Honokiol (BioDeep_00000017311)

 

Secondary id: BioDeep_00000003230, BioDeep_00000398491

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


InChI=1/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H

化学式: C18H18O2 (266.1306728)
中文名称: 和厚朴酚
谱图信息: 最多检出来源 Homo sapiens(blood) 0.49%

分子结构信息

SMILES: C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
InChI: InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

描述信息

Honokiol is a member of biphenyls.
Honokiol is a natural product found in Illicium simonsii, Illicium fargesii, and other organisms with data available.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D005765 - Gastrointestinal Agents
D000890 - Anti-Infective Agents
D000970 - Antineoplastic Agents
D018926 - Anti-Allergic Agents
D004791 - Enzyme Inhibitors
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].
Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4].

同义名列表

43 个代谢物同义名

InChI=1/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H; 2-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol; 4-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-2-(prop-2-en-1-yl)phenol; 2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol; Honokiol, European Pharmacopoeia (EP) Reference Standard; 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol; 3,5-(5,5-)Diallyl-[1,1-biphenyl]-2,4-(2,2-)diol; (1,1-biphenyl)-2,4-diol, 3,5-di-2-propen-1-yl-; [1,1-Biphenyl]-2,4-diol, 3,5-di-2-propen-1-yl; {1,1-Biphenyl]-2,4-diol, 3,5-di-2-propenyl-; 3,5-Di-2-propen-1-yl[1,1-biphenyl]-2,4-diol; [1,1-Biphenyl]-2,4-diol, 3,5-di-2-propenyl-; (1,1-BIPHENYL)-2,4-DIOL, 3,5-DI-2-PROPENYL-; 4-allyl-2-(3-allyl-4-hydroxy-phenyl)phenol; 3,5-di-2-propenyl-1,1-biphenyl-2,4-diol; 3,5-diallyl-[1,1-biphenyl]-2,4-diol; 3,5-diallyl-4,2-dihydroxybiphenyl; 3,5-diallyl-2,4-dihydroxybiphenyl; 5,3-Diallyl-2,4-dihydroxybiphenyl; 3,5-Diallyl-2,4-dihydroxybiphenyl; Honokiol, >=98\\% (HPLC), powder; 5,3-Diallyl-biphenyl-2,4-diol; Honokiol, analytical standard; 3,5-diallylbiphenyl-2,4-diol; 3,5-Diallylbiphenyl-2,4-diol; 3,5-diallyl-2,4-biphenyldiol; FVYXIJYOAGAUQK-UHFFFAOYSA-N; 3,1-biphenyl)-2,4-diol; -dihydroxydiphenyl; -Diallyl-2,4′ HONOKIOL [WHO-DD]; Honokiol - 95\\%; HONOKIOL [INCI]; HONOKIOL [MI]; FMLT BSASM H; Honokiol,(S); Honokiol, HO; SMP2_000040; 5,3′ Honokiol; C18H18O2; Purinol; NSC 293100



