I6783_SIGMA (BioDeep_00000861078)

Main id: BioDeep_00000000919

 

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,4aR,4bS,7S,10aR)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid

化学式: C20H30O2 (302.2246)
中文名称: 异海松酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCC2C(=CCC3C2(CCCC3(C)C(=O)O)C)C1)C=C
InChI: InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,7,15-16H,1,6,8-13H2,2-4H3,(H,21,22)/t15-,16+,18-,19+,20+/m0/s1

描述信息

D049990 - Membrane Transport Modulators
D007476 - Ionophores
Isopimaric acid is a potent opener of large conductance calcium activated K+ (BK) channels.
Isopimaric acid is a potent opener of large conductance calcium activated K+ (BK) channels.

同义名列表

10 个代谢物同义名

(1R,4aR,4bS,7S,10aR)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid; (1R,4aR,4bS,7S,10aR)-1,4a,7-trimethyl-7-vinyl-3,4,4b,5,6,8,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid; (5ξ,9ξ,13α)-Pimara-7,15-dien-18-oic acid; (13alpha)-pimara-7,15-dien-18-oic acid; Neoisodextropimaric acid; Isopimaric acid; I6783_SIGMA; 5835-26-7; C09118; Isopimaric acid



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

48 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, CNR1, CNR2, NR1H3, PPARG
Peripheral membrane protein 2 ACHE, CYP1B1
Endoplasmic reticulum membrane 4 ABCA1, ABCG1, CYP1B1, HMGCR
Nucleus 3 ACHE, NR1H3, PPARG
cytosol 4 APOA1, CA1, NR1H3, PPARG
dendrite 1 CNR2
phagocytic vesicle 1 ABCA1
nucleoplasm 2 NR1H3, PPARG
RNA polymerase II transcription regulator complex 2 NR1H3, PPARG
Cell membrane 8 ABCA1, ABCG1, ACHE, CNR1, DPP4, ITLN1, KCNMA1, OPRD1
lamellipodium 1 DPP4
Cell projection, axon 1 CNR1
Multi-pass membrane protein 10 ABCA1, ABCG1, CNR1, HMGCR, KCNA3, KCNMA1, KCNMB2, KCNMB3, KCNMB4, OPRD1
Golgi apparatus membrane 1 ABCG1
Synapse 3 ACHE, KCNMB1, KCNMB4
cell junction 1 DPP4
cell surface 2 ACHE, DPP4
glutamatergic synapse 2 CNR1, KCNA3
Golgi apparatus 3 ABCA1, ABCG1, ACHE
Golgi membrane 1 ABCG1
growth cone 1 CNR1
lysosomal membrane 1 DPP4
neuromuscular junction 1 ACHE
presynaptic membrane 3 CNR1, KCNA3, OPRD1
Presynapse 1 CNR1
endosome 2 ABCA1, ABCG1
plasma membrane 14 ABCA1, ABCG1, ACHE, APOA1, CNR1, CNR2, DPP4, KCNA3, KCNMA1, KCNMB1, KCNMB2, KCNMB3, KCNMB4, OPRD1
synaptic vesicle membrane 1 OPRD1
Membrane 12 ABCA1, ABCG1, ACHE, CYP1B1, DPP4, HMGCR, KCNA3, KCNMA1, KCNMB2, KCNMB3, KCNMB4, OPRD1
apical plasma membrane 2 DPP4, KCNMA1
axon 2 CNR1, KCNA3
basolateral plasma membrane 1 ABCA1
caveola 1 KCNMA1
extracellular exosome 4 APOA1, CA1, DPP4, ITLN1
endoplasmic reticulum 2 CNR2, HMGCR
extracellular space 3 ACHE, APOA1, ITLN1
perinuclear region of cytoplasm 4 ABCA1, ACHE, KCNA3, PPARG
intercellular canaliculus 1 DPP4
mitochondrion 2 ABCG1, CYP1B1
intracellular membrane-bounded organelle 3 ABCA1, CYP1B1, PPARG
Microsome membrane 1 CYP1B1
Secreted 4 ACHE, APOA1, DPP4, ITLN1
extracellular region 4 ACHE, APOA1, DPP4, ITLN1
Mitochondrion outer membrane 1 CNR1
Single-pass membrane protein 1 DPP4
mitochondrial outer membrane 1 CNR1
Extracellular side 1 ACHE
anchoring junction 1 DPP4
external side of plasma membrane 2 ABCA1, ABCG1
Extracellular vesicle 1 APOA1
chylomicron 1 APOA1
high-density lipoprotein particle 1 APOA1
low-density lipoprotein particle 1 APOA1
very-low-density lipoprotein particle 1 APOA1
actin cytoskeleton 1 CNR1
perikaryon 1 CNR2
cytoplasmic vesicle 1 APOA1
Early endosome 1 APOA1
recycling endosome 1 ABCG1
Single-pass type II membrane protein 1 DPP4
postsynaptic membrane 3 CNR2, KCNA3, KCNMA1
Apical cell membrane 1 DPP4
Membrane raft 5 ABCA1, CNR1, DPP4, ITLN1, KCNA3
focal adhesion 1 DPP4
GABA-ergic synapse 1 CNR1
basement membrane 1 ACHE
intracellular vesicle 1 ABCA1
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 1 APOA1
receptor complex 3 ITLN1, NR1H3, PPARG
neuron projection 1 OPRD1
chromatin 2 NR1H3, PPARG
brush border membrane 1 ITLN1
blood microparticle 1 APOA1
Lipid-anchor, GPI-anchor 2 ACHE, ITLN1
[Isoform 2]: Cell membrane 1 KCNA3
Endomembrane system 1 DPP4
Cell projection, dendrite 1 CNR2
side of membrane 2 ACHE, ITLN1
Peroxisome membrane 1 HMGCR
voltage-gated potassium channel complex 6 KCNA3, KCNMA1, KCNMB1, KCNMB2, KCNMB3, KCNMB4
secretory granule lumen 1 APOA1
endoplasmic reticulum lumen 1 APOA1
axon terminus 1 OPRD1
endocytic vesicle 3 ABCA1, APOA1, DPP4
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
calyx of Held 1 KCNA3
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
synaptic cleft 1 ACHE
[Isoform 1]: Cell membrane 1 KCNA3
dendrite membrane 1 OPRD1
spherical high-density lipoprotein particle 1 APOA1
lamellipodium membrane 1 DPP4
endocytic vesicle lumen 1 APOA1
Cell projection, lamellipodium membrane 1 DPP4
Cell projection, invadopodium membrane 1 DPP4
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
[Isoform H]: Cell membrane 1 ACHE
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4
spine apparatus 1 OPRD1


