978-1-0716-0787-9_2. [PMID: 32729072]
  • Mizuho Ichinose, Mamoru Sugita. Substitutional RNA Editing in Plant Organelles. Methods in molecular biology (Clifton, N.J.). 2021; 2181(?):1-12. doi: 10.1007/978-1-0716-0787-9_1. [PMID: 32729071]
  • Hailang Wang, Chao Xu, Youbing Zhang, Xu Yan, Xiaohuan Jin, Xiaoqing Yao, Peng Chen, Bo Zheng. PtKTI12 genes influence wobble uridine modifications and drought stress tolerance in hybrid poplar. Tree physiology. 2020 12; 40(12):1778-1791. doi: 10.1093/treephys/tpaa088. [PMID: 32705117]
  • Yang Yang, Guangjin Fan, Yan Zhao, Qujiang Wen, Peng Wu, Yuling Meng, Weixing Shan. Cytidine-to-Uridine RNA Editing Factor NbMORF8 Negatively Regulates Plant Immunity to Phytophthora Pathogens. Plant physiology. 2020 12; 184(4):2182-2198. doi: 10.1104/pp.20.00458. [PMID: 32972981]
  • Daisy Rymen, Martijn Lindhout, Maria Spanou, Farah Ashrafzadeh, Ira Benkel, Cornelia Betzler, Christine Coubes, Hans Hartmann, Julie D Kaplan, Diana Ballhausen, Johannes Koch, Jan Lotte, Mohammad Hasan Mohammadi, Marianne Rohrbach, Argirios Dinopoulos, Marieke Wermuth, Daniel Willis, Karin Brugger, Ron A Wevers, Eugen Boltshauser, Jörgen Bierau, Johannes A Mayr, Saskia B Wortmann. Expanding the clinical and genetic spectrum of CAD deficiency: an epileptic encephalopathy treatable with uridine supplementation. Genetics in medicine : official journal of the American College of Medical Genetics. 2020 10; 22(10):1589-1597. doi: 10.1038/s41436-020-0933-z. [PMID: 32820246]
  • Yue Li, Xinai Yang, Na Wang, Haiyan Wang, Bin Yin, Xiaoping Yang, Wenqing Jiang. Mutation profile of over 4500 SARS-CoV-2 isolations reveals prevalent cytosine-to-uridine deamination on viral RNAs. Future microbiology. 2020 09; 15(?):1343-1352. doi: 10.2217/fmb-2020-0149. [PMID: 33085541]
  • Yanxia Zhou, Lianghuan Liao, Chen Wang, Jialu Li, Pengliang Chi, Qingjie Xiao, Qingting Liu, Li Guo, Linfeng Sun, Dong Deng. Cryo-EM structure of the human concentrative nucleoside transporter CNT3. PLoS biology. 2020 08; 18(8):e3000790. doi: 10.1371/journal.pbio.3000790. [PMID: 32776918]
  • G D Mironova, N V Belosludtseva, M A Ananyan. Prospects for the use of regulators of oxidative stress in the comprehensive treatment of the novel Coronavirus Disease 2019 (COVID-19) and its complications. European review for medical and pharmacological sciences. 2020 08; 24(16):8585-8591. doi: 10.26355/eurrev_202008_22658. [PMID: 32894566]
  • Reema A Altaweraqi, Sylvia Y M Yao, Kyla M Smith, Carol E Cass, James D Young. HPLC reveals novel features of nucleoside and nucleobase homeostasis, nucleoside metabolism and nucleoside transport. Biochimica et biophysica acta. Biomembranes. 2020 07; 1862(7):183247. doi: 10.1016/j.bbamem.2020.183247. [PMID: 32126230]
  • Cancan Yang, Jing Li, Zhenling Huang, Xuefa Zhang, Xiaolei Gao, Chunyuang Zhu, Paul F Morris, XiuGuo Zhang. Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici. Scientific reports. 2020 06; 10(1):9051. doi: 10.1038/s41598-020-65935-9. [PMID: 32493959]
  • Linfeng Xie, Yunlin Cao, Zhikang Zhao, Chuanhong Ren, Mengyun Xing, Boping Wu, Bo Zhang, Changjie Xu, Kunsong Chen, Xian Li. Involvement of MdUGT75B1 and MdUGT71B1 in flavonol galactoside/glucoside biosynthesis in apple fruit. Food chemistry. 2020 May; 312(?):126124. doi: 10.1016/j.foodchem.2019.126124. [PMID: 31926461]
  • Emese Xochitl Szabo, Philipp Reichert, Marie-Kristin Lehniger, Marilena Ohmer, Marcella de Francisco Amorim, Udo Gowik, Christian Schmitz-Linneweber, Sascha Laubinger. Metabolic Labeling of RNAs Uncovers Hidden Features and Dynamics of the Arabidopsis Transcriptome. The Plant cell. 2020 04; 32(4):871-887. doi: 10.1105/tpc.19.00214. [PMID: 32060173]
  • Shreya Dubey, Suneel Kumar Madana, Monika Kallubai, Arijit Sarkar, Rajagopal Subramanyam. Unraveling the stability of plasma proteins upon interaction of synthesized uridine products: biophysical and molecular dynamics approach. Journal of biomolecular structure & dynamics. 2020 Apr; 38(7):1927-1937. doi: 10.1080/07391102.2019.1620127. [PMID: 31099311]
