Eupatilin (BioDeep_00000003626)

 

Secondary id: BioDeep_00000270140, BioDeep_00000864264

human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one; 5,7-Dihydroxy-3,4,6-trimethoxyflavone; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one; 4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5,7-dihydroxy-6-Methoxy-

化学式: C18H16O7 (344.0895986)
中文名称: 异泽兰黄素, 泽兰林素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.14%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1ccc(c(c1)OC)OC)O)OC)O
InChI: InChI=1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3

描述信息

Eupatilin is a trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3 and C-4 respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities. It has a role as an anti-ulcer drug, an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, an antineoplastic agent, an anti-inflammatory agent and a metabolite. It is a trimethoxyflavone and a dihydroxyflavone.
Eupatilin is a natural product found in Eupatorium capillifolium, Chromolaena odorata, and other organisms with data available.
A trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3 and C-4 respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities.
Eupatilin is found in herbs and spices. Eupatilin is isolated from Tanacetum vulgare (tansy
Isolated from Tanacetum vulgare (tansy). Eupatilin is found in herbs and spices.
Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.

同义名列表

18 个代谢物同义名

2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one; 5,7-Dihydroxy-3,4,6-trimethoxyflavone; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one; 4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5,7-dihydroxy-6-Methoxy-; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one, 9CI; 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one #; 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one; 2-(3,4-Dimethoxy-phenyl)-5,7-dihydroxy-6-methoxy-chromen-4-one; 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-chromen-4-one; 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one; 4-(2-METHACRYLOXY-ETHYL-1-OXY)BENZOICACID; 5,7-dihydroxy-3,4,6-trimethoxy flavone; 5,7-dihydroxy-3,4,6-trimethoxyflavone; Eupatilin, >=98\\% (HPLC); EUPATILIN [WHO-DD]; UNII-4D58O05490; 4D58O05490; Euptailin; Eupatilin



