Calycosin (BioDeep_00000000167)

Secondary id: BioDeep_00000270006, BioDeep_00000403130

human metabolite PANOMIX_OTCML-2023 blood metabolite

代谢物信息卡片

4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-

化学式: C16H12O5 (284.0684702)
中文名称: 毛蕊异黄酮, 异黄酮, 毛异黄酮
谱图信息: 最多检出来源 Homo sapiens(blood) 0.09%

分子结构信息

SMILES: c1(ccc2c(c1)occ(c2=O)c1cc(c(cc1)OC)O)O
InChI: InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3

描述信息

Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3 position and a methoxy group at the 4 position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4-methoxyisoflavones. It is functionally related to an isoflavone. It is a conjugate acid of a calycosin(1-).
Calycosin is a natural product found in Thermopsis lanceolata, Hedysarum polybotrys, and other organisms with data available.
A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Calycosin is a natural compound with antioxidant and anti-inflammatory activity.
Calycosin is a natural compound with antioxidant and anti-inflammatory activity.

同义名列表

21 个代谢物同义名

4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxy-phenyl)chromen-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one; CALYCOSIN (CONSTITUENT OF ASTRAGALUS) [DSC]; 7,3-dihydroxy-4-methoxyisoflavone; 3,7-dihydroxy-4-methoxyisoflavone; ZZAJQOPSWWVMBI-UHFFFAOYSA-N; 3-hydroxy-formononetin; 3-hydroxyformononetin; 3-Hydroxyformononetin; CALYCOSIN [USP-RS]; Calycosin (old); UNII-09N3E8P7TA; MEGxp0_001325; ACon1_000650; ?CALYCOSIN; 09N3E8P7TA; Calycosin; Cyclosin

数据库引用编号

20 个数据库交叉引用编号

ChEBI: CHEBI:17793
KEGG: C01562
PubChem: 5280448
HMDB: HMDB0249566
Metlin: METLIN47576
ChEMBL: CHEMBL241608
Wikipedia: Calycosin
LipidMAPS: LMPK12050056
MeSH: 7,3-dihydroxy-4-methoxyisoflavone
ChemIDplus: 0020575579
MetaCyc: CPD-9539
KNApSAcK: C00009389
foodb: FDB029972
chemspider: 4444104
CAS: 20575-57-9
medchemexpress: HY-N0519
PMhub: MS000011134
PubChem: 4720
3DMET: B00319
NIKKAJI: J16.804A

分类词条

代谢反应

31 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

rot-2'-enonate biosynthesis: 2',7-dihydroxy-4',5'-dimethoxyisoflavone + SAM ⟶ 7-hydroxy-2',4',5'-trimethoxyisoflavone + H⁺ + SAH
(-)-maackiain biosynthesis: (3R,4R)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-4,7-diol ⟶ (-)-maackiain + H₂O
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H₂O + an oxidized [NADPH-hemoprotein reductase]
superpathway of formononetin derivative biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H₂O + an oxidized [NADPH-hemoprotein reductase]
calycosin 7-O-glucoside biosynthesis: UDP-α-D-glucose + calycosin ⟶ H⁺ + UDP + calycosin 7-O-glucoside

WikiPathways(0)

Plant Reactome(3)

Metabolism and regulation: ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA
Secondary metabolism: GPP + H2O ⟶ PPi + geraniol
Maackiain biosynthesis: Oxygen + TPNH + formononetin ⟶ H2O + TPN + calycosin

INOH(0)

