Calycosin (BioDeep_00000000167)

 

Secondary id: BioDeep_00000270006, BioDeep_00000403130

human metabolite PANOMIX_OTCML-2023 blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-

化学式: C16H12O5 (284.0684702)
中文名称: 毛蕊异黄酮, 异黄酮, 毛异黄酮
谱图信息: 最多检出来源 Homo sapiens(blood) 0.09%

分子结构信息

SMILES: c1(ccc2c(c1)occ(c2=O)c1cc(c(cc1)OC)O)O
InChI: InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3

描述信息

Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3 position and a methoxy group at the 4 position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4-methoxyisoflavones. It is functionally related to an isoflavone. It is a conjugate acid of a calycosin(1-).
Calycosin is a natural product found in Thermopsis lanceolata, Hedysarum polybotrys, and other organisms with data available.
A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Calycosin is a natural compound with antioxidant and anti-inflammatory activity.
Calycosin is a natural compound with antioxidant and anti-inflammatory activity.

同义名列表

22 个代谢物同义名

4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxy-phenyl)chromen-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one; CALYCOSIN (CONSTITUENT OF ASTRAGALUS) [DSC]; 7,3-dihydroxy-4-methoxyisoflavone; 3,7-dihydroxy-4-methoxyisoflavone; ZZAJQOPSWWVMBI-UHFFFAOYSA-N; 3-hydroxy-formononetin; 3-hydroxyformononetin; 3-Hydroxyformononetin; CALYCOSIN [USP-RS]; Calycosin (old); UNII-09N3E8P7TA; MEGxp0_001325; ACon1_000650; ?CALYCOSIN; 09N3E8P7TA; Calycosin; Cyclosin; Calycosin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(3)

代谢反应

31 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(23)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