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

51 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kaicheng Du, Changwei Zheng, Zhulingzhi Kuang, Yiwei Sun, Yumeng Wang, Shuang Li, Dali Meng. Gastroprotective effect of eupatilin, a polymethoxyflavone from Artemisia argyi H.Lév. & Vaniot, in ethanol-induced gastric mucosal injury via NF-κB signaling pathway. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):116986. doi: 10.1016/j.jep.2023.116986. [PMID: 37536645]
  • Jinyuan Hu, Yuanyuan Liu, Zheng Pan, Xuekuan Huang, Jianwei Wang, Wenfu Cao, Zhiwei Chen. Eupatilin Ameliorates Hepatic Fibrosis and Hepatic Stellate Cell Activation by Suppressing β-catenin/PAI-1 Pathway. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065933. [PMID: 36983006]
  • Yanhong Sun, Xiaoyan Duan, Fenghe Wang, Huixin Tan, Jiahuan Hu, Wanting Bai, Xinbo Wang, Baolian Wang, Jinping Hu. Inhibitory effects of flavonoids on glucose transporter 1 (GLUT1): From library screening to biological evaluation to structure-activity relationship. Toxicology. 2023 Mar; ?(?):153475. doi: 10.1016/j.tox.2023.153475. [PMID: 36870413]
  • Tanja Hell, Adriano Rutz, Lara Dürr, Maciej Dobrzyński, Jakob K Reinhardt, Timo Lehner, Morris Keller, Anika John, Mahabir Gupta, Olivier Pertz, Matthias Hamburger, Jean-Luc Wolfender, Eliane Garo. Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma. Journal of natural products. 2022 06; 85(6):1540-1554. doi: 10.1021/acs.jnatprod.2c00146. [PMID: 35640148]
  • Donghui Bai, Tianxiao Sun, Fang Lu, Yancheng Shen, Yan Zhang, Bo Zhang, Guangli Yu, Haihua Li, Jiejie Hao. Eupatilin Suppresses OVA-Induced Asthma by Inhibiting NF-κB and MAPK and Activating Nrf2 Signaling Pathways in Mice. International journal of molecular sciences. 2022 Jan; 23(3):. doi: 10.3390/ijms23031582. [PMID: 35163503]
  • Antonella Rosa, Raffaella Isola, Federica Pollastro, Mariella Nieddu. Effect of the natural polymethoxylated flavone artemetin on lipid oxidation and its impact on cancer cell viability and lipids. Fitoterapia. 2022 Jan; 156(?):105102. doi: 10.1016/j.fitote.2021.105102. [PMID: 34921927]
  • Juan Francisco Palacios-Espinosa, Pablo Noé Núñez-Aragón, Erika Gomez-Chang, Edelmira Linares, Robert Bye, Irma Romero. Anti-Helicobacter pylori Activity of Artemisia ludoviciana subsp. mexicana and Two of Its Bioactive Components, Estafiatin and Eupatilin. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123654. [PMID: 34203927]
  • Ming Ma. Cilia and polycystic kidney disease. Seminars in cell & developmental biology. 2021 02; 110(?):139-148. doi: 10.1016/j.semcdb.2020.05.003. [PMID: 32475690]
  • A Rosa, R Isola, F Pollastro, P Caria, G Appendino, M Nieddu. The dietary flavonoid eupatilin attenuates in vitro lipid peroxidation and targets lipid profile in cancer HeLa cells. Food & function. 2020 Jun; 11(6):5179-5191. doi: 10.1039/d0fo00777c. [PMID: 32436500]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Jia-Xuan Xia, Bin-Bin Zhao, Jun-Feng Zan, Ping Wang, Lin-Lin Chen. Simultaneous determination of phenolic acids and flavonoids in Artemisiae Argyi Folium by HPLC-MS/MS and discovery of antioxidant ingredients based on relevance analysis. Journal of pharmaceutical and biomedical analysis. 2019 Oct; 175(?):112734. doi: 10.1016/j.jpba.2019.06.031. [PMID: 31330286]
  • Jakob K Reinhardt, Amy M Klemd, Ombeline Danton, Maria De Mieri, Martin Smieško, Roman Huber, Thomas Bürgi, Carsten Gründemann, Matthias Hamburger. Sesquiterpene Lactones from Artemisia argyi: Absolute Configuration and Immunosuppressant Activity. Journal of natural products. 2019 06; 82(6):1424-1433. doi: 10.1021/acs.jnatprod.8b00791. [PMID: 31181920]