PlantCyc(23)

rot-2'-enonate biosynthesis: SAM + calycosin ⟶ 2',7-dihydroxy-4',5'-dimethoxyisoflavone + SAH
superpathway of pterocarpan biosynthesis (via formononetin): H⁺ + NADPH + O₂ + calycosin ⟶ H₂O + NADP⁺ + pseudobaptigenin
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + calycosin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + pseudobaptigenin
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + calycosin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + pseudobaptigenin
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H₂O + an oxidized [NADPH-hemoprotein reductase]
superpathway of formononetin derivative biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H₂O + an oxidized [NADPH-hemoprotein reductase]
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + calycosin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + pseudobaptigenin
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + calycosin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + pseudobaptigenin
superpathway of formononetin derivative biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
superpathway of pterocarpan biosynthesis (via formononetin): O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
(-)-maackiain biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
superpathway of formononetin derivative biosynthesis: O₂ + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ H₂O + an oxidized [NADPH-hemoprotein reductase] + calycosin
(-)-maackiain biosynthesis: (3R)-sophorol + NADP⁺ ⟶ 2'-hydroxypseudobaptigenin + H⁺ + NADPH
superpathway of formononetin derivative biosynthesis: (3R)-sophorol + NADP⁺ ⟶ 2'-hydroxypseudobaptigenin + H⁺ + NADPH
calycosin 7-O-glucoside biosynthesis: UDP-α-D-glucose + calycosin ⟶ H⁺ + UDP + calycosin 7-O-glucoside

