Calycosin (BioDeep_00000000167)

 

Secondary id: BioDeep_00000270006, BioDeep_00000403130

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-

化学式: C16H12O5 (284.0685)
中文名称: 毛蕊异黄酮, 异黄酮, 毛异黄酮
谱图信息: 最多检出来源 Homo sapiens(blood) 32.92%

分子结构信息

SMILES: c1(ccc2c(c1)occ(c2=O)c1cc(c(cc1)OC)O)O
InChI: InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3

描述信息

Calycosin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3 position and a methoxy group at the 4 position. It has a role as a metabolite and an antioxidant. It is a member of 7-hydroxyisoflavones and a member of 4-methoxyisoflavones. It is functionally related to an isoflavone. It is a conjugate acid of a calycosin(1-).
Calycosin is a natural product found in Thermopsis lanceolata, Hedysarum polybotrys, and other organisms with data available.
A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Calycosin is a natural compound with antioxidant and anti-inflammatory activity.
Calycosin is a natural compound with antioxidant and anti-inflammatory activity.

同义名列表

22 个代谢物同义名

4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxy-phenyl)chromen-4-one; 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one; CALYCOSIN (CONSTITUENT OF ASTRAGALUS) [DSC]; 7,3-dihydroxy-4-methoxyisoflavone; 3,7-dihydroxy-4-methoxyisoflavone; ZZAJQOPSWWVMBI-UHFFFAOYSA-N; 3-hydroxy-formononetin; 3-hydroxyformononetin; 3-Hydroxyformononetin; CALYCOSIN [USP-RS]; Calycosin (old); UNII-09N3E8P7TA; MEGxp0_001325; ACon1_000650; ?CALYCOSIN; 09N3E8P7TA; Calycosin; Cyclosin; Calycosin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(3)

代谢反应

31 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(23)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

176 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 18 AKT1, ANG, BCL2, CASP3, CCND1, CTNNB1, EGFR, ESR1, MAPK14, MTOR, NFE2L2, NLRP3, PIK3CA, PRKAA2, PTGS2, RELA, STAT3, VEGFA
Peripheral membrane protein 3 ESR1, MTOR, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 BCL2, EGFR, MTOR, PTGS2
Nucleus 17 AKT1, ANG, BCL2, CASP3, CCND1, CTNNB1, EGFR, ESR1, ESR2, MAPK14, MTOR, NFE2L2, NLRP3, PRKAA2, RELA, STAT3, VEGFA
cytosol 15 AKT1, ANG, BCL2, CASP3, CCND1, CTNNB1, ESR1, MAPK14, MTOR, NFE2L2, NLRP3, PIK3CA, PRKAA2, RELA, STAT3
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 3 CCND1, CTNNB1, NFE2L2
nucleoplasm 12 AKT1, CASP3, CCND1, CTNNB1, ESR1, ESR2, MAPK14, MTOR, NFE2L2, PRKAA2, RELA, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 4 AKT1, CTNNB1, EGFR, ESR1
Cytoplasmic side 2 ESR1, MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 1 CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 2 CTNNB1, EGFR
cell surface 2 EGFR, VEGFA
glutamatergic synapse 6 AKT1, CASP3, CTNNB1, EGFR, MAPK14, RELA
Golgi apparatus 4 ESR1, NFE2L2, PRKAA2, VEGFA
Golgi membrane 4 EGFR, INS, MTOR, NLRP3
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 3 ANG, CASP3, PRKAA2
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 2 NFE2L2, NLRP3
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 7 AKT1, CTNNB1, EGFR, ESR1, NFE2L2, PIK3CA, STAT3
Membrane 9 AKT1, BCL2, CTNNB1, EGFR, ESR1, MTOR, NLRP3, PRKAA2, VEGFA
apical plasma membrane 1 EGFR
axon 1 PRKAA2
basolateral plasma membrane 2 CTNNB1, EGFR
caveola 1 PTGS2
extracellular exosome 1 CTNNB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, NLRP3, PTGS2, VEGFA
extracellular space 4 ANG, EGFR, INS, VEGFA
perinuclear region of cytoplasm 3 CTNNB1, EGFR, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, ESR2, MAPK14, NLRP3
protein-containing complex 6 AKT1, BCL2, CTNNB1, EGFR, ESR1, PTGS2
intracellular membrane-bounded organelle 1 ESR2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 EGFR
Secreted 4 ANG, INS, NLRP3, VEGFA
extracellular region 5 ANG, INS, MAPK14, NLRP3, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
transcription regulator complex 4 CTNNB1, ESR1, RELA, STAT3
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CCND1, EGFR
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 1 ANG
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Membrane raft 1 EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CTNNB1, EGFR
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 VEGFA
basement membrane 1 ANG
intracellular vesicle 1 EGFR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 MAPK14, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 5 ESR1, ESR2, NFE2L2, RELA, STAT3
mediator complex 1 NFE2L2
