Nobiletin (BioDeep_00000002607)

 

Secondary id: BioDeep_00000270592

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 9CI

化学式: C21H22O8 (402.1315)
中文名称: 蜜橘黄素, 川皮亭, 川皮苷, 川陈皮素
谱图信息: 最多检出来源 Viridiplantae(plant) 77.48%

分子结构信息

SMILES: c1(c(c(c2c(c1OC)oc(cc2=O)c1cc(c(cc1)OC)OC)OC)OC)OC
InChI: InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3

描述信息

Nobiletin is a methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3 and 4 respectively. It has a role as a plant metabolite and an antineoplastic agent. It is functionally related to a flavone.
Nobiletin is a natural product found in Citrus tankan, Citrus keraji, and other organisms with data available.
See also: Tangerine peel (part of); Citrus aurantium fruit rind (part of).
Isolated from peel of king orange (Citrus nobilis), seville orange (Citrus aurantium) and other Citrus subspecies, and the round kumquat (Fortunella japonica). Nobiletin is found in many foods, some of which are sweet bay, citrus, lemon, and grapefruit.
Nobiletin is found in citrus. Nobiletin is isolated from peel of king orange (Citrus nobilis), seville orange (Citrus aurantium) and other Citrus species, and the round kumquat (Fortunella japonica
A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3 and 4 respectively.
D020011 - Protective Agents > D000975 - Antioxidants
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis[1][2][3][4].
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce reactive oxygen species (ROS) levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis[1][2][3][4].

同义名列表

35 个代谢物同义名

2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 9CI; 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-; 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-; 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one; 2-(3,4-Dimethoxy-phenyl)-5,6,7,8-tetramethoxy-chromen-4-one; 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromen-4-one; 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one; 4,5,6,7,8,9,10,11,12,13-decahydrocyclododeca[d]oxazole; FLAVONE, 3,4,5,6,7,8-HEXAMETHOXY-; NOBILETIN, 20\\% (Technical Grade); Flavone, 5,6,7,8,3,4-hexamethoxy; 5,6,7,8,3,4-Hexamethoxyflavone; 3,4,5,6,7,8-Hexamethoxyflavone; Nobiletin (Hexamethoxyflavone); 5,6,7,8,3,4-hexamethoxyflavone; Nobiletin, analytical standard; 345,6,7,8-Hexamethoxyflavone; HEXAMETHOXYFLAVONE [WHO-DD]; NOBILETIN (USP-RS); NOBILETIN [USP-RS]; hexamethoxyflavone; Nobiletin, >=97\\%; NOBILETIN [INCI]; Spectrum4_001020; Spectrum2_001697; Spectrum3_000921; UNII-D65ILJ7WLY; MEGxp0_000930; NCI60_041691; ACon1_000921; KBio3_001922; D65ILJ7WLY; Nobiletin; Nobiletin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

