L-Glutamic acid (BioDeep_00000000342)

 

Secondary id: BioDeep_00000014820, BioDeep_00000398137, BioDeep_00000398611, BioDeep_00000400245, BioDeep_00001868016

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(1S)-2-[(3-O-beta-D-Glucopyranosyl-beta-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid

化学式: C5H9NO4 (147.0532)
中文名称: DL-谷氨酸, L-谷氨酸, 谷氨酸
谱图信息: 最多检出来源 Homo sapiens(plant) 14.49%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

L-Glutamic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-glutamic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000342). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CC(=O)O)C(C(=O)O)N
InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)

描述信息

Glutamic acid (Glu), also known as L-glutamic acid or as glutamate, the name of its anion, is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-glutamic acid is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Glutamic acid is found in all organisms ranging from bacteria to plants to animals. It is classified as an acidic, charged (at physiological pH), aliphatic amino acid. In humans it is a non-essential amino acid and can be synthesized via alanine or aspartic acid via alpha-ketoglutarate and the action of various transaminases. Glutamate also plays an important role in the bodys disposal of excess or waste nitrogen. Glutamate undergoes deamination, an oxidative reaction catalysed by glutamate dehydrogenase leading to alpha-ketoglutarate. In many respects glutamate is a key molecule in cellular metabolism. Glutamate is the most abundant fast excitatory neurotransmitter in the mammalian nervous system. At chemical synapses, glutamate is stored in vesicles. Nerve impulses trigger release of glutamate from the pre-synaptic cell. In the opposing post-synaptic cell, glutamate receptors, such as the NMDA receptor, bind glutamate and are activated. Because of its role in synaptic plasticity, it is believed that glutamic acid is involved in cognitive functions like learning and memory in the brain. Glutamate transporters are found in neuronal and glial membranes. They rapidly remove glutamate from the extracellular space. In brain injury or disease, they can work in reverse and excess glutamate can accumulate outside cells. This process causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death, and is called excitotoxicity. The mechanisms of cell death include: Damage to mitochondria from excessively high intracellular Ca2+. Glu/Ca2+-mediated promotion of transcription factors for pro-apoptotic genes, or downregulation of transcription factors for anti-apoptotic genes. Excitotoxicity due to glutamate occurs as part of the ischemic cascade and is associated with stroke and diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimers disease. Glutamic acid has been implicated in epileptic seizures. Microinjection of glutamic acid into neurons produces spontaneous depolarization around one second apart, and this firing pattern is similar to what is known as paroxysmal depolarizing shift in epileptic attacks. This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage activated calcium channels, leading to glutamic acid release and further depolarization (http://en.wikipedia.org/wiki/Glutamic_acid). Glutamate was discovered in 1866 when it was extracted from wheat gluten (from where it got its name. Glutamate has an important role as a food additive and food flavoring agent. In 1908, Japanese researcher Kikunae Ikeda identified brown crystals left behind after the evaporation of a large amount of kombu broth (a Japanese soup) as glutamic acid. These crystals, when tasted, reproduced a salty, savory flavor detected in many foods, most especially in seaweed. Professor Ikeda termed this flavor umami. He then patented a method of mass-producing a crystalline salt of glutamic acid, monosodium glutamate.
L-glutamic acid is an optically active form of glutamic acid having L-configuration. It has a role as a nutraceutical, a micronutrient, an Escherichia coli metabolite, a mouse metabolite, a ferroptosis inducer and a neurotransmitter. It is a glutamine family amino acid, a proteinogenic amino acid, a glutamic acid and a L-alpha-amino acid. It is a conjugate acid of a L-glutamate(1-). It is an enantiomer of a D-glutamic acid.
A peptide that is a homopolymer of glutamic acid.
L-Glutamic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Glutamic acid (Glu), also referred to as glutamate (the anion), is one of the 20 proteinogenic amino acids. It is not among the essential amino acids. Glutamate is a key molecule in cellular metabolism. In humans, dietary proteins are broken down by digestion into amino acids, which serves as metabolic fuel or other functional roles in the body. Glutamate is the most abundant fast excitatory neurotransmitter in the mammalian nervous system. At chemical synapses, glutamate is stored in vesicles. Nerve impulses trigger release of glutamate from the pre-synaptic cell. In the opposing post-synaptic cell, glutamate receptors, such as the NMDA receptor, bind glutamate and are activated. Because of its role in synaptic plasticity, it is believed that glutamic acid is involved in cognitive functions like learning and memory in the brain. Glutamate transporters are found in neuronal and glial membranes. They rapidly remove glutamate from the extracellular space. In brain injury or disease, they can work in reverse and excess glutamate can accumulate outside cells. This process causes calcium ions to enter cells via NMDA receptor channels, leading to neuronal damage and eventual cell death, and is called excitotoxicity. The mechanisms of cell death include: * Damage to mitochondria from excessively high intracellular Ca2+. * Glu/Ca2+-mediated promotion of transcription factors for pro-apoptotic genes, or downregulation of transcription factors for anti-apoptotic genes. Excitotoxicity due to glutamate occurs as part of the ischemic cascade and is associated with stroke and diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimers disease. glutamic acid has been implicated in epileptic seizures. Microinjection of glutamic acid into neurons produces spontaneous depolarization around one second apart, and this firing pattern is similar to what is known as paroxysmal depolarizing shift in epileptic attacks. This change in the resting membrane potential at seizure foci could cause spontaneous opening of voltage activated calcium channels, leading to glutamic acid release and further depolarization.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
See also: Monosodium Glutamate (active moiety of); Glatiramer Acetate (monomer of); Glatiramer (monomer of) ... View More ...
obtained from acid hydrolysis of proteins. Since 1965 the industrial source of glutamic acid for MSG production has been bacterial fermentation of carbohydrate sources such as molasses and corn starch hydrolysate in the presence of a nitrogen source such as ammonium salts or urea. Annual production approx. 350000t worldwide in 1988. Seasoning additive in food manuf. (as Na, K and NH4 salts). Dietary supplement, nutrient