cell periphery 1 CTNNB1
Chromosome 1 ANG
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 ANG
spindle pole 2 CTNNB1, MAPK14
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Endomembrane system 3 CTNNB1, MTOR, NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 2 CTNNB1, ESR1
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 ESR1
protein-DNA complex 2 CTNNB1, NFE2L2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
angiogenin-PRI complex 1 ANG
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Xin Ma, Guoshu Deng, Na Tian, Hao Wang, Hang Zhao, Le Kuai, Ying Luo, Chunjie Gao, Xiaojie Ding, Bin Li, Bin Li. Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis. Journal of ethnopharmacology. 2024 May; 326(?):117883. doi: 10.1016/j.jep.2024.117883. [PMID: 38331120]
  • Fangbing Ren, Yanhui Ma, Kexin Zhang, Youhong Luo, Ruiyan Pan, Jingwen Zhang, Chengxia Kan, Ningning Hou, Fang Han, Xiaodong Sun. Exploring the multi-targeting phytoestrogen potential of Calycosin for cancer treatment: A review. Medicine. 2024 May; 103(18):e38023. doi: 10.1097/md.0000000000038023. [PMID: 38701310]
  • Qiuxiang Chen, Juan Wang, Lihua Sun, Bayinsilema Ba, Difei Shen. Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking. Journal of cellular and molecular medicine. 2024 May; 28(10):e18331. doi: 10.1111/jcmm.18331. [PMID: 38780500]
  • Hong Su, Qiuju Yan, Wei Du, En Hu, Zhaoyu Yang, Wei Zhang, Yusheng Li, Tao Tang, Shushan Zhao, Yang Wang. Calycosin ameliorates osteoarthritis by regulating the imbalance between chondrocyte synthesis and catabolism. BMC complementary medicine and therapies. 2024 Jan; 24(1):48. doi: 10.1186/s12906-023-04314-z. [PMID: 38254101]
  • Chi-Cheng Li, Cheng-You Lu, Chiung-Hung Hsu, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Tsung-Jung Ho, Wei-Wen Kuo, Cecilia Hsuan Day, Shih-Chieh Liao, Ming-Cheng Chen, Chih-Yang Huang. Calycosin inhibits gemcitabine-resistant lung cancer cells proliferation through modulation of the LDOC1/GNL3L/NFκB. The Chinese journal of physiology. 2023 Jul; 66(4):189-199. doi: 10.4103/cjop.cjop-d-23-00009. [PMID: 37635478]
  • Yuhong Li, Shuying Hu, Yueqi Chen, Xing Zhang, Hanchi Gao, Jing Tian, Jian Chen. Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jun; 118(?):154924. doi: 10.1016/j.phymed.2023.154924. [PMID: 37393829]
  • Jia Chen, Huike Ma, Yujiao Meng, Qingwu Liu, Yan Wang, Yan Lin, Danyang Yang, Wentao Yao, Yazhuo Wang, Xiujuan He, Ping Li. Analysis of the mechanism underlying diabetic wound healing acceleration by Calycosin-7-glycoside using network pharmacology and molecular docking. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154773. doi: 10.1016/j.phymed.2023.154773. [PMID: 36990011]
  • Qiongdan Hu, Bingwen Zhu, Guoqiang Yang, Jian Jia, Honglian Wang, Ruizhi Tan, Qiong Zhang, Li Wang, Fahsai Kantawong. Calycosin pretreatment enhanced the therapeutic efficacy of mesenchymal stem cells to alleviate unilateral ureteral obstruction-induced renal fibrosis by inhibiting necroptosis. Journal of pharmacological sciences. 2023 Feb; 151(2):72-83. doi: 10.1016/j.jphs.2022.12.001. [PMID: 36707181]
  • Shaohua You, Yanfeng Wang, Yongxin Guo, Chao Guo, Fuyang Cao, Wenzhu Shi, Lujia Yang, Weidong Mi, Li Tong. Activation of the ERK1/2 pathway mediates the neuroprotective effect provided by calycosin treatment. Neuroscience letters. 2023 01; 792(?):136956. doi: 10.1016/j.neulet.2022.136956. [PMID: 36347338]
  • Xiao-Ming Qi, Yuan-Biao Qiao, Yuan-Lin Zhang, Ai-Cheng Wang, Jin-Hong Ren, Hui-Zhi Wei, Qing-Shan Li. PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113513. doi: 10.1016/j.fct.2022.113513. [PMID: 36436616]
  • Wen-Jun Ding, Guang-Hong Chen, Sui-Hui Deng, Ke-Feng Zeng, Kai-Li Lin, Bo Deng, Shuang-Wei Zhang, Zhang-Bin Tan, You-Cai Xu, Si Chen, Jun-Bang Chen, Ting-Fang Chen, Yong-Zhen Tan, Ying-Chun Zhou, Jing-Zhi Zhang, Bin Liu. Calycosin protects against oxidative stress-induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2. Phytotherapy research : PTR. 2023 Jan; 37(1):35-49. doi: 10.1002/ptr.7591. [PMID: 36059198]
  • Di Huang, Peicheng Shen, Chen Wang, Jiandong Gao, Chaoyang Ye, Feng Wu. Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis. Pharmaceutical biology. 2022 Dec; 60(1):990-996. doi: 10.1080/13880209.2022.2067572. [PMID: 35587919]
  • Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment. Drug delivery. 2022 Dec; 29(1):2815-2823. doi: 10.1080/10717544.2022.2118401. [PMID: 36047255]
  • Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded mitochondria targeted lipid-polymer hybrid nano-system: Preparation, characterization, and anti myocardial infarction activity assessment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113650. doi: 10.1016/j.biopha.2022.113650. [PMID: 36130421]
  • Guanghong Chen, Honglin Xu, Tong Xu, Wenjun Ding, Guoyong Zhang, Yue Hua, Yuting Wu, Xin Han, Lingpeng Xie, Bin Liu, Yingchun Zhou. Calycosin reduces myocardial fibrosis and improves cardiac function in post-myocardial infarction mice by suppressing TGFBR1 signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154277. doi: 10.1016/j.phymed.2022.154277. [PMID: 35752078]
  • Yingjun Song, Xu Li, Xiaozhou Liu, Zhaozhong Yu, Guofu Zhang. Calycosin Alleviates Oxidative Injury in Spinal Astrocytes by Regulating the GP130/JAK/STAT Pathway. Journal of oleo science. 2022 Jun; 71(6):881-887. doi: 10.5650/jos.ess21174. [PMID: 35584953]
  • Qianqian Chen, Jiayang Wan, Yangyang Zhang, Yu He, Yida Bao, Li Yu, Jiehong Yang. Pharmacokinetic-pharmacodynamic modeling analysis for hydroxysafflor yellow A-calycosin in compatibility in normal and cerebral ischemic rats: A comparative study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112950. doi: 10.1016/j.biopha.2022.112950. [PMID: 35427818]
  • Cheng-You Lu, Cecilia Hsuan Day, Chia-Hua Kuo, Tso-Fu Wang, Tsung-Jung Ho, Pei-Fang Lai, Ray-Jade Chen, Chun-Hsu Yao, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang. Calycosin alleviates H2 O2 -induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO-1 signaling pathway. Environmental toxicology. 2022 Apr; 37(4):858-867. doi: 10.1002/tox.23449. [PMID: 34990515]
  • Kun-Chang Wu, You-Cheng Hseu, Yu-Ching Shih, Govindan Sivakumar, Jyun-Ting Syu, Guan-Lin Chen, Meng-Tien Lu, Po-Chen Chu. Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031358. [PMID: 35163281]
  • Lei Zhang, Cundong Fan, Hua-Chen Jiao, Qian Zhang, Yue-Hua Jiang, Jie Cui, Yang Liu, Yong-Hao Jiang, Juan Zhang, Meng-Qi Yang, Yan Li, Yi-Tao Xue. Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation. Oxidative medicine and cellular longevity. 2022; 2022(?):1733834. doi: 10.1155/2022/1733834. [PMID: 35035656]
  • Chuanrui Ma, Han Wu, Guangyan Yang, Jiaqing Xiang, Ke Feng, Jing Zhang, Yunqing Hua, Lin Kang, Guanwei Fan, Shu Yang. Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice. British journal of pharmacology. 2022 01; 179(2):252-269. doi: 10.1111/bph.15720. [PMID: 34713437]
  • Chang-Ju Zhu, Wan-Guang Yang, De-Jian Li, Yao-Dong Song, San-Yang Chen, Qiao-Fang Wang, Yan-Na Liu, Yan Zhang, Bo Cheng, Zhong-Wei Wu, Zong-Chao Cui. Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation. World journal of gastroenterology. 2021 Nov; 27(44):7669-7686. doi: 10.3748/wjg.v27.i44.7669. [PMID: 34908806]
  • Nilupaier Tayier, Ning-Yi Qin, Li-Nan Zhao, Yi Zeng, Yu Wang, Guang Hu, Yuan-Qiang Wang. Theoretical Exploring of a Molecular Mechanism for Melanin Inhibitory Activity of Calycosin in Zebrafish. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226998. [PMID: 34834088]
  • Mao Deng, Huijuan Chen, Jiaying Long, Jiawen Song, Long Xie, Xiaofang Li. Calycosin: a Review of its Pharmacological Effects and Application Prospects. Expert review of anti-infective therapy. 2021 07; 19(7):911-925. doi: 10.1080/14787210.2021.1863145. [PMID: 33346681]
  • Xue Liu, Yumeng Shao, Xinyue Zhang, Xiang Ji, Min Xie, Huaman Liu. Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3β/β-catenin signaling pathway. Acta histochemica. 2021 Jul; 123(5):151746. doi: 10.1016/j.acthis.2021.151746. [PMID: 34217047]
  • Chunrong Huang, Lian-Fang Xue, Bo Hu, Huan-Huan Liu, Si-Bo Huang, Suliman Khan, Yu Meng. Calycosin-loaded nanoliposomes as potential nanoplatforms for treatment of diabetic nephropathy through regulation of mitochondrial respiratory function. Journal of nanobiotechnology. 2021 Jun; 19(1):178. doi: 10.1186/s12951-021-00917-1. [PMID: 34120609]
  • Xiaoguang Lu, Linghui Lu, Li Gao, Yong Wang, Wei Wang. Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111375. doi: 10.1016/j.biopha.2021.111375. [PMID: 33761601]
  • Li Pan, Xuan-Fen Zhang, Wan-Sheng Wei, Jing Zhang, Zhen-Zhen Li. The cardiovascular protective effect and mechanism of calycosin and its derivatives. Chinese journal of natural medicines. 2020 Dec; 18(12):907-915. doi: 10.1016/s1875-5364(20)60034-6. [PMID: 33357721]
