Nicotine (BioDeep_00000000185)

 

Secondary id: BioDeep_00000229715, BioDeep_00000398739

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019


代谢物信息卡片


(S)-(-)-NICOTINE; 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE

化学式: C10H14N2 (162.1157)
中文名称: 烟碱, (+/-)-尼古丁, (-)-尼古丁
谱图信息: 最多检出来源 Homo sapiens(otcml) 16.39%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Nicotine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/nicotine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000185). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN(C2)C(CC2)c(c1)cncc1
InChI: InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3

描述信息

Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae), predominantly in tobacco and in lower quantities in tomato, potato, eggplant (aubergine), and green pepper. Nicotine alkaloids are also found in the leaves of the coca plant. Nicotine constitutes 0.3 to 5\\\% of the tobacco plant by dry weight, with biosynthesis taking place in the root and accumulation in the leaves. It is a potent neurotoxin with particular specificity to insects; therefore nicotine was widely used as an insecticide in the past and nicotine derivatives such as imidacloprid continue to be widely used. It has been noted that the majority of people diagnosed with schizophrenia smoke tobacco. Estimates for the number of schizophrenics that smoke range from 75\\\% to 90\\\%. It was recently argued that the increased level of smoking in schizophrenia may be due to a desire to self-medicate with nicotine. More recent research has found the reverse: it is a risk factor without long-term benefit, used only for its short-term effects. However, research on nicotine as administered through a patch or gum is ongoing. As nicotine enters the body, it is distributed quickly through the bloodstream and can cross the blood-brain barrier. On average, it takes about seven seconds for the substance to reach the brain. The half-life of nicotine in the body is around 2 hours. The amount of nicotine inhaled with tobacco smoke is a fraction of the amount contained in the tobacco leaves (most of the substance is destroyed by the heat). The amount of nicotine absorbed by the body from smoking depends on many factors, including the type of tobacco, whether the smoke is inhaled, and whether a filter is used. For chewing tobacco, often called dip, snuff, or sinus, which is held in the mouth between the lip and gum, the amount released into the body tends to be much greater than smoked tobacco. The currently available literature indicates that nicotine, on its own, does not promote the development of cancer in healthy tissue and has no mutagenic properties. Its teratogenic properties have not yet been adequately researched, and while the likelihood of birth defects caused by nicotine is believed to be very small or nonexistent, nicotine replacement product manufacturers recommend consultation with a physician before using a nicotine patch or nicotine gum while pregnant or nursing. However, nicotine and the increased acetylcholinic activity it causes have been shown to impede apoptosis, which is one of the methods by which the body destroys unwanted cells (programmed cell death). Since apoptosis helps to remove mutated or damaged cells that may eventually become cancerous, the inhibitory actions of nicotine create a more favourable environment for cancer to develop. Thus, nicotine plays an indirect role in carcinogenesis. It is also important to note that its addictive properties are often the primary motivating factor for tobacco smoking, contributing to the proliferation of cancer. Nicotine is a highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. Nicotine is a hygroscopic, oily liquid that is miscible with water in its base form. As a nitrogenous base, nicotine forms salts with acids that are usually solid and water soluble. Nicotine easily penetrates the skin. As shown by the physical data, free base nicotine will burn at a temperature below its boiling point, and its vapours will combust at 95 °C in the air despite a low vapour pressure. Because of this, most nicotine is burned when a cigarette is smoked; however, enough is inhaled to provide the desired effects. Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nic...
Nicotine appears as a colorless to light yellow or brown liquid. Combustible. Toxic by inhalation and by skin absorption. Produces toxic oxides of nitrogen during combustion.
(S)-nicotine is a 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. It has a role as a phytogenic insecticide, a teratogenic agent, a neurotoxin, an anxiolytic drug, a nicotinic acetylcholine receptor agonist, a biomarker, an immunomodulator, a mitogen, a peripheral nervous system drug, a psychotropic drug, a plant metabolite and a xenobiotic. It is a conjugate base of a (S)-nicotinium(1+). It is an enantiomer of a (R)-nicotine.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Nicotine is a Cholinergic Nicotinic Agonist.
Nicotine is a natural alkyloid that is a major component of cigarettes and is used therapeutically to help with smoking cessation. Nicotine has not been associated with liver test abnormalities or with clinically apparent hepatotoxicity.
Nicotine is a natural product found in Cyphanthera tasmanica, Nicotiana cavicola, and other organisms with data available.
Nicotine is a plant alkaloid, found in the tobacco plant, and addictive central nervous system (CNS) stimulant that causes either ganglionic stimulation in low doses or ganglionic blockage in high doses. Nicotine acts as an agonist at the nicotinic cholinergic receptors in the autonomic ganglia, at neuromuscular junctions, and in the adrenal medulla and the brain. Nicotines CNS-stimulating activities may be mediated through the release of several neurotransmitters, including acetylcholine, beta-endorphin, dopamine, norepinephrine, serotonin, and ACTH. As a result, peripheral vasoconstriction, tachycardia, and elevated blood pressure may be observed with nicotine intake. This agent may also stimulate the chemoreceptor trigger zone, thereby inducing nausea and vomiting.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
See also: Tobacco Leaf (part of); Nicotine Polacrilex (related); Menthol; nicotine (component of) ... View More ...
Alkaloid from Nicotiana tabacum and other Nicotiana subspecies, Asclepias syriaca, Lycopodium subspecies, and other subspecies (Solanaceae, Asclepiadaceae, Crassulaceae). Rare spread of occurrence between angiosperms and cryptogametes (CCD)
A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.