Glutamic acid (symbol Glu or E;[4] the anionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can synthesize enough for its use. It is also the most abundant excitatory neurotransmitter in the vertebrate nervous system. It serves as the precursor for the synthesis of the inhibitory gamma-aminobutyric acid (GABA) in GABAergic neurons.

Its molecular formula is C
5H
9NO
4. Glutamic acid exists in two optically isomeric forms; the dextrorotatory l-form is usually obtained by hydrolysis of gluten or from the waste waters of beet-sugar manufacture or by fermentation.[5][full citation needed] Its molecular structure could be idealized as HOOC−CH(NH
2)−(CH
2)2−COOH, with two carboxyl groups −COOH and one amino group −NH
2. However, in the solid state and mildly acidic water solutions, the molecule assumes an electrically neutral zwitterion structure −OOC−CH(NH+
3)−(CH
2)2−COOH. It is encoded by the codons GAA or GAG.

The acid can lose one proton from its second carboxyl group to form the conjugate base, the singly-negative anion glutamate −OOC−CH(NH+
3)−(CH
2)2−COO−. This form of the compound is prevalent in neutral solutions. The glutamate neurotransmitter plays the principal role in neural activation.[6] This anion creates the savory umami flavor of foods and is found in glutamate flavorings such as MSG. In Europe, it is classified as food additive E620. In highly alkaline solutions the doubly negative anion −OOC−CH(NH
2)−(CH
2)2−COO− prevails. The radical corresponding to glutamate is called glutamyl.

The one-letter symbol E for glutamate was assigned in alphabetical sequence to D for aspartate, being larger by one methylene –CH2– group.[7]
DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1].
DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability[1].
L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases[1][2][3][4][5].
L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

