Cernuine (BioDeep_00000001077)

 

Secondary id: BioDeep_00000641031

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(2E)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-2,3-dihydro-1-benzofuran-3-one

化学式: C15H10O6 (286.0477)
中文名称: 噢弄斯定, 金鱼草素
谱图信息: 最多检出来源 Viridiplantae(plant) 19.78%

分子结构信息

SMILES: C1=CC(=C(C=C1C=C2C(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-5-11(19)14-12(6-8)21-13(15(14)20)4-7-1-2-9(17)10(18)3-7/h1-6,16-19H/b13-4+

描述信息

Aureusidin is a hydroxyaurone that is aurone substituted by hydroxy groups at positions 4, 6, 3 and 4 respectively. It has a role as a plant metabolite. It is functionally related to an aurone. It is a conjugate acid of an aureusidin-6-olate.
Aureusidin is a natural product found in Eleocharis dulcis, Eleocharis pallens, and other organisms with data available.
Cernuine is found in citrus. Cernuine is isolated from Citrus medica (citron).
Isolated from Citrus medica (citron). Cernuine is found in lemon and citrus.
Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. Aureusidin also shows anti-inflammatory effects[1].
Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. Aureusidin also shows anti-inflammatory effects[1].
Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. Aureusidin also shows anti-inflammatory effects[1].

同义名列表

23 个代谢物同义名

(2E)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-2,3-dihydro-1-benzofuran-3-one; (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-2,3-dihydro-1-benzofuran-3-one; (2Z)-2-((3,4-DIHYDROXYPHENYL)METHYLENE)-4,6-DIHYDROXY-3(2H)-BENZOFURANONE (ACI); (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-1-benzofuran-3(2H)-one; 3(2H)-BENZOFURANONE, 2-((3,4-DIHYDROXYPHENYL)METHYLENE)-4,6-DIHYDROXY-, (Z)-; (2E)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-1-benzofuran-3-one; (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-1-benzofuran-3-one; (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-4,6-dihydroxy-3(2H)-benzofuranone; 4,6-Dihydroxy-2-[(3,4-dihydroxyphenyl)methylene]-3(2H)-benzofuranone, 9ci; (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-4,6-dihydroxy-benzofuran-3-one; 2-(3,4-Dihydroxybenzylidene)-4,6-dihydroxybenzofuran-3(2H)-one; (Z)-4,6,3,4-TETRAHYDROXYAURONE; WBEFUVAYFSOUEA-PQMHYQBVSA-N; 4,6,3,4-Tetrahydroxyaurone; UNII-U8B4XHN2DX; AUREUSIDIN(RG); LMPK12130041; Auresudidin; U8B4XHN2DX; Aureusidin; Cernuine; Cernuin; Aureusidin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

