Clorgiline (BioDeep_00000858685)

Main id: BioDeep_00000008801

 

Volatile Flavor Compounds


代谢物信息卡片


Clorgiline

化学式: C13H15Cl2NO (271.053064)
中文名称: 氯吉灵, 氯精氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C#CCN(C)CCCOc1ccc(cc1Cl)Cl
InChI: InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
Same as: D03248

同义名列表

4 个代谢物同义名

Clorgiline; Clorgyline; Clorgyline; Clorgiline



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guohui Zhong, Jie Guo, Chengyun Pang, Di Su, Chunli Tang, Lin Jing, Fengling Zhang, Ping He, Yaqian Yan, Zongji Chen, Jing Liu, Neng Jiang. Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. Bioorganic chemistry. 2023 01; 130(?):106224. doi: 10.1016/j.bioorg.2022.106224. [PMID: 36332315]
  • Jing Guan, Xin Tong, Yi Zhang, Fan Xu, Yuxin Zhang, Xiurui Liang, Jiaqi Jin, Hongyan Jing, Liuxian Guo, Xinrui Ni, Jihua Fu. Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules. Chemico-biological interactions. 2021 Nov; 349(?):109662. doi: 10.1016/j.cbi.2021.109662. [PMID: 34560070]
  • John Sebastiani, M Danielle McDonald. The role of uptake and degradation in the regulation of peripheral serotonin dynamics in Gulf toadfish, Opsanus beta. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2021 08; 258(?):110980. doi: 10.1016/j.cbpa.2021.110980. [PMID: 34023534]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Zhipei Sang, Qing Song, Zhongcheng Cao, Yong Deng, Zhenghuai Tan, Li Zhang. Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease. European journal of medicinal chemistry. 2021 Apr; 216(?):113310. doi: 10.1016/j.ejmech.2021.113310. [PMID: 33667847]
  • Zhongcheng Cao, Qing Song, Guangjun Yu, Zhuoling Liu, Shiqing Cong, Zhenghuai Tan, Yong Deng. Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2021 04; 35(?):116074. doi: 10.1016/j.bmc.2021.116074. [PMID: 33640707]
  • Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease. European journal of medicinal chemistry. 2020 Sep; 202(?):112475. doi: 10.1016/j.ejmech.2020.112475. [PMID: 32652406]
  • Zhipei Sang, Keren Wang, Ping Bai, Anguo Wu, Jian Shi, Wenmin Liu, Gaofeng Zhu, Yiling Wang, Yu Lan, Zude Chen, Yiyang Zhao, Zhanpin Qiao, Changning Wang, Zhenghuai Tan. Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2020 May; 194(?):112265. doi: 10.1016/j.ejmech.2020.112265. [PMID: 32240904]
  • Luiz C Klein-Júnior, Sylvian Cretton, Yvan Vander Heyden, André L Gasper, Samad Nejad-Ebrahimi, Philippe Christen, Amélia T Henriques. Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa. Journal of natural products. 2020 04; 83(4):852-863. doi: 10.1021/acs.jnatprod.9b00469. [PMID: 32150413]
  • Li Luo, Qing Song, Yan Li, Zhongcheng Cao, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorganic & medicinal chemistry. 2020 04; 28(8):115400. doi: 10.1016/j.bmc.2020.115400. [PMID: 32146060]
  • Ziyi Yang, Qing Song, Zhongcheng Cao, Guangjun Yu, Zhuoling Liu, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. Bioorganic & medicinal chemistry. 2020 04; 28(7):115374. doi: 10.1016/j.bmc.2020.115374. [PMID: 32089390]
  • Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu. Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors. Bioorganic & medicinal chemistry. 2019 05; 27(10):2027-2040. doi: 10.1016/j.bmc.2019.03.060. [PMID: 30975503]
  • María Goretti Arvizu-Espinosa, Gilsane Lino von Poser, Amelia Teresinha Henriques, Aniceto Mendoza-Ruiz, Anaberta Cardador-Martínez, Reinier Gesto-Borroto, Pablo Noé Núñez-Aragón, María Luisa Villarreal-Ortega, Ashutosh Sharma, Alexandre Cardoso-Taketa. Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum. Journal of natural products. 2019 04; 82(4):785-791. doi: 10.1021/acs.jnatprod.8b00677. [PMID: 30920216]
  • Carolina Noble, Niels Bjerre Holm, Marie Mardal, Kristian Linnet. Bromo-dragonfly, a psychoactive benzodifuran, is resistant to hepatic metabolism and potently inhibits monoamine oxidase A. Toxicology letters. 2018 Oct; 295(?):397-407. doi: 10.1016/j.toxlet.2018.07.018. [PMID: 30036687]
  • Liulin Wang, Kabir H Biswas, Bo Kyeong Yoon, Lisa M Kawakami, Soohyun Park, Jay T Groves, Lin Li, Wei Huang, Nam-Joon Cho. Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers. Langmuir : the ACS journal of surfaces and colloids. 2018 09; 34(36):10764-10773. doi: 10.1021/acs.langmuir.8b01348. [PMID: 30049212]
  • Ronan Gealageas, Alice Devineau, Pauline P L So, Catrina M J Kim, Jayakumar Surendradoss, Christian Buchwalder, Markus Heller, Verena Goebeler, Edith M Dullaghan, David S Grierson, Edward E Putnins. Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases. Journal of medicinal chemistry. 2018 08; 61(16):7043-7064. doi: 10.1021/acs.jmedchem.7b01588. [PMID: 30016860]
