Viset (BioDeep_00000870939)

PANOMIX_OTCML-2023

代谢物信息卡片

InChI=1\C15H10O6\c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7\h1-6,16-18,20

化学式: C15H10O6 (286.047736)
中文名称: 漆黄素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H

描述信息

COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
C26170 - Protective Agent > C1509 - Neuroprotective Agent
C26170 - Protective Agent > C275 - Antioxidant
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

同义名列表

77 个代谢物同义名

InChI=1\C15H10O6\c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7\h1-6,16-18,20; Fisetin; 5-Deoxyquercetin; 3,3?,4?,7-Tetra??hydroxy??flavone; Natural Brown 1; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-; 3,7-Dihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-chromenone; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromone; 5-18-05-00291 (Beilstein Handbook Reference); FLAVONE, 3,3,4,7-TETRAHYDROXY-; 3,7,3,4-Tetrahydroxyflavone; 3,3,4,7-Tetrahydroxyflavone; 7,3,4-Trihydroxyflavonol; SDCCGMLS-0066657.P001; Young fustic crystals; Bois bleu de Honqrie; C.I. Natural Brown 1; Ungarisches gelbholz; BOIS bleude honqrie; 3,347-tetOH-Flavone; 5-Desoxyquercetin; Spectrum5_001797; Spectrum4_001070; Spectrum2_001160; Spectrum3_001536; EINECS 208-434-4; SpecPlus_000460; Spectrum_001196; SPECTRUM1502247; NCGC00095663-02; NCGC00017344-01; NCGC00017344-02; NCGC00095663-01; NCIMech_000006; Ventin sumach; DivK1c_006556; KBioGR_001400; Junger fustik; Superfustel K; KBioSS_001676; BSPBio_002952; Zante fustic; KBio2_001676; KBio2_004244; ZINC00039111; Young fustic; KBio1_001500; SPBio_001119; KBio3_002452; KBio2_006812; NCI60_003865; Superfustel; CHEBI:42567; AIDS-003057; BRN 0292829; NSC 656275; AIDS003057; NSC 407010; C.I. 75620; NSC656275; NSC407010; Fisetholz; ST057233; TNP00004; TNP00284; 528-48-3; Cotinin; Fisetin; Fustet; Fustel; Fietin; C10041; S00056; Viset; FSE

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:42567
KEGG: C10041
PubChem: 5281614
DrugBank: DB07795
ChEMBL: CHEMBL31574
CAS: 528-48-3
PubChem: 12227
LipidMAPS: LMPK12111566
KNApSAcK: C00004579
PDB-CCD: FSE
3DMET: B03484
NIKKAJI: J1.584I
medchemexpress: HY-N0182

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

122 个相关的物种来源信息

33090 皂角刺: -
74613 Glycyrrhiza uralensis: 10.1248/CPB.45.1485
289753 Rhus chinensis: 10.1007/S10600-015-1336-2
3847 Glycine max: 10.1007/BF02259383
43851 Schinus molle: 10.1007/BF01100201
289720 Lithraea molleoides: 10.1007/BF01100201
3900 Trifolium subterraneum: 10.1016/S0031-9422(00)85667-8
321567 Peltophorum africanum: 10.1016/0031-9422(88)80808-2
298662 Rhus glabra: 10.1016/0378-8741(94)90102-3
118891 Anthyllis vulneraria:
121718 Tilia tomentosa: 10.1016/0378-8741(94)90098-1
75744 Acer glabrum: 10.1016/0305-1978(95)00014-L
47247 Lotus corniculatus: 10.1016/S0031-9422(00)94254-7
149639 Dermatophyllum secundiflorum: 10.1016/0031-9422(95)93530-S
236730 Endosamara racemosa: 10.1016/0031-9422(89)80141-4
383638 Acacia cardiophylla:
383645 Acacia irrorata:
383632 Acacia baileyana:
383653 Acacia oshanesii:
1280824 Acacia rubida:
138518 Acacia leucoclada:
139006 Acacia calamifolia:
1174753 Acacia chrysotricha:
880440 Acacia pycnantha:
1173639 Acacia carneorum:
138017 Senegalia catechu:
1174746 Acacia buxifolia:
139008 Acacia falciformis:
1174755 Acacia clunies-rossiae:
383648 Acacia mollifolia:
1174771 Acacia decora:
383643 Acacia filicifolia:
383658 Acacia trachyphloia:
139012 Acacia mearnsii:
1378370 Acacia kettlewelliae:
205042 Acacia dealbata:
138022 Acacia fasciculifera:
1174866 Acacia peuce:
204988 Acacia adunca:
205063 Acacia silvestris:
138021 Acacia elata:
205356 Acacia deanei:
138037 Acacia parramattensis:
383647 Acacia mabellae:
383640 Acacia constablei:
1883 Streptomyces: 10.1016/J.ENZMICTEC.2018.02.007
269719 Cotinus coggygria: 10.1016/B978-0-12-013320-8.50007-1
162908 Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
499988 Dalbergia odorifera: 10.1055/S-2006-957394
469930 Garcinia kola: 10.1021/NP50023A026
53932 Xanthocercis zambesiaca: 10.1016/0031-9422(88)80154-7
210334 Picrasma quassioides: 10.1002/CBDV.201000137