176 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xin Ma, Guoshu Deng, Na Tian, Hao Wang, Hang Zhao, Le Kuai, Ying Luo, Chunjie Gao, Xiaojie Ding, Bin Li, Bin Li. Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis. Journal of ethnopharmacology. 2024 May; 326(?):117883. doi: 10.1016/j.jep.2024.117883. [PMID: 38331120]
  • Fangbing Ren, Yanhui Ma, Kexin Zhang, Youhong Luo, Ruiyan Pan, Jingwen Zhang, Chengxia Kan, Ningning Hou, Fang Han, Xiaodong Sun. Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment: A review. Medicine. 2024 May; 103(18):e38023. doi: 10.1097/md.0000000000038023. [PMID: 38701310]
  • Qiuxiang Chen, Juan Wang, Lihua Sun, Bayinsilema Ba, Difei Shen. Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking. Journal of cellular and molecular medicine. 2024 May; 28(10):e18331. doi: 10.1111/jcmm.18331. [PMID: 38780500]
  • Hong Su, Qiuju Yan, Wei Du, En Hu, Zhaoyu Yang, Wei Zhang, Yusheng Li, Tao Tang, Shushan Zhao, Yang Wang. Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism. BMC complementary medicine and therapies. 2024 Jan; 24(1):48. doi: 10.1186/s12906-023-04314-z. [PMID: 38254101]
  • Chi-Cheng Li, Cheng-You Lu, Chiung-Hung Hsu, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Tsung-Jung Ho, Wei-Wen Kuo, Cecilia Hsuan Day, Shih-Chieh Liao, Ming-Cheng Chen, Chih-Yang Huang. Calycosin inhibits gemcitabine-resistant lung cancer cells proliferation through modulation of the LDOC1/GNL3L/NFκB. The Chinese journal of physiology. 2023 Jul; 66(4):189-199. doi: 10.4103/cjop.cjop-d-23-00009. [PMID: 37635478]
  • Yuhong Li, Shuying Hu, Yueqi Chen, Xing Zhang, Hanchi Gao, Jing Tian, Jian Chen. Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jun; 118(?):154924. doi: 10.1016/j.phymed.2023.154924. [PMID: 37393829]
  • Jia Chen, Huike Ma, Yujiao Meng, Qingwu Liu, Yan Wang, Yan Lin, Danyang Yang, Wentao Yao, Yazhuo Wang, Xiujuan He, Ping Li. Analysis of the mechanism underlying diabetic wound healing acceleration by Calycosin-7-glycoside using network pharmacology and molecular docking. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154773. doi: 10.1016/j.phymed.2023.154773. [PMID: 36990011]
  • Qiongdan Hu, Bingwen Zhu, Guoqiang Yang, Jian Jia, Honglian Wang, Ruizhi Tan, Qiong Zhang, Li Wang, Fahsai Kantawong. Calycosin pretreatment enhanced the therapeutic efficacy of mesenchymal stem cells to alleviate unilateral ureteral obstruction-induced renal fibrosis by inhibiting necroptosis. Journal of pharmacological sciences. 2023 Feb; 151(2):72-83. doi: 10.1016/j.jphs.2022.12.001. [PMID: 36707181]
  • Shaohua You, Yanfeng Wang, Yongxin Guo, Chao Guo, Fuyang Cao, Wenzhu Shi, Lujia Yang, Weidong Mi, Li Tong. Activation of the ERK1/2 pathway mediates the neuroprotective effect provided by calycosin treatment. Neuroscience letters. 2023 01; 792(?):136956. doi: 10.1016/j.neulet.2022.136956. [PMID: 36347338]
  • Xiao-Ming Qi, Yuan-Biao Qiao, Yuan-Lin Zhang, Ai-Cheng Wang, Jin-Hong Ren, Hui-Zhi Wei, Qing-Shan Li. PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113513. doi: 10.1016/j.fct.2022.113513. [PMID: 36436616]
  • Wen-Jun Ding, Guang-Hong Chen, Sui-Hui Deng, Ke-Feng Zeng, Kai-Li Lin, Bo Deng, Shuang-Wei Zhang, Zhang-Bin Tan, You-Cai Xu, Si Chen, Jun-Bang Chen, Ting-Fang Chen, Yong-Zhen Tan, Ying-Chun Zhou, Jing-Zhi Zhang, Bin Liu. Calycosin protects against oxidative stress-induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2. Phytotherapy research : PTR. 2023 Jan; 37(1):35-49. doi: 10.1002/ptr.7591. [PMID: 36059198]
  • Di Huang, Peicheng Shen, Chen Wang, Jiandong Gao, Chaoyang Ye, Feng Wu. Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis. Pharmaceutical biology. 2022 Dec; 60(1):990-996. doi: 10.1080/13880209.2022.2067572. [PMID: 35587919]
  • Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment. Drug delivery. 2022 Dec; 29(1):2815-2823. doi: 10.1080/10717544.2022.2118401. [PMID: 36047255]
  • Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded mitochondria targeted lipid-polymer hybrid nano-system: Preparation, characterization, and anti myocardial infarction activity assessment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113650. doi: 10.1016/j.biopha.2022.113650. [PMID: 36130421]