同义名列表

244 个代谢物同义名

(S)-(-)-NICOTINE; 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; Pyridine, 3-(tetrahydro-1-methylpyrrol-2-yl), (S)-; (-)-Nicotine, PESTANAL(R), analytical standard; (-)-.beta.-Pyridyl-.alpha.-N-methylpyrrolidine; PYRIDINE, 3-(TETRAHYDRO-1-METHYL PYRROL-2-YL); Pyridine, 3-(tetrahydro-1-methylpyrrol-2-yl); Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-; Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-; Pyridine, 3-(1-methyl-2-pyrrolidinyl)-,(S)-; Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]-; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; Nicotac Nicotine PolacrilexCoated Cinnamon; 3-((2S)-1-METHYL-2-PYRROLIDINYL)PYRIDINE; 3-((2S)-1-methylpyrrolidin-2-yl)pyridine; LEADER NICOTINE TRANSDERMAL SYSTEMSTEP 2; LEADER NICOTINE TRANSDERMAL SYSTEMSTEP 1; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine; LEADER NICOTINE TRANSDERMAL SYSTEMSTEP 3; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine; (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine; beta-Pyridyl-alpha-N-methyl pyrrolidine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; beta-Pyridyl-alpha-N-methylpyrrolidine; Nicotac Nicotine PolacrilexCoated Mint; (-)-1-Methyl-2-(3-pyridyl)pyrrolidine; (-)-3-(1-Methyl-2-pyrrolidyl)pyridine; PYRROLIDENE, 1-METHYL-2-(3-PYRIDAL)-; NICOTINE PREPARATION, LIQUID, N.O.S.; Pyrrolidine, 1-methyl-2-(3-pyridyl)-; Pyrrolidine, 1-methyl-2-(3-pyridal)-; 3-(1-methyl-2-pyrrolidinyl)-Pyridine; good neighbor pharmacy nicotine mini; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(1-Methyl-2-pyrollidinyl)pyridine; L-3-(1-Methyl-2-pyrrolidyl)pyridine; 3-(1-methylpyrrolidin-2-yl)pyridine; Good Sense NicotineStop Smoking Aid; 3-(1-Methyl-2-pyrrolidinyl)pyridine; (-)-3-(N-Methylpyrrolidino)pyridine; 1-Methyl-2-(3-pyridiyl)pyrrolidine; Nicotine Polacrilexcoated cinnamon; Nicotine PolacrilexOrigianl Flavor; 1-methyl-2-(3-pyridal)-pyrrolidene; 1-methyl-2-(3-pyridal)-Pyrrolidine; Nicotine PolacrilexCoated Ice Mint; Nicotine PolacrilexOriginal Flavor; NICOTINE COMPOUND, LIQUID, N.O.S.; NICOTINETransdermal System Step 3; Nicotine Transdermal System Patch; NICOTINETransdermal System Step 1; Nicotine Transdermal SystemStep 1; Nicotine Transdermal SystemStep 2; (-)-Nicotine, >=99\\% (GC), liquid; Nicotinetransdermal system step 2; 1-Methyl-2-(3-pyridyl)pyrrolidine; Nicotine Transdermal SystemStep 3; Nicotine 10 microg/mL in Methanol; 3-(1-Methyl-2-pyrrolidyl)pyridine; 3-(N-Methylpyrrolidino)pyridine; Good Neighbor Pharmacy Nicotine; Habitrol LozengeOriginal Flavor; l-Nicotine, 50mg/ml in Methanol; l-Nicotine, 10mg/ml in Methanol; 3-(N-Methylpyrollidino)pyridine; NICOTINE COMPONENT OF NICORETTE; Nicotine Polacrilexcoated mint; l-Nicotine, 1mg/ml in Methanol; methyl-2-pyrrolidinyl)pyridine; NICOTINE COMPONENT OF COMMIT; Berkley and Jensen Nicotine; Nicotine Polacrilexoriginal; Kirkland Signature Nicotine; Nicotine polacrilex [USAN]; foster