58847 Virgilia oroboides: 10.1016/0031-9422(90)80205-U
4013 Toxicodendron vernicifluum:
210340 Bischofia javanica: 10.15625/0866-708X/55/2/8608
149628 Amburana cearensis: 10.1002/PTR.1139
1231556 Myroxylon peruiferum: 10.1016/0031-9422(79)80020-5
162715 Colophospermum mopane: 10.1016/S0031-9422(03)00152-3
173898 Sphaerostephanos penniger: 10.1016/0305-1978(93)90081-2
66093 Gleditsia japonica: 10.1248/YAKUSHI1947.77.11_1208
210348 Brucea javanica: 10.1016/J.FITOTE.2007.07.008
74613 Glycyrrhiza uralensis: 10.1248/CPB.45.1485
289753 Rhus chinensis: 10.1007/S10600-015-1336-2
3847 Glycine max: 10.1007/BF02259383
43851 Schinus molle: 10.1007/BF01100201
289720 Lithraea molleoides: 10.1007/BF01100201
3900 Trifolium subterraneum: 10.1016/S0031-9422(00)85667-8
321567 Peltophorum africanum: 10.1016/0031-9422(88)80808-2
298662 Rhus glabra: 10.1016/0378-8741(94)90102-3
118891 Anthyllis vulneraria:
121718 Tilia tomentosa: 10.1016/0378-8741(94)90098-1
75744 Acer glabrum: 10.1016/0305-1978(95)00014-L
47247 Lotus corniculatus: 10.1016/S0031-9422(00)94254-7
149639 Dermatophyllum secundiflorum: 10.1016/0031-9422(95)93530-S
236730 Endosamara racemosa: 10.1016/0031-9422(89)80141-4
383638 Acacia cardiophylla:
383645 Acacia irrorata:
383632 Acacia baileyana:
383653 Acacia oshanesii:
1280824 Acacia rubida:
138518 Acacia leucoclada:
139006 Acacia calamifolia:
1174753 Acacia chrysotricha:
880440 Acacia pycnantha:
1173639 Acacia carneorum:
138017 Senegalia catechu:
1174746 Acacia buxifolia:
139008 Acacia falciformis:
1174755 Acacia clunies-rossiae:
383648 Acacia mollifolia:
1174771 Acacia decora:
383643 Acacia filicifolia:
383658 Acacia trachyphloia:
139012 Acacia mearnsii:
1378370 Acacia kettlewelliae:
205042 Acacia dealbata:
138022 Acacia fasciculifera:
1174866 Acacia peuce:
204988 Acacia adunca:
205063 Acacia silvestris:
138021 Acacia elata:
205356 Acacia deanei:
138037 Acacia parramattensis:
383647 Acacia mabellae:
383640 Acacia constablei:
1883 Streptomyces: 10.1016/J.ENZMICTEC.2018.02.007
269719 Cotinus coggygria: 10.1016/B978-0-12-013320-8.50007-1
162908 Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
499988 Dalbergia odorifera: 10.1055/S-2006-957394
469930 Garcinia kola: 10.1021/NP50023A026
53932 Xanthocercis zambesiaca: 10.1016/0031-9422(88)80154-7
210334 Picrasma quassioides: 10.1002/CBDV.201000137
58847 Virgilia oroboides: 10.1016/0031-9422(90)80205-U
4013 Toxicodendron vernicifluum:
210340 Bischofia javanica: 10.15625/0866-708X/55/2/8608
149628 Amburana cearensis: 10.1002/PTR.1139
1231556 Myroxylon peruiferum: 10.1016/0031-9422(79)80020-5
162715 Colophospermum mopane: 10.1016/S0031-9422(03)00152-3
173898 Sphaerostephanos penniger: 10.1016/0305-1978(93)90081-2
66093 Gleditsia japonica: 10.1248/YAKUSHI1947.77.11_1208
210348 Brucea javanica: 10.1016/J.FITOTE.2007.07.008
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Yao Guo, Bing Liu, Yaping Geng, Ke Chen, Junyan Li, Xiangju Yin, Shenshen Zhang. Fisetin, a dietary flavonoid, promotes transintestinal cholesterol excretion through the activation of PPARδ. Food research international (Ottawa, Ont.). 2024 Jan; 175(?):113783. doi: 10.1016/j.foodres.2023.113783. [PMID: 38129008]
Xiufang Jiang, Yanling Lei, Yajuan Yin, Fangfang Ma, Mingqi Zheng, Gang Liu. Fisetin Suppresses Atherosclerosis by Inhibiting Ferroptosis-Related Oxidative Stress in Apolipoprotein E Knockout Mice. Pharmacology. 2024; 109(3):169-179. doi: 10.1159/000538535. [PMID: 38583431]
Randa Hanie Awadeen, Mariza Fouad Boughdady, Randa A Zaghloul, Wael M Elsaed, Irhan Ibrahim Abu Hashim, Mahasen Mohamed Meshali. Formulation of lipid polymer hybrid nanoparticles of the phytochemical Fisetin and its in vivo assessment against severe acute pancreatitis. Scientific reports. 2023 11; 13(1):19110. doi: 10.1038/s41598-023-46215-8. [PMID: 37925581]
A I Savko, T V Ilyich, A G Veiko, T A Kovalenia, E A Lapshina, I B Zavodnik. The flavonoids fisetin, apigenin, kaempferol, naringenin, naringin regulate respiratory activity and membrane potential of rat liver mitochondria and inhibit oxidative processes in erythrocytes. Biomeditsinskaia khimiia. 2023 Nov; 69(5):281-289. doi: 10.18097/pbmc20236905281. [PMID: 37937430]
