Clorgiline (BioDeep_00000008801)
Secondary id: BioDeep_00000858685
human metabolite blood metabolite
代谢物信息卡片
[3-(2,4-dichlorophenoxy)propyl](methyl)(prop-2-yn-1-yl)amine
化学式: C13H15Cl2NO (271.0531)
中文名称: 氯吉灵, 氯精氨酸
谱图信息:
最多检出来源 Homo sapiens(blood) 92.86%
分子结构信息
SMILES: C#CCN(C)CCCOc1ccc(cc1Cl)Cl
InChI: InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
描述信息
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
Same as: D03248
同义名列表
14 个代谢物同义名
[3-(2,4-dichlorophenoxy)propyl](methyl)(prop-2-yn-1-yl)amine; N-(3-(2,4-Dichlorophenoxy)propyl)-N-methyl-2-propynylamine; N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine; m And b 9302; Chlorgyline; Clorgilinum; m & b 9302; Clorgilina; Clorgiline; Clorgyline; Clorgilin; M&B 9302; Clorgyline; Clorgiline
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:3763
- KEGG: C11685
- PubChem: 4380
- HMDB: HMDB0250365
- Metlin: METLIN69153
- DrugBank: DB04017
- ChEMBL: CHEMBL8706
- Wikipedia: Clorgiline
- MeSH: Clorgyline
- MetaCyc: CPD-7656
- CAS: 17780-72-2
- PMhub: MS000022501
- PubChem: 13850
- PDB-CCD: MLG
- NIKKAJI: J10.191E
- RefMet: Clorgyline
- KNApSAcK: 3763
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guohui Zhong, Jie Guo, Chengyun Pang, Di Su, Chunli Tang, Lin Jing, Fengling Zhang, Ping He, Yaqian Yan, Zongji Chen, Jing Liu, Neng Jiang. Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
Bioorganic chemistry.
2023 01; 130(?):106224. doi:
10.1016/j.bioorg.2022.106224. [PMID: 36332315] - Jing Guan, Xin Tong, Yi Zhang, Fan Xu, Yuxin Zhang, Xiurui Liang, Jiaqi Jin, Hongyan Jing, Liuxian Guo, Xinrui Ni, Jihua Fu. Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules.
Chemico-biological interactions.
2021 Nov; 349(?):109662. doi:
10.1016/j.cbi.2021.109662. [PMID: 34560070] - John Sebastiani, M Danielle McDonald. The role of uptake and degradation in the regulation of peripheral serotonin dynamics in Gulf toadfish, Opsanus beta.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2021 08; 258(?):110980. doi:
10.1016/j.cbpa.2021.110980. [PMID: 34023534] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Zhipei Sang, Qing Song, Zhongcheng Cao, Yong Deng, Zhenghuai Tan, Li Zhang. Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease.
European journal of medicinal chemistry.
2021 Apr; 216(?):113310. doi:
10.1016/j.ejmech.2021.113310. [PMID: 33667847] - Zhongcheng Cao, Qing Song, Guangjun Yu, Zhuoling Liu, Shiqing Cong, Zhenghuai Tan, Yong Deng. Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2021 04; 35(?):116074. doi:
10.1016/j.bmc.2021.116074. [PMID: 33640707] - Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
European journal of medicinal chemistry.
2020 Sep; 202(?):112475. doi:
10.1016/j.ejmech.2020.112475. [PMID: 32652406] - Zhipei Sang, Keren Wang, Ping Bai, Anguo Wu, Jian Shi, Wenmin Liu, Gaofeng Zhu, Yiling Wang, Yu Lan, Zude Chen, Yiyang Zhao, Zhanpin Qiao, Changning Wang, Zhenghuai Tan. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2020 May; 194(?):112265. doi:
10.1016/j.ejmech.2020.112265. [PMID: 32240904] - Luiz C Klein-Júnior, Sylvian Cretton, Yvan Vander Heyden, André L Gasper, Samad Nejad-Ebrahimi, Philippe Christen, Amélia T Henriques. Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa.
Journal of natural products.
2020 04; 83(4):852-863. doi:
10.1021/acs.jnatprod.9b00469. [PMID: 32150413] - Li Luo, Qing Song, Yan Li, Zhongcheng Cao, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2020 04; 28(8):115400. doi:
10.1016/j.bmc.2020.115400. [PMID: 32146060] - Ziyi Yang, Qing Song, Zhongcheng Cao, Guangjun Yu, Zhuoling Liu, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2020 04; 28(7):115374. doi:
10.1016/j.bmc.2020.115374. [PMID: 32089390] - Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu. Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.
