Astragaloside A (BioDeep_00000171753)

Main id: BioDeep_00000000147

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


2-({14-hydroxy-15-[5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(3,4,5-trihydroxyoxan-2-yl)oxy]pentacyclo[9.7.0.0¹,³.0³,⁸.0¹²,¹⁶]octadecan-9-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C41H68O14 (784.4609)
中文名称: 黄芪甲苷A(黄芪甲苷 IV), 黄芪甲苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(O)C1CCC(C)(C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C5C(C)(C)C(OC6OCC(O)C(O)C6O)CCC56CC46CCC23C)O1
InChI: InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3

描述信息

Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

同义名列表

10 个代谢物同义名

2-({14-hydroxy-15-[5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(3,4,5-trihydroxyoxan-2-yl)oxy]pentacyclo[9.7.0.0¹,³.0³,⁸.0¹²,¹⁶]octadecan-9-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol; 3beta,6alpha,16beta,20R,24S; astragaloside IV of astragaloside A; astragaloside IV OF astragaloside a; 3beta,6alpha,16beta,20R,24S; cyclosiversioside F; astramembrannin I; Astragaloside IV; astragaloside A; astragaloside-A; Astragaloside IV



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

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62 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, ANG, CASP9, CTNNB1, EGFR, MAPK14, NOS2, PPARG, PRKAA2, PTGS2, RB1, SMAD2, STAT3, TLR4
Peripheral membrane protein 1 PTGS2
Endosome membrane 2 EGFR, TLR4
Endoplasmic reticulum membrane 3 CYBB, EGFR, PTGS2
Nucleus 12 ANG, CASP9, CTNNB1, EGFR, MAPK14, NOS2, PPARG, PPARGC1A, PRKAA2, RB1, SMAD2, STAT3
cytosol 11 ANG, CASP9, CTNNB1, MAPK14, NOS2, PPARG, PPARGC1A, PRKAA2, RB1, SMAD2, STAT3
dendrite 2 CYBB, PRKAA2
phagocytic vesicle 1 CYBB
centrosome 1 CTNNB1
nucleoplasm 9 CTNNB1, MAPK14, NOS2, PPARG, PPARGC1A, PRKAA2, RB1, SMAD2, STAT3
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 6 ABCB1, CTNNB1, CYBB, EGFR, PECAM1, TLR4
lamellipodium 1 CTNNB1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 ABCB1, CYBB
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 3 CTNNB1, EGFR, PECAM1
cell surface 3 ABCB1, EGFR, TLR4
glutamatergic synapse 3 CTNNB1, EGFR, MAPK14
Golgi apparatus 1 PRKAA2
Golgi membrane 1 EGFR
growth cone 1 ANG
neuronal cell body 3 ANG, CYBB, PRKAA2
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 NOS2
endosome 1 EGFR
plasma membrane 8 ABCB1, CTNNB1, CYBB, EGFR, NOS2, PECAM1, STAT3, TLR4
Membrane 7 ABCB1, CTNNB1, CYBB, EGFR, PRKAA2, SMAD2, TLR4
apical plasma membrane 2 ABCB1, EGFR
axon 1 PRKAA2
basolateral plasma membrane 2 CTNNB1, EGFR
caveola 1 PTGS2
extracellular exosome 3 ABCB1, CTNNB1, PECAM1
endoplasmic reticulum 1 PTGS2
extracellular space 6 ANG, CCL2, CXCL8, EGFR, IL17A, PECAM1
perinuclear region of cytoplasm 5 CTNNB1, EGFR, NOS2, PPARG, TLR4
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 2 CASP9, MAPK14
protein-containing complex 6 CASP9, CTNNB1, EGFR, PECAM1, PTGS2, SMAD2
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 3 EGFR, PECAM1, TLR4
Secreted 4 ANG, CCL2, CXCL8, IL17A
extracellular region 5 ANG, CCL2, CXCL8, IL17A, MAPK14
transcription regulator complex 3 CTNNB1, SMAD2, STAT3
nuclear membrane 1 EGFR
external side of plasma membrane 3 IL17A, PECAM1, TLR4
actin cytoskeleton 1 ANG
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 ANG
Wnt signalosome 1 CTNNB1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
apical part of cell 1 CTNNB1
cell-cell junction 2 CTNNB1, PECAM1
postsynaptic membrane 1 CTNNB1
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 2 EGFR, PECAM1
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CTNNB1, EGFR
spindle 1 RB1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 NOS2