and thrive nicotine; Members Mark Mini Nicotine; Nicotinetransdermal system; Nicotine [for single use]; Kirkland Signature Quit 2; Kirkland Signature Quit 4; alpha-N-methylpyrrolidine; S-()-Nicotine-pyridine-d4; exchange select nicotine; Nicotine COATED ice mint; NICOTINE [USP MONOGRAPH]; NicoretteSpearmint Burst; NICOTINE (USP MONOGRAPH); family wellness nicotine; basic care nicotine mini; DL-tetrahydronicotyrine; NicoretteCinnamon Surge; Nicotine PolacrilexMINT; good sense nicotinemint; Signature Care Nicotine; NICOTINE (EP MONOGRAPH); NICOTINE [EP MONOGRAPH]; up and up mini nicotine; NicoretteWhite Ice Mint; Ortho N-4 and N-5 dusts; NICOTINE [ORANGE BOOK]; a -N-methylpyrrolidine; Harris Teeter Nicotine; Habitrol LozengeCherry; Destruxol orchid spray; a-N-methylpyrrolidine; Nicotine-D salicylate; 3-N-methylpyrrolidine; Members Mark Nicotine; Health Mart Nicotine; Bitartrate, nicotine; NicoretteFruit Chill; Topcare Nicotine Gum; Nicotine Bitartrate; Nicotinetransdermal; Campbells nico-soap; Basic Care Nicotine; Good Sense Nicotine; Nicotine polacrilex; NicoretteFresh Mint; nicotinemint flavor; Tartrate, nicotine; NICOTINE, (LIQUID); Up and Up Nicotine; Nicotine [USP:BAN]; Nicotina [Italian]; DG Health nicotine; XL All Insecticide; Nicotine [BSI:ISO]; NicotineSugar Free; Nicotine (USP:BAN); Nicotine polarilex; Care One Nicotine; Equaline Nicotine; NicoretteOriginal; Niagara P.A. dust; Nicotine Tartrate; NICOTINE-L (BASE); Nikotyna [Polish]; Nicotine alkaloid; NICOTINE [WHO-DD]; 2-beta-H-Nicotine; (S)-(-)--nicotine; NICOTINUM [HPUS]; Sunmark Nicotine; (S)-(-)-Nicotine; NICOTINE [VANDF]; Nikotin [German]; Nicotine betadex; NICOTINE [MART.]; Nicotrol Inhaler; Careone Nicotine; Stop Smoking Aid; Topcare Nicotine; NICOTINE (MART.); Habitrol Lozenge; Rexall Nicotine; NIAGARA PA DUST; NICOTINE [HSDB]; Leader Nicotine; Equate Nicotine; R)-(+)-nicotine; euqate nicotine; UNII-6M3C89ZY6R; L-(-)-Nicotine; HabitrolStep 2; Nicotine (USP); Ortho N-5 dust; S-(-)-Nicotine; delta-Nicotine; (R,S)-Nicotine; HabitrolStep 3; Ortho N-4 dust; Nicotine [ISO]; HabitrolStep 1; bjwc nicotine; Nicotine Mini; Maxi Nicotine; Nicorette gum; NicoretteMint; Habitrol (TN); NICOTINE [MI]; Lucy nicotine; Mini Nicotine; L(-)-nicotine; nicotine s(-); nictoine gum; Tox21_300174; (-)-Nicotine; PDSP1_000113; Tox21_201814; PDSP2_000463; PDSP1_000465; PDSP2_000555; (S)-Nicotine; NicotineMini; (+)-Nicotine; HEB Nicotine; Nicotrol NS; CAS-54-11-5; Nicoderm Cq; D-Nicotine; Good Sense; 6M3C89ZY6R; Nicotinum,; L-Nicotine; fumeto bac; NICODERMCQ; Nicorelief; Nico-Fume; AI3-03424; destruxol; Fumetobac; Nicotinum; Flux MAAG; Nico-dust; Nicorette; ENT 3,424; Nicotine; Nicocide; Nicotrol; Nikotyna; Nicotina; Nicoderm; Micotine; Habitrol; Mach-Nic; Niquitin; Nicabate; TEN DUST; Emo-nik; Prostep; CHEMBL3; Nic-Sal; MACHNIC; Nikotin; Tabazur; Tendust; Nicotin; Exodus; blip; 1uw6; (±)-nicotine; Nicotine; (R,S)-Nicotine