Hitesh Kumar, Pallavi Chand, Shantanu Pachal, Sahid Mallick, Rupshee Jain, SubbaRao V Madhunapantula, Vikas Jain. Fisetin-Loaded Nanostructured Lipid Carriers: Formulation and Evaluations against Advanced and Metastatic Melanoma. Molecular pharmaceutics. 2023 Oct; ?(?):. doi: 10.1021/acs.molpharmaceut.3c00309. [PMID: 37906601]
Seul Gi Kim, Jin Young Sung, Young Jin Kang, Hyoung Chul Choi. PPARγ activation by fisetin mitigates vascular smooth muscle cell senescence via the mTORC2-FoxO3a-autophagy signaling pathway. Biochemical pharmacology. 2023 Oct; ?(?):115892. doi: 10.1016/j.bcp.2023.115892. [PMID: 37890594]
Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung. Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Oct; 167(?):115613. doi: 10.1016/j.biopha.2023.115613. [PMID: 37801904]
Wenli Shi, Wenxin Han, Yijing Liao, Jiaqi Wen, Guowen Zhang. Inhibition mechanism of fisetin on acetylcholinesterase and its synergistic effect with galantamine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2023 Sep; 305(?):123452. doi: 10.1016/j.saa.2023.123452. [PMID: 37769468]
Joanna Szymczak, Judyta Cielecka-Piontek. Fisetin-In Search of Better Bioavailability-From Macro to Nano Modifications: A Review. International journal of molecular sciences. 2023 Sep; 24(18):. doi: 10.3390/ijms241814158. [PMID: 37762460]
Bo Wang, Li-Na Yang, Le-Tian Yang, Yan Liang, Fan Guo, Ping Fu, Liang Ma. Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis. Acta pharmacologica Sinica. 2023 Sep; ?(?):. doi: 10.1038/s41401-023-01156-w. [PMID: 37696989]
Yizhen Jiang, Xiangwen Tang, Peng Deng, Chao Jiang, Yuqing He, Dingjun Hao, Hao Yang. The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review. Molecular neurobiology. 2023 Jul; ?(?):. doi: 10.1007/s12035-023-03469-7. [PMID: 37453993]
Robert Kubina, Kamil Krzykawski, Arkadiusz Dziedzic, Agata Kabała-Dzik. Kaempferol and Fisetin-Related Signaling Pathways Induce Apoptosis in Head and Neck Cancer Cells. Cells. 2023 06; 12(12):. doi: 10.3390/cells12121568. [PMID: 37371038]
Sweety Mehra, Aitizaz Ul Ahsan, Madhu Sharma, Muskan Budhwar, Mani Chopra. Neuroprotective Efficacy of Fisetin Against VPA-Induced Autistic Neurobehavioral Alterations by Targeting Dysregulated Redox Homeostasis. Journal of molecular neuroscience : MN. 2023 Jun; ?(?):. doi: 10.1007/s12031-023-02127-w. [PMID: 37261645]
Tae Woo Kim. Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24109076. [PMID: 37240422]
Guihong Liang, Jinlong Zhao, Jianke Pan, Yuan Yang, Yaoxing Dou, Weiyi Yang, Lingfeng Zeng, Jun Liu. Network pharmacology identifies fisetin as a treatment for osteoporosis that activates the Wnt/β-catenin signaling pathway in BMSCs. Journal of orthopaedic surgery and research. 2023 Apr; 18(1):312. doi: 10.1186/s13018-023-03761-1. [PMID: 37087476]
Parisa Sarvarian, Parisa Samadi, Elham Gholipour, Meisam Khodadadi, Ramin Pourakbari, Parvin Akbarzadelale, Karim Shamsasenjan. Fisetin-loaded grape-derived nanoparticles improve anticancer efficacy in MOLT-4 cells. Biochemical and biophysical research communications. 2023 Mar; 658(?):69-79. doi: 10.1016/j.bbrc.2023.03.040. [PMID: 37027907]
Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi. Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB/BDNF. European journal of pharmacology. 2023 Feb; 944(?):175583. doi: 10.1016/j.ejphar.2023.175583. [PMID: 36764352]
Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S Allemailem, Amjad Ali Khan, Saleh A Almatroodi. The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27249009. [PMID: 36558146]
Sara M Talaat, Yosra S R Elnaggar, Samar O El-Ganainy, Mennatallah A Gowayed, Amany Abdel-Bary, Ossama Y Abdallah. Novel bio-inspired lipid nanoparticles for improving the anti-tumoral efficacy of fisetin against breast cancer. International journal of pharmaceutics. 2022 11; 628(?):122184. doi: 10.1016/j.ijpharm.2022.122184. [PMID: 36252641]