basement membrane 1 ANG
intracellular vesicle 1 EGFR
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 PPARGC1A
PML body 2 PPARGC1A, RB1
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 EGFR, PPARG, TLR4
neuron projection 1 PTGS2
chromatin 5 PPARG, PPARGC1A, RB1, SMAD2, STAT3
phagocytic cup 1 TLR4
phagocytic vesicle membrane 1 CYBB
cell periphery 1 CTNNB1
Chromosome 1 ANG
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 ANG
spindle pole 2 CTNNB1, MAPK14
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 CYBB
Endomembrane system 1 CTNNB1
monoatomic ion channel complex 1 CYBB
specific granule membrane 1 CYBB
tertiary granule membrane 1 CYBB
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 CTNNB1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 PECAM1
endoplasmic reticulum lumen 1 PTGS2
endocytic vesicle 1 ANG
beta-catenin-TCF complex 1 CTNNB1
SWI/SNF complex 1 RB1
perinuclear endoplasmic reticulum 1 CYBB
apoptosome 1 CASP9
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 PPARGC1A
heteromeric SMAD protein complex 1 SMAD2
SMAD protein complex 1 SMAD2
protein-DNA complex 1 CTNNB1
external side of apical plasma membrane 1 ABCB1
nucleotide-activated protein kinase complex 1 PRKAA2
[Isoform Long]: Cell membrane 1 PECAM1
catenin complex 1 CTNNB1
platelet alpha granule membrane 1 PECAM1
activin responsive factor complex 1 SMAD2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
NADPH oxidase complex 1 CYBB
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
beta-catenin-TCF7L2 complex 1 CTNNB1
[Isoform Delta15]: Cell junction 1 PECAM1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
caspase complex 1 CASP9
homomeric SMAD protein complex 1 SMAD2
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Jianan Guo, Yifei Le, Aini Yuan, Jing Liu, Hang Chen, Jiannan Qiu, Cui Wang, Xiaobing Dou, Xingyu Yuan, Dezhao Lu. Astragaloside IV ameliorates cisplatin-induced liver injury by modulating ferroptosis-dependent pathways. Journal of ethnopharmacology. 2024 Jun; 328(?):118080. doi: 10.1016/j.jep.2024.118080. [PMID: 38521426]
  • Junfeng Guo, Yuwei Zhang, Rui Zhou, Yanwei Hao, Xuanyu Wu, Ganggang Li, Quanyu Du. Deciphering the molecular mechanism of Bu Yang Huan Wu Decoction in interference with diabetic pulmonary fibrosis via regulating oxidative stress and lipid metabolism disorder. Journal of pharmaceutical and biomedical analysis. 2024 Jun; 243(?):116061. doi: 10.1016/j.jpba.2024.116061. [PMID: 38430615]
  • Qiu-Yue Wang, Shu-Yu Liu, Dong-Hua Yu, Ping-Ping Chen, Yu Wang, Fang Lu, Shu-Min Liu. Evaluation of drug interactions of Saposhnikoviae Radix and its major components with astragaloside IV and paeoniflorin using in vitro and in vivo experiments. Journal of chromatography. A. 2024 May; 1723(?):464716. doi: 10.1016/j.chroma.2024.464716. [PMID: 38640881]
  • Tian-Ci Zhang, Yi-Can Lin, Ning-Ning Sun, Shan Liu, Wen-Zhu Hu, Yan Zhao, Xian-Hui Dong, Xiao-Ping He. Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation. Neurochemistry international. 2024 May; 175(?):105705. doi: 10.1016/j.neuint.2024.105705. [PMID: 38412923]
  • Xinhui Zhang, Fan Zhang, Yan Li, Na Fan, Ke Zhao, Anding Zhang, Jiefang Kang, Yan Lin, Xiaochang Xue, Xun Jiang. Blockade of PI3K/AKT signaling pathway by Astragaloside IV attenuates ulcerative colitis via improving the intestinal epithelial barrier. Journal of translational medicine. 2024 Apr; 22(1):406. doi: 10.1186/s12967-024-05168-w. [PMID: 38689349]
  • Guo Liu, Ye-Hui Wang, Ting Zhang, Ya-Qiong Li, Xin-Yue Chen, Wei Dong, Wei Li, Qi-Xiang Miao, Wen-Bo Qiao, Hui-Qiang Tian, Shi-Long Yin. Astragaloside-IV promotes autophagy via the Akt/mTOR pathway to improve cellular lipid deposition. Medicine. 2024 Apr; 103(16):e37846. doi: 10.1097/md.0000000000037846. [PMID: 38640324]
  • Xujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao, Wei Fu. Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathway. BMC cancer. 2024 Apr; 24(1):472. doi: 10.1186/s12885-024-12167-z. [PMID: 38622523]
  • Xiangyu Chen, Tong Yang, Yue Zhou, Zhigang Mei, Wenli Zhang. Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury. CNS neuroscience & therapeutics. 2024 04; 30(4):e14725. doi: 10.1111/cns.14725. [PMID: 38615367]
  • Yanyun Guan, Juan Zhang, Xinrui Cai, Yanan Cai, Ziqiong Song, Yuan Huang, Weibin Qian, Zhifeng Pan, Xingguo Zhang. Astragaloside IV inhibits epithelial-mesenchymal transition and pulmonary fibrosis via lncRNA-ATB/miR-200c/ZEB1 signaling pathway. Gene. 2024 Mar; 897(?):148040. doi: 10.1016/j.gene.2023.148040. [PMID: 38065426]
  • Tiaohao Li, Xiaojuan Gao, Rui Jia, Yanling Sun, Yeli Ding, Fei Wang, Yujuan Wang. Astragaloside IV inhibits idiopathic pulmonary fibrosis through activation of autophagy by miR-21-mediated PTEN/PI3K/AKT/mTOR pathway. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Feb; 70(2):128-136. doi: 10.14715/cmb/2024.70.2.18. [PMID: 38430031]
  • Yan-Ling Li, Zhan-Hui Lu, Yan-Yan Zhang, Sha-Sha Wu, Tian-Hao Xie, Huang Ding, Wei Zhang, Xiao-Dan Liu, Chang-Qing Deng. [Mechanism of astragaloside Ⅳ combined with Panax notoginseng saponins in regulating angiogenesis to treat cerebral ischemia based on network pharmacology and experimental verification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):1017-1027. doi: 10.19540/j.cnki.cjcmm.20230901.401. [PMID: 38621909]
  • Muzhe Li, Yuanyuan Niu, Linkun Tian, Tianchi Zhang, Shijie Zhou, Lining Wang, Jie Sun, Taxi Wumiti, Zhiwei Chen, Qinfeng Zhou, Yong Ma, Yang Guo. Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway. International immunopharmacology. 2024 Jan; 129(?):111588. doi: 10.1016/j.intimp.2024.111588. [PMID: 38290207]
  • Qing-Qing Yang, Hong-Ying Zhang, Xiao-Hong Duan, Mi-Hui Li, Jing Sun, Li-Xia Tian, Jing-Cheng Dong, Ling-Wen Kong. Astragaloside IV targeting autophagy of T cells improves inflammation of asthma. Journal of Asian natural products research. 2024 Jan; ?(?):1-15. doi: 10.1080/10286020.2023.2294069. [PMID: 38213072]
  • Xiaojie Liu, Senyan Wang, Xiaoling Wu, Ziyu Zhao, Chen Jian, Mengyu Li, Xuemei Qin. Astragaloside IV Alleviates Depression in Rats by Modulating Intestinal Microbiota, T-Immune Balance, and Metabolome. Journal of agricultural and food chemistry. 2024 Jan; 72(1):259-273. doi: 10.1021/acs.jafc.3c04063. [PMID: 38064688]
  • Jingge Xu, Zhiyu Zhang, Dongwen Ren, Luokun Liu, Haitao Xing, Dan Wang, Yuzheng Wu, Yi Zhang, Qian Chen, Tao Wang. Astragaloside Ⅳ negatively regulates Gpr97-TPL2 signaling to protect against hyperhomocysteine-exacerbated sepsis associated acute kidney injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 125(?):155346. doi: 10.1016/j.phymed.2024.155346. [PMID: 38237511]
  • Pengfei Kong, Xuemei Tang, Fang Liu, Xuegui Tang. Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression. Chemical biology & drug design. 2024 Jan; 103(1):e14423. doi: 10.1111/cbdd.14423. [PMID: 38230773]
  • Xu-Jun You, Zheng Wen, Qing-Xia Zheng, Qi-Xin Li, Wei Fu, Hai-Song Li, Bin Wang. [Explore the mechanism of astragaloside IV-PESV on proliferation, migration, and autophagy of prostate cancer cells based on the PI3K/AKT signaling pathway]. Zhonghua nan ke xue = National journal of andrology. 2023 Dec; 29(12):963-972. doi: ". [PMID: 38639947]