Bioorganic & medicinal chemistry.
2019 05; 27(10):2027-2040. doi:
10.1016/j.bmc.2019.03.060. [PMID: 30975503] - María Goretti Arvizu-Espinosa, Gilsane Lino von Poser, Amelia Teresinha Henriques, Aniceto Mendoza-Ruiz, Anaberta Cardador-Martínez, Reinier Gesto-Borroto, Pablo Noé Núñez-Aragón, María Luisa Villarreal-Ortega, Ashutosh Sharma, Alexandre Cardoso-Taketa. Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum.
Journal of natural products.
2019 04; 82(4):785-791. doi:
10.1021/acs.jnatprod.8b00677. [PMID: 30920216] - Carolina Noble, Niels Bjerre Holm, Marie Mardal, Kristian Linnet. Bromo-dragonfly, a psychoactive benzodifuran, is resistant to hepatic metabolism and potently inhibits monoamine oxidase A.
Toxicology letters.
2018 Oct; 295(?):397-407. doi:
10.1016/j.toxlet.2018.07.018. [PMID: 30036687] - Liulin Wang, Kabir H Biswas, Bo Kyeong Yoon, Lisa M Kawakami, Soohyun Park, Jay T Groves, Lin Li, Wei Huang, Nam-Joon Cho. Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers.
Langmuir : the ACS journal of surfaces and colloids.
2018 09; 34(36):10764-10773. doi:
10.1021/acs.langmuir.8b01348. [PMID: 30049212] - Ronan Gealageas, Alice Devineau, Pauline P L So, Catrina M J Kim, Jayakumar Surendradoss, Christian Buchwalder, Markus Heller, Verena Goebeler, Edith M Dullaghan, David S Grierson, Edward E Putnins. Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.
Journal of medicinal chemistry.
2018 08; 61(16):7043-7064. doi:
10.1021/acs.jmedchem.7b01588. [PMID: 30016860] - Wirginia Kukula-Koch, Wojciech Koch, Lidia Czernicka, Kazimierz Głowniak, Yoshinori Asakawa, Akemi Umeyama, Zbigniew Marzec, Takashi Kuzuhara. MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes-A Bioactivity Guided Fractionation.
Molecules (Basel, Switzerland).
2018 May; 23(6):. doi:
10.3390/molecules23061301. [PMID: 29844252] - Rui Xu, Ganyuan Xiao, Yan Li, Hongyan Liu, Qing Song, Xiaoyu Zhang, Ziyi Yang, Yunxiaozhu Zheng, Zhenghuai Tan, Yong Deng. Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2018 05; 26(8):1885-1895. doi:
10.1016/j.bmc.2018.02.037. [PMID: 29500132] - Zhongcheng Cao, Jie Yang, Rui Xu, Qin Song, Xiaoyu Zhang, Hongyan Liu, Xiaoming Qiang, Yan Li, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Bioorganic & medicinal chemistry.
2018 03; 26(5):1102-1115. doi:
10.1016/j.bmc.2018.01.030. [PMID: 29409707] - Xia Yang, Xiaoming Qiang, Yan Li, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.
Bioorganic chemistry.
2017 04; 71(?):305-314. doi:
10.1016/j.bioorg.2017.02.016. [PMID: 28267984] - Li Luo, Yan Li, Xiaoming Qiang, Zhongcheng Cao, Rui Xu, Xia Yang, Ganyuan Xiao, Qing Song, Zhenghuai Tan, Yong Deng. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2017 03; 25(6):1997-2009. doi:
10.1016/j.bmc.2017.02.027. [PMID: 28237559] - Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Bioorganic & medicinal chemistry letters.
2017 02; 27(4):718-722. doi:
10.1016/j.bmcl.2017.01.050. [PMID: 28131710] - Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng. Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2017 Jan; 126(?):762-775. doi:
10.1016/j.ejmech.2016.12.009. [PMID: 27951485] - Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Sei-Ryang Oh, Hoon Kim. Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens.
Bioorganic & medicinal chemistry letters.
2016 10; 26(19):4714-4719. doi:
10.1016/j.bmcl.2016.08.044. [PMID: 27575476] - M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
Psychopharmacology.