同义名列表

274 个代谢物同义名

(1S)-2-[(3-O-beta-D-Glucopyranosyl-beta-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid; (1S)-2-[(3-O-b-D-Glucopyranosyl-b-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid; (1S)-2-[(3-O-Β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoic acid; (1S)-2-[(3-O-Β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoate; (1S)-2-[(3-O-b-D-Glucopyranosyl-b-D-galactopyranosyl)oxy]-1-{[(9E)-octadec-9-enoyloxy]methyl}ethyl (10E)-nonadec-10-enoate; (3R,4S,5R)-5-[(1R)-1-Carboxy-2,2-difluoro-1-(phosphonooxy)ethoxy]-4-hydroxy-3-(phosphonooxy)cyclohex-1-ene-1-carboxylate; L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5\\%; N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine; 3alpha,7alpha,12alpha-Trihydroxy-N-(carboxymethyl)-5beta-cholan-24-amide; N-(Carboxymethyl)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-amide; Glutamic acid, United States Pharmacopeia (USP) Reference Standard; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid-24-glycine; N-[(3a,5b,7a,12a)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine; N-[(3Α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]glycine; Glutamic acid, European Pharmacopoeia (EP) Reference Standard; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine; L-Glutamic acid, certified reference material, TraceCERT(R); 3Α,7α,12α-trihydroxy-N-(carboxymethyl)-5β-cholan-24-amide; N-(Carboxymethyl)-3α,7α,12α-trihydroxy-5β-cholan-24-amide; L-Glutamic acid, >=99\\%, FCC, natural sourced, FG; 3Α,7α,12α-trihydroxy-5β-cholanic acid-24-glycine; L-Glutamic acid, Vetec(TM) reagent grade, >=99\\%; L-Glutamic acid, ReagentPlus(R), >=99\\% (HPLC); L-Glutamic acid, JIS special grade, >=99.0\\%; 3Α,7α,12α-trihydroxy-5β-cholan-24-oylglycine; L-Glutamic acid, tested according to Ph.Eur.; 3a,7a,12a-Trihydroxy-5b-cholan-24-oylglycine; (S)-1-Aminopropane-1,3-dicarboxylic acid; L-Glutamic acid, BioUltra, >=99.5\\% (NT); LYSINE ACETATE IMPURITY B [EP IMPURITY]; 3-Hydroxyestra-1,3,5(10)-triene-17-one; (2S)-2-aminopentanedioic acid;H-Glu-OH; 3-Hydroxyoestra-1,3,5(10)-trien-17-one; 3-Hydroxy-1,3,5(10)-estratrien-17-one; 1-amino-propane-1,3-dicarboxylic acid; 3-Hydroxyestra-1,3,5(10)-trien-17-one; 3-Hydroxy-17-keto-estra-1,3,5-triene; 1-Aminopropane-1,3-dicarboxylic acid; L-Glutamic acid, non-animal source; 1-amino-propane-1,3-dicarboxylate; (S)-2-AMINO-1,5-PENTANEDIOIC ACID; D1,3,5(10)-Estratrien-3-ol-17-one; Pentanedioic acid, 2-amino-, (S)-; Pentanedioic acid, 2-amino-, (S); (2R)-2,3-Dihydroxypropanoic acid; alpha,beta-Hydroxypropionic acid; ALANINE IMPURITY B [EP IMPURITY]; 1,3,5(10)-Estratrien-3-ol-17-one; 1-Aminopropane-1,3-dicarboxylate; Glutamic Acid (L-glutamic acid); L (+)-glutamic acid, alpha-form; (R)-2,3-Dihydroxypropanoic acid; 2-Aminopentanedioic acid, (S)-; alpha-Aminoglutaric acid (VAN); Glycoreductodehydrocholic acid; Acide glutamique [INN-French]; Envision conditioner PDD 9020; Acidum glutamicum [INN-Latin]; Acido glutamico [INN-Spanish]; Acide glutamique (INN-French); 2-Acetamido-2-deoxy-D-glucose; Glycocholic Acid, Sodium Salt; (2S)-2-Aminopentanedioic acid; D-2,3-Dihydroxypropanoic acid; Acido glutamico (INN-Spanish); 2 Acetamido 2 deoxy D glucose; Acidum glutamicum (INN-Latin); alpha,beta-Hydroxypropionate; GLUTAMIC ACID [EP MONOGRAPH]; GLUTAMIC ACID (EP MONOGRAPH); (S)-2-Aminopentanedioic acid; Glutamic acid, L- (7CI,8CI); S)-2-Aminopentanedioic acid; L-2-amino-pentanedioic acid; L-Glutamic acid, 99\\%, FCC; 2 Acetamido 2 