Curcumin (BioDeep_00000017309)

 

Secondary id: BioDeep_00000003752, BioDeep_00000177765

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Antitumor activity natural product


代谢物信息卡片


(1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one

化学式: C21H20O6 (368.126)
中文名称: 姜黄色素, 姜黄油, 姜黄素, 酸性黄
谱图信息: 最多检出来源 Viridiplantae(plant) 17.89%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
InChI: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

描述信息

Curcumin appears as orange-yellow needles. (NTP, 1992)
Curcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. It has a role as a metabolite, an anti-inflammatory agent, an antineoplastic agent, a hepatoprotective agent, a flavouring agent, a biological pigment, a nutraceutical, an antifungal agent, a dye, a lipoxygenase inhibitor, a ligand, a radical scavenger, a contraceptive drug, an EC 3.5.1.98 (histone deacetylase) inhibitor, an immunomodulator, an iron chelator, a neuroprotective agent, a food colouring, an EC 1.1.1.21 (aldehyde reductase) inhibitor, an EC 1.1.1.25 (shikimate dehydrogenase) inhibitor, an EC 1.1.1.205 (IMP dehydrogenase) inhibitor, an EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor, an EC 1.8.1.9 (thioredoxin reductase) inhibitor, an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor and a geroprotector. It is a polyphenol, a beta-diketone, an enone, a diarylheptanoid and an aromatic ether. It is functionally related to a ferulic acid.
Curcumin, also known as diferuloylmethane, is an active component in the golden spice turmeric (Curcuma longa) and in [Curcuma xanthorrhiza oil]. It is a highly pleiotropic molecule that exhibits antibacterial, anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Due to these properties, curcumin has been investigated for the treatment and supportive care of clinical conditions including proteinuria, breast cancer, multiple myeloma, depression, and Non Small Cell Lung Cancer (NSCLC). Despite proven efficacy against numerous experimental models, poor bioavailability due to poor absorption, rapid metabolism, and rapid systemic elimination have been shown to limit the therapeutic efficacy of curcumin. Curcumin is under investigation for the treatment and supportive care of various clinical conditions including mucositis, rectal cancer, prostate cancer, chronic schizophrenia, and Mild Cognitive Impairment (MCI).
curcumin is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Curcumin is a natural product found in Strychnos angustiflora, Curcuma amada, and other organisms with data available.
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agents observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04)
A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
See also: ... View More ...
Curcumin is a natural component of the rhizome of turmeric (Curcuma longa) and one of the most powerful chemopreventive and anticancer agents. Its biological effects range from antioxidant, anti-inflammatory to inhibition of angiogenesis and is also shown to possess specific antitumoral activity. The molecular mechanism of its varied cellular effects has been studied in some details and it has been shown to have multiple targets and interacting macromolecules within the cell. Curcumin has been shown to possess anti-angiogenic properties and the angioinhibitory effects of curcumin manifest due to down regulation of proangiogenic genes such as VEGF and angiopoitin and a decrease in migration and invasion of endothelial cells. One of the important factors implicated in chemoresistance and induced chemosensitivity is NFkB and curcumin has been shown to down regulate NFkB and inhibit IKB kinase thereby suppressing proliferation and inducing apoptosis. Cell lines that are resistant to certain apoptotic inducers and radiation become susceptible to apoptosis when treated in conjunction with curcumin. Besides this it can also act as a chemopreventive agent in cancers of colon, stomach and skin by suppressing colonic aberrant crypt foci formation and DNA adduct formation. This review focuses on the various aspects of curcumin as a potential drug for cancer treatment and its implications in a variety of biological and cellular processes vis-à-vis its mechanism of action (PMID: 16712454). Turmeric (Zingiberaceae family) rhizomes, has been widely used for centuries in indigenous medicine for the treatment of a variety of inflammatory conditions and other diseases. Its medicinal properties have been attributed mainly to the curcuminoids and the main component present in the rhizome is curcumin. Curcumin has been shown to possess wide range of pharmacological activities including anti-inflammatory, anti-cancer, anti-oxidant, wound healing and anti-microbial effects. Recently, curcumin treatment has been shown to correct defects associated with cystic fibrosis in homozygous DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) knock out mice. In vivo and in vitro studies have demonstrated curcumins ability to inhibit carcinogenesis at three stages: tumor promotion, angiogenesis and tumor growth. Curcumin suppresses mitogen-induced proliferation of blood mononuclear cells, inhibits neutrophil activation and mixed lymphocyte reaction and also inhibits both serum-induced and platelet derived growth factor (PDGF)-dependent mitogenesis of smooth muscle cells. It has also been reported to be a partial inhibitor of protein kinase. The other salient feature of turmeric/curcumin is that despite being consumed daily for centuries in Asian countries, it has not been shown to cause any toxicity (PMID: 16413584).
Isolated from Curcuma zedoaria (zedoary) and other Curcuma subspecies flavouring ingredient. Natural colouring matter used extensively in Indian curries etc. Nutriceutical with anticancer and antiinflammatory props. Curcumin is found in many foods, some of which are asian pear, leek, chayote, and coconut.
A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
D004396 - Coloring Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