2016 Aug; 233(15-16):2955-71. doi:
10.1007/s00213-016-4342-6. [PMID: 27259485] - Leonardo Pisani, Roberta Farina, Marco Catto, Rosa Maria Iacobazzi, Orazio Nicolotti, Saverio Cellamare, Giuseppe Felice Mangiatordi, Nunzio Denora, Ramon Soto-Otero, Lydia Siragusa, Cosimo Damiano Altomare, Angelo Carotti. Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.
Journal of medicinal chemistry.
2016 07; 59(14):6791-806. doi:
10.1021/acs.jmedchem.6b00562. [PMID: 27347731] - Juliana Maria de Mello Andrade, Carolina Dos Santos Passos, Maria Angélica Kieling Rubio, Jacqueline Nakau Mendonça, Norberto Peporine Lopes, Amélia Teresinha Henriques. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration.
Chemico-biological interactions.
2016 Jul; 254(?):135-45. doi:
10.1016/j.cbi.2016.06.005. [PMID: 27270453] - Yan Li, Xiaoming Qiang, Li Luo, Yuxing Li, Ganyuan Xiao, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2016 05; 24(10):2342-51. doi:
10.1016/j.bmc.2016.04.012. [PMID: 27079124] - Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells.
PloS one.
2016; 11(11):e0166750. doi:
10.1371/journal.pone.0166750. [PMID: 27861613] - Prachi Umbarkar, Sarojini Singh, Silpa Arkat, S L Bodhankar, Sathiyanarayanan Lohidasan, Sandhya L Sitasawad. Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy.
Free radical biology & medicine.
2015 Oct; 87(?):263-73. doi:
10.1016/j.freeradbiomed.2015.06.025. [PMID: 26122707] - Roberta Farina, Leonardo Pisani, Marco Catto, Orazio Nicolotti, Domenico Gadaleta, Nunzio Denora, Ramon Soto-Otero, Estefania Mendez-Alvarez, Carolina S Passos, Giovanni Muncipinto, Cosimo D Altomare, Alessandra Nurisso, Pierre-Alain Carrupt, Angelo Carotti. Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.
Journal of medicinal chemistry.
2015 Jul; 58(14):5561-78. doi:
10.1021/acs.jmedchem.5b00599. [PMID: 26107513] - Joanna S Fowler, Jean Logan, Nora D Volkow, Elena Shumay, Fred McCall-Perez, Millard Jayne, Gene-Jack Wang, David L Alexoff, Karen Apelskog-Torres, Barbara Hubbard, Pauline Carter, Payton King, Stanley Fahn, Michelle Gilmor, Frank Telang, Colleen Shea, Youwen Xu, Lisa Muench. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Feb; 40(3):650-7. doi:
10.1038/npp.2014.214. [PMID: 25249059] - Clara Grosso, Anna K Jäger, Dan Staerk. Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC-SPE-NMR for advanced bioactivity profiling of plant extracts.
Phytochemical analysis : PCA.
2013 Feb; 24(2):141-7. doi:
10.1002/pca.2393. [PMID: 22987664] - Maria Elena Manni, Gaetano De Siena, Alessandro Saba, Maja Marchini, Ilaria Dicembrini, Elisabetta Bigagli, Lorenzo Cinci, Maura Lodovici, Grazia Chiellini, Riccardo Zucchi, Laura Raimondi. 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice.
British journal of pharmacology.
2012 May; 166(2):650-8. doi:
10.1111/j.1476-5381.2011.01823.x. [PMID: 22225569] - Ann R Holmes, Mikhail V Keniya, Irena Ivnitski-Steele, Brian C Monk, Erwin Lamping, Larry A Sklar, Richard D Cannon. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.
Antimicrobial agents and chemotherapy.
2012 Mar; 56(3):1508-15. doi:
10.1128/aac.05706-11. [PMID: 22203607] - Zhi Zhou, Lingling Wang, Yang Gao, Mengqiang Wang, Huan Zhang, Leilei Wang, Limei Qiu, Linsheng Song. A monoamine oxidase from scallop Chlamys farreri serving as an immunomodulator in response against bacterial challenge.
Developmental and comparative immunology.