deoxyglucose; L-alpha-Aminoglutaric acid; 2-Acetamido-2-deoxyglucose; 2-Amino-pentanedioic acid; (2S)-2-aminopentanedioate; Glutamic Acid, (D)-Isomer; Estrone, (8 alpha)-isomer; Α,β-hydroxypropionic acid; a,b-Hydroxypropionic acid; 2-aminopentanedioic acid; Estrone, (9 beta)-isomer; alpha-aminoglutaric acid; Vortech brand OF estrone; (S)-2-Aminopentanedioate; Glutamic Acid [USAN:INN]; beta-Aminoethyl alcohol; L-Glutamic acid, 98.5\\%; 1-Amino-2-hydroxyethane; L-alpha-Aminoglutarate; GLUTAMIC ACID (USP-RS); L-GLUTAMIC ACID [FHFI]; Hauck brand OF estrone; L-2-Aminoglutaric acid; L-a-Aminoglutaric acid; N-Acetyl-D-glucosamine; GLUTAMIC ACID [USP-RS]; beta-Hydroxyethylamine; Polyglutamic acid(PGA); L-Glutamic acid (JP17); GLUTAMIC ACID [WHO-DD]; N Acetyl D glucosamine; Hyrex brand OF estrone; L-Glutamic acid (9CI); .alpha.-Glutamic acid; (S)-(+)-Glutamic acid; Α,β-hydroxypropionate; Glutaminic acid (VAN); GLUTAMIC ACID [VANDF]; Gamma-L-Glutamic Acid; L-GLUTAMIC ACID [JAN]; L-GLUTAMIC ACID [FCC]; a,b-Hydroxypropionate; L-Glutamate, Aluminum; Estrone, (+-)-isomer; GLUTAMIC ACID [USAN]; 2-Aminoglutaric acid; Aluminum L Glutamate; alpha-Aminoglutarate; b-Aminoethyl alcohol; Glutamate, Potassium; [3h]-l-glutamic acid; a-Aminoglutaric acid; 2-aminopentanedioate; GLUTAMIC ACID [INCI]; Β-aminoethyl alcohol; Aluminum L-Glutamate; L-Glutamic acid-13C5; 2-Aminoethyl alcohol; GLUTAMIC ACID [INN]; N-Acetylchitosamine; alpha-Glutamic acid; L-[14C(U)]glutamate; (+)-L-Glutamic acid; Glutamic acid (H-3); Acidum glutaminicum; Glutamic acid (USP); Β-hydroxyethylamine; Glutamic acid, (S)-; L-(+)-glutamic acid; 2-Hydroxyethylamine; b-Hydroxyethylamine; 2-Hydroxyethanamine; Glutamic acid (VAN); Potassium Glutamate; Glycocholate Sodium; aminoglutaric acid; L-a-Aminoglutarate; Follicular hormone; L(+)-Glutamic acid; GLUTAMIC ACID [MI]; N-choloyl-Glycine; (S)-(+)-Glutamate; Glycylcholic acid; Acidum glutamicum; (R)-Glyceric acid; 2-Amino-1-ethanol; beta-Ethanolamine; L-Acido glutamico; Glutamic acid, L-; (S)-Glutamic acid; (L)-glutamic acid; 2-Aminoethan-1-ol; beta-Aminoethanol; Acetylglucosamine; L-Glutaminic acid; a-Aminoglutarate; 2-Aminoglutarate; MONOETHANOLAMINE; Monoaethanolamin; DL-Glutamic acid; L-Glutaminsaeure; Acide glutamique; N-Choloylglycine; L-glutamic acid; D-Glyceric acid; Acido glutamico; L-Glutamic adid; alpha-Glutamate; glutaminic acid; L Glutamic Acid; 2-Amino-ethanol; Glycine Cholate; D-Glutamiensuur; L-glutamic-acid; R-Glyceric acid; L-(+)-Glutamate; a-Glutamic acid; UNII-3KX376GY7L; aminoglutarate; L-Glutamic,(S); 2-Ethanolamine; b-Ethanolamine; b-Aminoethanol; 2 Aminoethanol; 2-aminoethanol; Β-aminoethanol; Β-ethanolamine; Glutamate, L-; BPBio1_001132; Glycylcholate; (R)-Glycerate; L-Glutaminate; Cholylglycine; Lopac0_000529; Glutamic Acid; (S)-glutamate; PDSP1_000128; PDSP2_000127; glycocholate; HSCI1_000269; Aethanolamin; Aminoethanol; PDSP1_001539; Tox21_113053; Ethylolamine; PDSP2_001523; L-gluatmate; L Glutamate; Glutaminate; (+)-Estrone; CAS-56-86-0; L-glutamate; D Glutamate; R-Glycerate; D-Glutamate; a-Glutamate; D-Glycerate; 3KX376GY7L; Estrovarin; Folliculin; Glutamicol; Glutaminol; H-Glycinol; L-Glutamic; Glutamidex; glutamate; AI3-18472; Glycerate; glutacid; Kestrone; H-Glu-OH; Glycinol; Colamine; Glutaton; D-GlcNAc; Oestrone; (S)-Glu; Aciglut; C5H9NO4; Glusate; Olamine; Unigen; Wehgen; D-GroA; H-Glu; L-glu; 1ftj; glut; 1xff; 1ii5; MEA; glt; glu; Hea; ETA; E; Glutamic acid; L-Glutamate; Glutamic acid