  • Fusae Komura, Kana Okuzumi, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa. Development of RNA/DNA Hydrogel Targeting Toll-Like Receptor 7/8 for Sustained RNA Release and Potent Immune Activation. Molecules (Basel, Switzerland). 2020 Feb; 25(3):. doi: 10.3390/molecules25030728. [PMID: 32046113]
  • Yumei Zhang, Songge Guo, Chunyan Xie, Jun Fang. Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis. BioMed research international. 2020; 2020(?):7091718. doi: 10.1155/2020/7091718. [PMID: 32382566]
  • Dhafer S Zinad, Ahmed Mahal, Ranjan K Mohapatra, Ashish K Sarangi, Mohammad Rizki Fadhil Pratama. Medicinal chemistry of oxazines as promising agents in drug discovery. Chemical biology & drug design. 2020 01; 95(1):16-47. doi: 10.1111/cbdd.13633. [PMID: 31583840]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Zhenwei Shen, Xiaoxue Zhu, Hong Zhang, Hong Chen, Junqi Niu, Guiling Chen, Xiaojiao Li, Yanhua Ding. Pharmacokinetic Profile of a Generic Formulation of Sofosbuvir and Its Metabolite GS-331007 in Healthy Chinese Subjects. Clinical pharmacology in drug development. 2019 11; 8(8):1073-1080. doi: 10.1002/cpdd.674. [PMID: 30900816]
  • Chun-Yan Xie, Qinhua Wang, Guanya Li, Zhiyong Fan, Hong Wang, Xin Wu. Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate intestinal development and promote nucleotide transport in weaned piglets. Journal of the science of food and agriculture. 2019 Oct; 99(13):6108-6113. doi: 10.1002/jsfa.9850. [PMID: 31177538]
  • Melanie Donnette, Caroline Solas, Madeleine Giocanti, Geoffroy Venton, Laure Farnault, Yael Berda-Haddad, Le Thi Thu Hau, Régis Costello, L'Houcine Ouafik, Bruno Lacarelle, Joseph Ciccolini, Raphaëlle Fanciullino. Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics-pharmacogenetics pilot study in AML patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Sep; 1126-1127(?):121770. doi: 10.1016/j.jchromb.2019.121770. [PMID: 31454720]
  • Yilin Liu, Yumei Zhang, Jie Yin, Zheng Ruan, Xin Wu, Yulong Yin. Uridine dynamic administration affects circadian variations in lipid metabolisms in the liver of high-fat-diet-fed mice. Chronobiology international. 2019 09; 36(9):1258-1267. doi: 10.1080/07420528.2019.1637347. [PMID: 31296061]
  • Rafael Sandoval, Robert D Boyd, Alena N Kiszter, Yeva Mirzakhanyan, Paola Santibańez, Paul D Gershon, Michael L Hayes. Stable native RIP9 complexes associate with C-to-U RNA editing activity, PPRs, RIPs, OZ1, ORRM1 and ISE2. The Plant journal : for cell and molecular biology. 2019 09; 99(6):1116-1126. doi: 10.1111/tpj.14384. [PMID: 31077462]
  • Danning Huang, David A Gaul, Hongmei Nan, Jaeyeon Kim, Facundo M Fernández. Deep Metabolomics of a High-Grade Serous Ovarian Cancer Triple-Knockout Mouse Model. Journal of proteome research. 2019 08; 18(8):3184-3194. doi: 10.1021/acs.jproteome.9b00263. [PMID: 31290664]
  • Lisa Ohler, Sandra Niopek-Witz, Samuel E Mainguet, Torsten Möhlmann. Pyrimidine Salvage: Physiological Functions and Interaction with Chloroplast Biogenesis. Plant physiology. 2019 08; 180(4):1816-1828. doi: 10.1104/pp.19.00329. [PMID: 31101721]
  • V V Bulion, E N Selina, I B Krylova. [Protective effect of uridine on metabolic processes in rat myocardum during its ischemia/reperfusion damage]. Biomeditsinskaia khimiia. 2019 Aug; 65(5):398-402. doi: 10.18097/pbmc20196505398. [PMID: 31666412]
  • Shi-Fang Li, Mei-Jiao Gong, Yue-Feng Sun, Jun-Jun Shao, Yong-Guang Zhang, Hui-Yun Chang. Antiviral activity of brequinar against foot-and-mouth disease virus infection in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Aug; 116(?):108982. doi: 10.1016/j.biopha.2019.108982. [PMID: 31146110]
  • Jiapeng Fang, Yuhua Zhang, Tingting Liu, Bojun Yan, Jun Li, Liyao Dong. Target-Site and Metabolic Resistance Mechanisms to Penoxsulam in Barnyardgrass (Echinochloa crus-galli (L.) P. Beauv). Journal of agricultural and food chemistry. 2019 Jul; 67(29):8085-8095. doi: 10.1021/acs.jafc.9b01641. [PMID: 31265279]
  • Bojun Yan, Yuhua Zhang, Jun Li, Jiapeng Fang, Tingting Liu, Liyao Dong. Transcriptome profiling to identify cytochrome P450 genes involved in penoxsulam resistance in Echinochloa glabrescens. Pesticide biochemistry and physiology. 2019 Jul; 158(?):112-120. doi: 10.1016/j.pestbp.2019.04.017. [PMID: 31378345]