2011 Jul; 35(7):799-807. doi:
10.1016/j.dci.2011.03.014. [PMID: 21420424] - J Mihalik, J Maslankova, I Hodorova, P Ferenc, S Rybarova, M Marekova. Relationship between serotonin and norepinephrine levels and the preimplantation embryo development in rat.
Bratislavske lekarske listy.
2011; 112(2):52-7. doi:
. [PMID: 21456501] - Jozef Mihalik, Jana Mašlanková, Tatiana Špakovská, Mária Mareková, Ingrid Hodorová, Jaroslav Kušnír, Silvia Rybárová, Peter Ferenc, Katarína Schmidtová. Impact of 2 doses of clorgyline on the rat preimplantation embryo development and the monoamine levels in urine.
Reproductive sciences (Thousand Oaks, Calif.).
2010 Aug; 17(8):734-41. doi:
10.1177/1933719110369181. [PMID: 20595704] - Joanna S Fowler, Jean Logan, Albert J Azzaro, Robert M Fielding, Wei Zhu, Amy K Poshusta, Daniel Burch, Barry Brand, James Free, Mahnaz Asgharnejad, Gene-Jack Wang, Frank Telang, Barbara Hubbard, Millard Jayne, Payton King, Pauline Carter, Scott Carter, Youwen Xu, Colleen Shea, Lisa Muench, David Alexoff, Elena Shumay, Michael Schueller, Donald Warner, Karen Apelskog-Torres. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2010 Feb; 35(3):623-31. doi:
10.1038/npp.2009.167. [PMID: 19890267] - David M Thomas, Dina M Francescutti-Verbeem, Donald M Kuhn. Increases in cytoplasmic dopamine compromise the normal resistance of the nucleus accumbens to methamphetamine neurotoxicity.
Journal of neurochemistry.
2009 Jun; 109(6):1745-55. doi:
10.1111/j.1471-4159.2009.06094.x. [PMID: 19457119] - Meredith A Fox, Catherine L Jensen, Helen T French, Alison R Stein, Su-Jan Huang, Teresa J Tolliver, Dennis L Murphy. Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
Psychopharmacology.
2008 Dec; 201(2):203-18. doi:
10.1007/s00213-008-1268-7. [PMID: 18712364] - Olayinka A Dina, Sachia G Khasar, Nicole Alessandri-Haber, Oliver Bogen, Xiaojie Chen, Paul G Green, David B Reichling, Robert O Messing, Jon D Levine. Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
The European journal of neuroscience.
2008 Sep; 28(6):1180-90. doi:
10.1111/j.1460-9568.2008.06425.x. [PMID: 18783367] - Antonio Nocito, Felix Dahm, Wolfram Jochum, Jae Hwi Jang, Panco Georgiev, Michael Bader, Eberhard Ludwig Renner, Pierre-Alain Clavien. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
Gastroenterology.
2007 Aug; 133(2):608-18. doi:
10.1053/j.gastro.2007.05.019. [PMID: 17681180] - Joanna S Fowler, Jean Logan, Gene-Jack Wang, Nora D Volkow, Frank Telang, Wei Zhu, Dinko Franceschi, Colleen Shea, Victor Garza, Youwen Xu, Yu-Shin Ding, David Alexoff, Donald Warner, Noelwah Netusil, Pauline Carter, Millard Jayne, Payton King, Paul Vaska. Comparison of monoamine oxidase a in peripheral organs in nonsmokers and smokers.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2005 Sep; 46(9):1414-20. doi:
. [PMID: 16157522] - Jean Logan, Joanna S Fowler. Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers.
Nuclear medicine and biology.
2005 Jul; 32(5):521-9. doi:
10.1016/j.nucmedbio.2005.03.004. [PMID: 15982583] - Joanna S Fowler, Jean Logan, Gene-Jack Wang, Nora D Volkow, Frank Telang, Yu-Shin Ding, Colleen Shea, Victor Garza, Youwen Xu, Zizhong Li, David Alexoff, Paul Vaska, Richard Ferrieri, David Schlyer, Wei Zhu, S John Gatley. Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans.
Nuclear medicine and biology.
2004 Apr; 31(3):313-9. doi:
10.1016/j.nucmedbio.2003.10.003. [PMID: 15028243] - Joanna S Fowler, Jean Logan, Gene-Jack Wang, Dinko Franceschi, Nora D Volkow, Frank Telang, Naomi Pappas, Richard Ferrieri, Colleen Shea, Victor Garza, Youwen Xu, Payton King, David Schlyer, S John Gatley, Yu-Shin Ding, Donald Warner, Noelwah Netusil, Pauline Carter, Millard Jayne, David Alexoff, Wei Zhu, Paul Vaska. Monoamine oxidase A imaging in peripheral organs in healthy human subjects.
