24-Methylenecycloartan-3-ol (BioDeep_00000006999)

 

Secondary id: BioDeep_00000019561, BioDeep_00000637027, BioDeep_00001868795

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(1S,3R,6S,8R,11S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2R)-6-methyl-5-methylideneheptan-2-yl]pentacyclo[9.7.0.0^{1,3}.0^{3,8}.0^{12,16}]octadecan-6-ol

化学式: C31H52O (440.4018)
中文名称: 24-亚甲基环阿屯醇
谱图信息: 最多检出来源 Homo sapiens(plant) 16.91%

分子结构信息

SMILES: C1[C@@H](C([C@H]2[C@]3(C1)[C@]1([C@@H](CC2)[C@]2([C@](CC1)([C@H](CC2)[C@@H](CCC(=C)C(C)C)C)C)C)C3)(C)C)O
InChI: InChI=1S/C31H52O/c1-20(2)21(3)9-10-22(4)23-13-15-29(8)25-12-11-24-27(5,6)26(32)14-16-30(24)19-31(25,30)18-17-28(23,29)7/h20,22-26,32H,3,9-19H2,1-2,4-8H3/t22-,23-,24+,25+,26+,28-,29+,30-,31+/m1/s1

描述信息

24-methylenecycloartan-3-ol belongs to cycloartanols and derivatives class of compounds. Those are steroids containing a cycloartanol moiety. 24-methylenecycloartan-3-ol is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). 24-methylenecycloartan-3-ol can be found in a number of food items such as oregon yampah, common persimmon, pineapple, and climbing bean, which makes 24-methylenecycloartan-3-ol a potential biomarker for the consumption of these food products.

同义名列表

32 个代谢物同义名

(1S,3R,6S,8R,11S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2R)-6-methyl-5-methylideneheptan-2-yl]pentacyclo[9.7.0.0^{1,3}.0^{3,8}.0^{12,16}]octadecan-6-ol; 4alpha,4beta,14alpha-Trimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol; 4Α,4β,14α-trimethyl-9β,19-cyclo-5α-ergost-24(24(1))-en-3β-ol; 4a,4b,14a-Trimethyl-9b,19-cyclo-5a-ergost-24(24(1))-en-3b-ol; 9,19-Cyclolanostan-3-o1, 24-methylene-, (3β)-; (3beta,9beta)-24-Methylene-9,19-cyclolanostan-3-ol; 24-methylene-9beta,19-cyclo-lanostan-3beta-ol; (3Β,9β)-24-methylene-9,19-cyclolanostan-3-ol; (3b,9b)-24-Methylene-9,19-cyclolanostan-3-ol; (3beta)-24-Methylene-9,19-cyclolanostan-3-ol; (3β)-24-Methylene-9,19-cyclolanostan-3-ol; 9,19-Cyclo-24-methylenelanostan-3beta-ol; 24-Methylene-9,19-cyclolanostan-3beta-ol; 24-Methylene-9β,19-cyclo-lanostan-3β-ol; 24-Methylene-9b,19-cyclo-lanostan-3b-ol; 9,19-Cyclo-24-methylenelanostan-3β-ol; 3beta-Hydroxy-24-methylenecycloartane; 24-Methylene-9,19-cyclolanostan-3β-ol; 3β-Hydroxy-24-methylenecycloartane; 24-Methylenecycloartan-3beta-ol; 24-Methylencycloartan-3beta-ol; 24-Methylenecycloartan-3β-ol; 24-Methylenecycloartan-3b-ol; 24(28)-Methylenecycloartanol; 24-Methylencycloartan-3β-ol; 24-Methylenecycloartan-3-ol; 24-Methylidenecycloartanol; 24-methylene-cycloartanol; 24-Methylene cycloartanol; 24-methylenecycloartanol; 24-Methylenecycloartenol; 24-Methylidenecycloartanol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

24 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(24)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

