Tamoxifen (BioDeep_00000002259)

 

Secondary id: BioDeep_00000402574

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene

化学式: C26H29NO (371.2249)
中文名称: 他莫西芬
谱图信息: 最多检出来源 Homo sapiens(plant) 13.03%

分子结构信息

SMILES: CC/C(=C(\c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-

描述信息

Tamoxifen is only found in individuals that have used or taken this drug. It is one of the selective estrogen receptor modulators with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium. [PubChem]Tamoxifen binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes. The prolonged binding of tamoxifen to the nuclear chromatin of these results in reduced DNA polymerase activity, impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response. It is likely that tamoxifen interacts with other coactivators or corepressors in the tissue and binds with different estrogen receptors, ER-alpha or ER-beta, producing both estrogenic and antiestrogenic effects.
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02B - Hormone antagonists and related agents > L02BA - Anti-estrogens
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D020847 - Estrogen Receptor Modulators
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D050071 - Bone Density Conservation Agents
D000970 - Antineoplastic Agents
C1892 - Chemopreventive Agent

同义名列表

40 个代谢物同义名

1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine; (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine; 1-Para-b-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; 1-Para-β-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; (Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine; 2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine; 1-p-b-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; 1-p-Β-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; Savient brand OF tamoxifen citrate; Citrate, tamoxifen; Tamoxifen citrate; trans-Tamoxifen; Gen-tamoxifen; Tamoxifenum; Tamoxifeno; Tomaxithen; Zitazonium; Tamoxifene; Tamoxasta; Apo-tamox; Crisafeno; Tamoxifen; Tamoplex; Nolvadex; Novaldex; Soltamox; Nourytam; Istubol; Valodex; Tamofen; Retaxim; Citofen; Oncomox; Tamone; Zemide; Diemon; Noltam; Tamoxifen



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

52 个相关的代谢反应过程信息。

Reactome(50)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

  • Tamoxifen Metabolism Pathway: 4-Hydroxytamoxifen + Phosphoadenosine phosphosulfate ⟶ 4-Hydroxytamoxifen sulfate + Adenosine 3',5'-diphosphate
  • Tamoxifen Action Pathway: 4-Hydroxytamoxifen + Phosphoadenosine phosphosulfate ⟶ 4-Hydroxytamoxifen sulfate + Adenosine 3',5'-diphosphate