Synapse (New York, N.Y.).
2003 Sep; 49(3):178-87. doi:
10.1002/syn.10231. [PMID: 12774302] - J T Guimarães, C Vindis, P Soares-da-Silva, A Parini. Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex.
Life sciences.
2003 Jul; 73(8):955-67. doi:
10.1016/s0024-3205(03)00415-6. [PMID: 12818349] - Jean Logan, Joanna S Fowler, Yu-Shin Ding, Dinko Franceschi, Gene-Jack Wang, Nora D Volkow, Christoph Felder, David Alexoff. Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2002 Nov; 22(11):1367-76. doi:
10.1097/01.wcb.0000040947.67415.e1. [PMID: 12439294] - Bachtiar Indra, Takeshi Tadano, Osamu Nakagawasai, Yuichiro Arai, Hajime Yasuhara, Yasushi Ohizumi, Kensuke Kisara. Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice.
Life sciences.
2002 Apr; 70(22):2647-56. doi:
10.1016/s0024-3205(02)01562-x. [PMID: 12269391] - Wen-Xin Dong, Xiang-Lian Ni. Norepinephrine metabolism in neuron: dissociation between 3,4-dihydroxyphenylglycol and 3,4-dihydroxymandelic acid pathways.
Acta pharmacologica Sinica.
2002 Jan; 23(1):59-65. doi:
. [PMID: 11860739] - Richard D Lane, Tallat Rizk, Nicolas L Chiaia, Richard D Mooney, Robert W Rhoades. Effects of alterations of the vibrissae-related organization of thalamocortical axons upon the organization and outgrowth of intracortical connections in the barrelfield of the rat.
Somatosensory & motor research.
2002; 19(2):125-9. doi:
10.1080/08990220220131515. [PMID: 12088386] - Iu D Ivanov, N G Panova, O V Gnedenko, O A Buneeva, A E Medvedev, A I Archakov. [Study of the tissue and subcellular distribution of isatin-binding proteins with optical biosensor].
Voprosy meditsinskoi khimii.
2002 Jan; 48(1):73-83. doi:
NULL. [PMID: 12068500] - R K Nandigama, J R Miller, D E Edmondson. Loss of serotonin oxidation as a component of the altered substrate specificity in the Y444F mutant of recombinant human liver MAO A.
Biochemistry.
2001 Dec; 40(49):14839-46. doi:
10.1021/bi011113d. [PMID: 11732903] - F Trejo, V Nekrassov, M Sitges. Characterization of vinpocetine effects on DA and DOPAC release in striatal isolated nerve endings.
Brain research.
2001 Aug; 909(1-2):59-67. doi:
10.1016/s0006-8993(01)02621-x. [PMID: 11478921] - J S Fowler, N D Volkow, J Logan, D Franceschi, G J Wang, R MacGregor, C Shea, V Garza, N Pappas, P Carter, N Netusil, P Bridge, D Liederman, A Elkashef, J Rotrosen, R Hitzemann. Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain.
Life sciences.
2001 May; 68(24):2759-68. doi:
10.1016/s0024-3205(01)01079-7. [PMID: 11400918] - T Kawano, R Pinontoan, N Uozumi, Y Morimitsu, C Miyake, K Asada, S Muto. Phenylethylamine-induced generation of reactive oxygen species and ascorbate free radicals in tobacco suspension culture: mechanism for oxidative burst mediating Ca2+ influx.
Plant & cell physiology.
2000 Nov; 41(11):1259-66. doi:
10.1093/pcp/pcd053. [PMID: 11092911] - J S Fowler, G J Wang, N D Volkow, J Logan, D Franceschi, M Franceschi, R MacGregor, C Shea, V Garza, N Liu, Y S Ding. Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain.
Life sciences.
2000 Jan; 66(9):PL141-6. doi:
10.1016/s0024-3205(99)00660-8. [PMID: 10698362] - L F Callado, A M Gabilondo, J J Meana. Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment.
Life sciences.