  • Xiaohuan Ding, Jing Lv, Jia Luan, Jun Zhang. Calycosin may Alleviate Ang II-Induced Pro-proliferative Effects on Glomerular Mesangial Cells via Partially Inhibiting Autophagy and ERK Signaling Pathway. Biological & pharmaceutical bulletin. 2020 Dec; 43(12):1893-1898. doi: 10.1248/bpb.b20-00520. [PMID: 32999213]
  • Yulong Gu, Xianglan Piao, Dan Zhu. Simultaneous determination of calycosin, prim-O-glucosylcimifugin, and paeoniflorin in rat plasma by HPLC-MS/MS: application in the pharmacokinetic analysis of HQCF. The Journal of international medical research. 2020 Nov; 48(11):300060520972902. doi: 10.1177/0300060520972902. [PMID: 33213240]
  • Rong Hu, Ming-Qing Wang, Ling-Yu Liu, Hai-Yan You, Xiao-Hui Wu, Yang-Yang Liu, Yan-Jing Wang, Lu Lu, Wei Xiao, Lian-Bo Wei. Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway. Journal of cellular and molecular medicine. 2020 10; 24(19):11084-11099. doi: 10.1111/jcmm.15514. [PMID: 32910538]
  • Jin-Qiang Li, Chao-Jiang Xiao, Ye-Meng Li, Xin-Yan Tian, Xiang Dong, Bei Jiang. Astrernestin, a novel aurone-phenylpropanoid adduct from the roots of Astragalus ernestii. Natural product research. 2020 Oct; 34(20):2894-2899. doi: 10.1080/14786419.2019.1596101. [PMID: 30990071]
  • Yuan Li, Bide Duan, Ying Li, Shujun Yu, Yanyun Wang. The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression. Immunopharmacology and immunotoxicology. 2020 Aug; 42(4):366-372. doi: 10.1080/08923973.2020.1782426. [PMID: 32538204]
  • Wei-Yuan Yuan, Lian-Qu Li, Yan-Yan Chen, Yi-Jing Zhou, Kai-Fan Bao, Jie Zheng, Yong-Qing Hua, Guo-Rong Jiang, Min Hong. Frontline Science: Two flavonoid compounds attenuate allergic asthma by regulating epithelial barrier via G protein-coupled estrogen receptor: Probing a possible target for allergic inflammation. Journal of leukocyte biology. 2020 07; 108(1):59-71. doi: 10.1002/jlb.3hi0220-342rr. [PMID: 32303124]
  • Xuebing Cheng, Na Liu, Hangyu Liu, Na Huang, Xiaodong Sun, Guangdong Zhang. Bioinformatic and biochemical findings disclosed anti-hepatic steatosis mechanism of calycosin. Bioorganic chemistry. 2020 07; 100(?):103914. doi: 10.1016/j.bioorg.2020.103914. [PMID: 32417523]
  • Jong Min Oh, Hyun-Jae Jang, Won Jun Kim, Myung-Gyun Kang, Seung Cheol Baek, Jae Pil Lee, Daeui Park, Sei-Ryang Oh, Hoon Kim. Calycosin and 8-O-methylretusin isolated from Maackia amurensis as potent and selective reversible inhibitors of human monoamine oxidase-B. International journal of biological macromolecules. 2020 May; 151(?):441-448. doi: 10.1016/j.ijbiomac.2020.02.144. [PMID: 32087226]
  • Jie Huang, Hongyuan Shen, Mi Jiang, Lihua Huang, Yuan Yuan, Qian Wang. Calycosin reduces infarct size, oxidative stress and preserve heart function in isoproterenol-induced myocardial infarction model. Pakistan journal of pharmaceutical sciences. 2020 May; 33(3(Special)):1341-1347. doi: . [PMID: 33361020]
  • Zhu Zhang, Kathy Ka-Wai Auyeung, Stephen Cho-Wing Sze, Shiqing Zhang, Ken Kin-Lam Yung, Joshua Ka-Shun Ko. The dual roles of calycosin in growth inhibition and metastatic progression during pancreatic cancer development: A "TGF-β paradox". Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153177. doi: 10.1016/j.phymed.2020.153177. [PMID: 32106002]
  • Nehal M Elsherbiny, Eman Said, Hoda Atef, Sawsan A Zaitone. Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression. Chemico-biological interactions. 2020 Jan; 315(?):108897. doi: 10.1016/j.cbi.2019.108897. [PMID: 31726037]
  • Danyan Li, Luqing Zhao, Yuxin Li, Xiuhong Kang, Shengsheng Zhang. Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats. Drug design, development and therapy. 2020; 14(?):2207-2219. doi: 10.2147/dddt.s247958. [PMID: 32606591]
  • Mei-Ling Wu, Yi-Ping Lin, Yan-Li Wei, Hong-Jian Du, Xiao-Qian Ying, Wen-Zhuang Tan, Bi-E Tang. Calycosin Influences the Metabolism of Five Probe Drugs in Rats. Drug design, development and therapy. 2020; 14(?):429-434. doi: 10.2147/dddt.s236221. [PMID: 32099327]
  • Lu Yao, Siqi Wang, Pan Wei, Kaifan Bao, Weiyuan Yuan, Xiaotong Wang, Jie Zheng, Min Hong. Huangqi-Fangfeng protects against allergic airway remodeling through inhibiting epithelial-mesenchymal transition process in mice via regulating epithelial derived TGF-β1. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Nov; 64(?):153076. doi: 10.1016/j.phymed.2019.153076. [PMID: 31473579]