193 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 BMAL1, CASP3, CD36, HIF1A, MAPK1, MAPK14, MAPK8, MTOR, PIK3CA, PPARG, PRKAA2, PTGS2, STAT3, TP53, TYR, VEGFA
Peripheral membrane protein 3 CYP1B1, MTOR, PTGS2
Endoplasmic reticulum membrane 3 CYP1B1, MTOR, PTGS2
Nucleus 12 BMAL1, CASP3, HIF1A, MAPK1, MAPK14, MAPK8, MTOR, PPARG, PRKAA2, STAT3, TP53, VEGFA
cytosol 11 CASP3, HIF1A, MAPK1, MAPK14, MAPK8, MTOR, PIK3CA, PPARG, PRKAA2, STAT3, TP53
dendrite 2 MTOR, PRKAA2
nuclear body 1 HIF1A
phagocytic vesicle 2 CD36, MTOR
centrosome 2 MAPK1, TP53
nucleoplasm 11 BMAL1, CASP3, HIF1A, MAPK1, MAPK14, MAPK8, MTOR, PPARG, PRKAA2, STAT3, TP53
RNA polymerase II transcription regulator complex 3 HIF1A, PPARG, STAT3
Cell membrane 1 CD36
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 CD36
Golgi apparatus membrane 1 MTOR
Synapse 2 MAPK1, MAPK8
cell surface 2 CD36, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 4 CD36, MAPK1, PRKAA2, VEGFA
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, PRKAA2
Lysosome 2 MTOR, TYR
plasma membrane 4 CD36, MAPK1, PIK3CA, STAT3
Membrane 6 CD36, CYP1B1, MTOR, PRKAA2, TP53, VEGFA
apical plasma membrane 1 CD36
axon 3 CCK, MAPK8, PRKAA2
caveola 3 CD36, MAPK1, PTGS2
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 PTGS2, TP53, VEGFA
extracellular space 5 CCK, CD36, IL10, INS, VEGFA
perinuclear region of cytoplasm 3 PIK3CA, PPARG, TYR
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 4 CYP1B1, MAPK1, MAPK14, TP53
protein-containing complex 3 HIF1A, PTGS2, TP53
intracellular membrane-bounded organelle 4 BMAL1, CYP1B1, PPARG, TYR
Microsome membrane 3 CYP1B1, MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TYR
Secreted 4 CCK, IL10, INS, VEGFA
extracellular region 6 CCK, IL10, INS, MAPK1, MAPK14, VEGFA
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 BMAL1, STAT3, TP53
motile cilium 1 HIF1A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 MAPK1, TP53
external side of plasma membrane 1 CD36
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 TP53
axon cytoplasm 1 HIF1A
Melanosome membrane 1 TYR
Early endosome 1 MAPK1
Golgi-associated vesicle 1 TYR
Apical cell membrane 1 CD36
Membrane raft 1 CD36
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 1 MAPK1
spindle 1 MAPK1
extracellular matrix 1 VEGFA
collagen trimer 1 CD36
Nucleus, PML body 3 BMAL1, MTOR, TP53
PML body 3 BMAL1, MTOR, TP53
secretory granule 1 VEGFA
nuclear speck 3 HIF1A, MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK1
receptor complex 2 CD36, PPARG
neuron projection 1 PTGS2
chromatin 5 BMAL1, HIF1A, PPARG, STAT3, TP53
cell periphery 1 CD36
mitotic spindle 1 MAPK1
cytoskeleton 1 MAPK1
brush border membrane 1 CD36
spindle pole 1 MAPK14
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
Membrane, caveola 1 MAPK1
aryl hydrocarbon receptor complex 1 BMAL1
specific granule membrane 1 CD36
Melanosome 1 TYR
cytoplasmic stress granule 1 PRKAA2
Nucleus speckle 1 HIF1A
euchromatin 1 HIF1A
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 MAPK1
ficolin-1-rich granule lumen 2 MAPK1, MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 INS, MAPK1, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
chromatoid body 1 BMAL1
CLOCK-BMAL transcription complex 1 BMAL1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 CD36
transport vesicle 1 INS
azurophil granule lumen 1 MAPK1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 1]: Nucleus 1 TP53
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
platelet alpha granule membrane 1 CD36
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Yulia N Cajas, Karina Cañón-Beltrán, Rosane Mazzarella, Carolina Nuñez-Puente, Encina M González, Heriberto Rodriguez-Martinez, Dimitrios Rizos, Cristina A Martinez-Serrano. Nobiletin as a novel agent to enhance porcine in vitro embryo development and quality. Theriogenology. 2024 Jul; 223(?):36-46. doi: 10.1016/j.theriogenology.2024.04.011. [PMID: 38669840]