数据库引用编号

67 个数据库交叉引用编号

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代谢反应

825 个相关的代谢反应过程信息。

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WikiPathways(4)

Plant Reactome(146)

  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide

INOH(42)

PlantCyc(0)

COVID-19 Disease Map(2)

PathBank(631)

PharmGKB(0)

553 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CHAT, MTOR, NOS1, PC
Peripheral membrane protein 2 MTOR, NOS1
Endoplasmic reticulum membrane 1 MTOR
Nucleus 4 CHAT, GRM1, MTOR, NOS1
cytosol 5 CHAT, MTOR, NOS1, PC, SST
dendrite 4 DRD2, GRM1, GRM7, MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 4 ATP2B1, GRIK2, MTOR, NOS1
Cell membrane 11 ATP2B1, DRD2, GRIA3, GRIK2, GRM1, GRM3, GRM4, GRM7, GRM8, OPRD1, SLC17A8
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 11 ATP2B1, DRD2, GRIA3, GRIK2, GRM1, GRM3, GRM4, GRM7, GRM8, OPRD1, SLC17A8
Golgi apparatus membrane 2 DRD2, MTOR
Synapse 6 ATP2B1, CHAT, CRH, DRD2, NOS1, TAC1
cell cortex 1 GRM7
dendritic shaft 1 GRM7
glutamatergic synapse 6 ATP2B1, DRD2, GRIK2, GRM1, GRM3, SLC17A8
Golgi apparatus 1 NPY
Golgi membrane 2 DRD2, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 SST, TAC1
presynaptic membrane 5 ATP2B1, DRD2, GRIK2, GRM3, OPRD1
sarcolemma 1 NOS1
Lysosome 1 MTOR
Presynapse 1 GRM4
acrosomal vesicle 1 DRD2
plasma membrane 12 ATP2B1, DRD2, GRIA3, GRIK2, GRM1, GRM3, GRM4, GRM7, GRM8, NOS1, OPRD1, SLC17A8
presynaptic active zone 1 GRM7
synaptic vesicle membrane 4 ATP2B1, DRD2, OPRD1, SLC17A8
terminal bouton 1 GRIK2
Membrane 8 ATP2B1, GRIK2, GRM3, GRM4, GRM7, GRM8, MTOR, OPRD1
axon 4 DRD2, GRM3, GRM7, TAC1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 2 ATP2B1, LYZ
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 GRIK2
extracellular space 5 CRH, LYZ, NPY, SST, TAC1
perinuclear region of cytoplasm 1 NOS1
Schaffer collateral - CA1 synapse 1 GRM1
mitochondrion 2 NOS1, PC
protein-containing complex 1 NOS1
intracellular membrane-bounded organelle 1 ATP2B1
Microsome membrane 1 MTOR
postsynaptic density 3 GRIK2, GRM3, NOS1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 CRH, NPY, SST
extracellular region 5 CRH, LYZ, NPY, SST, TAC1
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
excitatory synapse 1 SLC17A8
hippocampal mossy fiber to CA3 synapse 1 GRIK2
Mitochondrion matrix 1 PC
mitochondrial matrix 1 PC
ciliary membrane 1 DRD2
photoreceptor inner segment 1 NOS1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 2 ATP2B1, SLC17A8
varicosity 1 CRH
multivesicular body 1 SLC17A8
dendritic spine 4 DRD2, GRIA3, GRM3, NOS1
neuronal dense core vesicle lumen 1 CRH
perikaryon 4 CRH, DRD2, GRIK2, SLC17A8
cytoplasmic vesicle 1 GRM4
postsynaptic membrane 5 DRD2, GRIA3, GRIK2, GRM3, GRM7
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 1 NOS1
Membrane raft 1 NOS1
GABA-ergic synapse 3 DRD2, NPY, SST
sarcoplasmic reticulum 1 NOS1
Cell projection, dendritic spine 1 NOS1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
lateral plasma membrane 2 ATP2B1, DRD2
Postsynaptic cell membrane 3 GRIA3, GRIK2, GRM1
dendrite cytoplasm 1 GRIK2
kainate selective glutamate receptor complex 1 GRIK2
mossy fiber rosette 1 GRIK2
receptor complex 1 GRM7
neuron projection 2 CHAT, OPRD1
cilium 1 DRD2
cell projection 2 ATP2B1, GRIK2
cell periphery 1 NOS1
cytoskeleton 1 NOS1
non-motile cilium 1 DRD2
Basolateral cell membrane 1 ATP2B1
sperm flagellum 1 DRD2
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
chloride channel complex 1 SLC17A8
AMPA glutamate receptor complex 1 GRIA3
Presynaptic cell membrane 2 ATP2B1, GRIK2
axon terminus 3 DRD2, OPRD1, SLC17A8
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
endocytic vesicle membrane 1 GRIA3
endocytic vesicle 1 DRD2
azurophil granule lumen 1 LYZ
postsynaptic density membrane 4 GRIA3, GRIK2, GRM1, OPRD1
immunological synapse 1 ATP2B1
neuronal dense core vesicle 3 NPY, OPRD1, SST
parallel fiber to Purkinje cell synapse 1 GRIA3
Synapse, synaptosome 1 SLC17A8
apical dendrite 1 SLC17A8
basal dendrite 1 SLC17A8
dopaminergic synapse 1 DRD2
dendrite membrane 1 OPRD1
Cytoplasmic vesicle, phagosome 1 MTOR
astrocyte projection 1 GRM3
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
glial limiting end-foot 1 SLC17A8
asymmetric synapse 1 GRM7
photoreceptor ribbon synapse 1 ATP2B1
G protein-coupled receptor complex 1 DRD2
spine apparatus 1 OPRD1
G protein-coupled receptor dimeric complex 1 GRM1
G protein-coupled receptor homodimeric complex 1 GRM1
pericellular basket 1 SLC17A8