  • Zehui Xu, Houle Zhou, Yihan Zhang, Ziji Cheng, Melisandre Wan, Wanting Qin, Peiyu Li, Jiaming Feng, Shuijin Shao, Wenlong Xue, Haidong Guo, Baonian Liu. Recent pharmacological advances in the treatment of cardiovascular events with Astragaloside IV. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115752. doi: 10.1016/j.biopha.2023.115752. [PMID: 37875045]
  • Shan Wu, Fei Wen, Xiangbin Zhong, Wenjing Du, Manlian Chen, Junyi Wang. Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3/caspase-1 signaling pathway. Annals of medicine. 2023 Dec; 55(1):2216942. doi: 10.1080/07853890.2023.2216942. [PMID: 37243569]
  • Xiulian Zhang, Xueliang Li, Wei Ma, Fangying Liu, Pinxian Huang, Lei Wei, Li Li, Yechang Qian. Astragaloside IV restores Th17/Treg balance via inhibiting CXCR4 to improve chronic obstructive pulmonary disease. Immunopharmacology and immunotoxicology. 2023 Dec; 45(6):682-691. doi: 10.1080/08923973.2023.2228479. [PMID: 37417915]
  • Lin Zhou, Xiaohui Wang, Jinlan Xia, Liyuan Zhang, Lianping Xue, Qingquan Jia, Zhihui Fu, Zhi Sun. Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells. Biopharmaceutics & drug disposition. 2023 Dec; 44(6):406-419. doi: 10.1002/bdd.2377. [PMID: 37679901]
  • Wu Xiong, Xue Bai, Xi Zhang, Huajuan Lei, Hui Xiao, Luyao Zhang, Yuting Xiao, Qianpei Yang, Xiaoling Zou. Endothelial Progenitor-Cell-Derived Exosomes Induced by Astragaloside IV Accelerate Type I Diabetic-wound Healing via the PI3K/AKT/mTOR Pathway in Rats. Frontiers in bioscience (Landmark edition). 2023 Nov; 28(11):282. doi: 10.31083/j.fbl2811282. [PMID: 38062822]
  • Yue Shi, Xiujie Shi, Mingming Zhao, Sijia Ma, Yu Zhang. Pharmacological potential of Astragali Radix for the treatment of kidney diseases. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 123(?):155196. doi: 10.1016/j.phymed.2023.155196. [PMID: 37952410]
  • Bing Zhang, Shiying Huang, Zhuoting Liu, Xinhui Liu, Zilan Jiang, Jianping Chen, Youjia Zeng. Investigation of the Metabolism of Astragaloside IV in a Puromycin-Damaged Rat Model by UPLC-Q-TOF-MS/MS Analysis. Planta medica. 2023 Nov; ?(?):. doi: 10.1055/a-2186-3182. [PMID: 37931776]
  • Man Zhang, Wenshuang Wang, Kaixin Liu, Chao Jia, Yuanyuan Hou, Gang Bai. Astragaloside IV protects against lung injury and pulmonary fibrosis in COPD by targeting GTP-GDP domain of RAS and downregulating the RAS/RAF/FoxO signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 120(?):155066. doi: 10.1016/j.phymed.2023.155066. [PMID: 37690229]
  • Haihao Yang, Na Yin, Qianlan Gu, Zhao Wu, Ying Xu, Jie Gao, Dongdong Qin, Chunping Wan. Astragaloside IV reduces lung injury in lethal sepsis via promoting treg cells expansion and inhibiting inflammatory responses. Pakistan journal of pharmaceutical sciences. 2023 Nov; 36(6):1709-1718. doi: . [PMID: 38124410]
  • Milton Packer. Qiliqiangxin: A multifaceted holistic treatment for heart failure or a pharmacological probe for the identification of cardioprotective mechanisms?. European journal of heart failure. 2023 Oct; ?(?):. doi: 10.1002/ejhf.3068. [PMID: 37877337]
  • Hong Wang, Liangyin Wei, Dengxuan Mao, Xiaoyu Che, Xietao Ye, Yuping Liu, Yan Chen. Combination of oxymatrine (Om) and astragaloside IV (As) enhances the infiltration and function of TILs in triple-negative breast cancer (TNBC). International immunopharmacology. 2023 Oct; 125(Pt A):111026. doi: 10.1016/j.intimp.2023.111026. [PMID: 37866315]
  • Jingjing Wan, Zhen Zhang, Chennan Wu, Saisai Tian, Yibei Zang, Ge Jin, Qingyan Sun, Pin Wang, Xin Luan, Yili Yang, Xuelin Zhan, Lingyu Linda Ye, Dayue Darrel Duan, Xia Liu, Weidong Zhang. Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456. Signal transduction and targeted therapy. 2023 10; 8(1):414. doi: 10.1038/s41392-023-01660-9. [PMID: 37857609]