  • Wirginia Kukula-Koch, Wojciech Koch, Lidia Czernicka, Kazimierz Głowniak, Yoshinori Asakawa, Akemi Umeyama, Zbigniew Marzec, Takashi Kuzuhara. MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes-A Bioactivity Guided Fractionation. Molecules (Basel, Switzerland). 2018 May; 23(6):. doi: 10.3390/molecules23061301. [PMID: 29844252]
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  • Zhongcheng Cao, Jie Yang, Rui Xu, Qin Song, Xiaoyu Zhang, Hongyan Liu, Xiaoming Qiang, Yan Li, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment. Bioorganic & medicinal chemistry. 2018 03; 26(5):1102-1115. doi: 10.1016/j.bmc.2018.01.030. [PMID: 29409707]
  • Xia Yang, Xiaoming Qiang, Yan Li, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease. Bioorganic chemistry. 2017 04; 71(?):305-314. doi: 10.1016/j.bioorg.2017.02.016. [PMID: 28267984]
  • Li Luo, Yan Li, Xiaoming Qiang, Zhongcheng Cao, Rui Xu, Xia Yang, Ganyuan Xiao, Qing Song, Zhenghuai Tan, Yong Deng. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease. Bioorganic & medicinal chemistry. 2017 03; 25(6):1997-2009. doi: 10.1016/j.bmc.2017.02.027. [PMID: 28237559]
  • Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):718-722. doi: 10.1016/j.bmcl.2017.01.050. [PMID: 28131710]
  • Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng. Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2017 Jan; 126(?):762-775. doi: 10.1016/j.ejmech.2016.12.009. [PMID: 27951485]
  • Hyun Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Sei-Ryang Oh, Hoon Kim. Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens. Bioorganic & medicinal chemistry letters. 2016 10; 26(19):4714-4719. doi: 10.1016/j.bmcl.2016.08.044. [PMID: 27575476]
  • M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology. 2016 Aug; 233(15-16):2955-71. doi: 10.1007/s00213-016-4342-6. [PMID: 27259485]
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  • Juliana Maria de Mello Andrade, Carolina Dos Santos Passos, Maria Angélica Kieling Rubio, Jacqueline Nakau Mendonça, Norberto Peporine Lopes, Amélia Teresinha Henriques. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chemico-biological interactions. 2016 Jul; 254(?):135-45. doi: 10.1016/j.cbi.2016.06.005. [PMID: 27270453]
  • Yan Li, Xiaoming Qiang, Li Luo, Yuxing Li, Ganyuan Xiao, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2016 05; 24(10):2342-51. doi: 10.1016/j.bmc.2016.04.012. [PMID: 27079124]
  • Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. PloS one. 2016; 11(11):e0166750. doi: 10.1371/journal.pone.0166750. [PMID: 27861613]
  • Prachi Umbarkar, Sarojini Singh, Silpa Arkat, S L Bodhankar, Sathiyanarayanan Lohidasan, Sandhya L Sitasawad. Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy. Free radical biology & medicine. 2015 Oct; 87(?):263-73. doi: 10.1016/j.freeradbiomed.2015.06.025. [PMID: 26122707]
  • Roberta Farina, Leonardo Pisani, Marco Catto, Orazio Nicolotti, Domenico Gadaleta, Nunzio Denora, Ramon Soto-Otero, Estefania Mendez-Alvarez, Carolina S Passos, Giovanni Muncipinto, Cosimo D Altomare, Alessandra Nurisso, Pierre-Alain Carrupt, Angelo Carotti. Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases. Journal of medicinal chemistry. 2015 Jul; 58(14):5561-78. doi: 10.1021/acs.jmedchem.5b00599. [PMID: 26107513]
  • Joanna S Fowler, Jean Logan, Nora D Volkow, Elena Shumay, Fred McCall-Perez, Millard Jayne, Gene-Jack Wang, David L Alexoff, Karen Apelskog-Torres, Barbara Hubbard, Pauline Carter, Payton King, Stanley Fahn, Michelle Gilmor, Frank Telang, Colleen Shea, Youwen Xu, Lisa Muench. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 Feb; 40(3):650-7. doi: 10.1038/npp.2014.214. [PMID: 25249059]
  • Clara Grosso, Anna K Jäger, Dan Staerk. Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC-SPE-NMR for advanced bioactivity profiling of plant extracts. Phytochemical analysis : PCA. 2013 Feb; 24(2):141-7. doi: 10.1002/pca.2393. [PMID: 22987664]
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  • Ann R Holmes, Mikhail V Keniya, Irena Ivnitski-Steele, Brian C Monk, Erwin Lamping, Larry A Sklar, Richard D Cannon. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrobial agents and chemotherapy. 2012 Mar; 56(3):1508-15. doi: 10.1128/aac.05706-11. [PMID: 22203607]
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