  • Xingran Kou, Min Hong, Fei Pan, Xin Huang, Qingran Meng, Yunchong Zhang, Qinfei Ke. Inhibitory effects of nobiletin-mediated interfacial instability of bile salt emulsified oil droplets on lipid digestion. Food chemistry. 2024 Jun; 444(?):138751. doi: 10.1016/j.foodchem.2024.138751. [PMID: 38412567]
  • Menglin Chen, Huaizhi Li, Shanshan Zheng, Junyu Shen, Yuxuan Chen, Yaqi Li, Mengyun Yuan, Jian Wu, Qingmin Sun. Nobiletin targets SREBP1/ACLY to induce autophagy-dependent cell death of gastric cancer cells through PI3K/Akt/mTOR signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155360. doi: 10.1016/j.phymed.2024.155360. [PMID: 38547624]
  • Qiqi Ran, Qianrong Gan, Ye Zhu, Li Song, Longyu Shen, Xinyi Duan, Xinyun Zhu, Wei Huang. Mechanism insights into the pleiotropic effects of nobiletin as a potential therapeutic agent on non-alcoholic fatty liver disease (NAFLD). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116322. doi: 10.1016/j.biopha.2024.116322. [PMID: 38401524]
  • Heng Wang, Qinqin Tian, Ruijing Zhang, Qiujing Du, Jie Hu, Tingting Gao, Siqi Gao, Keyi Fan, Xing Cheng, Sheng Yan, Guoping Zheng, Honglin Dong. Nobiletin alleviates atherosclerosis by inhibiting lipid uptake via the PPARG/CD36 pathway. Lipids in health and disease. 2024 Mar; 23(1):76. doi: 10.1186/s12944-024-02049-5. [PMID: 38468335]
  • Jingchun Bai, Xinyu Wang, Yiqiu Chen, Qiongyu Yuan, Zhaoyu Yang, Yuling Mi, Caiqiao Zhang. Nobiletin Ameliorates Aging of Chicken Ovarian Prehierarchical Follicles by Suppressing Oxidative Stress and Promoting Autophagy. Cells. 2024 Feb; 13(5):. doi: 10.3390/cells13050415. [PMID: 38474379]
  • Hongling Xu, Mingming Yuan, Kailin Niu, Wei Yang, Maoyuan Jiang, Lei Zhang, Jing Zhou. Involvement of Bile Acid Metabolism and Gut Microbiota in the Amelioration of Experimental Metabolism-Associated Fatty Liver Disease by Nobiletin. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050976. [PMID: 38474489]
  • Chaowen Fan, Anli Ling-Hu, Dali Sun, Weiman Gao, Chenfang Zhang, Xueqing Duan, Haiyang Li, Weiyi Tian, Qi Yu, Zunli Ke. Nobiletin Ameliorates Hepatic Lipid Deposition, Oxidative Stress, and Inflammation by Mechanisms That Involve the Nrf2/NF-κB Axis in Nonalcoholic Fatty Liver Disease. Journal of agricultural and food chemistry. 2023 Dec; 71(50):20105-20117. doi: 10.1021/acs.jafc.3c06498. [PMID: 38073108]
  • Areeg Almubarak, Sanghoon Lee, Il-Jeoung Yu, Yubyeol Jeon. Effects of Nobiletin supplementation on the freezing diluent on porcine sperm cryo-survival and subsequent in vitro embryo development. Theriogenology. 2023 Nov; 214(?):314-322. doi: 10.1016/j.theriogenology.2023.11.006. [PMID: 37956580]
  • Yueshan Pang, Juan Xiong, You Wu, Weijun Ding. A review on recent advances on nobiletin in central and peripheral nervous system diseases. European journal of medical research. 2023 Nov; 28(1):485. doi: 10.1186/s40001-023-01450-7. [PMID: 37932838]
  • Eunju Kim, Kazuaki Mawatari, Seung-Hee Yoo, Zheng Chen. The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes. Nutrients. 2023 Sep; 15(18):. doi: 10.3390/nu15183919. [PMID: 37764703]
  • Wei Huang, Hui Chen, Qi He, Weidang Xie, Zanlin Peng, Qiang Ma, Qiaobing Huang, Zhongqing Chen, Yanan Liu. Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota. Food & function. 2023 Aug; ?(?):. doi: 10.1039/d3fo01684f. [PMID: 37545398]
  • Menglin Chen, Ruijuan Zhang, Yaling Chen, Xu Chen, Yaqi Li, Junyu Shen, Mengyun Yuan, Yuxuan Chen, Jian Wu, Qingmin Sun. Nobiletin inhibits de novo FA synthesis to alleviate gastric cancer progression by regulating endoplasmic reticulum stress. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 116(?):154902. doi: 10.1016/j.phymed.2023.154902. [PMID: 37270969]