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

279 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ACE2, CNR1, CYP2A6, CYP2B6, CYP2E1, PHB1, PIK3C3, PRL, PTGS2, SLC6A3
Peripheral membrane protein 3 CYP2B6, CYP2E1, PTGS2
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 5 CYP2A6, CYP2B6, CYP2E1, FAAH, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 2 PHB1, PRL
autophagosome 1 PIK3C3
cytosol 2 COMT, PIK3C3
dendrite 4 COMT, DRD4, OPRM1, PDYN
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 DRD4
nucleoplasm 2 PHB1, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 10 ACE2, ADRB3, CNR1, COMT, DRD4, OPRD1, OPRM1, PHB1, SLC6A3, SLC6A4
Cell projection, axon 3 CNR1, OPRM1, SLC6A3
Multi-pass membrane protein 9 ADRB3, CHRNA5, CNR1, DRD4, FAAH, OPRD1, OPRM1, SLC6A3, SLC6A4
Synapse 5 CHRNA5, COMT, OPRM1, PDYN, SLC6A4
cell surface 3 ACE2, PHB1, SLC6A3
glutamatergic synapse 4 CNR1, DRD4, FAAH, PIK3C3
Golgi apparatus 1 OPRM1
growth cone 1 CNR1
mitochondrial inner membrane 2 CYP2E1, PHB1
neuronal cell body 2 PDYN, SLC6A3
postsynapse 2 DRD4, FAAH
presynaptic membrane 4 CNR1, OPRD1, SLC6A3, SLC6A4
Presynapse 4 CHRNA5, CNR1, FAAH, SLC6A4
endosome 2 OPRM1, PIK3C3
plasma membrane 12 ACE2, ADRB3, CHRNA5, CNR1, COMT, DRD4, OPRD1, OPRM1, PDYN, PHB1, SLC6A3, SLC6A4
synaptic vesicle membrane 1 OPRD1
Membrane 12 ACE2, CHRNA5, COMT, CYP2A6, DRD4, FAAH, OPRD1, OPRM1, PHB1, PIK3C3, SLC6A3, SLC6A4
apical plasma membrane 1 ACE2
axon 4 CNR1, COMT, OPRM1, SLC6A3
caveola 1 PTGS2
extracellular exosome 4 ACE2, BMP3, COMT, PHB1
endoplasmic reticulum 3 FAAH, OPRM1, PTGS2
extracellular space 3 ACE2, BMP3, PRL
mitochondrion 1 PHB1
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 4 COMT, CYP2A6, CYP2B6, CYP2E1
Microsome membrane 4 CYP2B6, CYP2E1, FAAH, PTGS2
Single-pass type I membrane protein 1 ACE2
Secreted 4 ACE2, BMP3, PDYN, PRL
extracellular region 4 ACE2, BMP3, PDYN, PRL
Mitochondrion outer membrane 1 CNR1
Single-pass membrane protein 1 FAAH
mitochondrial outer membrane 1 CNR1
hippocampal mossy fiber to CA3 synapse 1 PDYN
neuronal cell body membrane 1 SLC6A3
Extracellular side 1 COMT
Cell projection, cilium 1 ACE2
actin cytoskeleton 1 CNR1
perikaryon 1 OPRM1
midbody 1 PIK3C3
Early endosome 1 PHB1
Single-pass type II membrane protein 1 COMT
postsynaptic membrane 3 CHRNA5, SLC6A3, SLC6A4
Apical cell membrane 1 ACE2
Mitochondrion inner membrane 2 CYP2E1, PHB1
Membrane raft 4 ACE2, CNR1, SLC6A3, SLC6A4
Cell junction, focal adhesion 1 SLC6A4