Yedam Moon, Hayeong Kim, Choon Gil Kang, Chanho Park, Seung Wook Kim, Doman Kim. Biochemical characterization of synthesized fisetin glucoside by dextransucrase from Leuconostoc mesenteroides NRRL B-1299CB4 with enhanced water solubility. Enzyme and microbial technology. 2022 Nov; 161(?):110111. doi: 10.1016/j.enzmictec.2022.110111. [PMID: 35961060]
Shayan Khozooei, Konstanze Lettau, Francesca Barletta, Tina Jost, Simone Rebholz, Soundaram Veerappan, Mirita Franz-Wachtel, Boris Macek, George Iliakis, Luitpold V Distel, Daniel Zips, Mahmoud Toulany. Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells. Journal of experimental & clinical cancer research : CR. 2022 Aug; 41(1):256. doi: 10.1186/s13046-022-02442-x. [PMID: 35989353]
Su-Hwan Kim, Chang-Ki Huh. Isolation and Identification of Fisetin: An Antioxidative Compound Obtained from Rhus verniciflua Seeds. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144510. [PMID: 35889379]
Abha Mishra, Upinder Kaur, Amit Singh. Fisetin 8-C-glucoside as entry inhibitor in SARS CoV-2 infection: molecular modelling study. Journal of biomolecular structure & dynamics. 2022 07; 40(11):5128-5137. doi: 10.1080/07391102.2020.1868335. [PMID: 33382023]
Priyanka N Prem, Gino A Kurian. Fisetin attenuates renal ischemia/reperfusion injury by improving mitochondrial quality, reducing apoptosis and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. 2022 05; 395(5):547-561. doi: 10.1007/s00210-022-02204-8. [PMID: 35133446]
Bo Wang, Jing Wang, Xin-Huai Zhao. Bioactivity of Two Polyphenols Quercetin and Fisetin against Human Gastric Adenocarcinoma AGS Cells as Affected by Two Coexisting Proteins. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092877. [PMID: 35566228]
Shu-Ju Wu, Wen-Chung Huang, Ching-Yi Cheng, Meng-Chun Wang, Shu-Chen Cheng, Chian-Jiun Liou. Fisetin Suppresses the Inflammatory Response and Oxidative Stress in Bronchial Epithelial Cells. Nutrients. 2022 Apr; 14(9):. doi: 10.3390/nu14091841. [PMID: 35565807]
Hongguang Ding, Ya Li, Shenglong Chen, Yin Wen, Shiying Zhang, Ensi Luo, Xusheng Li, Wenhong Zhong, Hongke Zeng. Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy. CNS neuroscience & therapeutics. 2022 02; 28(2):247-258. doi: 10.1111/cns.13765. [PMID: 34837343]
Natsuko Tsurudome, Yuji Minami, Katsuko Kajiya. Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction. BioFactors (Oxford, England). 2022 Jan; 48(1):56-66. doi: 10.1002/biof.1798. [PMID: 34687255]
Zi-Shen Zhou, Chen-Fan Kong, Jian-Rong Sun, Xiang-Ke Qu, Jin-Hui Sun, An-Tao Sun. Fisetin Ameliorates Alcohol-Induced Liver Injury through Regulating SIRT1 and SphK1 Pathway. The American journal of Chinese medicine. 2022; 50(8):2171-2184. doi: 10.1142/s0192415x22500938. [PMID: 36266756]
Yanyi Xiao, Yilong Liu, Zhiwei Gao, Xian Li, Min Weng, Chenghao Shi, Cheng Wang, Linxiao Sun. Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling. Aging. 2021 11; 13(22):24753-24767. doi: 10.18632/aging.203713. [PMID: 34821587]
Johnna F Varghese, Rohit Patel, Mohit Singh, Umesh C S Yadav. Fisetin Prevents Oxidized Low-density Lipoprotein-Induced Macrophage Foam Cell Formation. Journal of cardiovascular pharmacology. 2021 11; 78(5):e729-e737. doi: 10.1097/fjc.0000000000001096. [PMID: 34173812]
Brandon P Verdoorn, Tamara K Evans, Gregory J Hanson, Yi Zhu, Larissa G P Langhi Prata, Robert J Pignolo, Elizabeth J Atkinson, Erin O Wissler-Gerdes, George A Kuchel, Joan B Mannick, Stephen B Kritchevsky, Sundeep Khosla, Stacey A Rizza, Jeremy D Walston, Nicolas Musi, Lewis A Lipsitz, Douglas P Kiel, Raymond Yung, Nathan K LeBrasseur, Ravinder J Singh, Teresa McCarthy, Michael A Puskarich, Laura J Niedernhofer, Paul D Robbins, Matthew Sorenson, Tamara Tchkonia, James L Kirkland. Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era. Journal of the American Geriatrics Society. 2021 11; 69(11):3023-3033. doi: 10.1111/jgs.17416. [PMID: 34375437]
Aynaz Mihanfar, Mohammad Nouri, Leila Roshangar, Mohammad Hassan Khadem-Ansari. Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome. The Journal of steroid biochemistry and molecular biology. 2021 10; 213(?):105954. doi: 10.1016/j.jsbmb.2021.105954. [PMID: 34298098]
