Viset (BioDeep_00000870939)

Main id: BioDeep_00000000244

 

PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


InChI=1\C15H10O6\c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7\h1-6,16-18,20

化学式: C15H10O6 (286.0477)
中文名称: 非瑟酮, 漆黄素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H

描述信息

COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
C26170 - Protective Agent > C1509 - Neuroprotective Agent
C26170 - Protective Agent > C275 - Antioxidant
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.

同义名列表

79 个代谢物同义名

InChI=1\C15H10O6\c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7\h1-6,16-18,20; Fisetin; 5-Deoxyquercetin; 3,3?,4?,7-Tetra??hydroxy??flavone; Natural Brown 1; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-; 3,7-Dihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-chromenone; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromone; 5-18-05-00291 (Beilstein Handbook Reference); FLAVONE, 3,3,4,7-TETRAHYDROXY-; 3,7,3,4-Tetrahydroxyflavone; 3,3,4,7-Tetrahydroxyflavone; 7,3,4-Trihydroxyflavonol; SDCCGMLS-0066657.P001; Young fustic crystals; Bois bleu de Honqrie; C.I. Natural Brown 1; Ungarisches gelbholz; BOIS bleude honqrie; 3,347-tetOH-Flavone; 5-Desoxyquercetin; Spectrum5_001797; Spectrum4_001070; Spectrum2_001160; Spectrum3_001536; EINECS 208-434-4; SpecPlus_000460; Spectrum_001196; SPECTRUM1502247; NCGC00095663-02; NCGC00017344-01; NCGC00017344-02; NCGC00095663-01; NCIMech_000006; Ventin sumach; DivK1c_006556; KBioGR_001400; Junger fustik; Superfustel K; KBioSS_001676; BSPBio_002952; Zante fustic; KBio2_001676; KBio2_004244; ZINC00039111; Young fustic; KBio1_001500; SPBio_001119; KBio3_002452; KBio2_006812; NCI60_003865; Superfustel; CHEBI:42567; AIDS-003057; BRN 0292829; NSC 656275; AIDS003057; NSC 407010; C.I. 75620; NSC656275; NSC407010; Fisetholz; ST057233; TNP00004; TNP00284; 528-48-3; Cotinin; Fisetin; Fustet; Fustel; Fietin; C10041; S00056; Viset; FSE; Fisetin; Fisetin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