1999; 64(25):2327-39. doi:
10.1016/s0024-3205(99)00186-1. [PMID: 10374896] - J P Finberg, T Takeshima, J M Johnston, J W Commissiong. Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.
Neuroreport.
1998 Mar; 9(4):703-7. doi:
10.1097/00001756-199803090-00026. [PMID: 9559942] - P Seth, Y J Fei, H W Li, W Huang, F H Leibach, V Ganapathy. Cloning and functional characterization of a sigma receptor from rat brain.
Journal of neurochemistry.
1998 Mar; 70(3):922-31. doi:
10.1046/j.1471-4159.1998.70030922.x. [PMID: 9489711] - D L Murphy, F Karoum, D Pickar, R M Cohen, S Lipper, A M Mellow, P N Tariot, T Sunderland. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline).
Journal of neural transmission. Supplementum.
1998; 52(?):39-48. doi:
10.1007/978-3-7091-6499-0_5. [PMID: 9564606] - S K Yeghiayan, S L Andersen, R J Baldessarini. Lack of effect of chronic clorgyline or selegiline on dopamine and serotonin transporters in rat caudate-putamen or nucleus accumbens septi.
Neuroscience letters.
1997 Nov; 236(3):147-50. doi:
10.1016/s0304-3940(97)00777-5. [PMID: 9406758] - U Sharma, E S Roberts, P F Hollenberg. Inactivation of cytochrome P4502B1 by the monoamine oxidase inhibitors R-(-)-deprenyl and clorgyline.
Drug metabolism and disposition: the biological fate of chemicals.
1996 Jun; 24(6):669-75. doi:
. [PMID: 8781784] - T Dennis, V Beauchemin, N Lavoie. Antidepressants reverse the olfactory bulbectomy-induced decreases in splenic peripheral-type benzodiazepine receptors in rats.
European journal of pharmacology.
1995 Jan; 272(2-3):279-88. doi:
10.1016/0014-2999(94)00654-p. [PMID: 7713172] - C H Gleiter, B Mühlbauer, R M Schulz, E Nilsson, K H Antonin, P R Bieck. Monoamine oxidase inhibition by the MAO-A inhibitors brofaromine and clorgyline in healthy volunteers.
Journal of neural transmission. General section.
1994; 95(3):241-5. doi:
10.1007/bf01271570. [PMID: 7865179] - C S Aulakh, J L Hill, D L Murphy. Attenuation of clonidine-induced growth hormone release following chronic glucocorticoid and 5-hydroxytryptamine uptake-inhibiting antidepressant treatments.
Neuroendocrinology.
1994 Jan; 59(1):35-41. doi:
10.1159/000126635. [PMID: 8145893] - C Ríos, S Bravo-Velazquez, M Altagracia, J Kravzov. Enhancement of striatal lipid peroxidation induced by 1-methyl-4-phenylpyridinium in mouse brain is blocked by MAO-B inhibitors.
Proceedings of the Western Pharmacology Society.
1994; 37(?):159-60. doi:
". [PMID: 7984654] - P Celada, F Artigas. Plasma 5-hydroxyindoleacetic acid as an indicator of monoamine oxidase-A inhibition in rat brain and peripheral tissues.
Journal of neurochemistry.
1993 Dec; 61(6):2191-8. doi:
10.1111/j.1471-4159.1993.tb07459.x. [PMID: 7504085] - C S Aulakh, J L Hill, D L Murphy. Attenuation of hypercortisolemia in fawn-hooded rats by antidepressant drugs.
European journal of pharmacology.
1993 Aug; 240(1):85-8. doi:
10.1016/0014-2999(93)90550-2. [PMID: 8405126] - A M Wheatley, J M McCrodden, E T Stuart, D Zhao, S G Shaw, K F Tipton, L H Blumgart. Effect of orthotopic liver transplantation and chemical denervation of the liver on the activities of hepatic monoamine oxidase and catechol-O-methyltransferase.
Transplantation.
1993 Jul; 56(1):202-7. doi:
10.1097/00007890-199307000-00037. [PMID: 8333043] - X F Gu, E C Azmitia. Integrative transporter-mediated release from cytoplasmic and vesicular 5-hydroxytryptamine stores in cultured neurons.
European journal of pharmacology.
1993 Apr; 235(1):51-7. doi:
10.1016/0014-2999(93)90819-4. [PMID: 8100196] - K P Lesch, C S Aulakh, B L Wolozin, T J Tolliver, J L Hill, D L Murphy. Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants.
