L-Aspartic acid (BioDeep_00000001362)

 

Secondary id: BioDeep_00000398115, BioDeep_00000398614

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(2S)-2-aminobutanedioic acid

化学式: C4H7NO4 (133.0375)
中文名称: DL-天门冬氨酸, L-天门冬氨酸, 天冬氨酸溶液, L-天冬氨酸, 天冬氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 14.99%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

L-Aspartic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-aspartic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001362). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(=O)O)N)C(=O)O
InChI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)

描述信息

Aspartic acid (Asp), also known as L-aspartic acid or as aspartate, the name of its anion, is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-aspartic acid is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Aspartic acid is found in all organisms ranging from bacteria to plants to animals. It is classified as an acidic, charged (at physiological pH), aliphatic amino acid. In humans, aspartic acid is a nonessential amino acid derived from glutamic acid by enzymes using vitamin B6. However, in the human body, aspartate is most frequently synthesized through the transamination of oxaloacetate. A non-essential amino acid is an amino acid that can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. As its name indicates, aspartic acid is the carboxylic acid analog of asparagine. The D-isomer of aspartic acid (D-aspartic acid) is one of two D-amino acids commonly found in mammals. Aspartic acid was first discovered in 1827 by Auguste-Arthur Plisson and Étienne Ossian Henry by hydrolysis of asparagine, which had been isolated from asparagus juice in 1806. Aspartate has many biochemical roles. It is a neurotransmitter, a metabolite in the urea cycle and it participates in gluconeogenesis. It carries reducing equivalents in the malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases which are key to DNA biosynthesis. In addition, aspartic acid acts as a hydrogen acceptor in a chain of ATP synthase. Aspartic acid is a major excitatory neurotransmitter, which is sometimes found to be increased in epileptic and stroke patients. It is decreased in depressed patients and in patients with brain atrophy. As a neurotransmitter, aspartic acid may provide resistance to fatigue and thus lead to endurance, although the evidence to support this idea is not strong (Wikipedia). Aspartic acid supplements are being evaluated. Five grams can raise blood levels. Magnesium and zinc may be natural inhibitors of some of the actions of aspartic acid. Aspartic acid, when chemically coupled with the amino acid D-phenylalanine, is a part of a natural sweetener, aspartame. This sweetener is an advance in artificial sweeteners, and is probably safe in normal doses to all except phenylketonurics. Aspartic acid may be a significant immunostimulant of the thymus and can protect against some of the damaging effects of radiation. Aspartic acid is found in higher abundance in: oysters, luncheon meats, sausage meat, wild game, sprouting seeds, oat flakes, avocado, asparagus, young sugarcane, and molasses from sugar beets.
[Spectral] L-Aspartate (exact mass = 133.03751) and Taurine (exact mass = 125.01466) and L-Asparagine (exact mass = 132.05349) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
[Spectral] L-Aspartate (exact mass = 133.03751) and L-Threonine (exact mass = 119.05824) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.