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

36 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xunliang Huang, Yue Xing, Hao Jiang, Ya Pu, Song Yang, Zhensheng Kang, Lin Cai. Nonphytotoxic and pH-responsive ZnO-ZIF‑8 loaded with honokiol as a 'nanoweapon' effectively controls the soil-borne bacterial pathogen Ralstonia solanacearum. Journal of hazardous materials. 2024 Jul; 472(?):134502. doi: 10.1016/j.jhazmat.2024.134502. [PMID: 38743980]
  • Xiuxia Li, Zhuo Yuan, Yuxia Wang, Wenjing Wang, Jianyou Shi. Recent advances of honokiol：pharmacological activities, manmade derivatives and structure-activity relationship. European journal of medicinal chemistry. 2024 Jun; 272(?):116471. doi: 10.1016/j.ejmech.2024.116471. [PMID: 38704945]
  • Weijuan Zou, Feng Gao, Zheying Meng, Xiaojun Cai, Wu Chen, Yuanyi Zheng, Tao Ying, Longchen Wang, Jianrong Wu. Lactic acid responsive sequential production of hydrogen peroxide and consumption of glutathione for enhanced ferroptosis tumor therapy. Journal of colloid and interface science. 2024 Jun; 663(?):787-800. doi: 10.1016/j.jcis.2024.03.001. [PMID: 38442520]
  • Zhuzhu Zhang, Tingting Chen, Xianhui Yin, Weizhen Wang, Wenzhi Li, Xuetang Chen, Jiling Ma, Youhua Long. Honokiol inhibits Botryosphaeria dothidea, the causal pathogen of kiwifruit soft rot, by targeting membrane lipid biosynthesis. Pest management science. 2024 Apr; 80(4):1779-1794. doi: 10.1002/ps.7910. [PMID: 38031205]
  • Katarzyna Szałabska-Rąpała, Maria Zych, Weronika Borymska, Piotr Londzin, Sławomir Dudek, Ilona Kaczmarczyk-Żebrowska. Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116265. doi: 10.1016/j.biopha.2024.116265. [PMID: 38364735]
  • Dan Liu, Linjiang Wang, Henan Li, Dong Li, Jianwen Zhou, Jing Wang, Qi Zhang, Defu Cai. Co-Delivery of Gemcitabine and Honokiol by Lipid Bilayer-Coated Mesoporous Silica Nanoparticles Enhances Pancreatic Cancer Therapy via Targeting Depletion of Tumor Stroma. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030675. [PMID: 38338418]
  • Lin Niu, Shilong Wang, Yanyan Xu, Xingwang Zu, Xinyu You, Qiuyang Zhang, Pengwei Zhuang, Min Jiang, Jie Gao, Xiaotao Hou, Yanjun Zhang, Gang Bai, Jiagang Deng. Honokiol targeting ankyrin repeat domain of TRPV4 ameliorates endothelial permeability in mice inflammatory bowel disease induced by DSS. Journal of ethnopharmacology. 2024 Jan; 325(?):117825. doi: 10.1016/j.jep.2024.117825. [PMID: 38296175]
  • Yanli Zhang, Hui Liu, Zongxin Chen, Jialei Meng, Yunfeng Li, Luyao Qi, Suiliang Zhang, Xiaofeng Chen, Ming Lei. A drug-drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine. Acta crystallographica Section B, Structural science, crystal engineering and materials. 2023 Dec; 79(Pt 6):519-524. doi: 10.1107/s2052520623008648. [PMID: 37966478]
  • Jie Li, Ya-Feng Chen, Lei Gao, Yi-Jie Li, Dian-Xu Feng. Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1. Chinese journal of integrative medicine. 2023 Nov; ?(?):. doi: 10.1007/s11655-023-3562-y. [PMID: 37943488]
  • Parteek Prasher, Rabab Fatima, Mousmee Sharma, Bekzat Tynybekov, Asma M Alshahrani, Dilek Arslan Ateşşahin, Javad Sharifi-Rad, Daniela Calina. Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship. Chemico-biological interactions. 2023 Oct; ?(?):110747. doi: 10.1016/j.cbi.2023.110747. [PMID: 37816447]
  • Ting Zhai, Junjun Wang, Yong Chen. Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice. Scientific reports. 2023 Sep; 13(1):15203. doi: 10.1038/s41598-023-42358-w. [PMID: 37709801]
  • Man Hu, Wen Jiang, Chen Ye, Ting Hu, Qingqing Yu, Moran Meng, Lijuan Sun, Jichao Liang, Yong Chen. Honokiol attenuates high glucose-induced peripheral neuropathy via inhibiting ferroptosis and activating AMPK/SIRT1/PGC-1ɑ pathway in Schwann cells. Phytotherapy research : PTR. 2023 Aug; ?(?):. doi: 10.1002/ptr.7984. [PMID: 37580045]