Qian Ren, Lu Cheng, Fan Guo, Sibei Tao, Chunle Zhang, Liang Ma, Ping Fu. Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation. Journal of agricultural and food chemistry. 2021 Sep; 69(37):10932-10942. doi: 10.1021/acs.jafc.1c03449. [PMID: 34505780]
Beiyun Shen, Xinchen Shangguan, Zhongping Yin, Shaofu Wu, Qingfeng Zhang, Wenwen Peng, Jingen Li, Lu Zhang, Jiguang Chen. Inhibitory Effect of Fisetin on α-Glucosidase Activity: Kinetic and Molecular Docking Studies. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175306. [PMID: 34500738]
Yuanyuan Huang, Jianlin Lu, Li Zhan, Ming Wang, Ronghua Shi, Xiao Yuan, Xinjiao Gao, Xing Liu, Jianye Zang, Wei Liu, Xuebiao Yao. Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism. The Journal of biological chemistry. 2021 08; 297(2):100929. doi: 10.1016/j.jbc.2021.100929. [PMID: 34216621]
Jun-Liang Pu, Zuo-Tian Huang, Yun-Hai Luo, Tong Mou, Ting-Ting Li, Zhong-Tang Li, Xu-Fu Wei, Zhong-Jun Wu. Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway. Hepatobiliary & pancreatic diseases international : HBPD INT. 2021 Aug; 20(4):352-360. doi: 10.1016/j.hbpd.2021.04.013. [PMID: 34024736]
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Ankita R Rane, Harshad Paithankar, Ramakrishna V Hosur, Sinjan Choudhary. Modulation of α-synuclein fibrillation by plant metabolites, daidzein, fisetin and scopoletin under physiological conditions. International journal of biological macromolecules. 2021 Jul; 182(?):1278-1291. doi: 10.1016/j.ijbiomac.2021.05.071. [PMID: 33991558]
Qian Ren, Sibei Tao, Fan Guo, Bo Wang, Letian Yang, Liang Ma, Ping Fu. Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 87(?):153552. doi: 10.1016/j.phymed.2021.153552. [PMID: 33994251]
Rita Rosado-Ramos, Joana Godinho-Pereira, Daniela Marques, Inês Figueira, Tiago Fleming Outeiro, Regina Menezes, Cláudia Nunes Dos Santos. Small Molecule Fisetin Modulates Alpha-Synuclein Aggregation. Molecules (Basel, Switzerland). 2021 Jun; 26(11):. doi: 10.3390/molecules26113353. [PMID: 34199487]
Xin Huang, Hong Shen, Yiran Liu, Sainan Qiu, Yan Guo. Fisetin attenuates periodontitis through FGFR1/TLR4/NLRP3 inflammasome pathway. International immunopharmacology. 2021 Jun; 95(?):107505. doi: 10.1016/j.intimp.2021.107505. [PMID: 33725636]
Shifeng Xiao, Yafei Lu, Qiuping Wu, Jiaying Yang, Jierui Chen, Suyue Zhong, David Eliezer, Qiulong Tan, Chengchen Wu. Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands. International journal of biological macromolecules. 2021 May; 178(?):381-393. doi: 10.1016/j.ijbiomac.2021.02.210. [PMID: 33662414]
Ge Chenxu, Dai Xianling, Kuang Qin, Hu Linfeng, Sun Yan, Xiong Mingxin, Tan Jun, Xu Minxuan. Fisetin protects against high fat diet-induced nephropathy by inhibiting inflammation and oxidative stress via the blockage of iRhom2/NF-κB signaling. International immunopharmacology. 2021 Mar; 92(?):107353. doi: 10.1016/j.intimp.2020.107353. [PMID: 33429334]
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Yoshiko Hada, Haruhito A Uchida, Jun Wada. Fisetin Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Macrophage. BioMed research international. 2021; 2021(?):5570885. doi: 10.1155/2021/5570885. [PMID: 33954178]
Fang Pei, Hua Pei, Chunhua Su, Lin Du, Jifen Wang, Fusheng Xie, Qi Yin, Zhao Gao. Fisetin Alleviates Neointimal Hyperplasia via PPARγ/PON2 Antioxidative Pathway in SHR Rat Artery Injury Model. Oxidative medicine and cellular longevity. 2021; 2021(?):6625517. doi: 10.1155/2021/6625517. [PMID: 33968295]
Kanakalatha Alikatte, Suresh Palle, Jadi Rajendra Kumar, Naveen Pathakala. Fisetin Improved Rotenone-Induced Behavioral Deficits, Oxidative Changes, and Mitochondrial Dysfunctions in Rat Model of Parkinson's Disease. Journal of dietary supplements. 2021; 18(1):57-71. doi: 10.1080/19390211.2019.1710646. [PMID: 31992104]
Hai-Feng Zhang, Hai-Bo Zhang, Xue-Ping Wu, Ya-Ling Guo, Wei-Dong Cheng, Feng Qian. Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling. Acta pharmacologica Sinica. 2020 Oct; 41(10):1348-1356. doi: 10.1038/s41401-020-0462-y. [PMID: 32661350]