62 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANG, BCL2, BCL2L1, BDNF, CASP8, CASP9, CDH1, CDKN1A, CDKN2A, EGFR, MAPK8, NFKB1, PPARG, PRKAA2, SIRT1
Peripheral membrane protein 1 ACHE
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 BCL2, EGFR
Mitochondrion membrane 1 BCL2L1
Nucleus 14 ACHE, ANG, BCL2, CASP8, CASP9, CDH1, CDKN1A, CDKN2A, EGFR, MAPK8, NFKB1, PPARG, PRKAA2, SIRT1
cytosol 13 ANG, BCL2, BCL2L1, CASP8, CASP9, CDH1, CDKN1A, CDKN2A, MAPK8, NFKB1, PPARG, PRKAA2, SIRT1
dendrite 2 BDNF, PRKAA2
nuclear body 1 CDKN1A
trans-Golgi network 1 CDH1
centrosome 1 BCL2L1
nucleoplasm 9 CASP8, CDH1, CDKN1A, CDKN2A, MAPK8, NFKB1, PPARG, PRKAA2, SIRT1
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 4 ACHE, CDH1, EGFR, TNF
Cytoplasmic side 1 BCL2L1
lamellipodium 2 CASP8, CDH1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Synapse 2 ACHE, MAPK8
cell junction 2 CDH1, EGFR
cell surface 3 ACHE, EGFR, TNF
glutamatergic synapse 2 CDH1, EGFR
Golgi apparatus 3 ACHE, CDH1, PRKAA2
Golgi membrane 2 EGFR, INS
growth cone 1 ANG
mitochondrial inner membrane 1 BCL2L1
neuromuscular junction 1 ACHE
neuronal cell body 3 ANG, PRKAA2, TNF
postsynapse 1 CDH1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 BCL2L1
endosome 2 CDH1, EGFR
plasma membrane 4 ACHE, CDH1, EGFR, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 6 ACHE, BCL2, BDNF, CDH1, EGFR, PRKAA2
apical plasma membrane 1 EGFR
axon 3 BDNF, MAPK8, PRKAA2
basolateral plasma membrane 1 EGFR
extracellular exosome 1 CDH1
endoplasmic reticulum 2 BCL2, BCL2L1
extracellular space 8 ACHE, ANG, BDNF, CXCL8, EGFR, IL10, INS, TNF
perinuclear region of cytoplasm 6 ACHE, BDNF, CDH1, CDKN1A, EGFR, PPARG
adherens junction 1 CDH1
mitochondrion 7 BCL2, BCL2L1, CASP8, CASP9, CDKN2A, NFKB1, SIRT1
protein-containing complex 6 BCL2, CASP8, CASP9, CDKN1A, CDKN2A, EGFR
intracellular membrane-bounded organelle 1 PPARG
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 2 CDH1, EGFR
Secreted 6 ACHE, ANG, BDNF, CXCL8, IL10, INS
extracellular region 9 ACHE, ANG, BDNF, CDH1, CXCL8, IL10, INS, NFKB1, TNF
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 3 BCL2, BCL2L1, CASP8
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 2 BCL2L1, CDKN2A
Extracellular side 1 ACHE
transcription regulator complex 1 NFKB1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 4 BCL2, BCL2L1, CDH1, EGFR
external side of plasma membrane 1 TNF
actin cytoskeleton 2 ANG, CDH1
nucleolus 4 ANG, CDKN1A, CDKN2A, SIRT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 CASP8
heterochromatin 1 SIRT1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
focal adhesion 1 EGFR
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
basement membrane 2 ACHE, ANG
intracellular vesicle 1 EGFR
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
lateral plasma membrane 1 CDH1
nuclear speck 1 PRKAA2
nuclear inner membrane 1 SIRT1
receptor complex 2 EGFR, PPARG
chromatin 3 NFKB1, PPARG, SIRT1
phagocytic cup 1 TNF
Chromosome 1 ANG
cytoskeleton 1 CASP8
Golgi apparatus, trans-Golgi network 1 CDH1
Nucleus, nucleolus 2 ANG, CDKN2A
Lipid-anchor, GPI-anchor 1 ACHE
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 INS
Nucleus, nucleoplasm 1 CDKN2A
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 SIRT1
cell body 1 CASP8
side of membrane 1 ACHE
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 2 INS, NFKB1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BDNF, INS
specific granule lumen 1 NFKB1
endocytic vesicle 1 ANG
transport vesicle 1 INS
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 2]: Nucleus 1 CDH1
synaptic cleft 1 ACHE
