Genistin (BioDeep_00000000023)

 

Secondary id: BioDeep_00000285152

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


5-hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one

化学式: C21H20O10 (432.1056)
中文名称: 染料木甙, 染料木苷(金雀异黄素), 染料木苷
谱图信息: 最多检出来源 Viridiplantae(plant) 19.24%

Reviewed

Last reviewed on 2024-11-05.

Cite this Page

Genistin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/genistin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000023). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(cc(c2c(c1)occ(c2=O)c1ccc(cc1)O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](O1)CO)O)O)O
InChI: InChI=1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2

描述信息

Genistein 7-O-beta-D-glucoside is a 7-hydroxyisoflavones 7-O-beta-D-glucoside. It is functionally related to a genistein. It is a conjugate acid of a genistein 7-O-beta-D-glucoside(1-).
Genistin is a natural product found in Ficus septica, Dalbergia sissoo, and other organisms with data available.
Genistin is found in fruits. Genistin is present in soy foods. Potential nutriceutical. It is isolated from Prunus avium (wild cherry) Genistin is one of several known isoflavones. Genistin is found in a number of plants and herbs like soy
Present in soy foods. Potential nutriceutical. Isolated from Prunus avium (wild cherry)
Genistin (Genistine), an isoflavone belonging to the phytoestrogen family, is a potent anti-adipogenic and anti-lipogenic agent. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway[1][2][3].

Genistin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=529-59-9 (retrieved 2024-11-05) (CAS RN: 529-59-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

50 个代谢物同义名

5-hydroxy-3-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-3-(4-hydroxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 5-hydroxy-3-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one; 5-hydroxy-3-(4-hydroxyphenyl)-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one; 5-hydroxy-3-(4-hydroxyphenyl)-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}chromen-4-one; 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-; 5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside; Genistin, United States Pharmacopeia (USP) Reference Standard; 5,4-DI-HYDROXYISOFLAVONE-7-O-.BETA.-D-GLUCOPYRANOSIDE; 4,5,7-Trihydroxyisoflavone 7-.beta.-D-glucopyranoside; Genistin, primary pharmaceutical reference standard; Genistin, from Glycine max (soybean), >=95\\% (HPLC); GENISTIN (CONSTITUENT OF SOY ISOFLAVONES) [DSC]; Isoflavone, 4,5,7-trihydroxy-, 7-D-glucoside; 4-18-00-02732 (Beilstein Handbook Reference); Prevention 10 (soy isoflavone concentrate); 4,5,7-trihydroxyisoflavone 7-D-glucoside; Genistein-7-O-β-D-glucopyranoside; 4,5,7-Trihydroxyisoflavone 7-glucoside; GENISTEIN 7-O-.BETA.-D-GLUCOPYRANOSIDE; Glucopyranoside, genistein-7, beta-D-; 7-O-.beta.-D-glucopyranosyl genistein; Genistein-7-O-beta-D-glucopyranoside; Genistein, 7-beta-D-glucopyranoside; Genistein 7-O-beta-glucopyranoside; Genistein 7-O-b-D-glucopyranoside; Genistein-7beta-D-glucopyranoside; Genistein, 7-O-beta-D-glucoside; Genistein 7-O-beta-D-glucoside; Genistin, analytical standard; Genisteol 7-monoglucoside; Genistin, >=97.5\\% (TLC); GENISTEIN GENISTIN [MI]; genistein 7-O-glucoside; Genistein-7-glucoside; Genistein 7-glucoside; Glucosyl-7-genistein; Genistein glucoside; GENISTIN [USP-RS]; UNII-1POG3SCN5T; Genistin (8ci); MEGxp0_000436; Genistin,(S); ACon1_001495; Genistoside; 1POG3SCN5T; Genistine; Genistin; Genistein 7-O-β-D-glucopyranoside; Genistein 7-O-beta-D-glucoside



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

10 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(8)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