文献列表

  • Jingbin Chen, Yali Liu, Yonggui Song, Huihui Liang, Genhua Zhu, Bike Zhang, Liangliang Liao, Jian Luo, Ming Yang, Dan Su. Neuro-stimulating effect of Citri Reticulata Pericarpium Viride essential oil through regulating Glu/NMDAR on olfactory bulb to improve anxiety-like behavior. Journal of ethnopharmacology. 2024 Sep; 331(?):118332. doi: 10.1016/j.jep.2024.118332. [PMID: 38735421]
  • Parham Khoshbakht Marvi, Syed Rahin Ahmed, Poushali Das, Raja Ghosh, Seshasai Srinivasan, Amin Reza Rajabzadeh. Prunella vulgaris-phytosynthesized platinum nanoparticles: Insights into nanozymatic activity for H2O2 and glutamate detection and antioxidant capacity. Talanta. 2024 Jul; 274(?):125998. doi: 10.1016/j.talanta.2024.125998. [PMID: 38574541]
  • Cheng-Wei Lu, Tzu-Yu Lin, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Gypenoside XVII Reduces Synaptic Glutamate Release and Protects against Excitotoxic Injury in Rats. Biomolecules. 2024 May; 14(5):. doi: 10.3390/biom14050589. [PMID: 38785996]
  • Giulia Leni, Gabriele Rocchetti, Terenzio Bertuzzi, Alessio Abate, Alessandra Scansani, Federico Froldi, Aldo Prandini. Volatile compounds, gamma-glutamyl-peptides and free amino acids as biomarkers of long-ripened protected designation of origin Coppa Piacentina. Food chemistry. 2024 May; 440(?):138225. doi: 10.1016/j.foodchem.2023.138225. [PMID: 38134826]
  • Anton Möllerke, Diogo Montes Vidal, Hans Petter Leinaas, Stefan Schulz. Socialane, a Nonaprenyl Terpene Hydrocarbon Surface Lipid from the Collembola Hypogastrura socialis. Chemistry (Weinheim an der Bergstrasse, Germany). 2024 May; 30(27):e202400272. doi: 10.1002/chem.202400272. [PMID: 38445549]
  • Tenghan Ling, Aiping Yin, Yan Cao, Jiali Li, Hengxi Li, Ying Zhou, Xiaobing Guo, Jinghui Li, Ruilin Zhang, Haiying Wu, Ping Li. Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury. Neuroscience. 2024 May; 545(?):31-46. doi: 10.1016/j.neuroscience.2024.03.002. [PMID: 38460903]
  • Fuming He, Baojun Gao, Xin Cheng, Jiao Zhai, Xinqing Zhang, Chuanlun Yang, Tian Jiewei. High-level production of poly-γ-glutamic acid by a newly isolated Bacillus sp. YJY-8 and potential use in increasing the production of tomato. Preparative biochemistry & biotechnology. 2024 May; 54(5):637-646. doi: 10.1080/10826068.2023.2261058. [PMID: 37768129]
  • Raissa Bayker Vieira Silva, Valdeci Geraldo Coelho Júnior, Adolfo de Paula Mattos Júnior, Henrique Julidori Garcia, Ester Siqueira Caixeta Nogueira, Talita Sarah Mazzoni, Juliana Ramos Martins, Lívia Maria Rosatto Moda, Angel Roberto Barchuk. Farnesol, a component of plant-derived honeybee-collected resins, shows JH-like effects in Apis mellifera workers. Journal of insect physiology. 2024 05; 154(?):104627. doi: 10.1016/j.jinsphys.2024.104627. [PMID: 38373613]
  • Stanislav Jabinski, Wesley D M Rangel, Marek Kopáček, Veronika Jílková, Jan Jansa, Travis B Meador. Constraining activity and growth substrate of fungal decomposers via assimilation patterns of inorganic carbon and water into lipid biomarkers. Applied and environmental microbiology. 2024 Apr; 90(4):e0206523. doi: 10.1128/aem.02065-23. [PMID: 38527003]