  • Guanghong Chen, Honglin Xu, Tong Xu, Wenjun Ding, Guoyong Zhang, Yue Hua, Yuting Wu, Xin Han, Lingpeng Xie, Bin Liu, Yingchun Zhou. Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154277. doi: 10.1016/j.phymed.2022.154277. [PMID: 35752078]
  • Yingjun Song, Xu Li, Xiaozhou Liu, Zhaozhong Yu, Guofu Zhang. Calycosin Alleviates Oxidative Injury in Spinal Astrocytes by Regulating the GP130/JAK/STAT Pathway. Journal of oleo science. 2022 Jun; 71(6):881-887. doi: 10.5650/jos.ess21174. [PMID: 35584953]
  • Qianqian Chen, Jiayang Wan, Yangyang Zhang, Yu He, Yida Bao, Li Yu, Jiehong Yang. Pharmacokinetic-pharmacodynamic modeling analysis for hydroxysafflor yellow A-calycosin in compatibility in normal and cerebral ischemic rats: A comparative study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112950. doi: 10.1016/j.biopha.2022.112950. [PMID: 35427818]
  • Cheng-You Lu, Cecilia Hsuan Day, Chia-Hua Kuo, Tso-Fu Wang, Tsung-Jung Ho, Pei-Fang Lai, Ray-Jade Chen, Chun-Hsu Yao, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang. Calycosin alleviates H2 O2 -induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO-1 signaling pathway. Environmental toxicology. 2022 Apr; 37(4):858-867. doi: 10.1002/tox.23449. [PMID: 34990515]
  • Kun-Chang Wu, You-Cheng Hseu, Yu-Ching Shih, Govindan Sivakumar, Jyun-Ting Syu, Guan-Lin Chen, Meng-Tien Lu, Po-Chen Chu. Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031358. [PMID: 35163281]
  • Lei Zhang, Cundong Fan, Hua-Chen Jiao, Qian Zhang, Yue-Hua Jiang, Jie Cui, Yang Liu, Yong-Hao Jiang, Juan Zhang, Meng-Qi Yang, Yan Li, Yi-Tao Xue. Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation. Oxidative medicine and cellular longevity. 2022; 2022(?):1733834. doi: 10.1155/2022/1733834. [PMID: 35035656]
  • Chuanrui Ma, Han Wu, Guangyan Yang, Jiaqing Xiang, Ke Feng, Jing Zhang, Yunqing Hua, Lin Kang, Guanwei Fan, Shu Yang. Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice. British journal of pharmacology. 2022 01; 179(2):252-269. doi: 10.1111/bph.15720. [PMID: 34713437]
  • Chang-Ju Zhu, Wan-Guang Yang, De-Jian Li, Yao-Dong Song, San-Yang Chen, Qiao-Fang Wang, Yan-Na Liu, Yan Zhang, Bo Cheng, Zhong-Wei Wu, Zong-Chao Cui. Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation. World journal of gastroenterology. 2021 Nov; 27(44):7669-7686. doi: 10.3748/wjg.v27.i44.7669. [PMID: 34908806]
  • Nilupaier Tayier, Ning-Yi Qin, Li-Nan Zhao, Yi Zeng, Yu Wang, Guang Hu, Yuan-Qiang Wang. Theoretical Exploring of a Molecular Mechanism for Melanin Inhibitory Activity of Calycosin in Zebrafish. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226998. [PMID: 34834088]
  • Mao Deng, Huijuan Chen, Jiaying Long, Jiawen Song, Long Xie, Xiaofang Li. Calycosin: a Review of its Pharmacological Effects and Application Prospects. Expert review of anti-infective therapy. 2021 07; 19(7):911-925. doi: 10.1080/14787210.2021.1863145. [PMID: 33346681]
  • Xue Liu, Yumeng Shao, Xinyue Zhang, Xiang Ji, Min Xie, Huaman Liu. Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3β/β-catenin signaling pathway. Acta histochemica. 2021 Jul; 123(5):151746. doi: 10.1016/j.acthis.2021.151746. [PMID: 34217047]
  • Chunrong Huang, Lian-Fang Xue, Bo Hu, Huan-Huan Liu, Si-Bo Huang, Suliman Khan, Yu Meng. Calycosin-loaded nanoliposomes as potential nanoplatforms for treatment of diabetic nephropathy through regulation of mitochondrial respiratory function. Journal of nanobiotechnology. 2021 Jun; 19(1):178. doi: 10.1186/s12951-021-00917-1. [PMID: 34120609]
  • Xiaoguang Lu, Linghui Lu, Li Gao, Yong Wang, Wei Wang. Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111375. doi: 10.1016/j.biopha.2021.111375. [PMID: 33761601]
  • Li Pan, Xuan-Fen Zhang, Wan-Sheng Wei, Jing Zhang, Zhen-Zhen Li. The cardiovascular protective effect and mechanism of calycosin and its derivatives. Chinese journal of natural medicines. 2020 Dec; 18(12):907-915. doi: 10.1016/s1875-5364(20)60034-6. [PMID: 33357721]
  • Xiaohuan Ding, Jing Lv, Jia Luan, Jun Zhang. Calycosin may Alleviate Ang II-Induced Pro-proliferative Effects on Glomerular Mesangial Cells via Partially Inhibiting Autophagy and ERK Signaling Pathway. Biological & pharmaceutical bulletin. 2020 Dec; 43(12):1893-1898. doi: 10.1248/bpb.b20-00520. [PMID: 32999213]