Cytoplasm, cytoskeleton 1 FAAH
focal adhesion 1 SLC6A4
GABA-ergic synapse 2 CNR1, PIK3C3
flotillin complex 1 SLC6A3
Peroxisome 1 PIK3C3
axoneme 1 PIK3C3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 CHRNA5
Late endosome 1 PIK3C3
receptor complex 1 ADRB3
Cell projection, neuron projection 2 SLC6A3, SLC6A4
neuron projection 6 CHRNA5, OPRD1, OPRM1, PTGS2, SLC6A3, SLC6A4
cilium 1 ACE2
chromatin 1 PRL
phagocytic vesicle membrane 1 PIK3C3
cytoskeleton 1 FAAH
brush border membrane 1 ACE2
organelle membrane 1 FAAH
Endomembrane system 2 FAAH, SLC6A4
endosome lumen 1 PRL
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cell projection, dendrite 1 OPRM1
endoplasmic reticulum lumen 2 ACE2, PTGS2
axon terminus 3 OPRD1, PDYN, SLC6A3
endocytic vesicle membrane 1 ACE2
postsynaptic density membrane 1 OPRD1
presynaptic endosome 1 PIK3C3
neuronal dense core vesicle 2 OPRD1, PDYN
cytoplasmic microtubule 1 CYP2A6
dopaminergic synapse 2 CHRNA5, SLC6A3
dendrite membrane 1 OPRD1
postsynaptic endosome 1 PIK3C3
cholinergic synapse 1 CHRNA5
acetylcholine-gated channel complex 1 CHRNA5
Autolysosome 1 PIK3C3
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
serotonergic synapse 1 SLC6A4
mitochondrial prohibitin complex 1 PHB1
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Xuemei Wang, Junaid Zafar, Xiaotong Yang, Surajit De Mandal, Yingying Hong, Fengliang Jin, Xiaoxia Xu. Gut bacterium Burkholderia cepacia (BsNLG8) and immune gene Defensin A contribute to the resistance against Nicotine-induced stress in Nilaparvata lugens (Stål). Ecotoxicology and environmental safety. 2024 Jun; 277(?):116371. doi: 10.1016/j.ecoenv.2024.116371. [PMID: 38663196]
  • Kimberly N Karin, Mohammed A Mustafa, Justin L Poklis, Belle Buzzi, Joel E Schlosburg, Linda Parker, M Imad Damaj, Aron H Lichtman. N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice. Drug and alcohol dependence. 2024 Jun; 259(?):111276. doi: 10.1016/j.drugalcdep.2024.111276. [PMID: 38676968]
  • Huiqi Zong, Zhekai Hu, Weina Li, Mina Wang, Qi Zhou, Xiang Li, Hongxu Liu. Electronic cigarettes and cardiovascular disease: epidemiological and biological links. Pflugers Archiv : European journal of physiology. 2024 Jun; 476(6):875-888. doi: 10.1007/s00424-024-02925-0. [PMID: 38376568]