同义名列表

115 个代谢物同义名

(1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-; (1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione; (1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; 5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one; (1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; (1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-1,6-diene-3,5-dione; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione #; (1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione; 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (E,E)-; ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione); (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; 1,7-BIS-(4-HYDROXY-3-METHOXYPHENYL)-HEPTA-1,6-DIENE-3,5-DIONE; Curcumin, United States Pharmacopeia (USP) Reference Standard; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-; 2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-; 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; 1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione; 1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione; 1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione; Curcumin, >=94\\% (curcuminoid content), >=80\\% (Curcumin); 1,7-BIS(4-HYDROXYMETHOXYPHENYL)-1,6-HEPTADIENE-3,5-DIONE; Curcumin, matrix substance for MALDI-MS, >=99.5\\% (HPLC); Curcumin, primary pharmaceutical reference standard; 1,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-; 4-08-00-03697 (Beilstein Handbook Reference); Turmeric oleoresin (79\\%-85\\% curcumin); CURCUMIN (CONSTITUENT OF TURMERIC); 1,5-Divanillyliden-2,4-pentandion; 1,5-Di(vanillyliden)acetylaceton; WLN: 1OR BQ E1U1V1V1U1R DQ CO1; Curcumin, analytical standard; Turmeric (>98\\% curcurmin); Zlut prirodni 3 [Czech]; C.I. Natural Yellow 3; trans,trans-Curcumin; Curcumin (synthetic); Victory 19 Virus Out; Phytosome, Curcumin; CI Natural Yellow 3; Curcumin Phytosome; CURCUMIN [WHO-DD]; Diferuloylmethane; CURCUMIN (USP-RS); Tumeric oleoresin; Diferaloylmethane; CURCUMIN [USP-RS]; Kurkumin [Czech]; CURCUMIN [MART.]; Natural yellow 3; Yellow, Turmeric; CURCUMIN (MART.); Zlut prirodni 3; CURCUMIN [HSDB]; CURCUMIN [INCI]; Turmeric Yellow; Yellow puccoon; Indian saffron; (E/Z)-Curcumin; Tumeric yellow; Yellow Ginger; CURCUMIN [MI]; Tox21_201116; Tox21_111505; Safran dInde; Terra Merita; Jianghuangsu; Tox21_110803; Curcuminoids; Curcumin,(S); Merita earth; Yellow root; Golden seal; Curcuma oil; C Yellow 15; kachs haldi; safra dinde; Kacha haldi; Orange root; C.I. 75300; Ukon (dye); Curcumin I; Hydrastis; Curcumine; Curcurmin; Gelbwurz; Cucurmin; Kurkumin; Lipocurc; NanoCurc; Turmeric; Curcumin; Curcuma; curouma; Tumeric; Souchet; Haldar; Mervia; Yo-Kin; Kurkum; Halad; e 100; Haidr; Halud; Ukon; Curcumin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