  • Golnoush Mirzahosseini, Azadeh Manayi, Mahnaz Khanavi, Maliheh Safavi, Ali Salari, Alireza Madjid Ansari, Hassan San'ati, Mahdi Vazirian. Bio-guided isolation of Centaurea bruguierana subsp. belangerana cytotoxic components. Natural product research. 2019 Jun; 33(11):1687-1690. doi: 10.1080/14786419.2018.1428590. [PMID: 29457735]
  • Weifeng Zhong, Zhiming Wu, Nanhui Chen, Kaihua Zhong, Yifeng Lin, Huiming Jiang, Pei Wan, Shanming Lu, Lawei Yang, Siping Liu. Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1. BioMed research international. 2019; 2019(?):5016483. doi: 10.1155/2019/5016483. [PMID: 31179326]
  • Xixiao Wang, Jie Ren, Shixing Zhu, Guoqing Ren, Lei Wang, Xiaoyan Chen, Zhixia Qiu, Chaofeng Zhang. Pharmacokinetics and tissue distribution of eupatilin and its metabolite in rats by an HPLC-MS/MS method. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 159(?):113-118. doi: 10.1016/j.jpba.2018.06.037. [PMID: 29980012]
  • Jin Soo Kim, Seul Gi Lee, Kyoungjin Min, Taeg Kyu Kwon, Ha-Jeong Kim, Ju-Ock Nam. Eupatilin inhibits adipogenesis through suppression of PPARγ activity in 3T3-L1 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jul; 103(?):135-139. doi: 10.1016/j.biopha.2018.03.073. [PMID: 29649628]
  • Joo-Il Kim, Sang-Wook Park, Jhong-Jae Lim, Se-Il Sohn, Ji-Su Shin, Sang Cheol Park, Young Pyo Jang, Eun Kyoung Chung, Hong-Woo Lee, Kyung-Tae Lee. Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury. Acta pharmaceutica (Zagreb, Croatia). 2017 Dec; 67(4):479-494. doi: 10.1515/acph-2017-0037. [PMID: 29337669]
  • Yujung Jung, Jin-Chul Kim, Yongsoo Choi, Sullim Lee, Ki Sung Kang, Yong Kee Kim, Su-Nam Kim. Eupatilin with PPARα agonistic effects inhibits TNFα-induced MMP signaling in HaCaT cells. Biochemical and biophysical research communications. 2017 11; 493(1):220-226. doi: 10.1016/j.bbrc.2017.09.043. [PMID: 28899779]
  • Xian-Zhang Huang, Li-Ping Kang, Li Gao, Yuan Zhang, Lan-Ping Guo, Lu-Qi Huang. [Quantative analysis of eupatilin and jaceosidin in folium of Artemisia argyi from different areas in China by RP-HPLC based on ancient medicine books]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Sep; 42(18):3504-3508. doi: 10.19540/j.cnki.cjcmm.20170814.009. [PMID: 29218934]
  • S H Choo, S W Lee, M R Chae, S J Kang, H H Sung, D H Han, J N Chun, J K Park, C Y Kim, H K Kim, I So. Effects of eupatilin on the contractility of corpus cavernosal smooth muscle through nitric oxide-independent pathways. Andrology. 2017 Sep; 5(5):1016-1022. doi: 10.1111/andr.12397. [PMID: 28719725]
  • Lei Du, Jia Chen, Yi-Qiao Xing. Eupatilin prevents H2O2-induced oxidative stress and apoptosis in human retinal pigment epithelial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Jan; 85(?):136-140. doi: 10.1016/j.biopha.2016.11.108. [PMID: 27930977]
  • Arjun Sapkota, Bhakta Prasad Gaire, Kyu Suk Cho, Se Jin Jeon, Oh Wook Kwon, Dae Sik Jang, Sun Yeou Kim, Jong Hoon Ryu, Ji Woong Choi. Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation. PloS one. 2017; 12(2):e0171479. doi: 10.1371/journal.pone.0171479. [PMID: 28178289]
  • Feng Li, Ya Tao, Yan Qiao, Ke Li, Yanan Jiang, Chang Cao, Shuxin Ren, Xiaobin Chang, Xiaona Wang, Yanhong Wang, Yifei Xie, Ziming Dong, Jimin Zhao, Kangdong Liu. Eupatilin inhibits EGF-induced JB6 cell transformation by targeting PI3K. International journal of oncology. 2016 Sep; 49(3):1148-54. doi: 10.3892/ijo.2016.3600. [PMID: 27573489]
  • Qian Sun, Di Wang, Fei-Fei Li, Guo-Dong Yao, Xue Li, Ling-Zhi Li, Xiao-Xiao Huang, Shao-Jiang Song. Cytotoxic prenylated flavones from the stem and root bark of Daphne giraldii. Bioorganic & medicinal chemistry letters. 2016 08; 26(16):3968-72. doi: 10.1016/j.bmcl.2016.07.002. [PMID: 27400887]
  • Zengyong Qiao, Ya-Wei Xu, Jingyu Yang. Eupatilin inhibits the apoptosis in H9c2 cardiomyocytes via the Akt/GSK-3β pathway following hypoxia/reoxygenation injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Aug; 82(?):373-8. doi: 10.1016/j.biopha.2016.05.026. [PMID: 27470375]