Brain research. Molecular brain research.
1993 Jan; 17(1-2):31-5. doi:
10.1016/0169-328x(93)90069-2. [PMID: 8381906] - G Lavian, J P Finberg, M B Youdim. The advent of a new generation of monoamine oxidase inhibitor antidepressants: pharmacologic studies with moclobemide and brofaromine.
Clinical neuropharmacology.
1993; 16 Suppl 2(?):S1-7. doi:
NULL. [PMID: 8313392] - A Fujimura, T Sudoh, T Shiga, K Ohashi, A Ebihara. Influence of clorgyline treatment on chronopharmacology of furosemide in rats.
Life sciences.
1993; 52(9):819-24. doi:
10.1016/0024-3205(93)90080-m. [PMID: 8437511] - C S Aulakh, J Zohar, K M Wozniak, J L Hill, M Haass, D L Murphy. Differential effects of antidepressant treatments on fenfluramine-induced increases in plasma prolactin and corticosterone in rats.
Pharmacology, biochemistry, and behavior.
1991 May; 39(1):91-5. doi:
10.1016/0091-3057(91)90402-n. [PMID: 1924518] - M Cox, N Garrick, M Reite, M Gennaro. Minipump clorgyline administration and CSF amine metabolites in unrestrained monkeys.
Pharmacology, biochemistry, and behavior.
1991 Mar; 38(3):677-9. doi:
10.1016/0091-3057(91)90033-x. [PMID: 1712497] - J D Newman, J T Winslow, D L Murphy. Modulation of vocal and nonvocal behavior in adult squirrel monkeys by selective MAO-A and MAO-B inhibition.
Brain research.
1991 Jan; 538(1):24-8. doi:
10.1016/0006-8993(91)90371-2. [PMID: 1902133] - G A Lyles, A Holt, C M Marshall. Further studies on the metabolism of methylamine by semicarbazide-sensitive amine oxidase activities in human plasma, umbilical artery and rat aorta.
The Journal of pharmacy and pharmacology.
1990 May; 42(5):332-8. doi:
10.1111/j.2042-7158.1990.tb05421.x. [PMID: 1976780] - T Obata, Y Yamanaka. Comparative studies on semicarbazide-sensitive amine oxidase in heart and plasma of rats treated with hepatotoxin allyl formate.
The International journal of biochemistry.
1990; 22(8):837-9. doi:
10.1016/0020-711x(90)90286-c. [PMID: 2126247] - J P Finberg, G Ari, G Lavian, D Hovevey-Sion. Modification of alpha-2 presynaptic receptor activity and catecholamine release following chronic MAO inhibition.
Journal of neural transmission. Supplementum.
1990; 32(?):405-12. doi:
10.1007/978-3-7091-9113-2_55. [PMID: 1965197] - D Hovevey-Sion, I J Kopin, R W Stull, D S Goldstein. Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma.
Neuropharmacology.
1989 Aug; 28(8):791-7. doi:
10.1016/0028-3908(89)90169-x. [PMID: 2506486] - M Toraason, M E Luken, M Breitenstein, J A Krueger, R E Biagini. Comparative toxicity of allylamine and acrolein in cultured myocytes and fibroblasts from neonatal rat heart.
Toxicology.
1989 May; 56(1):107-17. doi:
10.1016/0300-483x(89)90216-3. [PMID: 2728003] - M B Youdim, D K Banerjee, K Kelner, L Offutt, H B Pollard. Steroid regulation of monoamine oxidase activity in the adrenal medulla.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1989 Apr; 3(6):1753-9. doi:
10.1096/fasebj.3.6.2495232. [PMID: 2495232] - A M O'Carroll, M C Anderson, I Tobbia, J P Phillips, K F Tipton. Determination of the absolute concentrations of monoamine oxidase A and B in human tissues.
Biochemical pharmacology.
1989 Mar; 38(6):901-5. doi:
10.1016/0006-2952(89)90278-5. [PMID: 2495009] - G Eisenhofer, D S Goldstein, I J Kopin. Plasma dihydroxyphenylglycol for estimation of noradrenaline neuronal re-uptake in the sympathetic nervous system in vivo.
Clinical science (London, England : 1979).