136 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, BCL2L1, BIRC5, EP300, ERBB2, HIF1A, MAPK14, MSMP, MYC, NFKB1, PIK3C3, PTEN, SNCA
Peripheral membrane protein 1 CYP1B1
Endosome membrane 2 ERBB2, NOTCH1
Endoplasmic reticulum membrane 3 CD4, CYP1B1, NOTCH1
Mitochondrion membrane 1 BCL2L1
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 11 BIRC5, EP300, ERBB2, HIF1A, JUND, MAPK14, MYC, NFKB1, NOTCH1, PTEN, SNCA
autophagosome 1 PIK3C3
cytosol 12 BCL2L1, BIRC5, EP300, ERBB2, HIF1A, MAPK14, NFKB1, NOTCH1, PIK3C3, PRKCQ, PTEN, SNCA
nuclear body 1 HIF1A
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 BCL2L1
nucleoplasm 10 BIRC5, EP300, ERBB2, HIF1A, JUND, MAPK14, MYC, NFKB1, NOTCH1, PTEN
RNA polymerase II transcription regulator complex 2 HIF1A, JUND
Cell membrane 4 ABCB1, CD4, ERBB2, NOTCH1
Cytoplasmic side 1 BCL2L1
ruffle membrane 1 ERBB2
Cell projection, axon 1 SNCA
Multi-pass membrane protein 1 ABCB1
Synapse 1 SNCA
cell cortex 1 SNCA
cell surface 2 ABCB1, NOTCH1
glutamatergic synapse 3 MAPK14, NOTCH1, PIK3C3
Golgi membrane 1 NOTCH1
growth cone 1 SNCA
lysosomal membrane 1 EGF
mitochondrial inner membrane 1 BCL2L1
neuromuscular junction 1 ERBB2
neuronal cell body 1 SNCA
postsynapse 1 SNCA
presynaptic membrane 1 ERBB2
Cytoplasm, cytosol 1 BCL2L1
Lysosome 1 SNCA
acrosomal vesicle 1 NOTCH1
endosome 1 PIK3C3
plasma membrane 8 ABCB1, CD4, EGF, ERBB2, NOTCH1, PRKCQ, PTEN, SNCA
synaptic vesicle membrane 2 BCL2L1, SNCA
Membrane 8 ABCB1, CYP1B1, EGF, ERBB2, MYC, NOTCH1, PIK3C3, SNCA
apical plasma membrane 4 ABCB1, ERBB2, NOTCH1, PTEN
axon 1 SNCA
basolateral plasma membrane 1 ERBB2
extracellular exosome 2 ABCB1, EGF
endoplasmic reticulum 2 BCL2L1, NOTCH1
extracellular space 3 EGF, MSMP, SNCA
perinuclear region of cytoplasm 2 ERBB2, SNCA
Schaffer collateral - CA1 synapse 1 NOTCH1
adherens junction 1 NOTCH1
mitochondrion 5 BCL2L1, CYP1B1, MAPK14, NFKB1, SNCA
protein-containing complex 4 BIRC5, HIF1A, MYC, SNCA
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
postsynaptic density 1 PTEN
Single-pass type I membrane protein 3 CD4, ERBB2, NOTCH1
Secreted 2 MSMP, SNCA
extracellular region 7 EGF, ERBB2, MAPK14, NFKB1, NOTCH1, PTEN, SNCA
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 BCL2L1
Single-pass membrane protein 1 BCL2L1
mitochondrial outer membrane 1 BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
transcription regulator complex 3 EP300, JUND, NFKB1
centriolar satellite 1 PRKCQ