70 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ARG1, CDK5, IL18, MARVELD1, MYD88, PIK3CA, RHOA, SNCA, SRARP, TLR4, TYR, ZBP1
Endosome membrane 3 LY96, MYD88, TLR4
Endoplasmic reticulum membrane 2 HMOX1, RHOA
Nucleus 11 ARG1, CDK5, GABPA, HMOX1, MARVELD1, MYD88, PARP1, RHOA, SNCA, SRARP, ZBP1
cytosol 11 ARG1, CDK5, DCTN5, HMOX1, IL18, MYD88, PARP1, PIK3CA, RHOA, SNCA, ZBP1
dendrite 1 CDK5
nuclear body 1 PARP1
centrosome 1 DCTN5
nucleoplasm 6 CDK5, DCTN5, GABPA, HMOX1, PARP1, ZBP1
Cell membrane 6 CDK5, CLDN1, MARVELD1, RHOA, TLR4, TNF
Lipid-anchor 1 RHOA
Cytoplasmic side 2 HMOX1, RHOA
Cleavage furrow 1 RHOA
lamellipodium 4 CDK5, PIK3CA, RHOA, ZBP1
ruffle membrane 1 RHOA
Cell projection, axon 2 SNCA, ZBP1
Cell projection, growth cone 1 CDK5
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 2 CLDN1, MARVELD1
Synapse 2 CDK5, SNCA
cell cortex 2 RHOA, SNCA
cell junction 2 CDK5, RHOA
cell surface 3 MYD88, TLR4, TNF
glutamatergic synapse 1 RHOA
growth cone 3 CDK5, SNCA, ZBP1
neuromuscular junction 1 CDK5
neuronal cell body 4 CDK5, SNCA, TNF, ZBP1
postsynapse 2 RHOA, SNCA
Cytoplasm, cytosol 2 IL18, PARP1
Lysosome 2 SNCA, TYR
Presynapse 1 CDK5
endosome 1 RHOA
plasma membrane 10 CDK5, CLDN1, LY96, MARVELD1, MYD88, PIK3CA, RHOA, SNCA, TLR4, TNF
synaptic vesicle membrane 1 SNCA
Membrane 7 CDK5, CLDN1, HMOX1, MARVELD1, PARP1, SNCA, TLR4
apical plasma membrane 1 CLDN1
axon 2 CDK5, SNCA
basolateral plasma membrane 1 CLDN1
extracellular exosome 1 RHOA
endoplasmic reticulum 1 HMOX1
extracellular space 6 ARG1, CTRL, HMOX1, IL18, SNCA, TNF
perinuclear region of cytoplasm 6 HMOX1, PIK3CA, SNCA, TLR4, TYR, ZBP1
Cell junction, tight junction 1 CLDN1
bicellular tight junction 1 CLDN1
intercalated disc 1 PIK3CA
mitochondrion 2 PARP1, SNCA
protein-containing complex 4 CLDN1, MYD88, PARP1, SNCA
intracellular membrane-bounded organelle 1 TYR
filopodium 2 CDK5, ZBP1
postsynaptic density 1 CDK5
protein kinase 5 complex 1 CDK5
Single-pass type I membrane protein 2 TLR4, TYR
Secreted 3 IL18, LY96, SNCA
extracellular region 5 ARG1, IL18, LY96, SNCA, TNF
cytoplasmic side of plasma membrane 1 RHOA
mitochondrial outer membrane 1 HMOX1
transcription regulator complex 1 PARP1
nuclear membrane 1 DCTN5
external side of plasma membrane 2 TLR4, TNF
actin cytoskeleton 1 SNCA
dendritic spine 2 RHOA, ZBP1
perikaryon 1 CDK5
nucleolus 1 PARP1
Melanosome membrane 1 TYR
midbody 1 RHOA
Cytoplasm, P-body 1 ZBP1
P-body 1 ZBP1
Early endosome 1 TLR4
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 RHOA
Cell projection, lamellipodium 2 CDK5, RHOA
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 2 DCTN5, MARVELD1
focal adhesion 1 RHOA
Cell projection, dendritic spine 1 ZBP1
lateral plasma membrane 1 CLDN1
Cell projection, filopodium 1 ZBP1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 LY96, TLR4
neuron projection 1 CDK5
chromatin 2 GABPA, PARP1
phagocytic cup 2 TLR4, TNF
cell periphery 1 RHOA
supramolecular fiber 1 SNCA
Chromosome 1 PARP1
cytoskeleton 2 MARVELD1, RHOA
Secreted, extracellular space 1 LY96
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Cytoplasm, cell cortex 1 RHOA
Basolateral cell membrane 1 CLDN1
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Chromosome, centromere, kinetochore 1 DCTN5
Cell projection, dendrite 2 RHOA, ZBP1
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ZBP1
cytoplasmic stress granule 1 ZBP1
[Isoform 1]: Cytoplasm 1 CDK5
lipopolysaccharide receptor complex 2 LY96, TLR4
secretory granule membrane 1 RHOA
axon terminus 1 SNCA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 ARG1
dynactin complex 1 DCTN5
kinetochore 1 DCTN5
tight junction 1 CLDN1
azurophil granule lumen 1 ARG1
Single-pass type IV membrane protein 1 HMOX1
ribonucleoprotein complex 1 ZBP1
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 RHOA
apical junction complex 1 RHOA
CRD-mediated mRNA stability complex 1 ZBP1
extrinsic component of plasma membrane 1 MYD88
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CDK5
[Isoform 7]: Cytoplasm 1 ZBP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 SNCA
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Roshani Shakya, Jingsong Ye, Caius M Rommens. Altered leaf colour is associated with increased superoxide-scavenging activity in aureusidin-producing transgenic plants. Plant biotechnology journal. 2012 Dec; 10(9):1046-55. doi: 10.1111/j.1467-7652.2012.00732.x. [PMID: 22924954]
  • M Jiménez-Atiénzar, M Pérez-Gilabert, J Cabanes, J Escribano, F Gandía-Herrero, F García-Carmona. A continuous spectrophotometric assay for determination of the aureusidin synthase activity of tyrosinase. Phytochemical analysis : PCA. 2010 May; 21(3):273-8. doi: 10.1002/pca.1197. [PMID: 20029997]
  • Anastasia Detsi, Maya Majdalani, Christos A Kontogiorgis, Dimitra Hadjipavlou-Litina, Panagiotis Kefalas. Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. Bioorganic & medicinal chemistry. 2009 Dec; 17(23):8073-85. doi: 10.1016/j.bmc.2009.10.002. [PMID: 19853459]
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