  • Jinpeng Li, Xingbei Liu, Shumin Chang, Wei Chu, Jingchen Lin, Hui Zhou, Zhuoran Hu, Mancang Zhang, Mingming Xin, Yingyin Yao, Weilong Guo, Xiaodong Xie, Huiru Peng, Zhongfu Ni, Qixin Sun, Yu Long, Zhaorong Hu. The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat. Science advances. 2024 Apr; 10(15):eadk4027. doi: 10.1126/sciadv.adk4027. [PMID: 38608020]
  • František Sedlák, Aleš Kvasnička, Barbora Marešová, Radana Brumarová, Dana Dobešová, Kateřina Dostálová, Karolína Šrámková, Martin Pehr, Pavel Šácha, David Friedecký, Jan Konvalinka. Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition. ACS chemical neuroscience. 2024 Apr; 15(7):1342-1355. doi: 10.1021/acschemneuro.3c00494. [PMID: 38377674]
  • Ting Shen, Baocheng Tian, Wei Liu, Xuesong Yang, Qi Sheng, Mengxin Li, Haiyan Wang, Xiuwen Wang, Huihui Zhou, Yanchun Han, Chen Ding, Sixiang Sai. Transdermal administration of farnesol-ethosomes enhances the treatment of cutaneous candidiasis induced by Candida albicans in mice. Microbiology spectrum. 2024 Apr; 12(4):e0424723. doi: 10.1128/spectrum.04247-23. [PMID: 38415658]
  • Lei Zhang, Xin Yue Bai, Ke Yao Sun, Xuan Li, Zhao Qi Zhang, Yi Ding Liu, Yang Xiang, Xiao Long Liu. A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis. Neurochemical research. 2024 Apr; 49(4):815-833. doi: 10.1007/s11064-023-04096-3. [PMID: 38170383]
  • Giuseppe Forlani, Giuseppe Sabbioni, Simone Barera, Dietmar Funck. A complex array of factors regulate the activity of Arabidopsis thaliana δ1 -pyrroline-5-carboxylate synthetase isoenzymes to ensure their specific role in plant cell metabolism. Plant, cell & environment. 2024 Apr; 47(4):1348-1362. doi: 10.1111/pce.14817. [PMID: 38223941]
  • Samantha Vivia The, James P Santiago, Clara Pappenberger, Ulrich Z Hammes, Mechthild Tegeder. UMAMIT44 is a key player in glutamate export from Arabidopsis chloroplasts. The Plant cell. 2024 Mar; 36(4):1119-1139. doi: 10.1093/plcell/koad310. [PMID: 38092462]
  • Raul Sanchez-Muñoz. Highway to cell: Unravelling the main player in Arabidopsis chloroplast glutamate export. The Plant cell. 2024 Mar; 36(4):805-806. doi: 10.1093/plcell/koad322. [PMID: 38134387]
  • Siyu Zhang, Dong Wang, Yawen Ding, Fuyang Song, Yong Li, Jin Zeng, Yujiong Wang. Injury of Macrophages Induced by Clostridium perfringens Type C Exotoxins. International journal of molecular sciences. 2024 Mar; 25(7):. doi: 10.3390/ijms25073718. [PMID: 38612529]
  • Pei Wang, Miao Liu, Changhong Lv, Zhen Tian, Ruichi Li, Yifan Li, Yalin Zhang, Jiyuan Liu. Identifying the Key Role of Plutella xylostella General Odorant Binding Protein 2 in Perceiving a Larval Attractant, (E,E)-2,6-Farnesol. Journal of agricultural and food chemistry. 2024 Mar; 72(11):5690-5698. doi: 10.1021/acs.jafc.4c00621. [PMID: 38447177]