  • Riccardo Fontana, Laura Beatrice Mattioli, Giulia Biotti, Roberta Budriesi, Roberto Gotti, Matteo Micucci, Ivan Corazza, Peggy Marconi, Maria Frosini, Stefano Manfredini, Raissa Buzzi, Silvia Vertuani. Magnolia officinalis L. bark extract and respiratory diseases: From traditional Chinese medicine to western medicine via network target. Phytotherapy research : PTR. 2023 Jul; 37(7):2915-2938. doi: 10.1002/ptr.7786. [PMID: 36879409]
  • Xian Wei, Yuzhi Wang, Yunlan Lao, Jiali Weng, Ruyu Deng, Shunmin Li, Jiandong Lu, Shudong Yang, Xinhui Liu. Effects of honokiol protects against chronic kidney disease via BNIP3/NIX and FUNDC1-mediated mitophagy and AMPK pathways. Molecular biology reports. 2023 Jun; ?(?):. doi: 10.1007/s11033-023-08592-1. [PMID: 37338733]
  • Zhi Zhang, Xin Shu, Qian Cao, Lushan Xu, Zibu Wang, Chenggang Li, Shengnan Xia, Pengfei Shao, Xinyu Bao, Liang Sun, Yuhao Xu, Yun Xu. Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models. Neuroscience bulletin. 2023 Jun; ?(?):. doi: 10.1007/s12264-023-01068-z. [PMID: 37291477]
  • Jae Hwa Seo, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Chi-Hoon Ahn, Su-Yeon Park, Ah-Reum Cho, Jinsuk Koo, Bum Sang Shim, Bonglee Kim, Sung-Hoon Kim. Honokiol inhibits epithelial-mesenchymal transition and hepatic fibrosis via activation of Ecadherin/GSK3β/JNK and inhibition of AKT/ERK/p38/β-catenin/TMPRSS4 signaling axis. Phytotherapy research : PTR. 2023 May; ?(?):. doi: 10.1002/ptr.7871. [PMID: 37253375]
  • Jing Wang, Hui-Juan Mu, Yu-Li Sun, Bo Yuan, Ying Wang. Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism. Journal of Asian natural products research. 2023 Apr; ?(?):1-9. doi: 10.1080/10286020.2023.2193695. [PMID: 37010929]
  • Anamika, Anima Roy, Surendra K Trigun. Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1α in a rat model of ammonia neurotoxicity. Journal of cellular biochemistry. 2023 Mar; ?(?):. doi: 10.1002/jcb.30393. [PMID: 36922709]
  • Ishfaq Ahmad Rather, Nadeem Khan, Ajay Singh Kushwah, Gurunath Surampalli, Manish Kumar. Nephroprotective effects of honokiol in a high-fat diet-streptozotocin rat model of diabetic nephropathy. Life sciences. 2023 Mar; ?(?):121543. doi: 10.1016/j.lfs.2023.121543. [PMID: 36871934]
  • Shirui Ren, Yingming Yang, Mengying Xia, Yalan Deng, Yuling Zuo, Lei Lei, Tao Hu. A Chinese herb preparation, honokiol, inhibits Streptococcus mutans biofilm formation. Archives of oral biology. 2023 Mar; 147(?):105610. doi: 10.1016/j.archoralbio.2022.105610. [PMID: 36603516]
  • Qing Ma, Mengyang Xu, Xin Jing, Jiang Qiu, Shuo Huang, Honghao Yan, Lu Yin, Jiang Lou, Lisha Zhao, Yongsheng Fan, Ping Qiu. Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis. Cell death & disease. 2023 Mar; 14(3):174. doi: 10.1038/s41419-023-05680-9. [PMID: 36859530]
  • Chenchen Yang, Yinglian Zhao, Zhipan Luo, Ying Hu, Shuxian Wang, Shuang Hu, Yan Yao, Linxin Pan, Chuanpu Shen, Tao Xu. Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38α in Alcoholic Liver Disease. Planta medica. 2023 Mar; 89(3):273-285. doi: 10.1055/a-1878-3991. [PMID: 35714651]
  • Xianxian Wang, Xiaobin Han, Shu Wang, Yaobin Wang, Peng Wang, Zhongli Zhao, Huimin Qin, Changliang Jing, Chen Liang. Extraction of honokiol from Artemisia argyi and in vitro and in vivo investigation of its antifungal activity. Natural product research. 2023 Feb; 37(4):651-656. doi: 10.1080/14786419.2022.2071887. [PMID: 35506313]
  • Xudong Cheng, Fei Wang, Yu Qiao, Ting Chen, Ling Fan, Xikun Shen, Dongwei Yu, Yuyu Huang, Minggang Wei. Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway. Chemico-biological interactions. 2023 Jan; 370(?):110295. doi: 10.1016/j.cbi.2022.110295. [PMID: 36470525]
  • Junzhao Yuan, Xiaoqian Huang, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian. Honokiol reduces cadmium-induced oxidative injury and endosomal/lysosomal vacuolation via protecting mitochondrial function in quail (Coturnix japonica) liver tissues. The Science of the total environment. 2023 Jan; 857(Pt 3):159626. doi: 10.1016/j.scitotenv.2022.159626. [PMID: 36280083]