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AR, BRCA1, CDK4, CTNNB1, CYP2C19, CYP2C9, EGFR, PIK3C3, PRKX, PRL, PTEN, PTGS2, TBX20, TNK1
Peripheral membrane protein 2 PTGS2, TNK1
Endosome membrane 2 CLCN5, EGFR
Endoplasmic reticulum membrane 5 CD4, CYP2C19, CYP2C9, EGFR, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 9 AR, BRCA1, CDK4, CTNNB1, EGFR, PRKX, PRL, PTEN, TBX20
autophagosome 1 PIK3C3
cytosol 7 AR, CDK4, CLCN5, CTNNB1, PIK3C3, PRKCQ, PTEN
nuclear body 1 BRCA1
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 CTNNB1
nucleoplasm 7 AR, BRCA1, CDK4, CTNNB1, PRKX, PRL, PTEN
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 4 CD4, CLCN5, CTNNB1, EGFR
lamellipodium 1 CTNNB1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 CLCN5
Golgi apparatus membrane 1 CLCN5
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 2 CTNNB1, EGFR
cell surface 1 EGFR
glutamatergic synapse 3 CTNNB1, EGFR, PIK3C3
Golgi apparatus 1 CLCN5
Golgi membrane 2 CLCN5, EGFR
lysosomal membrane 2 CLCN5, EGF
presynaptic membrane 1 CTNNB1
synaptic vesicle 1 CLCN5
endosome 2 EGFR, PIK3C3
plasma membrane 12 AR, BRCA1, CD4, CLCN5, CTNNB1, CYP2C19, CYP2C9, EGF, EGFR, PRKCQ, PTEN, TNK1
Membrane 8 AR, BRCA1, CLCN5, CTNNB1, EGF, EGFR, PIK3C3, TNK1
apical plasma membrane 2 EGFR, PTEN
basolateral plasma membrane 2 CTNNB1, EGFR
caveola 1 PTGS2
extracellular exosome 2 CTNNB1, EGF
endoplasmic reticulum 1 PTGS2
extracellular space 5 EGF, EGFR, GNRH1, PRL, XCL1
perinuclear region of cytoplasm 2 CTNNB1, EGFR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CDK4, CTNNB1
protein-containing complex 5 AR, BRCA1, CTNNB1, EGFR, PTGS2
intracellular membrane-bounded organelle 2 CYP2C19, CYP2C9
Microsome membrane 2 CYP2C9, PTGS2
postsynaptic density 1 PTEN
Single-pass type I membrane protein 2 CD4, EGFR
Secreted 1 PRL
extracellular region 5 EGF, GNRH1, PRL, PTEN, XCL1
cytoplasmic side of plasma membrane 1 PTEN
transcription regulator complex 2 CDK4, CTNNB1
centriolar satellite 1 PRKCQ
Nucleus membrane 1 CDK4
nuclear membrane 2 CDK4, EGFR
external side of plasma membrane 1 CD4
dendritic spine 1 PTEN
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 CDK4
Wnt signalosome 1 CTNNB1
midbody 1 PIK3C3
Early endosome 2 CD4, CLCN5
apical part of cell 2 CLCN5, CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Membrane raft 2 CD4, EGFR
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CTNNB1, EGFR
GABA-ergic synapse 1 PIK3C3
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 PIK3C3
intracellular vesicle 1 EGFR
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
axoneme 1 PIK3C3
nuclear speck 1 AR
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 PIK3C3
receptor complex 1 EGFR
Cell projection, neuron projection 1 PTEN
neuron projection 2 PTEN, PTGS2
chromatin 4 AR, CDK4, PRL, TBX20
cell projection 1 PTEN
phagocytic vesicle membrane 1 PIK3C3
cell periphery 1 CTNNB1
Chromosome 1 BRCA1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
[Isoform 5]: Cytoplasm 1 BRCA1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
Endomembrane system 1 CTNNB1
endosome lumen 1 PRL
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
lateral element 1 BRCA1
euchromatin 1 CTNNB1
ubiquitin ligase complex 1 BRCA1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 2 CD4, PTGS2
male germ cell nucleus 1 BRCA1
platelet alpha granule lumen 1 EGF
XY body 1 BRCA1
Schmidt-Lanterman incisure 1 PTEN
beta-catenin-TCF complex 1 CTNNB1
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
aggresome 1 PRKCQ
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 3 CD4, EGF, EGFR
ribonucleoprotein complex 1 BRCA1
protein-DNA complex 1 CTNNB1
intracellular non-membrane-bounded organelle 1 BRCA1
DNA repair complex 1 BRCA1
catenin complex 1 CTNNB1
BRCA1-C complex 1 BRCA1
cyclin-dependent protein kinase holoenzyme complex 1 CDK4
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
T cell receptor complex 1 CD4
Autolysosome 1 PIK3C3
myelin sheath adaxonal region 1 PTEN
cyclin D1-CDK4 complex 1 CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
[Isoform alpha]: Secreted 1 PTEN
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 1 BRCA1