  • Zhen Guo, Jian Wang, Tianqing Chen, Haiou Zhang, Xiandong Hou, Juan Li. Effects of γ-polyglutamic acid supplementation on alfalfa growth and rhizosphere soil microorganisms in sandy soil. Scientific reports. 2024 03; 14(1):6440. doi: 10.1038/s41598-024-57197-6. [PMID: 38499631]
  • Hongqian Zhang, Xue Gao, Qian Sun, Xiaoxue Dong, Zongwei Zhu, Chuanxu Yang. Incorporation of poly(γ-glutamic acid) in lipid nanoparticles for enhanced mRNA delivery efficiency in vitro and in vivo. Acta biomaterialia. 2024 Mar; 177(?):361-376. doi: 10.1016/j.actbio.2024.02.004. [PMID: 38342193]
  • Namita Nabar, Tamara G Dacoba, Gil Covarrubias, Denisse Romero-Cruz, Paula T Hammond. Electrostatic adsorption of polyanions onto lipid nanoparticles controls uptake, trafficking, and transfection of RNA and DNA therapies. Proceedings of the National Academy of Sciences of the United States of America. 2024 Mar; 121(11):e2307809121. doi: 10.1073/pnas.2307809121. [PMID: 38437543]
  • Ju-Bin Kang, Hyun-Kyoung Son, Dong-Ju Park, Yeung-Bae Jin, Fawad-Ali Shah, Phil-Ok Koh. Modulation of thioredoxin by chlorogenic acid in an ischemic stroke model and glutamate-exposed neurons. Neuroscience letters. 2024 Mar; 825(?):137701. doi: 10.1016/j.neulet.2024.137701. [PMID: 38395190]
  • Yueruxin Jin, Canying Li, Shuran Zhang, Jiaqi Liu, Miao Wang, Yan Guo, Hengping Xu, Yonghong Ge. Sucrose, cell wall, and polyamine metabolisms involve in preserving postharvest quality of 'Zaosu' pear fruit by L-glutamate treatment. Plant physiology and biochemistry : PPB. 2024 Mar; 208(?):108455. doi: 10.1016/j.plaphy.2024.108455. [PMID: 38428157]
  • Ying Li, Weijie Zhang, Chao Tang, Chen Wang, Changhui Liu, Qian Chen, Kai Yang, Yian Gu, Peng Lei, Hong Xu, Rui Wang. Antidiabetic effects and mechanism of γ-polyglutamic acid on type II diabetes mice. International journal of biological macromolecules. 2024 Mar; 261(Pt 1):129809. doi: 10.1016/j.ijbiomac.2024.129809. [PMID: 38290633]
  • Carlos Jonnathan Castro-Juárez, Silvia Luna-Suárez, Flor de Fátima Rosas-Cárdenas, Nemesio Villa-Ruano. Hernandulcin Production in Elicited Hairy Roots of Phyla scaberrima: Toward Sustainable Production of a Non-Caloric Sweetener with Nutraceutical Properties. Chemistry & biodiversity. 2024 Mar; 21(3):e202302095. doi: 10.1002/cbdv.202302095. [PMID: 38334300]
  • Tomasz Skalski, Ewelina Zając, Elżbieta Jędrszczyk, Katarzyna Papaj, Joanna Kohyt, Artur Góra, Anna Kasprzycka, Divine Shytum, Barbara Skowera, Agnieszka Ziernicka-Wojtaszek. Effects of γ-polyglutamic acid on grassland sandy soil properties and plant functional traits exposed to drought stress. Scientific reports. 2024 02; 14(1):3769. doi: 10.1038/s41598-024-54459-1. [PMID: 38355917]
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  • Yangxia Han, Manchang Kou, Kaijun Quan, Juanjuan Wang, Haixia Zhang, Hirotaka Ihara, Makoto Takafuji, Hongdeng Qiu. Enantioselective Glutamic Acid Discrimination and Nanobiological Imaging by Chiral Fluorescent Silicon Nanoparticles. Analytical chemistry. 2024 02; 96(5):2173-2182. doi: 10.1021/acs.analchem.3c05150. [PMID: 38261544]
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