motile cilium 1 HIF1A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 1 BCL2L1
Bcl-2 family protein complex 1 BCL2L1
nuclear membrane 1 BCL2L1
external side of plasma membrane 1 CD4
actin cytoskeleton 1 SNCA
dendritic spine 1 PTEN
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 1 BIRC5
nucleolus 1 MYC
axon cytoplasm 1 HIF1A
midbody 2 BIRC5, PIK3C3
Early endosome 2 CD4, ERBB2
Apical cell membrane 1 ABCB1
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 1 CD4
Cytoplasm, cytoskeleton, spindle 1 BIRC5
microtubule 1 BIRC5
spindle 1 BIRC5
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
axoneme 1 PIK3C3
nuclear speck 2 HIF1A, MAPK14
interphase microtubule organizing center 1 BIRC5
Late endosome 1 PIK3C3
receptor complex 2 ERBB2, NOTCH1
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
chromatin 5 EP300, HIF1A, JUND, MYC, NFKB1
Late endosome membrane 1 NOTCH1
cell projection 1 PTEN
phagocytic vesicle membrane 1 PIK3C3
supramolecular fiber 1 SNCA
Chromosome 2 BIRC5, EP300
centriole 1 BIRC5
Nucleus, nucleolus 1 MYC
spindle pole 1 MAPK14
nuclear chromosome 1 BIRC5
nuclear envelope 1 MYC
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Nucleus, nucleoplasm 1 MYC
Nucleus speckle 1 HIF1A
euchromatin 1 HIF1A
myelin sheath 1 ERBB2
basal plasma membrane 1 ERBB2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 MAPK14, NFKB1
endoplasmic reticulum lumen 1 CD4
transcription repressor complex 1 JUND
platelet alpha granule lumen 1 EGF
axon terminus 1 SNCA
specific granule lumen 1 NFKB1
kinetochore 1 BIRC5
RNA polymerase II transcription repressor complex 1 MYC
Schmidt-Lanterman incisure 1 PTEN
postsynaptic density membrane 1 NOTCH1
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
aggresome 1 PRKCQ
chromosome, centromeric region 1 BIRC5
semaphorin receptor complex 1 ERBB2
clathrin-coated endocytic vesicle membrane 2 CD4, EGF
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 ERBB2
Rough endoplasmic reticulum 1 MYC
postsynaptic endosome 1 PIK3C3
transcription factor AP-1 complex 1 JUND
Myc-Max complex 1 MYC
T cell receptor complex 1 CD4
Autolysosome 1 PIK3C3
inclusion body 1 SNCA
ERBB3:ERBB2 complex 1 ERBB2
myelin sheath adaxonal region 1 PTEN
[Isoform alpha]: Secreted 1 PTEN
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Notch 1 intracellular domain]: Nucleus 1 NOTCH1
MAML1-RBP-Jkappa- ICN1 complex 1 NOTCH1
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
nucleoplasmic reticulum 1 MYC