Rajan Kumar, Rakesh Kumar, Navneet Khurana, Sachin Kumar Singh, Shelly Khurana, Surajpal Verma, Neha Sharma, Bhupinder Kapoor, Manish Vyas, Rubiya Khursheed, Ankit Awasthi, Jaskiran Kaur, Leander Corrie. Enhanced oral bioavailability and neuroprotective effect of fisetin through its SNEDDS against rotenone-induced Parkinson's disease rat model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Oct; 144(?):111590. doi: 10.1016/j.fct.2020.111590. [PMID: 32710995]
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Thasleem Moolakkadath, Mohd Aqil, Abdul Ahad, Syed Sarim Imam, Arshiya Praveen, Yasmin Sultana, Mohd Mujeeb. Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design. International journal of pharmaceutics. 2020 Mar; 578(?):119125. doi: 10.1016/j.ijpharm.2020.119125. [PMID: 32036010]
Shuntaro Takahashi, Snehasish Bhattacharjee, Saptarshi Ghosh, Naoki Sugimoto, Sudipta Bhowmik. Preferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications. Scientific reports. 2020 02; 10(1):2504. doi: 10.1038/s41598-020-59343-2. [PMID: 32054927]
Qian Ren, Fan Guo, Sibei Tao, Rongshuang Huang, Liang Ma, Ping Fu. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Feb; 122(?):109772. doi: 10.1016/j.biopha.2019.109772. [PMID: 31918290]
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Vaithish Velazhahan, Przemyslaw Glaza, Alvaro I Herrera, Om Prakash, Michal Zolkiewski, Brian V Geisbrecht, Kathrin Schrick. Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53. PloS one. 2020; 15(6):e0234468. doi: 10.1371/journal.pone.0234468. [PMID: 32530958]
QingLing Jia, Hui Cao, DingZhu Shen, Li Yan, Chuan Chen, Sanli Xing. Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells. European journal of pharmacology. 2019 Dec; 865(?):172748. doi: 10.1016/j.ejphar.2019.172748. [PMID: 31655030]
Hina Agraval, Umesh C S Yadav. MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: Amelioration by fisetin. Chemico-biological interactions. 2019 Dec; 314(?):108846. doi: 10.1016/j.cbi.2019.108846. [PMID: 31606474]
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Min-Hong Hsieh, Jen-Pi Tsai, Shun-Fa Yang, Hui-Ling Chiou, Chia-Liang Lin, Yi-Hsien Hsieh, Horng-Rong Chang. Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9. Cells. 2019 08; 8(9):. doi: 10.3390/cells8090948. [PMID: 31438640]
Tajamul Hussain, Omar S Al-Attas, Salman Alamery, Mukhtar Ahmed, Hamza A M Odeibat, Salman Alrokayan. The plant flavonoid, fisetin alleviates cigarette smoke-induced oxidative stress, and inflammation in Wistar rat lungs. Journal of food biochemistry. 2019 08; 43(8):e12962. doi: 10.1111/jfbc.12962. [PMID: 31368542]
Hanaa H Gaballah, Hemat E El-Horany, Duaa S Helal. Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats. Journal of cellular biochemistry. 2019 08; 120(8):12762-12774. doi: 10.1002/jcb.28544. [PMID: 30861601]
Sandeep Singh, Geetika Garg, Abhishek Kumar Singh, Akalabya Bissoyi, Syed Ibrahim Rizvi. Fisetin, a potential caloric restriction mimetic, attenuates senescence biomarkers in rat erythrocytes. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2019 08; 97(4):480-487. doi: 10.1139/bcb-2018-0159. [PMID: 30624963]
Chenxu Ge, Minxuan Xu, Yuting Qin, Tingting Gu, Deshuai Lou, Qiang Li, Linfeng Hu, Xuyuan Nie, Mingxing Wang, Jun Tan. Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation. Food & function. 2019 May; 10(5):2970-2985. doi: 10.1039/c8fo01653d. [PMID: 31074472]
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Licong Zhao, Jiaqi Zhang, Lingyun Pan, Long Chen, Yu Wang, Xinhua Liu, Lisha You, Yiqun Jia, Cheng Hu. Protective effect of 7,3',4'-flavon-3-ol (fisetin) on acetaminophen-induced hepatotoxicity in vitro and in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 May; 58(?):152865. doi: 10.1016/j.phymed.2019.152865. [PMID: 30831465]
Thasleem Moolakkadath, Mohd Aqil, Abdul Ahad, Syed Sarim Imam, Arshiya Praveen, Yasmin Sultana, Mohd Mujeeb, Zeenat Iqbal. Fisetin loaded binary ethosomes for management of skin cancer by dermal application on UV exposed mice. International journal of pharmaceutics. 2019 Apr; 560(?):78-91. doi: 10.1016/j.ijpharm.2019.01.067. [PMID: 30742987]