  • Yulong Gu, Xianglan Piao, Dan Zhu. Simultaneous determination of calycosin, prim-O-glucosylcimifugin, and paeoniflorin in rat plasma by HPLC-MS/MS: application in the pharmacokinetic analysis of HQCF. The Journal of international medical research. 2020 Nov; 48(11):300060520972902. doi: 10.1177/0300060520972902. [PMID: 33213240]
  • Rong Hu, Ming-Qing Wang, Ling-Yu Liu, Hai-Yan You, Xiao-Hui Wu, Yang-Yang Liu, Yan-Jing Wang, Lu Lu, Wei Xiao, Lian-Bo Wei. Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway. Journal of cellular and molecular medicine. 2020 10; 24(19):11084-11099. doi: 10.1111/jcmm.15514. [PMID: 32910538]
  • Jin-Qiang Li, Chao-Jiang Xiao, Ye-Meng Li, Xin-Yan Tian, Xiang Dong, Bei Jiang. Astrernestin, a novel aurone-phenylpropanoid adduct from the roots of Astragalus ernestii. Natural product research. 2020 Oct; 34(20):2894-2899. doi: 10.1080/14786419.2019.1596101. [PMID: 30990071]
  • Yuan Li, Bide Duan, Ying Li, Shujun Yu, Yanyun Wang. The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression. Immunopharmacology and immunotoxicology. 2020 Aug; 42(4):366-372. doi: 10.1080/08923973.2020.1782426. [PMID: 32538204]
  • Wei-Yuan Yuan, Lian-Qu Li, Yan-Yan Chen, Yi-Jing Zhou, Kai-Fan Bao, Jie Zheng, Yong-Qing Hua, Guo-Rong Jiang, Min Hong. Frontline Science: Two flavonoid compounds attenuate allergic asthma by regulating epithelial barrier via G protein-coupled estrogen receptor: Probing a possible target for allergic inflammation. Journal of leukocyte biology. 2020 07; 108(1):59-71. doi: 10.1002/jlb.3hi0220-342rr. [PMID: 32303124]
  • Xuebing Cheng, Na Liu, Hangyu Liu, Na Huang, Xiaodong Sun, Guangdong Zhang. Bioinformatic and biochemical findings disclosed anti-hepatic steatosis mechanism of calycosin. Bioorganic chemistry. 2020 07; 100(?):103914. doi: 10.1016/j.bioorg.2020.103914. [PMID: 32417523]
  • Jong Min Oh, Hyun-Jae Jang, Won Jun Kim, Myung-Gyun Kang, Seung Cheol Baek, Jae Pil Lee, Daeui Park, Sei-Ryang Oh, Hoon Kim. Calycosin and 8-O-methylretusin isolated from Maackia amurensis as potent and selective reversible inhibitors of human monoamine oxidase-B. International journal of biological macromolecules. 2020 May; 151(?):441-448. doi: 10.1016/j.ijbiomac.2020.02.144. [PMID: 32087226]
  • Jie Huang, Hongyuan Shen, Mi Jiang, Lihua Huang, Yuan Yuan, Qian Wang. Calycosin reduces infarct size, oxidative stress and preserve heart function in isoproterenol-induced myocardial infarction model. Pakistan journal of pharmaceutical sciences. 2020 May; 33(3(Special)):1341-1347. doi: . [PMID: 33361020]
  • Zhu Zhang, Kathy Ka-Wai Auyeung, Stephen Cho-Wing Sze, Shiqing Zhang, Ken Kin-Lam Yung, Joshua Ka-Shun Ko. The dual roles of calycosin in growth inhibition and metastatic progression during pancreatic cancer development: A "TGF-β paradox". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153177. doi: 10.1016/j.phymed.2020.153177. [PMID: 32106002]
  • Nehal M Elsherbiny, Eman Said, Hoda Atef, Sawsan A Zaitone. Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression. Chemico-biological interactions. 2020 Jan; 315(?):108897. doi: 10.1016/j.cbi.2019.108897. [PMID: 31726037]
  • Danyan Li, Luqing Zhao, Yuxin Li, Xiuhong Kang, Shengsheng Zhang. Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats. Drug design, development and therapy. 2020; 14(?):2207-2219. doi: 10.2147/dddt.s247958. [PMID: 32606591]
  • Mei-Ling Wu, Yi-Ping Lin, Yan-Li Wei, Hong-Jian Du, Xiao-Qian Ying, Wen-Zhuang Tan, Bi-E Tang. Calycosin Influences the Metabolism of Five Probe Drugs in Rats. Drug design, development and therapy. 2020; 14(?):429-434. doi: 10.2147/dddt.s236221. [PMID: 32099327]
  • Lu Yao, Siqi Wang, Pan Wei, Kaifan Bao, Weiyuan Yuan, Xiaotong Wang, Jie Zheng, Min Hong. Huangqi-Fangfeng protects against allergic airway remodeling through inhibiting epithelial-mesenchymal transition process in mice via regulating epithelial derived TGF-β1. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Nov; 64(?):153076. doi: 10.1016/j.phymed.2019.153076. [PMID: 31473579]