文献列表

  • Jawaharlal Nehru Garimella, Rama Chandra Pradhan. Effect of (multi pin) atmospheric cold plasma treatment on curcumin extraction and investigating phytochemicals, antioxidants, physical and morphological properties of turmeric (Curcuma longa L.) powder. Food chemistry. 2024 Aug; 449(?):139233. doi: 10.1016/j.foodchem.2024.139233. [PMID: 38593725]
  • Pengmin Zhang, Shuang Li, Wenxiu Wang, Jianfeng Sun, Zhizhou Chen, Jie Wang, Qianyun Ma. Enhanced photodynamic inactivation against Escherichia coli O157:H7 provided by chitosan/curcumin coating and its application in food contact surfaces. Carbohydrate polymers. 2024 Aug; 337(?):122160. doi: 10.1016/j.carbpol.2024.122160. [PMID: 38710575]
  • Wujiao Wang, Peifen Chang, Jialin Jin, Fenglan Pu, Dan Li, Ying Bai, Ke Dong, Qingshu Yang, Tianli Li. Cardioprotective effects of curcumin against Diabetic Cardiomyopathies: A systematic review and meta-analysis of preclinical studies. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155619. doi: 10.1016/j.phymed.2024.155619. [PMID: 38723524]
  • Hualu Zhou, Giang Vu, Qian Ju, David Julian McClements. Development of plant-based whole egg analogs using emulsion technology. Food research international (Ottawa, Ont.). 2024 Jul; 187(?):114406. doi: 10.1016/j.foodres.2024.114406. [PMID: 38763658]
  • Malihe Keramat, Mohammad-Taghi Golmakani. Antioxidant potency and inhibitory mechanism of curcumin and its derivatives in oleogel and emulgel produced by linseed oil. Food chemistry. 2024 Jul; 445(?):138754. doi: 10.1016/j.foodchem.2024.138754. [PMID: 38364496]
  • Yuying Wang, Jing Shen, Bowen Zou, Ling Zhang, Xianbing Xu, Chao Wu. Unveiling the critical pH values triggering the unfolding of soy 7S and 11S globulins and enhancing their encapsulation efficiency. Food chemistry. 2024 Jul; 445(?):138707. doi: 10.1016/j.foodchem.2024.138707. [PMID: 38354644]
  • Qi Wang, Shizhang Yan, Yijie Ning, Yan Zhu, Irina Sergeeva, Yang Li, Baokun Qi. Effect of sodium alginate block type on the physicochemical properties and curcumin release behavior of quaternized chitosan-oxidized sodium alginate Schiff base hydrogels. Food chemistry. 2024 Jun; 444(?):138688. doi: 10.1016/j.foodchem.2024.138688. [PMID: 38341919]
  • Jia-Feng Duan, Qiu-Juan Zhang, Jin Zhu, Jia-Hui Lu. Curcumin affects autophagy of prolactinoma cells by upregulating miR-206 to exert antitumor effects. Journal of biochemical and molecular toxicology. 2024 Jun; 38(6):e23734. doi: 10.1002/jbt.23734. [PMID: 38764151]
  • Huiping Tao, Lihan Shen. RESEARCH PROGRESS OF CURCUMIN IN THE TREATMENT OF SEPSIS. Shock (Augusta, Ga.). 2024 Jun; 61(6):805-816. doi: 10.1097/shk.0000000000002342. [PMID: 38664750]
  • Maryam Wahab, Srinivas Janaswamy. Porous corn starch granules as effective host matrices for encapsulation and sustained release of curcumin and resveratrol. Carbohydrate polymers. 2024 Jun; 333(?):121967. doi: 10.1016/j.carbpol.2024.121967. [PMID: 38494222]
  • Daniela Pastorim Vaiss, Jamile Lima Rodrigues, Virginia Campello Yurgel, Frank do Carmo Guedes, Lauanda Larissa Mendonça da Matta, Paula Alice Bezerra Barros, Gustavo Richter Vaz, Raíssa Nunes Dos Santos, Bibiana Franzen Matte, Larine Kupski, Jaqueline Garda-Buffon, Juliana Bidone, Ana Luiza Muccillo-Baisch, Fabio Sonvico, Cristiana Lima Dora. Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: A promising therapeutic and prophylactic treatment for viral respiratory infections. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2024 Jun; 197(?):106766. doi: 10.1016/j.ejps.2024.106766. [PMID: 38615970]
  • Meiqi Chang, Lu Zhang, Tingting Zhang, Yanqiu Duan, Wei Feng, Shaoling Yang, Yu Chen, Zeyu Wang. Ultrasound-augmented enzyodynamic-Ca2+ overload synergetic tumor nanotherapy. Biomaterials. 2024 Jun; 307(?):122513. doi: 10.1016/j.biomaterials.2024.122513. [PMID: 38432005]
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