Reem Elkholy, Mohamed Balaha, Noha El-Anwar, Samah Kandeel, Sabiha Hedya, Mohamed-Nabih Abd-El Rahman. Fisetin and telmisartan each alone or in low-dose combination alleviate OVA-induced food allergy in mice. Pharmacological reports : PR. 2019 Apr; 71(2):330-337. doi: 10.1016/j.pharep.2018.12.009. [PMID: 30826574]
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Osama Y Althunibat, Amir M Al Hroob, Mohammad H Abukhalil, Mousa O Germoush, May Bin-Jumah, Ayman M Mahmoud. Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy. Life sciences. 2019 Mar; 221(?):83-92. doi: 10.1016/j.lfs.2019.02.017. [PMID: 30742869]
Shanky Garg, Rajiv Kumar Malhotra, Sana Irfan Khan, Satyaki Sarkar, P N Susrutha, Vishwajeet Singh, Sameer Goyal, Tapas Chandra Nag, Ruma Ray, Jagriti Bhatia, Dharamvir Singh Arya. Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-κB mediated oxidative stress, apoptosis and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 56(?):147-155. doi: 10.1016/j.phymed.2018.09.187. [PMID: 30668335]
Priyansha Choubey, Mohit Kwatra, Surya Narayan Pandey, Dinesh Kumar, Durgesh Kumar Dwivedi, Prabha Rajput, Abhishek Mishra, Mangala Lahkar, Ashok Jangra. Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1. Psychopharmacology. 2019 Feb; 236(2):741-752. doi: 10.1007/s00213-018-5105-3. [PMID: 30426184]
Tao Ma, Amit D Kandhare, Anwesha A Mukherjee-Kandhare, Subhash L Bodhankar. Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: the decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-α. Molecular biology reports. 2019 Feb; 46(1):105-118. doi: 10.1007/s11033-018-4450-y. [PMID: 30362071]
Yibing Si, Junfeng Liu, Hongliang Shen, Chen Zhang, Yuanhao Wu, Yongyi Huang, Zhangbin Gong, Jun Xue, Te Liu. Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell. Journal of cellular and molecular medicine. 2019 02; 23(2):1095-1105. doi: 10.1111/jcmm.14010. [PMID: 30411496]
Limin Wang, Di Cao, Huijun Wu, Hongning Jia, Chaoping Yang, Lihua Zhang. Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2019 Jan; 25(?):1076029619871359. doi: 10.1177/1076029619871359. [PMID: 31434498]
Malathi Rajendran, Rajamurugan Ramachandran. Fisetin protects against rotenone-induced neurotoxicity through signaling pathway. Frontiers in bioscience (Elite edition). 2019 01; 11(1):20-28. doi: 10.2741/e843. [PMID: 30468635]
Paurnima Talele, Saugata Sahu, Ashok Kumar Mishra. Physicochemical characterization of solid lipid nanoparticles comprised of glycerol monostearate and bile salts. Colloids and surfaces. B, Biointerfaces. 2018 Dec; 172(?):517-525. doi: 10.1016/j.colsurfb.2018.08.067. [PMID: 30212689]
Su-Ping Xu, Yong-Sheng Li. Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation. International journal of molecular medicine. 2018 Dec; 42(6):3220-3230. doi: 10.3892/ijmm.2018.3903. [PMID: 30272314]
Matthew J Yousefzadeh, Yi Zhu, Sara J McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I Melos, Tamar Pirtskhalava, Christina L Inman, Collin McGuckian, Erin A Wade, Jonathon I Kato, Diego Grassi, Mark Wentworth, Christin E Burd, Edgar A Arriaga, Warren L Ladiges, Tamara Tchkonia, James L Kirkland, Paul D Robbins, Laura J Niedernhofer. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct; 36(?):18-28. doi: 10.1016/j.ebiom.2018.09.015. [PMID: 30279143]
Biswapathik Pahari, Sandipan Chakraborty, Pradeep K Sengupta. Molecular insight into the inclusion of the dietary plant flavonol fisetin and its chromophore within a chemically modified γ-cyclodextrin: Multi-spectroscopic, molecular docking and solubility studies. Food chemistry. 2018 Sep; 260(?):221-230. doi: 10.1016/j.foodchem.2018.03.128. [PMID: 29699666]
Seon-Ok Lee, Sung-Ji Kim, Ju-Sung Kim, Hyuk Ji, Eun-Ok Lee, Hyo-Jeong Lee. Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods. BMC complementary and alternative medicine. 2018 Aug; 18(1):242. doi: 10.1186/s12906-018-2310-x. [PMID: 30165848]