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 1 CASP8
ripoptosome 1 CASP8
apical junction complex 1 CDH1
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 1 CDH1
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
senescence-associated heterochromatin focus 1 CDKN2A
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform smARF]: Mitochondrion 1 CDKN2A
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Yao Guo, Bing Liu, Yaping Geng, Ke Chen, Junyan Li, Xiangju Yin, Shenshen Zhang. Fisetin, a dietary flavonoid, promotes transintestinal cholesterol excretion through the activation of PPARδ. Food research international (Ottawa, Ont.). 2024 Jan; 175(?):113783. doi: 10.1016/j.foodres.2023.113783. [PMID: 38129008]
  • Xiufang Jiang, Yanling Lei, Yajuan Yin, Fangfang Ma, Mingqi Zheng, Gang Liu. Fisetin Suppresses Atherosclerosis by Inhibiting Ferroptosis-Related Oxidative Stress in Apolipoprotein E Knockout Mice. Pharmacology. 2024; 109(3):169-179. doi: 10.1159/000538535. [PMID: 38583431]
  • Randa Hanie Awadeen, Mariza Fouad Boughdady, Randa A Zaghloul, Wael M Elsaed, Irhan Ibrahim Abu Hashim, Mahasen Mohamed Meshali. Formulation of lipid polymer hybrid nanoparticles of the phytochemical Fisetin and its in vivo assessment against severe acute pancreatitis. Scientific reports. 2023 11; 13(1):19110. doi: 10.1038/s41598-023-46215-8. [PMID: 37925581]
  • A I Savko, T V Ilyich, A G Veiko, T A Kovalenia, E A Lapshina, I B Zavodnik. The flavonoids fisetin, apigenin, kaempferol, naringenin, naringin regulate respiratory activity and membrane potential of rat liver mitochondria and inhibit oxidative processes in erythrocytes. Biomeditsinskaia khimiia. 2023 Nov; 69(5):281-289. doi: 10.18097/pbmc20236905281. [PMID: 37937430]
  • Hitesh Kumar, Pallavi Chand, Shantanu Pachal, Sahid Mallick, Rupshee Jain, SubbaRao V Madhunapantula, Vikas Jain. Fisetin-Loaded Nanostructured Lipid Carriers: Formulation and Evaluations against Advanced and Metastatic Melanoma. Molecular pharmaceutics. 2023 Oct; ?(?):. doi: 10.1021/acs.molpharmaceut.3c00309. [PMID: 37906601]
  • Seul Gi Kim, Jin Young Sung, Young Jin Kang, Hyoung Chul Choi. PPARγ activation by fisetin mitigates vascular smooth muscle cell senescence via the mTORC2-FoxO3a-autophagy signaling pathway. Biochemical pharmacology. 2023 Oct; ?(?):115892. doi: 10.1016/j.bcp.2023.115892. [PMID: 37890594]
  • Nayun Kim, Junhye Kwon, Ui Sup Shin, Joohee Jung. Fisetin induces the upregulation of AKAP12 mRNA and anti-angiogenesis in a patient-derived organoid xenograft model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Oct; 167(?):115613. doi: 10.1016/j.biopha.2023.115613. [PMID: 37801904]
  • Wenli Shi, Wenxin Han, Yijing Liao, Jiaqi Wen, Guowen Zhang. Inhibition mechanism of fisetin on acetylcholinesterase and its synergistic effect with galantamine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2023 Sep; 305(?):123452. doi: 10.1016/j.saa.2023.123452. [PMID: 37769468]
  • Joanna Szymczak, Judyta Cielecka-Piontek. Fisetin-In Search of Better Bioavailability-From Macro to Nano Modifications: A Review. International journal of molecular sciences. 2023 Sep; 24(18):. doi: 10.3390/ijms241814158. [PMID: 37762460]
  • Bo Wang, Li-Na Yang, Le-Tian Yang, Yan Liang, Fan Guo, Ping Fu, Liang Ma. Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis. Acta pharmacologica Sinica. 2023 Sep; ?(?):. doi: 10.1038/s41401-023-01156-w. [PMID: 37696989]
  • Yizhen Jiang, Xiangwen Tang, Peng Deng, Chao Jiang, Yuqing He, Dingjun Hao, Hao Yang. The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review. Molecular neurobiology. 2023 Jul; ?(?):. doi: 10.1007/s12035-023-03469-7. [PMID: 37453993]