L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

同义名列表

98 个代谢物同义名

Aspartic Acid, Magnesium (1:1) Salt, Hydrochloride, Trihydrate; Aspartic Acid, Magnesium-Potassium (2:1:2) Salt; Aspartic Acid, Magnesium (2:1) Salt; Hydrochloride, aspartate magnesium; Aspartic Acid, Monopotassium Salt; Aspartate Magnesium Hydrochloride; Aspartic Acid, Dipotassium Salt; Aspartic Acid, Monosodium Salt; 2-Amino-3-methylsuccinic acid; Aspartic Acid, Potassium Salt; Aspartic Acid, Disodium Salt; (2S)-2-aminobutanedioic acid; Aspartic Acid, Hydrochloride; Aspartic Acid, Ammonium Salt; Aspartic Acid, Calcium Salt; Hydrochloride aspartic acid; (S)-2-Aminobutanedioic acid; Aspartic Acid, Hydrobromide; Hydrobromide aspartic acid; (S)-Amino-butanedioic acid; Aspartic Acid, Sodium Salt; 2-Amino-3-methylsuccinate; (S)-Aminobutanedioic acid; (S)-2-Aminosuccinic acid; Aspartate, Monopotassium; alpha-Aminosuccinic acid; (S)-2-Aminobutanedioate; Monopotassium Aspartate; Aspartate, Dipotassium; (S)-Amino-butanedioate; Aspartate, Monosodium; (S)-(+)-Aspartic acid; Dipotassium Aspartate; (S)-Aminobutanedioate; Aspartate, Potassium; (S)-2-Aminosuccinate; (R)-2-Aminosuccinate; 2-Aminosuccinic acid; L-Aminosuccinic acid; Monosodium Aspartate; alpha-Aminosuccinate; Aspartate, Magnesium; Poly-DL-succinimide; L-(+)-Aspartic acid; Potassium Aspartate; Aspartate, Ammonium; Aspartate, Disodium; Magnesium Aspartate; (R,S)-Aspartic Acid; L-Asparaginic acid; (2S)-Aspartic acid; Disodium Aspartate; Ammonium Aspartate; (+-)-Aspartic Acid; Aspartate, Calcium; L-Asparaginsaeure; (L)-Aspartic acid; Calcium aspartate; (S)-Aspartic acid; Aspartate, Sodium; (+)-Aspartic acid; (S)-(+)-Aspartate; Asparaginic acid; Sodium Aspartate; L-Asparagic acid; DL-Aspartic Acid; L-Aminosuccinate; 2-Aminosuccinate; L Aspartic Acid; L-Aspartic Acid; L-(+)-Aspartate; Polysuccinimide; (2S)-Aspartate; L-Asparaginate; Aminosuccinate; Asparagic acid; Aspartic Acid; MG 5 Longoral; Mg-5-Longoral; (+)-Aspartate; (L)-Aspartate; (S)-Aspartate; Asparaginate; L-Asparagate; Magnesiocard; L-Aspartate; MG5Longoral; L Aspartate; Asparatate; Asparagate; Aspartate; H-Asp-OH; L-Asp; Asp; D; Aspartic acid; L-Aspartate; Aspartic acid



数据库引用编号

60 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

25 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(12)

WikiPathways(7)

Plant Reactome(0)

INOH(5)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

425 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, CA1, DARS1, GLUL, PC, TP53
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 SPP1
Nucleus 6 ACHE, AKT1, ALB, CS, GLUL, TP53
cytosol 11 AKT1, ALB, ATP12A, CA1, DARS1, GLS, GLUL, LIPE, PC, PRKCQ, TP53
centrosome 2 ALB, TP53
nucleoplasm 2 AKT1, TP53
Cell membrane 7 ACHE, AKT1, GLUL, GPRC5A, GRID1, LIPE, SPP1
Lipid-anchor 1 GLUL
lamellipodium 1 AKT1
Multi-pass membrane protein 5 ATP12A, GPRC5A, GRID1, RHO, SPP1
Synapse 3 ACHE, DARS1, GLS
cell cortex 1 AKT1
cell surface 1 ACHE
glutamatergic synapse 2 AKT1, GRID1
Golgi apparatus 4 ACHE, ALB, RHO, SPP1
Golgi membrane 2 INS, RHO
neuromuscular junction 1 ACHE
postsynapse 1 AKT1
Cytoplasm, cytosol 4 DARS1, GLS, GLUL, LIPE
plasma membrane 10 ACHE, AKT1, ATP12A, F2, GLUL, GPRC5A, GRID1, PRKCQ, RHO, SPP1
Membrane 7 ACHE, AKT1, CS, DARS1, LIPE, RHO, TP53
apical plasma membrane 1 ATP12A
basolateral plasma membrane 1 ATP12A
caveola 1 LIPE
extracellular exosome 10 ALB, CA1, CS, DARS1, F2, GLUL, GPRC5A, GRID1, LYZ, SPP1
endoplasmic reticulum 3 ALB, GLUL, TP53
extracellular space 6 ACHE, ALB, F2, INS, LYZ, SPP1
perinuclear region of cytoplasm 2 ACHE, SPP1
mitochondrion 5 CS, GLS, GLUL, PC, TP53
protein-containing complex 3 AKT1, ALB, TP53
intracellular membrane-bounded organelle 1 GPRC5A
Secreted 5 ACHE, ALB, F2, INS, SPP1
extracellular region 6 ACHE, ALB, F2, INS, LYZ, SPP1
Mitochondrion matrix 3 CS, PC, TP53
mitochondrial matrix 4 CS, GLS, PC, TP53
Extracellular side 1 ACHE
anchoring junction 1 ALB
transcription regulator complex 1 TP53
centriolar satellite 1 PRKCQ
ciliary membrane 1 RHO
photoreceptor inner segment 1 RHO
photoreceptor outer segment 1 RHO
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
actin cytoskeleton 1 ATP12A
microtubule cytoskeleton 1 AKT1
nucleolus 2 GPRC5A, TP53
cell-cell junction 2 AKT1, RHO
vesicle 2 AKT1, GPRC5A
postsynaptic membrane 1 GRID1
Apical cell membrane 1 ATP12A
Cytoplasm, cytoskeleton 1 TP53
spindle 1 AKT1
GABA-ergic synapse 1 GRID1
basement membrane 1 ACHE
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 F2
Postsynaptic cell membrane 1 GRID1
receptor complex 1 GPRC5A
ciliary basal body 2 AKT1, ALB
chromatin 1 TP53
cell projection 1 SPP1
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 1 RHO
[Isoform 1]: Mitochondrion 1 GLS
spindle pole 1 ALB
blood microparticle 2 ALB, F2
sperm midpiece 1 RHO
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cytoplasmic vesicle membrane 1 GPRC5A
Golgi-associated vesicle membrane 1 RHO
cell body 1 GLUL
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
Microsome 1 GLUL
secretory granule lumen 1 INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 4 ALB, F2, INS, SPP1
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 ALB
Photoreceptor inner segment membrane 1 RHO
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
aminoacyl-tRNA synthetase multienzyme complex 1 DARS1
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
[Isoform 3]: Mitochondrion 1 GLS
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
glial cell projection 1 GLUL
photoreceptor disc membrane 1 RHO
rod photoreceptor outer segment 1 RHO
potassium:proton exchanging ATPase complex 1 ATP12A
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB


文献列表

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  • Qing Xiao, Qingrong Huang, Chi-Tang Ho. Asparagine-Glucose Amadori Compounds: Formation, Characterization, and Analysis in Dry Jujube Fruit. Journal of agricultural and food chemistry. 2024 Apr; 72(13):7344-7353. doi: 10.1021/acs.jafc.4c00526. [PMID: 38502793]
  • Xiao-Ping Li, Michael J Rudolph, Yang Chen, Nilgun E Tumer. Structure-Function Analysis of the A1 Subunit of Shiga Toxin 2 with Peptides That Target the P-Stalk Binding Site and Inhibit Activity. Biochemistry. 2024 Apr; 63(7):893-905. doi: 10.1021/acs.biochem.3c00733. [PMID: 38467020]
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  • Yi Shen, Yi-Qi Sun, He-Ming Li, Quan-Long Zhang, Qi-Ming Zhao, Jin-Long Xu, Lu-Ping Qin, Qiao-Yan Zhang. [UPLC-Q-TOF-MS-based metabolomics reveals mechanism of Morinda officinalis iridoid glycosides in treating rheumatoid arthritis and bone loss]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(2):453-460. doi: 10.19540/j.cnki.cjcmm.20230914.705. [PMID: 38403321]
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  • Leyi Shao, Wei Wang, Xin Gong, Yinghao Yu, Junao Xue, Xinnian Zeng, Jiali Liu. The Toxicity Differences of Fluralaner against the Red Imported Fire Ant (Solenopsis invicta) at Different Developmental Stages. International journal of molecular sciences. 2023 Oct; 24(21):. doi: 10.3390/ijms242115627. [PMID: 37958611]
  • Spenser Waller, Avery Powell, Randi Noel, Michael J Schueller, Richard A Ferrieri. Radiocarbon Flux Measurements Reveal Mechanistic Insight into Heat-Stress Induction of Nicotine Biosynthesis in Nicotiana attenuata. International journal of molecular sciences. 2023 Oct; 24(21):. doi: 10.3390/ijms242115509. [PMID: 37958493]
  • Jing Zhao, Xin-Chen Tian, Jia-Qi Zhang, Chen Huang, Yan Sun, Sen Qiao, Shu-Long Jiang. Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics. Chinese journal of integrative medicine. 2023 Oct; ?(?):. doi: 10.1007/s11655-023-3706-0. [PMID: 37861961]
  • Min Xu, Qiyu Yue, Ziyang He, Xiaoyang Ling, Wenhua Wang, Mingjie Gong. Wu-zhu-yu Decoction reduces early brain injury following subarachnoid hemorrhage in vivo and in vitro by activating the Nrf2 antioxidant system via SIRT6 targeting. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117335. doi: 10.1016/j.jep.2023.117335. [PMID: 37863400]
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