文献列表

  • Jing Zhao, Dongming Yan, Yue Li, Xiaoqing Xu, Fengling Li, Shuang Zhang, Jingyi Jin, Furong Qiu. Simultaneous determination of 11 oral targeted antineoplastic drugs and 2 active metabolites by LC-MS/MS in human plasma and its application to therapeutic drug monitoring in cancer patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Apr; 1237(?):124100. doi: 10.1016/j.jchromb.2024.124100. [PMID: 38547701]
  • Roy Eerlings, Purvi Gupta, Xiao Yin Lee, Tien Nguyen, Sarah El Kharraz, Florian Handle, Elien Smeets, Lisa Moris, Wout Devlies, Bram Vandewinkel, Irina Thiry, Duy Tien Ta, Anton Gorkovskiy, Karin Voordeckers, Els Henckaerts, Vitor B Pinheiro, Frank Claessens, Kevin J Verstrepen, Arnout Voet, Christine Helsen. Rational evolution for altering the ligand preference of estrogen receptor alpha. Protein science : a publication of the Protein Society. 2024 Apr; 33(4):e4940. doi: 10.1002/pro.4940. [PMID: 38511482]
  • Yuying Zhao, Hanxu Tan, Juping Zhang, Dandan Zhan, Bowen Yang, Shicui Hong, Bo Pan, Neng Wang, Tongkai Chen, Yafei Shi, Zhiyu Wang. Developing liver-targeted naringenin nanoparticles for breast cancer endocrine therapy by promoting estrogen metabolism. Journal of nanobiotechnology. 2024 Mar; 22(1):122. doi: 10.1186/s12951-024-02356-0. [PMID: 38504208]
  • Junyu Luo, Yaohui Luo, Chunlai Dong, Guangli Qi, Liang Zhong, Fang Liu, Weibo Wen. Enhancing Sperm Motility Parameters in Patients with Asthenospermia: A Combined Approach of Acupuncture at Fusiguan Point and Tamoxifen Citrate Tablets. Archivos espanoles de urologia. 2024 Mar; 77(2):142-147. doi: 10.56434/j.arch.esp.urol.20247702.19. [PMID: 38583006]
  • Maoxuan Wu, Jie Wang, Wanqing Zhou, Mengting Wang, Chunyan Hu, Ming Zhou, Kailin Jiao, Zhong Li. Vitamin D inhibits tamoxifen-induced non-alcoholic fatty liver disease through a nonclassical estrogen receptor/liver X receptor pathway. Chemico-biological interactions. 2024 Feb; 389(?):110865. doi: 10.1016/j.cbi.2024.110865. [PMID: 38191086]
  • Wenxia Wang, Xiao'an Liu. Comparison of effects of tamoxifen and Toremifene on hepatic function and serum lipids in breast cancer patients during adjuvant endocrine therapy. Anti-cancer drugs. 2024 Jan; ?(?):. doi: 10.1097/cad.0000000000001572. [PMID: 38241197]
  • Fatima Ahmad, Abrar Ahmed, Alishba Shakeel, Hafiza A Hussain, Syed A Raza. The efficacy of Linum usitatissimum seeds to inhibit estrogen receptor as a natural therapy for PCOS: An in silico and in vitro analysis. Cell biochemistry and function. 2024 Jan; 42(1):e3897. doi: 10.1002/cbf.3897. [PMID: 38063410]
  • Yinan Wang, WeiYi Cheng, Jingjing Zhu, Li He, WeiYe Ren, Dandan Bao, Ji-Gang Piao. Programmed Co-delivery of tamoxifen and docetaxel using lipid-coated mesoporous silica nanoparticles for overcoming CYP3A4-mediated resistance in triple-negative breast cancer treatment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116084. doi: 10.1016/j.biopha.2023.116084. [PMID: 38157645]
  • Xuan Li, Yuan Zhang, Tengjiang Zhang, Luyang Zhao, Christopher G Lin, Haitian Hu, Hanqiu Zheng. Tafazzin mediates tamoxifen resistance by regulating cellular phospholipid composition in ER-positive breast cancer. Cancer gene therapy. 2023 Nov; ?(?):. doi: 10.1038/s41417-023-00683-2. [PMID: 37935981]
  • Kazuki Nishimoto, Nobuyuki Okahashi, Masaharu Maruyama, Yoshihiro Izumi, Kohta Nakatani, Yuki Ito, Junko Iida, Takeshi Bamba, Fumio Matsuda. Lipidome and metabolome analyses reveal metabolic alterations associated with MCF-7 apoptosis upon 4-hydroxytamoxifen treatment. Scientific reports. 2023 10; 13(1):18549. doi: 10.1038/s41598-023-45764-2. [PMID: 37899460]
  • Suman Kumar Samanta, Paramita Choudhury, Raghuram Kandimalla, Farrukh Aqil, Disha N Moholkar, Ramesh C Gupta, Momita Das, Bhaskarjyoti Gogoi, Neelutpal Gogoi, Partha Pratim Sarma, Rajlakshmi Devi, Narayan C Talukdar. Mahanine mediated therapeutic inhibition of estrogen receptor-α and CDK4/6 expression, decipher the chemoprevention-signaling cascade in preclinical model of breast cancer. Journal of ethnopharmacology. 2023 Oct; 319(Pt 2):117235. doi: 10.1016/j.jep.2023.117235. [PMID: 37804924]