  • Faiza Khushdil, Farzana Gul Jan, Gul Jan, Muhammad Hamayun, Amjad Iqbal, Anwar Hussain, Nusrat Bibi. Salt stress alleviation in Pennisetum glaucum through secondary metabolites modulation by Aspergillus terreus. Plant physiology and biochemistry : PPB. 2019 Nov; 144(?):127-134. doi: 10.1016/j.plaphy.2019.09.038. [PMID: 31563093]
  • Lvkeng Luo, Shuling Wu, Xiaoxiao Zhu, Weiwei Su. The profiling and identification of the absorbed constituents and metabolites of Naoshuantong capsule in mice biofluids and brain by ultra- fast liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121791. doi: 10.1016/j.jchromb.2019.121791. [PMID: 31610480]
  • Qi Ni, Yani Fan, Xiong Zhang, Hongwei Fan, Yingbin Li. In vitro and in vivo Study on Glioma Treatment Enhancement by Combining Temozolomide with Calycosin and Formononetin. Journal of ethnopharmacology. 2019 Oct; 242(?):111699. doi: 10.1016/j.jep.2019.01.023. [PMID: 31005632]
  • Mingya Ding, Wenfang Ma, Xiaoyan Wang, Shujing Chen, Shuhan Zou, Jinna Wei, Yuqiao Yang, Jin Li, Xuejing Yang, Hui Wang, Yuhong Li, Qilong Wang, Haoping Mao, Xiu-Mei Gao, Yan-Xu Chang. A network pharmacology integrated pharmacokinetics strategy for uncovering pharmacological mechanism of compounds absorbed into the blood of Dan-Lou tablet on coronary heart disease. Journal of ethnopharmacology. 2019 Oct; 242(?):112055. doi: 10.1016/j.jep.2019.112055. [PMID: 31276751]
  • Chen Huang, Rong Li, Wuxiang Shi, Zhaoquan Huang. Discovery of the Anti-Tumor Mechanism of Calycosin Against Colorectal Cancer by Using System Pharmacology Approach. Medical science monitor : international medical journal of experimental and clinical research. 2019 Jul; 25(?):5589-5593. doi: 10.12659/msm.918250. [PMID: 31352466]
  • Qing-Yan Gai, Jiao Jiao, Xin Wang, Jing Liu, Zi-Ying Wang, Yu-Jie Fu. Chitosan promoting formononetin and calycosin accumulation in Astragalus membranaceus hairy root cultures via mitogen-activated protein kinase signaling cascades. Scientific reports. 2019 07; 9(1):10367. doi: 10.1038/s41598-019-46820-6. [PMID: 31316129]
  • Ling He, Xiaoqian Shi, S W Seto, C Dennis, Heng Wang, Sheng Zhang, Weidong Chen, Jian Wang. Using 3D-UPLC-DAD and a new method-verification by adding mixture standard compounds to determine the fingerprint and eight active components of Naoluoxintong decoction. Journal of pharmaceutical and biomedical analysis. 2019 May; 169(?):60-69. doi: 10.1016/j.jpba.2018.12.046. [PMID: 30836247]
  • Aditi Wagle, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi. Identifying an isoflavone from the root of Pueraria lobata as a potent tyrosinase inhibitor. Food chemistry. 2019 Mar; 276(?):383-389. doi: 10.1016/j.foodchem.2018.10.008. [PMID: 30409609]
  • Ying-Ying Zhang, Rui-Zhi Tan, Xiao-Qin Zhang, Ying Yu, Chen Yu. Calycosin Ameliorates Diabetes-Induced Renal Inflammation via the NF-κB Pathway In Vitro and In Vivo. Medical science monitor : international medical journal of experimental and clinical research. 2019 Mar; 25(?):1671-1678. doi: 10.12659/msm.915242. [PMID: 30830898]
  • Xiang Liu, Zhi-Hong Xie, Chen-Yuan Liu, Ying Zhang. Effect of Chinese Herbal Monomer Hairy Calycosin on Nonalcoholic Fatty Liver Rats and its Mechanism. Combinatorial chemistry & high throughput screening. 2019; 22(3):194-200. doi: 10.2174/1386207322666190411112814. [PMID: 30973105]
  • Jing Xie, Jing Xiong, Li-Sheng Ding, Li Chen, Hua Zhou, Liang Liu, Zhi-Feng Zhang, Xue-Mei Hu, Pei Luo, Lin-Sen Qing. A efficient method to identify cardioprotective components of Astragali Radix using a combination of molecularly imprinted polymers-based knockout extract and activity evaluation. Journal of chromatography. A. 2018 Nov; 1576(?):10-18. doi: 10.1016/j.chroma.2018.09.027. [PMID: 30245072]
  • John Nii Addotey, Isabelle Lengers, Joachim Jose, Nóra Gampe, Szabolcs Béni, Frank Petereit, Andreas Hensel. Isoflavonoids with inhibiting effects on human hyaluronidase-1 and norneolignan clitorienolactone B from Ononis spinosa L. root extract. Fitoterapia. 2018 Oct; 130(?):169-174. doi: 10.1016/j.fitote.2018.08.013. [PMID: 30176279]
  • Haitao Sun, Mengfan Yin, Weiqing Qian, Hong Yin. Calycosin, a Phytoestrogen Isoflavone, Induces Apoptosis of Estrogen Receptor-Positive MG-63 Osteosarcoma Cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2018 Sep; 24(?):6178-6186. doi: 10.12659/msm.910201. [PMID: 30182951]