  • Konglong Feng, Yashan Duan, Huiting Zhang, Jie Xiao, Chi-Tang Ho, Qingrong Huang, Yong Cao. Influence of 1,3-diacylglycerol on physicochemical and digestion properties of nanoemulsions and its enhancement of encapsulation and bioaccessibility of hydrophobic nobiletin. Food & function. 2023 Jul; 14(13):6212-6225. doi: 10.1039/d3fo00543g. [PMID: 37345830]
  • Zhitian Lu, Xudong Li, Min Wang, Xiaojun Zhang, Runxuan Zhuang, Fan Wu, Wenxue Li, Wei Zhu, Bo Zhang. Liver-Specific Bmal1 Depletion Reverses the Beneficial Effects of Nobiletin on Liver Cholesterol Homeostasis in Mice Fed with High-Fat Diet. Nutrients. 2023 May; 15(11):. doi: 10.3390/nu15112547. [PMID: 37299510]
  • Cunzhen Zhao, Jiahua Guo, Chunyu Du, Yongjie Xu. Modulation of Fat Deposition-Gut Interactions in Obese Mice by Administrating with Nobiletin. Genes. 2023 May; 14(5):. doi: 10.3390/genes14051062. [PMID: 37239422]
  • Shang-Zhen Li, Ning-Ning Zhang, Xing Yang, Tian-Qing Huang, Yang Lin, Zheng-Meng Jiang, Yongxiang Yi, E-Hu Liu. Nobiletin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Gut Microbiota and Myristoleic Acid Metabolism. Journal of agricultural and food chemistry. 2023 May; ?(?):. doi: 10.1021/acs.jafc.2c08637. [PMID: 37139957]
  • Xushan Yang, Linye Sun, Dongliang Feng, Yudi Deng, Wenzhen Liao. A Lipidomic Study: Nobiletin ameliorates hepatic steatosis through regulation of lipid alternation. The Journal of nutritional biochemistry. 2023 Apr; ?(?):109353. doi: 10.1016/j.jnutbio.2023.109353. [PMID: 37116815]
  • Xiaoshan Liao, Jiaxuan Zou, Mengting Wu, Yudi Deng, Jinwei Shi, Yuting Hao, Hong Deng, Wenzhen Liao. Hypoglycemic Effect of Nobiletin via Gut Microbiota-Metabolism Axis on Hyperglycemic Mice. Molecular nutrition & food research. 2023 Mar; ?(?):e2200289. doi: 10.1002/mnfr.202200289. [PMID: 36906890]
  • Zunli Ke, Chaowen Fan, Jun Li, La Wang, Haiyang Li, Weiyi Tian, Qi Yu. Nobiletin Intake Attenuates Hepatic Lipid Profiling and Oxidative Stress in HFD-Induced Nonalcoholic-Fatty-Liver-Disease Mice. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062570. [PMID: 36985541]
  • Yanhong Sun, Xiaoyan Duan, Fenghe Wang, Huixin Tan, Jiahuan Hu, Wanting Bai, Xinbo Wang, Baolian Wang, Jinping Hu. Inhibitory effects of flavonoids on glucose transporter 1 (GLUT1): From library screening to biological evaluation to structure-activity relationship. Toxicology. 2023 Mar; ?(?):153475. doi: 10.1016/j.tox.2023.153475. [PMID: 36870413]
  • Chiara Corrado, Maria Magdalena Barreca, Stefania Raimondo, Patrizia Diana, Giacomo Pepe, Maria Giovanna Basilicata, Alice Conigliaro, Riccardo Alessandro. Nobiletin and xanthohumol counteract the TNFα-mediated activation of endothelial cells through the inhibition of the NF-κB signaling pathway. Cell biology international. 2023 Mar; 47(3):634-647. doi: 10.1002/cbin.11963. [PMID: 36378586]
  • Yuan Wu, Qiong Li, Ling-Ling Lv, Jing-Xian Chen, Hai-Feng Ying, Ming Ruan, Wen-Hua Zhu, Jia-Yue Xu, Chen-Yiyu Zhang, Kai-Yuan Zhang, Yuan-Biao Guo, Wei-Rong Zhu, Lan Zheng. Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 110(?):154610. doi: 10.1016/j.phymed.2022.154610. [PMID: 36584607]
  • Q-J Du, Q Li, R-H Zhou, H Wang, Q Yan, W-J Dang, J-J Guo. An investigation into the mechanism of nobiletin's inhibition of papillary thyroid cancer using network pharmacology analysis and experimental pharmacology. European review for medical and pharmacological sciences. 2023 Feb; 27(4):1553-1564. doi: 10.26355/eurrev_202302_31398. [PMID: 36876711]
  • Muhammad Umar Ijaz, Aqsa Ahmed, Khalid Abdullah Al-Ghanim, Fahad Al-Misned, Mian Nadeem Riaz, Zahid Ali Kaimkhani, Shahid Mahboob. Evaluation of the Possible Protective Role of Nobiletin against Arsenic-Induced Liver Damage in Male Albino Rats. Toxics. 2023 Jan; 11(2):. doi: 10.3390/toxics11020110. [PMID: 36850985]