Xu Sun, Xueman Ma, Qiwei Li, Yong Yang, Xiaolong Xu, Jiaqi Sun, Mingwei Yu, Kexin Cao, Lin Yang, Guowang Yang, Ganlin Zhang, Xiaomin Wang. Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies. International journal of molecular medicine. 2018 Aug; 42(2):811-820. doi: 10.3892/ijmm.2018.3654. [PMID: 29749427]
Hui-Ling Peng, Wen-Chung Huang, Shu-Chen Cheng, Chian-Jiun Liou. Fisetin inhibits the generation of inflammatory mediators in interleukin-1β-induced human lung epithelial cells by suppressing the NF-κB and ERK1/2 pathways. International immunopharmacology. 2018 Jul; 60(?):202-210. doi: 10.1016/j.intimp.2018.05.004. [PMID: 29758489]
Tao Guo, Xue Dong, Gang Shi. [In vitro and in vivo Antitumor Effects of Fisetin and Fisetin Nanopartical on Ovarian Cancer]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2018 Jul; 49(4):551-555. doi: NULL. [PMID: 30378308]
Miao-Chan Huang, Thomas Y Hsueh, Yung-Yi Cheng, Lie-Chwen Lin, Tung-Hu Tsai. Pharmacokinetics and Biliary Excretion of Fisetin in Rats. Journal of agricultural and food chemistry. 2018 Jun; 66(25):6300-6307. doi: 10.1021/acs.jafc.8b00917. [PMID: 29862816]
Alireza Farsad-Naeimi, Mohammad Alizadeh, Ali Esfahani, Esmaeil Darvish Aminabad. Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients. Food & function. 2018 Apr; 9(4):2025-2031. doi: 10.1039/c7fo01898c. [PMID: 29541713]
Elżbieta Łodyga-Chruscińska, Maria Pilo, Antonio Zucca, Eugenio Garribba, Elżbieta Klewicka, Magdalena Rowińska-Żyrek, Marzena Symonowicz, Longin Chrusciński, Vitalij T Cheshchevik. Physicochemical, antioxidant, DNA cleaving properties and antimicrobial activity of fisetin-copper chelates. Journal of inorganic biochemistry. 2018 03; 180(?):101-118. doi: 10.1016/j.jinorgbio.2017.12.006. [PMID: 29247867]
Ryoko Watanabe, Takumi Kurose, Yuta Morishige, Ko Fujimori. Protective Effects of Fisetin Against 6-OHDA-Induced Apoptosis by Activation of PI3K-Akt Signaling in Human Neuroblastoma SH-SY5Y Cells. Neurochemical research. 2018 Feb; 43(2):488-499. doi: 10.1007/s11064-017-2445-z. [PMID: 29204750]
Jin-Oh Chung, Seon-Bong Lee, Kang-Hyun Jeong, Ji-Hoon Song, Su-Kyung Kim, Kyung-Mi Joo, Hyun-Woo Jeong, Jin-Kyu Choi, Jeong-Kee Kim, Wan-Gi Kim, Song-Seok Shin, Soon-Mi Shim. Quercetin and fisetin enhanced the small intestine cellular uptake and plasma levels of epi-catechins in in vitro and in vivo models. Food & function. 2018 Jan; 9(1):234-242. doi: 10.1039/c7fo01576c. [PMID: 29168878]
Kai Kai Li, Shan Shan Shen, Xiangyi Deng, Hoi Ting Shiu, Wing Sum Siu, Ping Chung Leung, Chun Hay Ko, Bao Hui Cheng. Dihydrofisetin exerts its anti-inflammatory effects associated with suppressing ERK/p38 MAPK and Heme Oxygenase-1 activation in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced mice paw edema. International immunopharmacology. 2018 Jan; 54(?):366-374. doi: 10.1016/j.intimp.2017.11.034. [PMID: 29202300]
Atmaram Pawar, Srishti Singh, S Rajalakshmi, Karimunnisa Shaikh, C Bothiraja. Development of fisetin-loaded folate functionalized pluronic micelles for breast cancer targeting. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup1):347-361. doi: 10.1080/21691401.2018.1423991. [PMID: 29334247]
Kiruthika Sundarraj, Azhwar Raghunath, Ekambaram Perumal. A review on the chemotherapeutic potential of fisetin: In vitro evidences. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jan; 97(?):928-940. doi: 10.1016/j.biopha.2017.10.164. [PMID: 29136771]
Chian-Jiun Liou, Ciao-Han Wei, Ya-Ling Chen, Ching-Yi Cheng, Chia-Ling Wang, Wen-Chung Huang. Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 49(5):1870-1884. doi: 10.1159/000493650. [PMID: 30235452]
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Pamela Maher. Protective effects of fisetin and other berry flavonoids in Parkinson's disease. Food & function. 2017 Sep; 8(9):3033-3042. doi: 10.1039/c7fo00809k. [PMID: 28714503]
Kyoung-Jin Min, Ju-Ock Nam, Taeg Kyu Kwon. Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells. Molecules (Basel, Switzerland). 2017 Aug; 22(8):. doi: 10.3390/molecules22081285. [PMID: 28767099]