  • Jie Xi, Yan Ma, Dongmei Liu, Rong Li. Astragaloside IV restrains pyroptosis and fibrotic development of pulmonary artery smooth muscle cells to ameliorate pulmonary artery hypertension through the PHD2/HIF1α signaling pathway. BMC pulmonary medicine. 2023 Oct; 23(1):386. doi: 10.1186/s12890-023-02660-9. [PMID: 37828459]
  • Tang Ziyang, Hu Xirong, An Chongming, Li Tingxin. The potential molecular pathways of Astragaloside-IV in colorectal cancer: A systematic review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Oct; 167(?):115625. doi: 10.1016/j.biopha.2023.115625. [PMID: 37793276]
  • Zemei Liu, Yuanju Lv, Guangyan Zheng, Wenli Wu, Xin Che. Chitosan/Polylactic Acid Nanofibers Containing Astragaloside IV as a New Biodegradable Wound Dressing for Wound Healing. AAPS PharmSciTech. 2023 Oct; 24(7):202. doi: 10.1208/s12249-023-02650-4. [PMID: 37783916]
  • Jia-Xin Long, Meng-Zhi Tian, Xiao-Yi Chen, Yu Xiong, Huang-He Yu, Yong-Zhen Gong, Huang Ding, Ming-Xia Xie, Ke DU. [Mechanism of astragaloside Ⅳ in regulating autophagy of PC12 cells under oxygen-glucose deprivation by medicating Akt/mTOR/HIF-1α pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Oct; 48(19):5271-5277. doi: 10.19540/j.cnki.cjcmm.20230630.402. [PMID: 38114116]
  • Wu Xiong, Xi Zhang, Jianda Zhou, Jie Chen, Yu Liu, Yu Yan, Meixin Tan, Hongyu Huang, Yuqi Si, Yang Wei. Astragaloside IV promotes exosome secretion of endothelial progenitor cells to regulate PI3KR2/SPRED1 signaling and inhibit pyroptosis of diabetic endothelial cells. Cytotherapy. 2023 Sep; ?(?):. doi: 10.1016/j.jcyt.2023.08.013. [PMID: 37747393]
  • Xiao Zhao, Lixue Sun, Jing Wang, Xiaolu Xu, Shuting Ni, Mei Liu, Kaili Hu. Nose to brain delivery of Astragaloside IV by β-Asarone modified chitosan nanoparticles for multiple sclerosis therapy. International journal of pharmaceutics. 2023 Sep; 644(?):123351. doi: 10.1016/j.ijpharm.2023.123351. [PMID: 37640088]
  • Zhilin Li, En Hu, Fei Zheng, Song Wang, Wei Zhang, Jiekun Luo, Tao Tang, Qing Huang, Yang Wang. The effects of astragaloside IV on gut microbiota and serum metabolism in a mice model of intracerebral hemorrhage. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155086. doi: 10.1016/j.phymed.2023.155086. [PMID: 37783132]
  • Ning Liu, Yansu Ji, Rui Liu, Xin Jin. The state of astragaloside IV research: A bibliometric and visualized analysis. Fundamental & clinical pharmacology. 2023 Sep; ?(?):e12956. doi: 10.1111/fcp.12956. [PMID: 37700611]
  • Jianwei Ren, Yuetian Ding, Shangze Li, Ming Lei. Predicting the anti-inflammatory mechanism of Radix Astragali using network pharmacology and molecular docking. Medicine. 2023 Sep; 102(35):e34945. doi: 10.1097/md.0000000000034945. [PMID: 37657026]
  • Yunlong Chen, Mianhua Wu. Exploration of molecular mechanism underlying protective effect of astragaloside IV against radiation-induced lung injury by suppressing ferroptosis. Archives of biochemistry and biophysics. 2023 09; 745(?):109717. doi: 10.1016/j.abb.2023.109717. [PMID: 37573925]
  • Yutong Liang, Biqiong Chen, Di Liang, Xiaoxiao Quan, Ruolan Gu, Zhiyun Meng, Hui Gan, Zhuona Wu, Yunbo Sun, Shuchen Liu, Guifang Dou. Pharmacological Effects of Astragaloside IV: A Review. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166118. [PMID: 37630371]
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  • Wei Ning, Xiaogang Liao, Xingyou Dong, Yangcai Wang, Xingliang Yang, Jie Xu, Shanhong Yi, Zhenxing Yang. Protective effect of astragaloside IV on cadmium-induced spermatogenesis microenvironment damage in rats. Systems biology in reproductive medicine. 2022 Jun; 68(3):203-212. doi: 10.1080/19396368.2021.1983888. [PMID: 34711125]
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