文献列表

  • Jiacheng Li, Xiaozhen Liu, Lin Chen, Xinping Zhu, Zhihong Yu, Liyao Dong, Xinyun Zhao, Hongling Zou, Qin Wei, Yongcai Feng, Yongqiang Zhu, Kequn Chai, Qun Li, Mingqian Li. Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis. Toxicology and applied pharmacology. 2023 Mar; 462(?):116415. doi: 10.1016/j.taap.2023.116415. [PMID: 36754215]
  • Doudou Huang, Jiaxi Cheng, Junqin Mao, Senlin Ma, Zenan Du, Wansheng Chen, Feng Zhang, Lianna Sun. The LC-MS/MS-Based Measurement of Isopimaric Acid in Rat Plasma and Application of Pharmacokinetics. BioMed research international. 2021; 2021(?):2310422. doi: 10.1155/2021/2310422. [PMID: 34692827]
  • S Salari, M Silverå Ejneby, J Brask, F Elinder. Isopimaric acid - a multi-targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line. Acta physiologica (Oxford, England). 2018 01; 222(1):. doi: 10.1111/apha.12895. [PMID: 28514017]
  • Katrin Geisler, Niels Berg Jensen, Macaire M S Yuen, Lina Madilao, Jörg Bohlmann. Modularity of Conifer Diterpene Resin Acid Biosynthesis: P450 Enzymes of Different CYP720B Clades Use Alternative Substrates and Converge on the Same Products. Plant physiology. 2016 05; 171(1):152-64. doi: 10.1104/pp.16.00180. [PMID: 26936895]
  • Dawn E Hall, Philipp Zerbe, Sharon Jancsik, Alfonso Lara Quesada, Harpreet Dullat, Lina L Madilao, Macaire Yuen, Jörg Bohlmann. Evolution of conifer diterpene synthases: diterpene resin acid biosynthesis in lodgepole pine and jack pine involves monofunctional and bifunctional diterpene synthases. Plant physiology. 2013 Feb; 161(2):600-16. doi: 10.1104/pp.112.208546. [PMID: 23370714]
  • Axel Schmidt, Raimund Nagel, Trygve Krekling, Erik Christiansen, Jonathan Gershenzon, Paal Krokene. Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). Plant molecular biology. 2011 Dec; 77(6):577-90. doi: 10.1007/s11103-011-9832-7. [PMID: 22002747]
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  • Young Bae Ryu, Hyung Jae Jeong, Jang Hoon Kim, Young Min Kim, Ji-Young Park, Doman Kim, Thi Thanh Hanh Nguyen, Su-Jin Park, Jong Sun Chang, Ki Hun Park, Mun-Chual Rho, Woo Song Lee. Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition. Bioorganic & medicinal chemistry. 2010 Nov; 18(22):7940-7. doi: 10.1016/j.bmc.2010.09.035. [PMID: 20934345]
  • Eric Abbott, Dawn Hall, Björn Hamberger, Jörg Bohlmann. Laser microdissection of conifer stem tissues: isolation and analysis of high quality RNA, terpene synthase enzyme activity and terpenoid metabolites from resin ducts and cambial zone tissue of white spruce (Picea glauca). BMC plant biology. 2010 Jun; 10(?):106. doi: 10.1186/1471-2229-10-106. [PMID: 20540781]
  • Reiko Tanaka, Harukuni Tokuda, Yoichiro Ezaki. Cancer chemopreventive activity of "rosin" constituents of Pinus spez. and their derivatives in two-stage mouse skin carcinogenesis test. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Nov; 15(11):985-92. doi: 10.1016/j.phymed.2008.02.020. [PMID: 18424098]
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