  • H M Lee, H J Jang, S S Kim, H J Kim, S Y Lee, M Y Oh, H C Kwan, D S Jang, D W Eom. Protective Effect of Eupatilin Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice. Transplantation proceedings. 2016 May; 48(4):1226-33. doi: 10.1016/j.transproceed.2016.01.024. [PMID: 27320593]
  • Jeong Soo Kim, Kwang Ho Cha, Seung Yeob Kang, Donghan Won, Sun Woo Jang, Miwon Son, Moon Ho Son, Ho Jung Choi, Young Won Lee, Myung Joo Kang. In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs. Drug design, development and therapy. 2016; 10(?):1917-25. doi: 10.2147/dddt.s102918. [PMID: 27354765]
  • Amer Tarawneh, Francisco León, Sara Pettaway, Khaled M Elokely, Michael L Klein, Janet Lambert, Arsala Mansoor, Stephen J Cutler. Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors. Journal of natural products. 2015 Jun; 78(6):1461-5. doi: 10.1021/acs.jnatprod.5b00218. [PMID: 26035635]
  • Hyun-Ja Jeong, Jeong-Hwa Kim, Na-Rae Kim, Myoung-schook Yoou, Sun-Young Nam, Kyu-Youb Kim, Youngjin Choi, Jae-Bum Jang, In-Cheol Kang, Nam-In Baek, Hyung-Min Kim. Antidepressant effect of Stillen. Archives of pharmacal research. 2015 Jun; 38(6):1223-31. doi: 10.1007/s12272-014-0472-8. [PMID: 25163682]
  • Jae Won Chang, Hye Sook Hwang, Yeon Soo Kim, Haeng Jun Kim, Yoo Seob Shin, Tatsanachat Jittreetat, Chul-Ho Kim. Protective effect of Artemisia asiatica (Pamp.) Nakai ex Kitam ethanol extract against cisplatin-induced apoptosis of human HaCaT keratinocytes: Involvement of NF-kappa B- and Bcl-2-controlled mitochondrial signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Jun; 22(6):679-88. doi: 10.1016/j.phymed.2015.04.003. [PMID: 26055133]
  • J Y Kim, S S Kim, H J Jang, M Y Oh, D H Lee, D W Eom, K S Kang, S N Kim, H C Kwan, J Y Ham, W J Kim, D S Jang, D J Han. 5,7-dihydroxy-3,4,6-trimethoxyflavone attenuates ischemic damage and apoptosis in mouse islets. Transplantation proceedings. 2015 May; 47(4):1073-8. doi: 10.1016/j.transproceed.2014.12.049. [PMID: 26036523]
  • E K Jeong, H J Jang, S S Kim, M Y Oh, D H Lee, D W Eom, K S Kang, H C Kwan, J Y Ham, C S Park, D S Jang, D J Han. Protective effect of eupatilin against renal ischemia-reperfusion injury in mice. Transplantation proceedings. 2015 Apr; 47(3):757-62. doi: 10.1016/j.transproceed.2014.12.044. [PMID: 25891726]
  • Juryun Kim, Youngkyun Kim, Hyoju Yi, Hyerin Jung, Yeri Alice Rim, Narae Park, Seung Min Jung, Sung-Hwan Park, Ji Hyeon Ju. Eupatilin ameliorates collagen induced arthritis. Journal of Korean medical science. 2015 Mar; 30(3):233-9. doi: 10.3346/jkms.2015.30.3.233. [PMID: 25729243]
  • Qiang Wei, Xiao-ying Ji, Xian-shun Long, Qian-rong Li, Hao Yin. [Chemical Constituents from Leaves of "Chuju" Chrysanthemum morifolium and Their Antioxidant Activities in vitro]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Feb; 38(2):305-10. doi: . [PMID: 26415406]
  • Heejung Yang, Dong Young Lee, Minji Jeon, Youngbae Suh, Sang Hyun Sung. Determination of five active compounds in Artemisia princeps and A. capillaris based on UPLC-DAD and discrimination of two species with multivariate analysis. Archives of pharmacal research. 2014 May; 37(5):617-25. doi: 10.1007/s12272-013-0204-5. [PMID: 23835834]
  • Kaan Polatoğlu, Omer Cem Karakoç, Fatih Demirci, Ayhan Gökçe, Nezhun Gören. Chemistry and biological activities of Tanacetum chiliophyllum var. oligocephalum extracts. Journal of AOAC International. 2013 Nov; 96(6):1222-7. doi: 10.5740/jaoacint.sgepolatoglu. [PMID: 24645497]
  • Byeong Bae Park, Jin sun Yoon, Eun shil Kim, Jiyoung Choi, Young woong Won, Jung hye Choi, Young Yiul Lee. Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2013 Apr; 34(2):875-85. doi: 10.1007/s13277-012-0621-y. [PMID: 23292941]