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

47 个相关的物种来源信息

126911 - Ammopiptanthus mongolicus:
48131 - Amorpha fruticosa: 10.1016/S0031-9422(97)00960-6
53825 - Andira inermis:
588922 - Andira surinamensis: 10.1002/MRC.2138
649199 - Astragalus membranaceus:
1960787 - Astragalus microcephalus: 10.1007/S10600-011-9800-0
119829 - Astragalus mongholicus:
53838 - Bolusanthus speciosus: 10.1016/J.PHYTOCHEM.2004.02.011
149685 - Bowdichia virgilioides: 10.1080/14786410500160942
480422 - Butea superba: 10.3987/COM-05-10350
49799 - Calicotome villosa: 10.1016/S0367-326X(03)00061-3
500179 - Centrolobium paraense: 10.1016/S0031-9422(00)97984-6
500181 - Centrolobium sclerophyllum:
3827 - Cicer arietinum:
140906 - Cyclolobium brasiliense: 10.1016/0031-9422(75)80372-4
384038 - Cyclopia intermedia: 10.1021/JF980258X
1353466 - Dalbergia parviflora: 10.1021/NP900676Y
149639 - Dermatophyllum secundiflorum:
74859 - Glycyrrhiza pallidiflora:
74613 - Glycyrrhiza uralensis:
119828 - Hedysarum polybotrys: 10.1248/CPB.32.3267
9606 - Homo sapiens: -
37501 - Maackia amurensis:
2654228 - Machaerium aristulatum: 10.1055/S-2006-960825
1279044 - Melilotus messanensis: 10.1016/S0031-9422(98)00453-1
2747815 - Millettia laurentii: 10.1016/S0031-9422(99)00043-6
53906 - Myroxylon balsamum: 10.1016/S0031-9422(00)89391-7
1231556 - Myroxylon peruiferum: 10.1016/0031-9422(79)80020-5
1479707 - Oxytropis falcata: 10.1021/NP100339U
33090 - Plants: -
248527 - Psorothamnus arborescens: 10.1021/NP0502600
248528 - Psorothamnus arborescens var. minutifolius: 10.1021/NP0502600
224864 - Pycnanthus angolensis: 10.1080/14786419.2010.522577
49840 - Sophora flavescens: 10.1016/S0031-9422(02)00671-4
479969 - Sophora fraseri: 10.1016/S0031-9422(00)90868-9
1323965 - Sophora moorcroftiana: 10.1248/CPB.36.2220
455371 - Spatholobus suberectus:
455371 - Spatholobus Suberectus Dunn: -
3897 - Styphnolobium japonicum: 10.1007/S12272-010-0805-1
49853 - Thermopsis fabacea: 10.1248/CPB.28.3686
114320 - Thermopsis lanceolata: 10.1248/CPB.28.3686
57577 - Trifolium pratense:
78534 - Trigonella foenum-graecum: 10.1007/S11418-010-0407-8
58847 - Virgilia oroboides: 10.1016/0031-9422(90)80205-U
185975 - Wisteria brachybotrys: 10.1016/0031-9422(88)80628-9
33090 - 红芪: -
33090 - 黄芪: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Xin Ma, Guoshu Deng, Na Tian, Hao Wang, Hang Zhao, Le Kuai, Ying Luo, Chunjie Gao, Xiaojie Ding, Bin Li, Bin Li. Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis. Journal of ethnopharmacology. 2024 May; 326(?):117883. doi: 10.1016/j.jep.2024.117883. [PMID: 38331120]
Fangbing Ren, Yanhui Ma, Kexin Zhang, Youhong Luo, Ruiyan Pan, Jingwen Zhang, Chengxia Kan, Ningning Hou, Fang Han, Xiaodong Sun. Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment: A review. Medicine. 2024 May; 103(18):e38023. doi: 10.1097/md.0000000000038023. [PMID: 38701310]
Qiuxiang Chen, Juan Wang, Lihua Sun, Bayinsilema Ba, Difei Shen. Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking. Journal of cellular and molecular medicine. 2024 May; 28(10):e18331. doi: 10.1111/jcmm.18331. [PMID: 38780500]
Hong Su, Qiuju Yan, Wei Du, En Hu, Zhaoyu Yang, Wei Zhang, Yusheng Li, Tao Tang, Shushan Zhao, Yang Wang. Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism. BMC complementary medicine and therapies. 2024 Jan; 24(1):48. doi: 10.1186/s12906-023-04314-z. [PMID: 38254101]
Chi-Cheng Li, Cheng-You Lu, Chiung-Hung Hsu, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Tsung-Jung Ho, Wei-Wen Kuo, Cecilia Hsuan Day, Shih-Chieh Liao, Ming-Cheng Chen, Chih-Yang Huang. Calycosin inhibits gemcitabine-resistant lung cancer cells proliferation through modulation of the LDOC1/GNL3L/NFκB. The Chinese journal of physiology. 2023 Jul; 66(4):189-199. doi: 10.4103/cjop.cjop-d-23-00009. [PMID: 37635478]