  • Ghulam Haider, Zoya Shaikh, Pavan Kumar, Paras Memon, Raja Rahul, Jai Parkash, Maryum Nouman, Khalil Ahmed, Mehwish Roshan Shaikh. Effect Of Tamoxifen On Plasma Lipid Profile In Patients Of Breast Cancer. Journal of Ayub Medical College, Abbottabad : JAMC. 2023 Oct; 35(4):558-562. doi: 10.55519/jamc-04-7330. [PMID: 38406935]
  • Gabriella Bianca Henriques Palma, Mandeep Kaur. miRNA-128 and miRNA-223 regulate cholesterol-mediated drug resistance in breast cancer. IUBMB life. 2023 09; 75(9):743-764. doi: 10.1002/iub.2726. [PMID: 37070323]
  • Emily A Morris, Ahlenne Abreu, Stylianos P Scordilis. Effect of Tamoxifen on Proteome Expression during In Vitro Myogenesis in Murine Skeletal Muscle C2C12 Cells. Journal of proteome research. 2023 09; 22(9):3040-3053. doi: 10.1021/acs.jproteome.3c00340. [PMID: 37552804]
  • Kevine Kamga Silihe, William Defo Mbou, Judith Christiane Ngo Pambe, Larissa Vanelle Kenmogne, Laure Fotso Maptouom, Marius Trésor Kemegne Sipping, Stéphane Zingue, Dieudonné Njamen. Comparative anticancer effects of Annona muricata Linn (Annonaceae) leaves and fruits on DMBA-induced breast cancer in female rats. BMC complementary medicine and therapies. 2023 Jul; 23(1):234. doi: 10.1186/s12906-023-04073-x. [PMID: 37454062]
  • Dhivya Shanmugarajan, Charles David. Estrogen receptor potentially stable conformations from molecular dynamics as a structure-based pharmacophore model for mapping, screening, and identifying ligands-a new paradigm shift in pharmacophore screening. Journal of biomolecular structure & dynamics. 2023 07; 41(11):4939-4948. doi: 10.1080/07391102.2022.2074543. [PMID: 35543232]
  • Sewon Hwang, Soojun Park, Jee Hyun Kim, Sang-Beom Bang, Hyeon-Ji Kim, Na-Lee Ka, Yoonae Ko, Seung-Su Kim, Ga Young Lim, Seunghee Lee, Young Kee Shin, So Yeon Park, Sanghee Kim, Mi-Ock Lee. Targeting HMG-CoA synthase 2 suppresses tamoxifen-resistant breast cancer growth by augmenting mitochondrial oxidative stress-mediated cell death. Life sciences. 2023 Jun; ?(?):121827. doi: 10.1016/j.lfs.2023.121827. [PMID: 37276910]
  • Yahyea Baktiar Laskar, Kasturi Bhattacharjee, Moumita Nath, Yashmin Choudhury, Pranab Behari Mazumder, Anupam Das Talukdar. Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies. Nutrition and cancer. 2023 May; ?(?):1-21. doi: 10.1080/01635581.2023.2219027. [PMID: 37255368]
  • Neha Tyagi, Tanya Ralli, Asgar Ali, Kanchan Kohli. Hypothesizing the Green Synthesis of Tamoxifen Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer. Current molecular medicine. 2023 May; ?(?):. doi: 10.2174/1566524023666230525104730. [PMID: 37231732]
  • Stuart R Castillo, Michael H L Nguyen, Mitchell DiPasquale, Elizabeth G Kelley, Drew Marquardt. Mitocans induce lipid flip-flop and permeabilize the membrane to signal apoptosis. Biophysical journal. 2023 Mar; ?(?):. doi: 10.1016/j.bpj.2023.03.039. [PMID: 36992561]
  • Sorelle Ines Fotsing, Judith Christiane Ngo Pambe, Kevine Kamga Silihe, Natacha Lena Yembeau, Armand Choupo, Dieudonné Njamen, Constant Anatole Pieme, Stéphane Zingue. Breast cancer cell growth arrest and chemopreventive effects of Passiflora edulis Sims (Passifloraceae) ethanolic leaves extract on a rat model of mammary carcinoma. Journal of ethnopharmacology. 2023 Mar; 311(?):116408. doi: 10.1016/j.jep.2023.116408. [PMID: 36966851]
  • Leila Karami. Interaction of neutral and protonated Tamoxifen with the DPPC lipid bilayer using molecular dynamics simulation. Steroids. 2023 Mar; 194(?):109225. doi: 10.1016/j.steroids.2023.109225. [PMID: 36948347]
  • Zhiqiang Fang, Hao Xu, Juanli Duan, Bai Ruan, Jingjing Liu, Ping Song, Jian Ding, Chen Xu, Zhiwen Li, Kefeng Dou, Lin Wang. Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice. Signal transduction and targeted therapy. 2023 Mar; 8(1):94. doi: 10.1038/s41392-022-01299-y. [PMID: 36864030]