118 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ACE2, EGFR, MAPKAPK2, PSAT1, VEGFA
Peripheral membrane protein 1 ACHE
Endosome membrane 2 EGFR, LEPR
Endoplasmic reticulum membrane 5 EGFR, ERG28, HMGCR, HSP90B1, RAC2
Nucleus 5 ACHE, EGFR, HSP90B1, MAPKAPK2, VEGFA
cytosol 5 HSP90B1, LIPE, MAPKAPK2, PSAT1, RAC2
centrosome 1 MAPKAPK2
nucleoplasm 2 MAPKAPK2, TMPRSS2
Cell membrane 6 ACE2, ACHE, EGFR, LEPR, LIPE, TMPRSS2
lamellipodium 1 RAC2
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 4 ERG28, HMGCR, LEPR, SLC5A1
Golgi apparatus membrane 1 LEPR
Synapse 1 ACHE
cell junction 1 EGFR
cell surface 4 ACE2, ACHE, EGFR, VEGFA
glutamatergic synapse 1 EGFR
Golgi apparatus 3 ACHE, LEPR, VEGFA
Golgi membrane 3 EGFR, INS, LEPR
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 1 GIP
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 LIPE
Lysosome 1 GAA
endosome 2 EGFR, LEPR
plasma membrane 8 ACE2, ACHE, BCHE, EGFR, GAA, RAC2, SLC5A1, TMPRSS2
Membrane 11 ACE2, ACHE, EGFR, ERG28, GAA, HMGCR, HSP90B1, LEPR, LIPE, TMPRSS2, VEGFA
apical plasma membrane 3 ACE2, EGFR, SLC5A1
basolateral plasma membrane 2 EGFR, LEPR
caveola 1 LIPE
extracellular exosome 8 ACE2, GAA, HSP90B1, MAPKAPK2, PSAT1, RAC2, SLC5A1, TMPRSS2
Lysosome membrane 1 GAA
endoplasmic reticulum 4 ERG28, HMGCR, HSP90B1, VEGFA
extracellular space 7 ACE2, ACHE, BCHE, EGFR, GIP, INS, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 ACHE, EGFR, HSP90B1, SLC5A1
adherens junction 1 VEGFA
protein-containing complex 2 EGFR, HSP90B1
intracellular membrane-bounded organelle 1 GAA
Single-pass type I membrane protein 3 ACE2, EGFR, LEPR
Secreted 6 ACE2, ACHE, BCHE, GAA, INS, VEGFA
extracellular region 10 ACE2, ACHE, BCHE, GAA, GIP, HSP90B1, INS, LEPR, TMPRSS2, VEGFA
mitochondrial outer membrane 1 RAC2
Extracellular side 1 ACHE
Cell projection, cilium 1 ACE2
nuclear membrane 1 EGFR
external side of plasma membrane 1 LEPR
Secreted, extracellular space, extracellular matrix 1 VEGFA
midbody 1 HSP90B1
Early endosome 1 SLC5A1
Single-pass type II membrane protein 1 TMPRSS2
Apical cell membrane 2 ACE2, SLC5A1
Membrane raft 2 ACE2, EGFR
focal adhesion 3 EGFR, HSP90B1, RAC2
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
intracellular vesicle 2 EGFR, SLC5A1
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 VEGFA
receptor complex 2 EGFR, LEPR
cilium 1 ACE2
phagocytic vesicle membrane 1 RAC2
brush border membrane 2 ACE2, SLC5A1
blood microparticle 1 BCHE
Basolateral cell membrane 1 LEPR
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 RAC2
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
Melanosome 1 HSP90B1
side of membrane 1 ACHE
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 2 GIP, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ACE2, BCHE, GIP, HSP90B1, INS
platelet alpha granule lumen 1 VEGFA
endocytic vesicle membrane 1 ACE2
transport vesicle 2 ERG28, INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 EGFR
Sarcoplasmic reticulum lumen 1 HSP90B1
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
[Transmembrane protease serine 2 catalytic chain]: Secreted 1 TMPRSS2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 HSP90B1
NADPH oxidase complex 1 RAC2
endoplasmic reticulum chaperone complex 1 HSP90B1
autolysosome lumen 1 GAA
intracellular organelle 1 SLC5A1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
[Isoform E]: Secreted 1 LEPR
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Vanessa Suaza-Gaviria, Ana María Mesa-Vanegas, Omar Ocampo-Jiménez, Zulma Isabel Monsalve-Fonnegra. Antioxidant Activity and Phytopathogenic Control of Extracts and Fraction from Struthanthus calophyllus A.C.Sm. (Loranthaceae). Chemistry & biodiversity. 2023 Feb; 20(2):e202200830. doi: 10.1002/cbdv.202200830. [PMID: 36650106]
  • Fumiaki Okahara, Junko Suzuki, Kohjiro Hashizume, Noriko Osaki, Akira Shimotoyodome. Triterpene alcohols and sterols from rice bran reduce postprandial hyperglycemia in rodents and humans. Molecular nutrition & food research. 2016 07; 60(7):1521-31. doi: 10.1002/mnfr.201500897. [PMID: 26935127]
  • Faouzi Sakouhi, Christelle Absalon, Guido Flamini, Pier Luigi Cioni, Habib Kallel, Sadok Boukhchina. Lipid components of olive oil from Tunisian Cv. Sayali: characterization and authenticity. Comptes rendus biologies. 2010 Sep; 333(9):642-8. doi: 10.1016/j.crvi.2010.05.001. [PMID: 20816644]
  • Wahid Herchi, Saoussem Harrabi, Khaled Sebei, Sophie Rochut, Sadok Boukhchina, Claude Pepe, Habib Kallel. Phytosterols accumulation in the seeds of Linum usitatissimum L. Plant physiology and biochemistry : PPB. 2009 Oct; 47(10):880-5. doi: 10.1016/j.plaphy.2009.07.001. [PMID: 19616960]
  • Patricia Walter Rosa, Marina da Silva Machado, Fátima de Campos-Buzzi, Rivaldo Niero, Franco Delle Monache, Valdir Cechinel Filho. Seasonal and biological variations of Epidendrum mosenii: quantification of 24-methylenecycloartanol using gas chromatography. Natural product research. 2007 Sep; 21(11):975-81. doi: 10.1080/14786410701371553. [PMID: 17691046]
  • Shun Yao, Renming Liu, Xuefeng Huang, Lingyi Kong. Preparative isolation and purification of chemical constituents from the root of Adenophora tetraphlla by high-speed counter-current chromatography with evaporative light scattering detection. Journal of chromatography. A. 2007 Jan; 1139(2):254-62. doi: 10.1016/j.chroma.2006.11.056. [PMID: 17150224]
  • C Ma, N Nakamura, M Hattori, H Kakuda, J Qiao, H Yu. Inhibitory effects on HIV-1 protease of constituents from the wood of Xanthoceras sorbifolia. Journal of natural products. 2000 Feb; 63(2):238-42. doi: 10.1021/np9902441. [PMID: 10691716]
  • S Pascal, M Taton, A Rahier. Oxidative C4-demethylation of 24-methylene cycloartanol by a cyanide-sensitive enzymatic system from higher plant microsomes. Biochemical and biophysical research communications. 1990 Oct; 172(1):98-106. doi: 10.1016/s0006-291x(05)80178-0. [PMID: 2222486]