  • Mudan Cai, Phuong-Thuy T Phan, Jin Gyu Hong, Dong Hyun Kim, Jong Min Kim, Se Jin Park, Xiaotong Liu, Jeong Eun Han, Haeil Park, Ji Woong Choi, Jong Hoon Ryu. The neuroprotective effect of eupatilin against ischemia/reperfusion-induced delayed neuronal damage in mice. European journal of pharmacology. 2012 Aug; 689(1-3):104-10. doi: 10.1016/j.ejphar.2012.05.042. [PMID: 22683875]
  • Agung Nugroho, Myung-Hoe Kim, Jongwon Choi, Nam-In Baek, Hee-Juhn Park. In vivo sedative and gastroprotective activities of Salvia plebeia extract and its composition of polyphenols. Archives of pharmacal research. 2012 Aug; 35(8):1403-11. doi: 10.1007/s12272-012-0810-7. [PMID: 22941483]
  • Mi Ja Chung, Jeong-Mi Kim, Sangchul Lee, Taewoo Kim, Daejung Kim, Jongmi Baek, Taehyuk Kim, Jaesung Lee, Kyoungkon Kim, Jin A Yoon, Myeon Choe. Suppressive effects of Schizandra chinensis Baillon water extract on allergy-related cytokine generation and degranulation in IgE-antigen complex-stimulated RBL-2H3 cells. Nutrition research and practice. 2012 Apr; 6(2):97-105. doi: 10.4162/nrp.2012.6.2.97. [PMID: 22586497]
  • Jung-Hoon Cho, Jong-Gyu Lee, Yeong-In Yang, Ji-Hyun Kim, Ji-Hye Ahn, Nam-In Baek, Kyung-Tae Lee, Jung-Hye Choi. Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Aug; 49(8):1737-44. doi: 10.1016/j.fct.2011.04.019. [PMID: 21554918]
  • Kang Nyeong Lee, Oh Young Lee, Myung-Gyu Choi, Seok Reyol Choi, Dong Ho Lee, Yong Chan Lee, Tae Nyeun Kim, Suck Chei Choi, Jong Sun Rew, Sang-Yong Seol. Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol. Journal of Korean medical science. 2011 Aug; 26(8):1074-80. doi: 10.3346/jkms.2011.26.8.1074. [PMID: 21860559]
  • Ji-Young Choi, Su-Kyung Shin, Seon-Min Jeon, Nam-In Baek, Hae-Gon Chung, Tae-Sook Jeong, Kyung Tae Lee, Mi-Kyung Lee, Myung-Sook Choi. Dose-response study of sajabalssuk ethanol extract from Artemisia princeps Pampanini on blood glucose in subjects with impaired fasting glucose or mild type 2 diabetes. Journal of medicinal food. 2011 Jan; 14(1-2):101-7. doi: 10.1089/jmf.2010.1266. [PMID: 21138376]
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  • Bence Csapi, Zsuzsanna Hajdú, István Zupkó, Agnes Berényi, Peter Forgo, Pál Szabó, Judit Hohmann. Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria. Phytotherapy research : PTR. 2010 Nov; 24(11):1664-9. doi: 10.1002/ptr.3187. [PMID: 21031625]
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  • Eun-Ju Choi, Hyun-Mee Oh, Hyun Wee, Chang-Soo Choi, Suck-Chei Choi, Ki-Hoon Kim, Weon-Cheol Han, Tae-Young Oh, Sang-Hyun Kim, Chang-Duk Jun. Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells. Differentiation; research in biological diversity. 2009 Apr; 77(4):412-23. doi: 10.1016/j.diff.2008.12.004. [PMID: 19281788]
  • Young-Jin Kang, Un Ju Jung, Mi-Kyung Lee, Hye-Jin Kim, Seon-Min Jeon, Yong Bok Park, Hae-Gon Chung, Nam-In Baek, Kyung Tae Lee, Tae-Sook Jeong, Myung-Sook Choi. Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic beta-cell function in type 2 diabetic mice. Diabetes research and clinical practice. 2008 Oct; 82(1):25-32. doi: 10.1016/j.diabres.2008.06.012. [PMID: 18703253]
  • Jianghong Tang, Ning Lian, Chenglu Bi, Weihua Li. Analysis of eupatilin-human serum albumin interactions by means of spectroscopic and computational modelling. The Journal of pharmacy and pharmacology. 2007 May; 59(5):637-43. doi: 10.1211/jpp.59.5.0003. [PMID: 17524228]
  • Yan Hua, Han-qing Wang. [Studies on the flavonoids from whole herbs of Seriphidium terrae-albae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 May; 31(10):820-2. doi: . [PMID: 17048665]
  • Do-Hee Kim, Hye-Kyung Na, Tae Young Oh, Chang-Yell Shin, Young-Joon Surh. Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2005; 24(4):251-9. doi: 10.1615/jenvironpatholtoxicoloncol.v24.i4.20. [PMID: 16393119]
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