  • Faiza Khushdil, Farzana Gul Jan, Gul Jan, Muhammad Hamayun, Amjad Iqbal, Anwar Hussain, Nusrat Bibi. Salt stress alleviation in Pennisetum glaucum through secondary metabolites modulation by Aspergillus terreus. Plant physiology and biochemistry : PPB. 2019 Nov; 144(?):127-134. doi: 10.1016/j.plaphy.2019.09.038. [PMID: 31563093]
  • Lvkeng Luo, Shuling Wu, Xiaoxiao Zhu, Weiwei Su. The profiling and identification of the absorbed constituents and metabolites of Naoshuantong capsule in mice biofluids and brain by ultra- fast liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121791. doi: 10.1016/j.jchromb.2019.121791. [PMID: 31610480]
  • Qi Ni, Yani Fan, Xiong Zhang, Hongwei Fan, Yingbin Li. In vitro and in vivo Study on Glioma Treatment Enhancement by Combining Temozolomide with Calycosin and Formononetin. Journal of ethnopharmacology. 2019 Oct; 242(?):111699. doi: 10.1016/j.jep.2019.01.023. [PMID: 31005632]
  • Mingya Ding, Wenfang Ma, Xiaoyan Wang, Shujing Chen, Shuhan Zou, Jinna Wei, Yuqiao Yang, Jin Li, Xuejing Yang, Hui Wang, Yuhong Li, Qilong Wang, Haoping Mao, Xiu-Mei Gao, Yan-Xu Chang. A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease. Journal of ethnopharmacology. 2019 Oct; 242(?):112055. doi: 10.1016/j.jep.2019.112055. [PMID: 31276751]
  • Chen Huang, Rong Li, Wuxiang Shi, Zhaoquan Huang. Discovery of the Anti-Tumor Mechanism of Calycosin Against Colorectal Cancer by Using System Pharmacology Approach. Medical science monitor : international medical journal of experimental and clinical research. 2019 Jul; 25(?):5589-5593. doi: 10.12659/msm.918250. [PMID: 31352466]
  • Qing-Yan Gai, Jiao Jiao, Xin Wang, Jing Liu, Zi-Ying Wang, Yu-Jie Fu. Chitosan promoting formononetin and calycosin accumulation in Astragalus membranaceus hairy root cultures via mitogen-activated protein kinase signaling cascades. Scientific reports. 2019 07; 9(1):10367. doi: 10.1038/s41598-019-46820-6. [PMID: 31316129]
  • Ling He, Xiaoqian Shi, S W Seto, C Dennis, Heng Wang, Sheng Zhang, Weidong Chen, Jian Wang. Using 3D-UPLC-DAD and a new method-verification by adding mixture standard compounds to determine the fingerprint and eight active components of Naoluoxintong decoction. Journal of pharmaceutical and biomedical analysis. 2019 May; 169(?):60-69. doi: 10.1016/j.jpba.2018.12.046. [PMID: 30836247]
  • Aditi Wagle, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi. Identifying an isoflavone from the root of Pueraria lobata as a potent tyrosinase inhibitor. Food chemistry. 2019 Mar; 276(?):383-389. doi: 10.1016/j.foodchem.2018.10.008. [PMID: 30409609]
  • Ying-Ying Zhang, Rui-Zhi Tan, Xiao-Qin Zhang, Ying Yu, Chen Yu. Calycosin Ameliorates Diabetes-Induced Renal Inflammation via the NF-κB Pathway In Vitro and In Vivo. Medical science monitor : international medical journal of experimental and clinical research. 2019 Mar; 25(?):1671-1678. doi: 10.12659/msm.915242. [PMID: 30830898]
  • Xiang Liu, Zhi-Hong Xie, Chen-Yuan Liu, Ying Zhang. Effect of Chinese Herbal Monomer Hairy Calycosin on Nonalcoholic Fatty Liver Rats and its Mechanism. Combinatorial chemistry & high throughput screening. 2019; 22(3):194-200. doi: 10.2174/1386207322666190411112814. [PMID: 30973105]
  • Jing Xie, Jing Xiong, Li-Sheng Ding, Li Chen, Hua Zhou, Liang Liu, Zhi-Feng Zhang, Xue-Mei Hu, Pei Luo, Lin-Sen Qing. A efficient method to identify cardioprotective components of Astragali Radix using a combination of molecularly imprinted polymers-based knockout extract and activity evaluation. Journal of chromatography. A. 2018 Nov; 1576(?):10-18. doi: 10.1016/j.chroma.2018.09.027. [PMID: 30245072]
  • John Nii Addotey, Isabelle Lengers, Joachim Jose, Nóra Gampe, Szabolcs Béni, Frank Petereit, Andreas Hensel. Isoflavonoids with inhibiting effects on human hyaluronidase-1 and norneolignan clitorienolactone B from Ononis spinosa L. root extract. Fitoterapia. 2018 Oct; 130(?):169-174. doi: 10.1016/j.fitote.2018.08.013. [PMID: 30176279]
  • Haitao Sun, Mengfan Yin, Weiqing Qian, Hong Yin. Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2018 Sep; 24(?):6178-6186. doi: 10.12659/msm.910201. [PMID: 30182951]
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