Yuhong Li, Shuying Hu, Yueqi Chen, Xing Zhang, Hanchi Gao, Jing Tian, Jian Chen. Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jun; 118(?):154924. doi: 10.1016/j.phymed.2023.154924. [PMID: 37393829]
Jia Chen, Huike Ma, Yujiao Meng, Qingwu Liu, Yan Wang, Yan Lin, Danyang Yang, Wentao Yao, Yazhuo Wang, Xiujuan He, Ping Li. Analysis of the mechanism underlying diabetic wound healing acceleration by Calycosin-7-glycoside using network pharmacology and molecular docking. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154773. doi: 10.1016/j.phymed.2023.154773. [PMID: 36990011]
Qiongdan Hu, Bingwen Zhu, Guoqiang Yang, Jian Jia, Honglian Wang, Ruizhi Tan, Qiong Zhang, Li Wang, Fahsai Kantawong. Calycosin pretreatment enhanced the therapeutic efficacy of mesenchymal stem cells to alleviate unilateral ureteral obstruction-induced renal fibrosis by inhibiting necroptosis. Journal of pharmacological sciences. 2023 Feb; 151(2):72-83. doi: 10.1016/j.jphs.2022.12.001. [PMID: 36707181]
Shaohua You, Yanfeng Wang, Yongxin Guo, Chao Guo, Fuyang Cao, Wenzhu Shi, Lujia Yang, Weidong Mi, Li Tong. Activation of the ERK1/2 pathway mediates the neuroprotective effect provided by calycosin treatment. Neuroscience letters. 2023 01; 792(?):136956. doi: 10.1016/j.neulet.2022.136956. [PMID: 36347338]
Xiao-Ming Qi, Yuan-Biao Qiao, Yuan-Lin Zhang, Ai-Cheng Wang, Jin-Hong Ren, Hui-Zhi Wei, Qing-Shan Li. PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113513. doi: 10.1016/j.fct.2022.113513. [PMID: 36436616]
Wen-Jun Ding, Guang-Hong Chen, Sui-Hui Deng, Ke-Feng Zeng, Kai-Li Lin, Bo Deng, Shuang-Wei Zhang, Zhang-Bin Tan, You-Cai Xu, Si Chen, Jun-Bang Chen, Ting-Fang Chen, Yong-Zhen Tan, Ying-Chun Zhou, Jing-Zhi Zhang, Bin Liu. Calycosin protects against oxidative stress-induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2. Phytotherapy research : PTR. 2023 Jan; 37(1):35-49. doi: 10.1002/ptr.7591. [PMID: 36059198]
Di Huang, Peicheng Shen, Chen Wang, Jiandong Gao, Chaoyang Ye, Feng Wu. Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis. Pharmaceutical biology. 2022 Dec; 60(1):990-996. doi: 10.1080/13880209.2022.2067572. [PMID: 35587919]
Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment. Drug delivery. 2022 Dec; 29(1):2815-2823. doi: 10.1080/10717544.2022.2118401. [PMID: 36047255]
Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded mitochondria targeted lipid-polymer hybrid nano-system: Preparation, characterization, and anti myocardial infarction activity assessment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113650. doi: 10.1016/j.biopha.2022.113650. [PMID: 36130421]
Guanghong Chen, Honglin Xu, Tong Xu, Wenjun Ding, Guoyong Zhang, Yue Hua, Yuting Wu, Xin Han, Lingpeng Xie, Bin Liu, Yingchun Zhou. Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154277. doi: 10.1016/j.phymed.2022.154277. [PMID: 35752078]
Yingjun Song, Xu Li, Xiaozhou Liu, Zhaozhong Yu, Guofu Zhang. Calycosin Alleviates Oxidative Injury in Spinal Astrocytes by Regulating the GP130/JAK/STAT Pathway. Journal of oleo science. 2022 Jun; 71(6):881-887. doi: 10.5650/jos.ess21174. [PMID: 35584953]
Qianqian Chen, Jiayang Wan, Yangyang Zhang, Yu He, Yida Bao, Li Yu, Jiehong Yang. Pharmacokinetic-pharmacodynamic modeling analysis for hydroxysafflor yellow A-calycosin in compatibility in normal and cerebral ischemic rats: A comparative study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112950. doi: 10.1016/j.biopha.2022.112950. [PMID: 35427818]
Cheng-You Lu, Cecilia Hsuan Day, Chia-Hua Kuo, Tso-Fu Wang, Tsung-Jung Ho, Pei-Fang Lai, Ray-Jade Chen, Chun-Hsu Yao, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang. Calycosin alleviates H2 O2 -induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO-1 signaling pathway. Environmental toxicology. 2022 Apr; 37(4):858-867. doi: 10.1002/tox.23449. [PMID: 34990515]