  • Yun-Yi Chen, Jiao-Jiao Liang, Deng-Liang Wang, Jie-Biao Chen, Jin-Ping Cao, Yue Wang, Chong-De Sun. Nobiletin as a chemopreventive natural product against cancer, a comprehensive review. Critical reviews in food science and nutrition. 2023; 63(23):6309-6329. doi: 10.1080/10408398.2022.2030297. [PMID: 35089821]
  • Yueshan Pang, Ni Yang, Yali Zheng, Lu Zhang, Yan He, Weijun Ding. Nobiletin protects enteric nerves and ameliorates disordered bowel motility in diet-induced obese mice via increasing Trem2 expression. Biochemical and biophysical research communications. 2022 12; 635(?):19-29. doi: 10.1016/j.bbrc.2022.10.008. [PMID: 36252333]
  • Shiwei Su, Denggao Zhao, Bo Yuan, Yanyan Ma, Siyue Zhu, Kuangyu Xu, Grace Lee, Chi-Tang Ho, Qingrong Huang. Biosynthesis of 6- and 7-Mono-Demethylated Nobiletins by a Newly Isolated Strain of Yeast. Journal of agricultural and food chemistry. 2022 Dec; 70(49):15439-15448. doi: 10.1021/acs.jafc.2c03822. [PMID: 36454712]
  • Ching-Yen Lin, Pei-Yi Chen, Hao-Jen Hsu, Wan-Yun Gao, Ming-Jiuan Wu, Jui-Hung Yen. The Citrus Flavonoid Nobiletin Downregulates Angiopoietin-like Protein 3 (ANGPTL3) Expression and Exhibits Lipid-Modulating Effects in Hepatic Cells and Adult Zebrafish Models. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012485. [PMID: 36293338]
  • Xushan Yang, Yudi Deng, Yali Tu, Dongliang Feng, Wenzhen Liao. Nobiletin mitigates NAFLD via lipophagy and inflammation. Food & function. 2022 Oct; 13(19):10186-10199. doi: 10.1039/d2fo01682f. [PMID: 36111578]
  • Sebastian Larion, Caleb A Padgett, Joshua T Butcher, James D Mintz, David J Fulton, David W Stepp. The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm. American journal of physiology. Gastrointestinal and liver physiology. 2022 Oct; 323(4):G387-G400. doi: 10.1152/ajpgi.00130.2022. [PMID: 35997288]
  • Metee Iampanichakul, Anuson Poasakate, Prapassorn Potue, Siwayu Rattanakanokchai, Putcharawipa Maneesai, Parichat Prachaney, Wannapa Settheetham-Ishida, Poungrat Pakdeechote. Nobiletin resolves left ventricular and renal changes in 2K-1C hypertensive rats. Scientific reports. 2022 06; 12(1):9289. doi: 10.1038/s41598-022-13513-6. [PMID: 35662276]
  • Ying Zhou, Hong-Liang Zeng, Xin-Yue Wen, Ling Jiang, Chu-Han Fu, Yi-Bo Hu, Xin-Xin Lei, Li Zhang, Xing Yu, Si-Yu Yang, Li-Hua Huang, Hong Xiang, Jin-Hua Huang, Jing Chen, Li Lei, Qing-Hai Zeng. Selaginellin Inhibits Melanogenesis via the MAPK Signaling Pathway. Journal of natural products. 2022 04; 85(4):838-845. doi: 10.1021/acs.jnatprod.1c00971. [PMID: 35290062]
  • Wen Chai, Ji Zhang, Zhengbing Xiang, Honglian Zhang, Zhujun Mei, Hongbing Nie, Renxu Xu, Ping Zhang. Potential of nobiletin against Alzheimer's disease through inhibiting neuroinflammation. Metabolic brain disease. 2022 04; 37(4):1145-1154. doi: 10.1007/s11011-022-00932-7. [PMID: 35267136]
  • Michio Hashimoto, Kentaro Matsuzaki, Koji Maruyama, Shahdat Hossain, Eri Sumiyoshi, Harumi Wakatsuki, Setsushi Kato, Miho Ohno, Yoko Tanabe, Yoko Kuroda, Shuhei Yamaguchi, Koji Kajima, Yasushi Ohizumi, Osamu Shido. Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly. Food & function. 2022 Mar; 13(5):2768-2781. doi: 10.1039/d1fo03508h. [PMID: 35171190]
  • Shuyu Li, Xi Li, Fangyuan Chen, Min Liu, Liuxin Ning, Yufeng Yan, Shuncai Zhang, Shaoping Huang, Chuantao Tu. Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction. The Journal of nutritional biochemistry. 2022 02; 100(?):108888. doi: 10.1016/j.jnutbio.2021.108888. [PMID: 34695558]
  • Nadya M Morrow, Natasha A Trzaskalski, Antonio A Hanson, Evgenia Fadzeyeva, Dawn E Telford, Sanjiv S Chhoker, Brian G Sutherland, Jane Y Edwards, Murray W Huff, Erin E Mulvihill. Nobiletin Prevents High-Fat Diet-Induced Dysregulation of Intestinal Lipid Metabolism and Attenuates Postprandial Lipemia. Arteriosclerosis, thrombosis, and vascular biology. 2022 02; 42(2):127-144. doi: 10.1161/atvbaha.121.316896. [PMID: 34911361]
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