226 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ADIG, BCL2, CASP3, CAT, ESR1, MYLK, PTGS2, TNK1, TP53, TYR
Peripheral membrane protein 5 ACHE, ESR1, GBA1, PTGS2, TNK1
Endosome membrane 1 BACE1
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 7 ACHE, ADIG, BCL2, CASP3, ESR1, ESR2, TP53
cytosol 8 ACACA, BCL2, CASP3, CAT, ESR1, GPT, MYLK, TP53
dendrite 1 BACE1
trans-Golgi network 2 BACE1, GBA1
centrosome 1 TP53
nucleoplasm 4 CASP3, ESR1, ESR2, TP53
Cell membrane 3 ACHE, BACE1, ESR1
Cytoplasmic side 1 ESR1
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Cell projection, axon 1 BACE1
Synapse 2 ACHE, MYLK
cell surface 2 ACHE, BACE1
glutamatergic synapse 1 CASP3
Golgi apparatus 4 ACHE, BACE1, ESR1, GBA1
Golgi membrane 1 INS
lysosomal membrane 3 EGF, GAA, GBA1
neuromuscular junction 1 ACHE
neuronal cell body 2 BACE1, CASP3
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 1 ACACA
Lysosome 4 BACE1, GAA, GBA1, TYR
endosome 1 BACE1
plasma membrane 7 ACHE, BACE1, EGF, ESR1, GAA, MYLK, TNK1
Membrane 10 ACHE, ADIG, BACE1, BCL2, CAT, EGF, ESR1, GAA, TNK1, TP53
axon 1 BACE1
caveola 1 PTGS2
extracellular exosome 5 CAT, EGF, GAA, GBA1, GPT
Lysosome membrane 2 GAA, GBA1
Lumenal side 1 GBA1
endoplasmic reticulum 5 BACE1, BCL2, GBA1, PTGS2, TP53
extracellular space 4 ACHE, EGF, IL6, INS
lysosomal lumen 2 GAA, GBA1
perinuclear region of cytoplasm 2 ACHE, TYR
mitochondrion 5 ACACA, BCL2, CAT, ESR2, TP53
protein-containing complex 5 BCL2, CAT, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 4 CAT, ESR2, GAA, TYR
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 BACE1, TYR
Secreted 5 ACHE, ADIG, GAA, IL6, INS
extracellular region 7 ACHE, ADIG, CAT, EGF, GAA, IL6, INS
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 ADIG, BCL2
mitochondrial outer membrane 1 BCL2
hippocampal mossy fiber to CA3 synapse 1 BACE1
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
Extracellular side 1 ACHE
transcription regulator complex 2 ESR1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
multivesicular body 1 BACE1
actin cytoskeleton 2 ACACA, MYLK
nucleolus 1 TP53
Melanosome membrane 1 TYR
Early endosome 1 BACE1
Golgi-associated vesicle 1 TYR
recycling endosome 1 BACE1
Cell projection, lamellipodium 1 MYLK
Membrane raft 1 BACE1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 BACE1
neuron projection 1 PTGS2
chromatin 3 ESR1, ESR2, TP53
Golgi apparatus, trans-Golgi network 1 BACE1
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
fibrillar center 1 ACACA
Endomembrane system 1 BACE1
endosome lumen 1 INS
Lipid droplet 1 ADIG
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
tertiary granule membrane 1 GAA
Melanosome 1 TYR
euchromatin 1 ESR1
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
stress fiber 1 MYLK
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BACE1, IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 EGF
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 EGF
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
[Isoform 1]: Nucleus 2 ESR1, TP53
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
Golgi-associated vesicle lumen 1 BACE1


文献列表

  • Xiaoqin Tang, Rui Liao, Ling Zhou, Taian Yi, Mei Ran, Jiesi Luo, Feihong Huang, Anguo Wu, Qibing Mei, Long Wang, Xinwu Huang, Jianming Wu. Genistin: A Novel Estrogen Analogue Targeting ERβ to Alleviate Thrombocytopenia. International journal of biological sciences. 2024; 20(6):2236-2260. doi: 10.7150/ijbs.90483. [PMID: 38617546]
  • Jie Chen, Yishu Ni, Pingjing Zhang, Xianrui Liang, Sheng Fang. Acidic natural deep eutectic solvents as dual solvents and catalysts for the solubilization and deglycosylation of soybean isoflavone extracts: Genistin as a model compound. Food chemistry. 2023 Apr; 406(?):134999. doi: 10.1016/j.foodchem.2022.134999. [PMID: 36459802]
  • Zhe Li, Weichao Dong, Yanan Li, Xin Liu, Hong Wang, Long Dai, Jiayu Zhang, Shaoping Wang. The Metabolites and Mechanism Analysis of Genistin against Hyperlipidemia via the UHPLC-Q-Exactive Orbitrap Mass Spectrometer and Metabolomics. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052242. [PMID: 36903488]
  • Zhe Wang, Xiaonan Li, Yiqiang Dai, Liqing Yin, Fidelis Azi, Jianzhong Zhou, Mingsheng Dong, Xiudong Xia. Sustainable production of genistin from glycerol by constructing and optimizing Escherichia coli. Metabolic engineering. 2022 11; 74(?):206-219. doi: 10.1016/j.ymben.2022.10.015. [PMID: 36336175]
  • Dong Meng, Biying Dong, Lili Niu, Zhihua Song, Litao Wang, Rohul Amin, Hongyan Cao, Hanghang Li, Qing Yang, Yujie Fu. The pigeon pea CcCIPK14-CcCBL1 pair positively modulates drought tolerance by enhancing flavonoid biosynthesis. The Plant journal : for cell and molecular biology. 2021 06; 106(5):1278-1297. doi: 10.1111/tpj.15234. [PMID: 33733535]
  • Miwako Toyofuku, Fuki Okutani, Masaru Nakayasu, Shoichiro Hamamoto, Hisabumi Takase, Kazufumi Yazaki, Akifumi Sugiyama. Enhancement of developmentally regulated daidzein secretion from soybean roots in field conditions as compared with hydroponic culture. Bioscience, biotechnology, and biochemistry. 2021 Apr; 85(5):1165-1169. doi: 10.1093/bbb/zbab017. [PMID: 33784734]
  • Yae Rim Choi, Jaewon Shim, Min Jung Kim. Genistin: A Novel Potent Anti-Adipogenic and Anti-Lipogenic Agent. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092042. [PMID: 32349444]
  • Anowarul Islam, Md Sadikul Islam, Md Nazim Uddin, Mir Md Iqbal Hasan, Md Rashedunnabi Akanda. The potential health benefits of the isoflavone glycoside genistin. Archives of pharmacal research. 2020 Apr; 43(4):395-408. doi: 10.1007/s12272-020-01233-2. [PMID: 32253713]
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