  • Tao Guo, Zu-Long Liu, Qiang Zhao, Zhi-Min Zhao, Cheng-Hai Liu. A combination of astragaloside I, levistilide A and calycosin exerts anti-liver fibrosis effects in vitro and in vivo. Acta pharmacologica Sinica. 2018 Sep; 39(9):1483-1492. doi: 10.1038/aps.2017.175. [PMID: 29849130]
  • Ran Ma, Fang Yuan, Shaoxuan Wang, Yingping Liu, Tingting Fan, Fulai Wang. Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-κB signal pathways in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Sep; 105(?):599-605. doi: 10.1016/j.biopha.2018.05.080. [PMID: 29890468]
  • Fang Han, Kai Li, Ruiyan Pan, Wenjie Xu, Xue Han, Ningning Hou, Xiaodong Sun. Calycosin directly improves perivascular adipose tissue dysfunction by upregulating the adiponectin/AMPK/eNOS pathway in obese mice. Food & function. 2018 Apr; 9(4):2409-2415. doi: 10.1039/c8fo00328a. [PMID: 29595858]
  • Cha Zhang, Jia-Xing Zhang, Yi-Fan Xiong, Lu Lu, Ming-Qing Wang, Si-Ming Liu, Wei Xiao. [Screening active ingredients of Shenkangwan that regulate endothelial-mesenchymal transition of endothelial cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2018 Mar; 38(3):312-317. doi: . [PMID: 29643037]
  • Wei-Wei Zhang, Feng Xu, Ding Wang, Jia Ye, Shao-Qing Cai. Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences. Chinese journal of natural medicines. 2018 Mar; 16(3):194-202. doi: 10.1016/s1875-5364(18)30047-5. [PMID: 29576055]
  • Xingping Duan, Qiang Meng, Changyuan Wang, Zhihao Liu, Huijun Sun, Xiaokui Huo, Pengyuan Sun, Xiaodong Ma, Jinyong Peng, Kexin Liu. Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice. Journal of gastroenterology and hepatology. 2018 Feb; 33(2):533-542. doi: 10.1111/jgh.13884. [PMID: 28699662]
  • Xiaoting Tian, Shuoji Chen, Yuanyuan Zhang, Luying Chen, Xiaozhen Guo, Zhou Xu, Huan Liu, Pei Hu, Zhenyuan Chen, Zhixiong Li, Chenggang Huang. Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of calycosin-7-O-ß-d-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2018 Jan; 148(?):350-354. doi: 10.1016/j.jpba.2017.10.027. [PMID: 29111489]
  • Yang Liu, Jia Liu, Yu Wang, Ann Abozeid, Dong-Mei Tian, Xiao-Ning Zhang, Zhong-Hua Tang. The Different Resistance of Two Astragalus Plants to UV-B Stress is Tightly Associated with the Organ-specific Isoflavone Metabolism. Photochemistry and photobiology. 2018 01; 94(1):115-125. doi: 10.1111/php.12841. [PMID: 28881500]
  • Jiao Jiao, Qing-Yan Gai, Li-Li Niu, Xi-Qing Wang, Na Guo, Yu-Ping Zang, Yu-Jie Fu. Enhanced Production of Two Bioactive Isoflavone Aglycones in Astragalus membranaceus Hairy Root Cultures by Combining Deglycosylation and Elicitation of Immobilized Edible Aspergillus niger. Journal of agricultural and food chemistry. 2017 Oct; 65(41):9078-9086. doi: 10.1021/acs.jafc.7b03148. [PMID: 28950698]
  • Yan Song, Lan Pan, Wenjie Li, Yingying Si, Di Zhou, Chengjian Zheng, Xiaofang Hao, Xinyue Jia, Yuemei Jia, Minghui Shi, Xiaoguang Jia, Ning Li, Yue Hou. Natural neuro-inflammatory inhibitors from Caragana turfanensis. Bioorganic & medicinal chemistry letters. 2017 10; 27(20):4765-4769. doi: 10.1016/j.bmcl.2017.08.047. [PMID: 28911817]
  • Jia Yu, Lijun Zhu, Haihui Zheng, Xia Gong, Huangyu Jiang, Jiamei Chen, Yuhuan Li, Hongming Zheng, Xiaoxiao Qi, Ying Wang, Ming Hu, Linlin Lu, Zhongqiu Liu. Sulfotransferases and Breast Cancer Resistance Protein Determine the Disposition of Calycosin in Vitro and in Vivo. Molecular pharmaceutics. 2017 09; 14(9):2917-2929. doi: 10.1021/acs.molpharmaceut.7b00042. [PMID: 28445053]
  • Xingping Duan, Qiang Meng, Changyuan Wang, Zhihao Liu, Qi Liu, Huijun Sun, Pengyuan Sun, Xiaobo Yang, Xiaokui Huo, Jinyong Peng, Kexin Liu. Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Feb; 25(?):83-92. doi: 10.1016/j.phymed.2016.12.006. [PMID: 28190475]
  • Di Zhou, Hongyan Wei, Zhe Jiang, Xuezheng Li, Kun Jiao, Xiaoguang Jia, Yue Hou, Ning Li. Natural potential neuroinflammatory inhibitors from Alhagi sparsifolia Shap. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):973-978. doi: 10.1016/j.bmcl.2016.12.075. [PMID: 28073678]
  • Yu Tao, Yan Wang, Xiaoyu Wang, Can Wang, Kaifang Bao, Lv Ji, Guorong Jiang, Min Hong. Calycosin Suppresses Epithelial Derived Initiative Key Factors and Maintains Epithelial Barrier in Allergic Inflammation via TLR4 Mediated NF-κB Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 44(3):1106-1119. doi: 10.1159/000485416. [PMID: 29179209]
  • Lin Li, Sihao Zheng, Josef A Brinckmann, Juan Fu, Rui Zeng, Linfang Huang, Shilin Chen. Chemical and genetic diversity of Astragalus mongholicus grown in different eco-climatic regions. PloS one. 2017; 12(9):e0184791. doi: 10.1371/journal.pone.0184791. [PMID: 28945770]