  • Wei Zhang, Bangbang Li, Yangyong Lv, Shan Wei, Shuaibing Zhang, Yuansen Hu. Transcriptomic analysis shows the antifungal mechanism of honokiol against Aspergillus flavus. International journal of food microbiology. 2023 Jan; 384(?):109972. doi: 10.1016/j.ijfoodmicro.2022.109972. [PMID: 36279642]
  • Yu-Syuan Wei, Yu-Liang Chen, Wei-Yun Li, Ya-Yi Yang, Sung-Jan Lin, Ching-Ho Wu, Jiue-In Yang, Tse-En Wang, Jiashing Yu, Pei-Shiue Tsai. Antioxidant Nanoparticles Restore Cisplatin-Induced Male Fertility Defects by Promoting MDC1-53bp1-Associated Non-Homologous DNA Repair Mechanism and Sperm Intracellular Calcium Influx. International journal of nanomedicine. 2023; 18(?):4313-4327. doi: 10.2147/ijn.s408623. [PMID: 37576465]
  • Linzhou Yin, Pengyu Liu, Yue Jin, Zunxi Ning, Yiren Yang, Huiyuan Gao. Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications. European journal of medicinal chemistry. 2022 Dec; 244(?):114861. doi: 10.1016/j.ejmech.2022.114861. [PMID: 36332549]
  • Hui Li, Wanfang Li, Jie Li, Sizheng Li, Lian Kuang, Fei Pang, Haiyan Jiang, Hongtao Jin, Xiaolan Bian. Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway. Cells. 2022 11; 11(22):. doi: 10.3390/cells11223562. [PMID: 36428991]
  • Xin-Yuan Jiang, Zong-Yi Ren, Nian-Kun Zhang, Ke-Chen Yang, Gao-Xue Wang, Hai-Feng Jiang. Screening and evaluating honokiol from Magnolia officinalis against Nocardia seriolae infection in largemouth bass (Micropterus Salmoides). Journal of fish diseases. 2022 Nov; 45(11):1599-1607. doi: 10.1111/jfd.13683. [PMID: 35801398]
  • Jidan Zhang, Hongmei Li, Liwei Hou, Jianhui Sun, Weihao Wang, Hua Li, Weipeng Yang, Peijing Rong, Tiegui Nan, Liping Kang, Bin Yang. Pharmacokinetics and metabolites of glycosides and lignans of the stem bark of Magnolia officinalis in functional dyspepsia and normal rats using liquid chromatography-tandem mass spectrometry. Journal of separation science. 2022 Oct; 45(19):3663-3678. doi: 10.1002/jssc.202100982. [PMID: 35908283]
  • Nan Wang, Rui Kong, Wei Han, Wen Bao, Yihai Shi, LiPing Ye, Jie Lu. Honokiol alleviates ulcerative colitis by targeting PPAR-γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro. International immunopharmacology. 2022 Oct; 111(?):109058. doi: 10.1016/j.intimp.2022.109058. [PMID: 35901530]
  • Xinyue Lu, Xiaoyu Lu, Pei Yang, Zhenhai Zhang, Huixia Lv. Honokiol nanosuspensions loaded thermosensitive hydrogels as the local delivery system in combination with systemic paclitaxel for synergistic therapy of breast cancer. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Aug; 175(?):106212. doi: 10.1016/j.ejps.2022.106212. [PMID: 35598854]
  • Ting Xu, Jie-Ru Meng, Wanqing Cheng, Jia-Zheng Liu, Junyan Chu, Qian Zhang, Nannan Ma, Li-Ping Bai, Yong Guo. Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors. Bioorganic & medicinal chemistry. 2022 08; 67(?):116838. doi: 10.1016/j.bmc.2022.116838. [PMID: 35617790]
  • Rui-Wen Mao, Shan-Ping He, Jun-Gang Lan, Wu-Zheng Zhu. Honokiol ameliorates cisplatin-induced acute kidney injury via inhibition of mitochondrial fission. British journal of pharmacology. 2022 07; 179(14):3886-3904. doi: 10.1111/bph.15837. [PMID: 35297042]
  • Fang Chen, Hao Zhang, Na Zhao, Encun Du, Feng Jin, Qiwen Fan, Wanzheng Guo, Shaowen Huang, Jintao Wei. Effects of magnolol and honokiol blend on performance, egg quality, hepatic lipid metabolism, and intestinal morphology of hens at late laying cycle. Animal : an international journal of animal bioscience. 2022 Jun; 16(6):100532. doi: 10.1016/j.animal.2022.100532. [PMID: 35576638]
  • Fawzy Elbarbry, Nicholas Moshirian. The Modulation of Arachidonic Acid Metabolism and Blood Pressure-Lowering Effect of Honokiol in Spontaneously Hypertensive Rats. Molecules (Basel, Switzerland). 2022 May; 27(11):. doi: 10.3390/molecules27113396. [PMID: 35684335]
  • Lin Niu, Jie Wang, Fukui Shen, Jie Gao, Min Jiang, Gang Bai. Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle. Journal of ethnopharmacology. 2022 May; 290(?):115105. doi: 10.1016/j.jep.2022.115105. [PMID: 35157953]