  • Xiao Zhao, Des R Richardson. The role of the NDRG1 in the pathogenesis and treatment of breast cancer. Biochimica et biophysica acta. Reviews on cancer. 2023 Feb; ?(?):188871. doi: 10.1016/j.bbcan.2023.188871. [PMID: 36841367]
  • Jeong-Ju Yoo, Eun-Ae Jung, Zisun Kim, Bo-Yeon Kim. Risk of Cardiovascular Events and Lipid Profile Change in Patients with Breast Cancer Taking Aromatase Inhibitor: A Systematic Review and Meta-Analysis. Current oncology (Toronto, Ont.). 2023 02; 30(2):1831-1843. doi: 10.3390/curroncol30020142. [PMID: 36826103]
  • Karunya Jenin Ravindranath, Simon Durairaj Christian, Hemalatha Srinivasan. Screening of Anti-carcinogenic Properties of Phytocompounds from Allium ascalonicum for Treating Breast Cancer Through In Silico and In Vitro Approaches. Applied biochemistry and biotechnology. 2023 Feb; 195(2):1136-1157. doi: 10.1007/s12010-022-04202-1. [PMID: 36331692]
  • Muhammad Hassan Naeem Goraya, Ehsan Ul Haq Abbasi, Muhammad Kashif Amin, Faisal Inayat, Muhammad Junaid Ashraf, Mahrukh Qayyum, Nadeem Hussain, Gul Nawaz, Muhammad Adnan Zaman, Adnan Malik. Acute pancreatitis secondary to tamoxifen-associated hypertriglyceridemia: A clinical update. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2023 Jan; 29(1):218-225. doi: 10.1177/10781552221093969. [PMID: 35410558]
  • Yue Zhang, Yuxuan Song, Shuang Ren, Minqin Zhang, Zhao Zhang, Shuangqin Fan, Xing Liu, Xiaoyu Peng, Qi Qi, Xiangchun Shen, Yan Chen. GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells. Oncogene. 2023 01; 42(3):184-197. doi: 10.1038/s41388-022-02506-4. [PMID: 36400971]
  • Kaiyue Wang, Lu Shen, Wei Tian, Suzhan Zhang. Comparison of changes in lipid profiles of premenopausal women with early-stage breast cancer treated with different endocrine therapies. Scientific reports. 2022 12; 12(1):22650. doi: 10.1038/s41598-022-27008-x. [PMID: 36587111]
  • Ahmed Ismail, Hamada Ahmed Mokhlis, Marwa Sharaky, Mohamed H Sobhy, Sherif S Hassanein, Ahmed S Doghish, Salama A Salama, Amr D Mariee, Yasmin M Attia. Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase. Pathology, research and practice. 2022 Dec; 240(?):154211. doi: 10.1016/j.prp.2022.154211. [PMID: 36401980]
  • Lei Tian, Yanfei Peng, Kuo Yang, Jiasong Cao, Xiaoling Du, Zhixian Liang, Jiandang Shi, Ju Zhang. The ERα-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer. Cell communication and signaling : CCS. 2022 11; 20(1):178. doi: 10.1186/s12964-022-00979-0. [PMID: 36376959]
  • Katharina Bottermann, Lisa Kalfhues, Rianne Nederlof, Anne Hemmers, Lucia M Leitner, Vici Oenarto, Jana Nemmer, Mirjam Pfeffer, Vidisha Raje, Rene Deenen, Patrick Petzsch, Heba Zabri, Karl Köhrer, Andreas S Reichert, Maria Grandoch, Jens W Fischer, Diran Herebian, Johannes Stegbauer, Thurl E Harris, Axel Gödecke. Cardiomyocyte p38 MAPKα suppresses a heart-adipose tissue-neutrophil crosstalk in heart failure development. Basic research in cardiology. 2022 10; 117(1):48. doi: 10.1007/s00395-022-00955-2. [PMID: 36205817]
  • Deanna K Sosnowski, K Lockhart Jamieson, Artiom Gruzdev, Yingxi Li, Robert Valencia, Ala Yousef, Zamaneh Kassiri, Darryl C Zeldin, John M Seubert. Cardiomyocyte-specific disruption of soluble epoxide hydrolase limits inflammation to preserve cardiac function. American journal of physiology. Heart and circulatory physiology. 2022 10; 323(4):H670-H687. doi: 10.1152/ajpheart.00217.2022. [PMID: 35985007]
  • Carolina Furtado Macruz, Sônia Maria Rolim Rosa Lima. Effects of Cimicifuga racemosa (L.) Nutt on sexual function in women receiving tamoxifen for breast cancer. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2022 Oct; 42(7):3236-3240. doi: 10.1080/01443615.2022.2111517. [PMID: 35993523]
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