  • Nikolina Kastratovic, Vladimir Markovic, Carl Randall Harrell, Aleksandar Arsenijevic, Milica Dimitrijevic Stojanovic, Valentin Djonov, Vladislav Volarevic. Effects of Combustible Cigarettes and Electronic Nicotine Delivery Systems on the Development and Progression of Chronic Lung Inflammation in Mice. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2024 May; 26(6):704-714. doi: 10.1093/ntr/ntad235. [PMID: 38018885]
  • Nour M Hammad, Julia A Wolfson, Sarah D de Ferranti, Walter C Willett, Cindy W Leung. Food Insecurity and Ideal Cardiovascular Health Risk Factors Among US Adolescents. Journal of the American Heart Association. 2024 Apr; 13(8):e033323. doi: 10.1161/jaha.123.033323. [PMID: 38591328]
  • S K Johnsy Sugitha, Raja Venkatesan, R Gladis Latha, Alexandre A Vetcher, Bandar Ali Al-Asbahi, Seong-Cheol Kim. A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton). Molecules (Basel, Switzerland). 2024 Mar; 29(7):. doi: 10.3390/molecules29071464. [PMID: 38611744]
  • Tsubasa Shoji, Takashi Hashimoto, Kazuki Saito. Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids. Journal of experimental botany. 2024 Mar; 75(6):1741-1753. doi: 10.1093/jxb/erad341. [PMID: 37647764]
  • Hari Pradhyumnan, Shahil H Patel, Ofelia Furones-Alonso, Weizhao Zhao, Helen M Bramlett, Ami P Raval. Electronic Cigarette Vape Exposure Exacerbates Post-Ischemic Outcomes in Female but Not in Male Rats. Stroke. 2024 Mar; 55(3):735-746. doi: 10.1161/strokeaha.123.046101. [PMID: 38323450]
  • Qiang Li, Jingtan Li, Jingting Wang, Jing Wang, Tong Lu, Yanfei Jia, Haiji Sun, Xiaoli Ma. PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma. Molecular carcinogenesis. 2024 Feb; 63(2):253-265. doi: 10.1002/mc.23649. [PMID: 37921560]
  • Hyun Jun Lee, Darlene Mae Ortiz, Leandro Val Sayson, Mikyung Kim, Jae Hoon Cheong, Hee Jin Kim. Ameliorating effects of Acanthopanax koreanum extract and components on nicotine dependence and withdrawal symptoms. Addiction biology. 2024 Feb; 29(2):e13360. doi: 10.1111/adb.13360. [PMID: 38380695]
  • Shambhavi Dwivedi, Deeksha Singh, Nivedita Singh, Prabodh Kumar Trivedi. Advances in regulatory mechanism(s) and biotechnological approaches to modulate nicotine content in tobacco. Plant physiology and biochemistry : PPB. 2024 Jan; 207(?):108397. doi: 10.1016/j.plaphy.2024.108397. [PMID: 38316099]
  • K Xiao, P S Xu, H Lin. [Research progress on the prevalence and harm of heated tobacco products]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. 2024 Jan; 47(1):64-69. doi: 10.3760/cma.j.cn112147-20230812-00072. [PMID: 38062698]
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