  • Robert Kubina, Kamil Krzykawski, Arkadiusz Dziedzic, Agata Kabała-Dzik. Kaempferol and Fisetin-Related Signaling Pathways Induce Apoptosis in Head and Neck Cancer Cells. Cells. 2023 06; 12(12):. doi: 10.3390/cells12121568. [PMID: 37371038]
  • Sweety Mehra, Aitizaz Ul Ahsan, Madhu Sharma, Muskan Budhwar, Mani Chopra. Neuroprotective Efficacy of Fisetin Against VPA-Induced Autistic Neurobehavioral Alterations by Targeting Dysregulated Redox Homeostasis. Journal of molecular neuroscience : MN. 2023 Jun; ?(?):. doi: 10.1007/s12031-023-02127-w. [PMID: 37261645]
  • Tae Woo Kim. Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24109076. [PMID: 37240422]
  • Guihong Liang, Jinlong Zhao, Jianke Pan, Yuan Yang, Yaoxing Dou, Weiyi Yang, Lingfeng Zeng, Jun Liu. Network pharmacology identifies fisetin as a treatment for osteoporosis that activates the Wnt/β-catenin signaling pathway in BMSCs. Journal of orthopaedic surgery and research. 2023 Apr; 18(1):312. doi: 10.1186/s13018-023-03761-1. [PMID: 37087476]
  • Parisa Sarvarian, Parisa Samadi, Elham Gholipour, Meisam Khodadadi, Ramin Pourakbari, Parvin Akbarzadelale, Karim Shamsasenjan. Fisetin-loaded grape-derived nanoparticles improve anticancer efficacy in MOLT-4 cells. Biochemical and biophysical research communications. 2023 Mar; 658(?):69-79. doi: 10.1016/j.bbrc.2023.03.040. [PMID: 37027907]
  • Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi. Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB/BDNF. European journal of pharmacology. 2023 Feb; 944(?):175583. doi: 10.1016/j.ejphar.2023.175583. [PMID: 36764352]
  • Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S Allemailem, Amjad Ali Khan, Saleh A Almatroodi. The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27249009. [PMID: 36558146]
  • Sara M Talaat, Yosra S R Elnaggar, Samar O El-Ganainy, Mennatallah A Gowayed, Amany Abdel-Bary, Ossama Y Abdallah. Novel bio-inspired lipid nanoparticles for improving the anti-tumoral efficacy of fisetin against breast cancer. International journal of pharmaceutics. 2022 11; 628(?):122184. doi: 10.1016/j.ijpharm.2022.122184. [PMID: 36252641]
  • Yedam Moon, Hayeong Kim, Choon Gil Kang, Chanho Park, Seung Wook Kim, Doman Kim. Biochemical characterization of synthesized fisetin glucoside by dextransucrase from Leuconostoc mesenteroides NRRL B-1299CB4 with enhanced water solubility. Enzyme and microbial technology. 2022 Nov; 161(?):110111. doi: 10.1016/j.enzmictec.2022.110111. [PMID: 35961060]
  • Shayan Khozooei, Konstanze Lettau, Francesca Barletta, Tina Jost, Simone Rebholz, Soundaram Veerappan, Mirita Franz-Wachtel, Boris Macek, George Iliakis, Luitpold V Distel, Daniel Zips, Mahmoud Toulany. Fisetin induces DNA double-strand break and interferes with the repair of radiation-induced damage to radiosensitize triple negative breast cancer cells. Journal of experimental & clinical cancer research : CR. 2022 Aug; 41(1):256. doi: 10.1186/s13046-022-02442-x. [PMID: 35989353]
  • Su-Hwan Kim, Chang-Ki Huh. Isolation and Identification of Fisetin: An Antioxidative Compound Obtained from Rhus verniciflua Seeds. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144510. [PMID: 35889379]
  • Abha Mishra, Upinder Kaur, Amit Singh. Fisetin 8-C-glucoside as entry inhibitor in SARS CoV-2 infection: molecular modelling study. Journal of biomolecular structure & dynamics. 2022 07; 40(11):5128-5137. doi: 10.1080/07391102.2020.1868335. [PMID: 33382023]