  • Ningxu Li, Yan Tu, Yin Shen, Yanqiong Qin, Chao Lei, Xiangjie Liu. Calycosin attenuates osteoporosis and regulates the expression of OPG/RANKL in ovariectomized rats via MAPK signaling. Die Pharmazie. 2016 Oct; 71(10):607-612. doi: 10.1691/ph.2016.6627. [PMID: 29441931]
  • Fu-sheng Wang, Hu-shan Shang, Xiao-chun Pan. [Cultivation and Standardized Technology Research on A New Astragalus Variety of Longqi 4]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Sep; 39(9):1930-4. doi: ". [PMID: 30207647]
  • Amy G W Gong, Kei M Lau, Miranda L Xu, Huang Q Lin, Tina T X Dong, Ken Y Z Zheng, K J Zhao, Karl W K Tsim. The estrogenic properties of Danggui Buxue Tang, a Chinese herbal decoction, are triggered predominantly by calycosin in MCF-7 cells. Journal of ethnopharmacology. 2016 Aug; 189(?):81-9. doi: 10.1016/j.jep.2016.05.035. [PMID: 27196297]
  • Nóra Gampe, András Darcsi, Szilvia Lohner, Szabolcs Béni, László Kursinszki. Characterization and identification of isoflavonoid glycosides in the root of Spiny restharrow (Ononis spinosa L.) by HPLC-QTOF-MS, HPLC-MS/MS and NMR. Journal of pharmaceutical and biomedical analysis. 2016 May; 123(?):74-81. doi: 10.1016/j.jpba.2016.01.058. [PMID: 26874257]
  • Xiao-ya Liu, Ji-ping Li, Xin-yue Chen, Ya-li Chen, Yan Hong, Shi-lan Feng. [Determination of eight active components in Radix Hedysari by HPLC and its cluster analysis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 05; 51(5):786-91. doi: . [PMID: 29878726]
  • Yichen Hu, Weijun Kong, Hongli Luo, Lianhua Zhao, Meihua Yang. Dynamic variation of bioactive compounds and aflatoxins in contaminated Radix Astragali during extraction process. Journal of the science of food and agriculture. 2016 Mar; 96(5):1571-9. doi: 10.1002/jsfa.7257. [PMID: 25974204]
  • Guiyu Zhang, Rilan Ou, Fangyuan Li, Jinjun Wu, Liang Zheng, Yunli Tong, Yuting Liu, Zhongqiu Liu, Linlin Lu. Regulation of drug-metabolizing enzymes and efflux transporters by Astragali radix decoction and its main bioactive compounds: Implication for clinical drug-drug interactions. Journal of ethnopharmacology. 2016 Mar; 180(?):104-13. doi: 10.1016/j.jep.2016.01.031. [PMID: 26805467]
  • Bin Liu, Jingzhi Zhang, Weihua Liu, Ningning Liu, Xiuqiong Fu, Hiuyee Kwan, Shaojun Liu, Benrong Liu, Shuangwei Zhang, Zhiling Yu, Shiming Liu. Calycosin inhibits oxidative stress-induced cardiomyocyte apoptosis via activating estrogen receptor-α/β. Bioorganic & medicinal chemistry letters. 2016 Jan; 26(1):181-5. doi: 10.1016/j.bmcl.2015.11.005. [PMID: 26620254]
  • Xiao-hu Nie, Jia Ou-yang, Ying Xing, Dan-yan Li, Ru-en Liu, Ru-xiang Xu. Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells. Drug design, development and therapy. 2016; 10(?):767-79. doi: 10.2147/dddt.s90457. [PMID: 26955262]
  • Xu-Dong Cheng, Jun-Fei Gu, Jia-Rui Yuan, Liang Feng, Xiao-Bin Jia. Suppression of A549 cell proliferation and metastasis by calycosin via inhibition of the PKC‑α/ERK1/2 pathway: An in vitro investigation. Molecular medicine reports. 2015 Dec; 12(6):7992-8002. doi: 10.3892/mmr.2015.4449. [PMID: 26498639]
  • Dong-qing Zhang, Hai-bao Wang, Shu-fang Wang, De-qing Wang. [Research achievements on biological activities of calycosin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Nov; 40(22):4339-45. doi: . [PMID: 27097403]
  • Pham Anh Tuan, Eunsook Chung, Aye Aye Thwe, Xiaohua Li, Yeon Bok Kim, Valan Arasu Mariadhas, Naif Abdullah Al-Dhabi, Jai-Heon Lee, Sang Un Park. Transcriptional Profiling and Molecular Characterization of Astragalosides, Calycosin, and Calycosin-7-O-β-D-glucoside Biosynthesis in the Hairy Roots of Astragalus membranaceus in Response to Methyl Jasmonate. Journal of agricultural and food chemistry. 2015 Jul; 63(27):6231-40. doi: 10.1021/acs.jafc.5b01822. [PMID: 26072674]
  • Amy Guo-wei Gong, Ning Li, Kei-man Lau, Pinky Sum-chi Lee, Lu Yan, Miranda Li Xu, Candy Ting-wai Lam, Ava Yeung-yeung Kong, Huang-quan Lin, Tina Ting-xia Dong, Karl Wah-keung Tsim. Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract. Journal of ethnopharmacology. 2015 Jun; 168(?):150-7. doi: 10.1016/j.jep.2015.03.033. [PMID: 25796405]
  • Gao Junqing, Chen Tao, Jin Huigen, Liu Zongjun, Zhao Deqiang. Effect of calycosin on left ventricular ejection fraction and angiogenesis in rat models with myocardial infarction. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2015 Apr; 35(2):160-7. doi: 10.1016/s0254-6272(15)30023-6. [PMID: 25975048]