  • Akash Sabarwal, Johannes Wedel, Kaifeng Liu, David Zurakowski, Samik Chakraborty, Evelyn Flynn, David M Briscoe, Murugabaskar Balan, Soumitro Pal. A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation. Carcinogenesis. 2022 05; 43(4):360-370. doi: 10.1093/carcin/bgab126. [PMID: 34965300]
  • Zili Ren, Min Lv, Yuling Zhang, Tianze Li, Hui Xu. High Value-Added Application of Natural Plant Products in Crop Protection: Honokiol Monoester/Diester Derivatives Containing the Novel Core Scaffold of Benzodihydrofuran and Their Agricultural Bioactivities and Control Effects. Journal of agricultural and food chemistry. 2022 May; 70(17):5319-5329. doi: 10.1021/acs.jafc.1c08292. [PMID: 35441514]
  • An-Liang Huang, Fan Yang, Ping Cheng, Dian-Ying Liao, Li Zhou, Xing-Li Ji, Dou-Dou Peng, Li Zhang, Ting-Ting Cheng, Li Ma, Xian-Gen Xia. Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis. Pharmacology research & perspectives. 2022 04; 10(2):e00914. doi: 10.1002/prp2.914. [PMID: 35171536]
  • Xiaolin Dai, Long Xie, Kai Liu, Youdan Liang, Yi Cao, Jing Lu, Xian Wang, Xumin Zhang, Xiaofang Li. The neuropharmacological effects of magnolol and honokiol：a review of signal pathways and molecular mechanisms. Current molecular pharmacology. 2022 Feb; ?(?):. doi: 10.2174/1874467215666220223141101. [PMID: 35196977]
  • Mari Endo, Tetsuro Oikawa, Miki Tonooka, Toshihiko Hanawa, Hiroshi Odaguchi, Masatoshi Hori. Hangekobokuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus through its anti-inflammatory action. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2022; 58(?):78-88. doi: 10.1540/jsmr.58.78. [PMID: 36216552]
  • Lu Wang, Junping Wang. Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier. Oxidative medicine and cellular longevity. 2022; 2022(?):1755608. doi: 10.1155/2022/1755608. [PMID: 36578522]
  • Linhua Lv, Qiuhuan Kong, Zhiying Li, Ying Zhang, Bijiao Chen, Lihua Lv, Yubi Zhang. Honokiol Provides Cardioprotection from Myocardial Ischemia/Reperfusion Injury (MI/RI) by Inhibiting Mitochondrial Apoptosis via the PI3K/AKT Signaling Pathway. Cardiovascular therapeutics. 2022; 2022(?):1001692. doi: 10.1155/2022/1001692. [PMID: 35414825]
  • Xiangxiang Zhang, Huaen Chen, Yang Zhang, Qijing Huang, Jianjia Feng, Haoyu Xing, Xiaguo Fu, Xiufang Yan, Yingying Zhang, Qin Xu, Jianming Liang. HA-DOPE-Modified Honokiol-Loaded Liposomes Targeted Therapy for Osteosarcoma. International journal of nanomedicine. 2022; 17(?):5137-5151. doi: 10.2147/ijn.s371934. [PMID: 36345507]
  • Sayeh Mottaghi, Hassan Abbaszadeh. Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review. Nutrition and cancer. 2022; 74(3):761-778. doi: 10.1080/01635581.2021.1931364. [PMID: 34047218]
  • Linhua Li, Chong Chen, Chunle Zhang, Rifang Luo, Xiaorong Lan, Fan Guo, Liang Ma, Ping Fu, Yunbing Wang. A honokiol-mediated robust coating for blood-contacting devices with anti-inflammatory, antibacterial and antithrombotic properties. Journal of materials chemistry. B. 2021 12; 9(47):9770-9783. doi: 10.1039/d1tb01617b. [PMID: 34806726]
  • Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Yu-Chi Hou. Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration. Molecules (Basel, Switzerland). 2021 Dec; 26(23):. doi: 10.3390/molecules26237390. [PMID: 34885972]
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  • Daria D Vaulina, Kira I Stosman, Konstantin V Sivak, Andrey G Aleksandrov, Nikolai B Viktorov, Nikolay N Kuzmich, Mariia M Kiseleva, Olga F Kuznetsova, Natalia A Gomzina. Preliminary Assessment of the Anti-inflammatory Activity of New Structural Honokiol Analogs with a 4'-O-(2-Fluoroethyl) Moiety and the Potential of Their 18F-Labeled Derivatives for Neuroinflammation Imaging. Molecules (Basel, Switzerland). 2021 Nov; 26(21):. doi: 10.3390/molecules26216630. [PMID: 34771039]
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