Kun-Chang Wu, You-Cheng Hseu, Yu-Ching Shih, Govindan Sivakumar, Jyun-Ting Syu, Guan-Lin Chen, Meng-Tien Lu, Po-Chen Chu. Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031358. [PMID: 35163281]
Lei Zhang, Cundong Fan, Hua-Chen Jiao, Qian Zhang, Yue-Hua Jiang, Jie Cui, Yang Liu, Yong-Hao Jiang, Juan Zhang, Meng-Qi Yang, Yan Li, Yi-Tao Xue. Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation. Oxidative medicine and cellular longevity. 2022; 2022(?):1733834. doi: 10.1155/2022/1733834. [PMID: 35035656]
Chuanrui Ma, Han Wu, Guangyan Yang, Jiaqing Xiang, Ke Feng, Jing Zhang, Yunqing Hua, Lin Kang, Guanwei Fan, Shu Yang. Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice. British journal of pharmacology. 2022 01; 179(2):252-269. doi: 10.1111/bph.15720. [PMID: 34713437]
Chang-Ju Zhu, Wan-Guang Yang, De-Jian Li, Yao-Dong Song, San-Yang Chen, Qiao-Fang Wang, Yan-Na Liu, Yan Zhang, Bo Cheng, Zhong-Wei Wu, Zong-Chao Cui. Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation. World journal of gastroenterology. 2021 Nov; 27(44):7669-7686. doi: 10.3748/wjg.v27.i44.7669. [PMID: 34908806]
Nilupaier Tayier, Ning-Yi Qin, Li-Nan Zhao, Yi Zeng, Yu Wang, Guang Hu, Yuan-Qiang Wang. Theoretical Exploring of a Molecular Mechanism for Melanin Inhibitory Activity of Calycosin in Zebrafish. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226998. [PMID: 34834088]
Mao Deng, Huijuan Chen, Jiaying Long, Jiawen Song, Long Xie, Xiaofang Li. Calycosin: a Review of its Pharmacological Effects and Application Prospects. Expert review of anti-infective therapy. 2021 07; 19(7):911-925. doi: 10.1080/14787210.2021.1863145. [PMID: 33346681]
Xue Liu, Yumeng Shao, Xinyue Zhang, Xiang Ji, Min Xie, Huaman Liu. Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3β/β-catenin signaling pathway. Acta histochemica. 2021 Jul; 123(5):151746. doi: 10.1016/j.acthis.2021.151746. [PMID: 34217047]
Chunrong Huang, Lian-Fang Xue, Bo Hu, Huan-Huan Liu, Si-Bo Huang, Suliman Khan, Yu Meng. Calycosin-loaded nanoliposomes as potential nanoplatforms for treatment of diabetic nephropathy through regulation of mitochondrial respiratory function. Journal of nanobiotechnology. 2021 Jun; 19(1):178. doi: 10.1186/s12951-021-00917-1. [PMID: 34120609]
Xiaoguang Lu, Linghui Lu, Li Gao, Yong Wang, Wei Wang. Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111375. doi: 10.1016/j.biopha.2021.111375. [PMID: 33761601]
Li Pan, Xuan-Fen Zhang, Wan-Sheng Wei, Jing Zhang, Zhen-Zhen Li. The cardiovascular protective effect and mechanism of calycosin and its derivatives. Chinese journal of natural medicines. 2020 Dec; 18(12):907-915. doi: 10.1016/s1875-5364(20)60034-6. [PMID: 33357721]
Xiaohuan Ding, Jing Lv, Jia Luan, Jun Zhang. Calycosin may Alleviate Ang II-Induced Pro-proliferative Effects on Glomerular Mesangial Cells via Partially Inhibiting Autophagy and ERK Signaling Pathway. Biological & pharmaceutical bulletin. 2020 Dec; 43(12):1893-1898. doi: 10.1248/bpb.b20-00520. [PMID: 32999213]
Yulong Gu, Xianglan Piao, Dan Zhu. Simultaneous determination of calycosin, prim-O-glucosylcimifugin, and paeoniflorin in rat plasma by HPLC-MS/MS: application in the pharmacokinetic analysis of HQCF. The Journal of international medical research. 2020 Nov; 48(11):300060520972902. doi: 10.1177/0300060520972902. [PMID: 33213240]
Rong Hu, Ming-Qing Wang, Ling-Yu Liu, Hai-Yan You, Xiao-Hui Wu, Yang-Yang Liu, Yan-Jing Wang, Lu Lu, Wei Xiao, Lian-Bo Wei. Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway. Journal of cellular and molecular medicine. 2020 10; 24(19):11084-11099. doi: 10.1111/jcmm.15514. [PMID: 32910538]
Jin-Qiang Li, Chao-Jiang Xiao, Ye-Meng Li, Xin-Yan Tian, Xiang Dong, Bei Jiang. Astrernestin, a novel aurone-phenylpropanoid adduct from the roots of Astragalus ernestii. Natural product research. 2020 Oct; 34(20):2894-2899. doi: 10.1080/14786419.2019.1596101. [PMID: 30990071]
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