  • Xinyue Chen, Xiaoya Liu, Yali Chen, Yan Hong, Shilan Feng. [Spectrum-effect relationship on anti-hepatic fibrosis effect of Radix Hedysari]. Se pu = Chinese journal of chromatography. 2015 Apr; 33(4):413-8. doi: 10.3724/sp.j.1123.2014.12035. [PMID: 26292413]
  • Xinli Chen, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Xiaokui Huo, Pengyuan Sun, Xiaobo Yang, Jinyong Peng, Kexin Liu. Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice. Pharmaceutical research. 2015 Feb; 32(2):538-48. doi: 10.1007/s11095-014-1483-3. [PMID: 25143196]
  • Yuanyuan Cheng, Jia Zhao, Hung Fat Tse, X Chris Le, Jianhui Rong. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase?. Oxidative medicine and cellular longevity. 2015; 2015(?):434052. doi: 10.1155/2015/434052. [PMID: 26265982]
  • Youhua Xu, Jianfeng Xiong, Yonghua Zhao, Bao He, Zhaoguang Zheng, Gejin Chu, Quan Zhu. Calycosin Rebalances Advanced Glycation End Products-Induced Glucose Uptake Dysfunction of Hepatocyte In Vitro. The American journal of Chinese medicine. 2015; 43(6):1191-210. doi: 10.1142/s0192415x15500688. [PMID: 26446203]
  • Sheng-Yuan Zhang, Chun-Lin Fan, Xiao-Jun Huang, Wen-Hua Huang, Xue-Hua Liu, Lei Wang, Wen-Cai Ye. A new phenylpropanoid and a new isoflavone glycoside from Shenqi Fuzheng Injection. Journal of Asian natural products research. 2015; 17(3):274-9. doi: 10.1080/10286020.2014.965161. [PMID: 25296028]
  • JunQing Gao, Zong Jun Liu, Tao Chen, DeQiang Zhao. Pharmaceutical properties of calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali. Pharmaceutical biology. 2014 Sep; 52(9):1217-22. doi: 10.3109/13880209.2013.879188. [PMID: 24635389]
  • Liwu Chen, Jian Du, Qiwen Dai, Hongcheng Zhang, Wensheng Pang, Juan Hu. Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. European journal of medicinal chemistry. 2014 Aug; 83(?):294-306. doi: 10.1016/j.ejmech.2014.06.037. [PMID: 24974349]
  • Xuehui Sun, Pingping Zhang, Xiujun Wu, Qiong Wu, Mengmeng Zhang, Ye An, Guobing Shi. Simultaneous determination of calycosin-7-O-β-d-glucoside, calycosin, formononetin, astragaloside IV and schisandrin in rat plasma by LC-MS/MS: application to a pharmacokinetic study after oral administration of Shenqi Wuwei chewable tablets. Biomedical chromatography : BMC. 2014 Aug; 28(8):1118-25. doi: 10.1002/bmc.3128. [PMID: 24652759]
  • Zhou Le, Xiao-Li Zhao, Liu-Qing Di. [Absorption and transportation of calycosin in Astragali Radix by using Caco-2 monolayer model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 May; 39(9):1709-13. doi: . [PMID: 25095389]
  • Wen-Yuan Lee, Hsin-Yi Chen, Kuan-Chung Chen, Calvin Yu-Chian Chen. Treatment of rheumatoid arthritis with traditional chinese medicine. BioMed research international. 2014; 2014(?):528018. doi: 10.1155/2014/528018. [PMID: 24991562]
  • Fei Wang, Shancang Zhao, Feng Li, Bo Zhang, Yi Qu, Tianlei Sun, Ting Luo, Dapeng Li. Investigation of antioxidant interactions between Radix Astragali and Cimicifuga foetida and identification of synergistic antioxidant compounds. PloS one. 2014; 9(1):e87221. doi: 10.1371/journal.pone.0087221. [PMID: 24498048]
  • Adam Kokotkiewicz, Maria Luczkiewicz, Wiktor Kowalski, Anna Badura, Natalia Piekus, Adam Bucinski. Isoflavone production in Cyclopia subternata Vogel (honeybush) suspension cultures grown in shake flasks and stirred-tank bioreactor. Applied microbiology and biotechnology. 2013 Oct; 97(19):8467-77. doi: 10.1007/s00253-013-5099-z. [PMID: 23872960]
  • Fan Bai, Toshiaki Makino, Keiko Kono, Akito Nagatsu, Takahiko Ono, Hajime Mizukami. Calycosin and formononetin from astragalus root enhance dimethylarginine dimethylaminohydrolase 2 and nitric oxide synthase expressions in Madin Darby Canine Kidney II cells. Journal of natural medicines. 2013 Oct; 67(4):782-9. doi: 10.1007/s11418-013-0749-0. [PMID: 23417504]
  • Wendy Li Zhang, Roy Chi-Yan Choi, Janis Ya-Xian Zhan, Jian-Ping Chen, Wilson Kin-Wai Luk, Ping Yao, Tina Ting-Xia Dong, Karl Wah-Keung Tsim. Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Sep; 20(12):1076-81. doi: 10.1016/j.phymed.2013.04.016. [PMID: 23746954]
  • Lee-Hsin Shaw, Wei-Ming Chen, Tung-Hu Tsai. Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. Molecules (Basel, Switzerland). 2013 Sep; 18(9):11281-98. doi: 10.3390/molecules180911281. [PMID: 24036516]