1989 Feb; 76(2):171-82. doi:
10.1042/cs0760171. [PMID: 2924508] - S S Tang, C O Chichester, H M Kagan. Comparative sensitivities of purified preparations of lysyl oxidase and other amine oxidases to active site-directed enzyme inhibitors.
Connective tissue research.
1989; 19(1):93-103. doi:
10.3109/03008208909016817. [PMID: 2571459] - C S Aulakh, K M Wozniak, J L Hill, D L Murphy. Differential effects of long-term antidepressant treatments on 8-OHDPAT-induced increases in plasma prolactin and corticosterone in rats.
European journal of pharmacology.
1988 Nov; 156(3):395-400. doi:
10.1016/0014-2999(88)90285-3. [PMID: 2975226] - G Eisenhofer, D S Goldstein, T G Ropchak, I J Kopin. Source and physiological significance of plasma 3,4-dihydroxyphenylalanine in the rat.
Journal of neurochemistry.
1988 Oct; 51(4):1204-13. doi:
10.1111/j.1471-4159.1988.tb03088.x. [PMID: 2901461] - G Eisenhofer, D S Goldstein, T G Ropchak, H Q Nguyen, H R Keiser, I J Kopin. Source and physiological significance of plasma 3,4-dihydroxyphenylglycol and 3-methoxy-4-hydroxyphenylglycol.
Journal of the autonomic nervous system.
1988 Sep; 24(1-2):1-14. doi:
10.1016/0165-1838(88)90130-0. [PMID: 3209794] - K Ramos, S L Grossman, L R Cox. Allylamine-induced vascular toxicity in vitro: prevention by semicarbazide-sensitive amine oxidase inhibitors.
Toxicology and applied pharmacology.
1988 Aug; 95(1):61-71. doi:
10.1016/s0041-008x(88)80008-5. [PMID: 2842890] - F Lasbennes, P Lacombe, J Seylaz. Effect of monoamine oxidase inhibition on the regional cerebral blood flow response to circulating noradrenaline.
Brain research.
1988 Jun; 454(1-2):205-11. doi:
10.1016/0006-8993(88)90819-0. [PMID: 3409003] - C S Aulakh, J Zohar, K M Wozniak, J L Hill, D L Murphy. Clorgyline treatment differentially affects m-chlorophenylpiperazine-induced neuroendocrine changes.
European journal of pharmacology.
1988 Jun; 150(3):239-46. doi:
10.1016/0014-2999(88)90004-0. [PMID: 2901357] - G Banchelli, F Buffoni, L Raimondi. On the presence of a clorgyline resistant benzylamine oxidase activity in mouse kidney.
Pharmacological research communications.
1988 Jun; 20(6):465-83. doi:
10.1016/s0031-6989(88)80075-4. [PMID: 3138700] - R L Hauger, M Scheinin, L J Siever, M Linnoila, W Z Potter. Dissociation of norepinephrine turnover from alpha-2 responses after clorgiline.
Clinical pharmacology and therapeutics.
1988 Jan; 43(1):32-8. doi:
10.1038/clpt.1988.8. [PMID: 2826065] - N A Goroshinskaia, N P Miliutina, A A Khodakova, E Z Tsvetnenko, V Z Gorkin. [Effect of clorgyline on the intensity of lipid peroxidation and on erythrocyte membrane stability in hyperoxia].
Biulleten' eksperimental'noi biologii i meditsiny.
1987 Jan; 103(1):54-6. doi:
. [PMID: 3801652] - J P Sullivan, L McDonnell, O M Hardiman, M A Farrell, J P Phillips, K F Tipton. The oxidation of tryptamine by the two forms of monoamine oxidase in human tissues.
Biochemical pharmacology.
1986 Oct; 35(19):3255-60. doi:
10.1016/0006-2952(86)90421-1. [PMID: 3094536] - T Inagaki, N A Rao, K Yagi. Modulation by phospholipids of the activity of monoamine oxidase purified from pig liver.
Journal of biochemistry.
1986 Sep; 100(3):597-603. doi:
10.1093/oxfordjournals.jbchem.a121751. [PMID: 3096981] - M Senjo, N Yamazaki, M Minami, M Hirokami, H Saito, H Parvez. Decreased monoamine oxidase activity in stroke-prone spontaneously hypertensive rat kidneys.
Research communications in chemical pathology and pharmacology.
1986 May; 52(2):207-16. doi:
NULL. [PMID: 3086955]