  • Priyanka N Prem, Gino A Kurian. Fisetin attenuates renal ischemia/reperfusion injury by improving mitochondrial quality, reducing apoptosis and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. 2022 05; 395(5):547-561. doi: 10.1007/s00210-022-02204-8. [PMID: 35133446]
  • Bo Wang, Jing Wang, Xin-Huai Zhao. Bioactivity of Two Polyphenols Quercetin and Fisetin against Human Gastric Adenocarcinoma AGS Cells as Affected by Two Coexisting Proteins. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092877. [PMID: 35566228]
  • Shu-Ju Wu, Wen-Chung Huang, Ching-Yi Cheng, Meng-Chun Wang, Shu-Chen Cheng, Chian-Jiun Liou. Fisetin Suppresses the Inflammatory Response and Oxidative Stress in Bronchial Epithelial Cells. Nutrients. 2022 Apr; 14(9):. doi: 10.3390/nu14091841. [PMID: 35565807]
  • Hongguang Ding, Ya Li, Shenglong Chen, Yin Wen, Shiying Zhang, Ensi Luo, Xusheng Li, Wenhong Zhong, Hongke Zeng. Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy. CNS neuroscience & therapeutics. 2022 02; 28(2):247-258. doi: 10.1111/cns.13765. [PMID: 34837343]
  • Natsuko Tsurudome, Yuji Minami, Katsuko Kajiya. Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction. BioFactors (Oxford, England). 2022 Jan; 48(1):56-66. doi: 10.1002/biof.1798. [PMID: 34687255]
  • Zi-Shen Zhou, Chen-Fan Kong, Jian-Rong Sun, Xiang-Ke Qu, Jin-Hui Sun, An-Tao Sun. Fisetin Ameliorates Alcohol-Induced Liver Injury through Regulating SIRT1 and SphK1 Pathway. The American journal of Chinese medicine. 2022; 50(8):2171-2184. doi: 10.1142/s0192415x22500938. [PMID: 36266756]
  • Yanyi Xiao, Yilong Liu, Zhiwei Gao, Xian Li, Min Weng, Chenghao Shi, Cheng Wang, Linxiao Sun. Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling. Aging. 2021 11; 13(22):24753-24767. doi: 10.18632/aging.203713. [PMID: 34821587]
  • Johnna F Varghese, Rohit Patel, Mohit Singh, Umesh C S Yadav. Fisetin Prevents Oxidized Low-density Lipoprotein-Induced Macrophage Foam Cell Formation. Journal of cardiovascular pharmacology. 2021 11; 78(5):e729-e737. doi: 10.1097/fjc.0000000000001096. [PMID: 34173812]
  • Brandon P Verdoorn, Tamara K Evans, Gregory J Hanson, Yi Zhu, Larissa G P Langhi Prata, Robert J Pignolo, Elizabeth J Atkinson, Erin O Wissler-Gerdes, George A Kuchel, Joan B Mannick, Stephen B Kritchevsky, Sundeep Khosla, Stacey A Rizza, Jeremy D Walston, Nicolas Musi, Lewis A Lipsitz, Douglas P Kiel, Raymond Yung, Nathan K LeBrasseur, Ravinder J Singh, Teresa McCarthy, Michael A Puskarich, Laura J Niedernhofer, Paul D Robbins, Matthew Sorenson, Tamara Tchkonia, James L Kirkland. Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era. Journal of the American Geriatrics Society. 2021 11; 69(11):3023-3033. doi: 10.1111/jgs.17416. [PMID: 34375437]
  • Aynaz Mihanfar, Mohammad Nouri, Leila Roshangar, Mohammad Hassan Khadem-Ansari. Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome. The Journal of steroid biochemistry and molecular biology. 2021 10; 213(?):105954. doi: 10.1016/j.jsbmb.2021.105954. [PMID: 34298098]
  • Qian Ren, Lu Cheng, Fan Guo, Sibei Tao, Chunle Zhang, Liang Ma, Ping Fu. Fisetin Improves Hyperuricemia-Induced Chronic Kidney Disease via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Aryl Hydrocarbon Receptor Activation. Journal of agricultural and food chemistry. 2021 Sep; 69(37):10932-10942. doi: 10.1021/acs.jafc.1c03449. [PMID: 34505780]
  • Beiyun Shen, Xinchen Shangguan, Zhongping Yin, Shaofu Wu, Qingfeng Zhang, Wenwen Peng, Jingen Li, Lu Zhang, Jiguang Chen. Inhibitory Effect of Fisetin on α-Glucosidase Activity: Kinetic and Molecular Docking Studies. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175306. [PMID: 34500738]
  • Yuanyuan Huang, Jianlin Lu, Li Zhan, Ming Wang, Ronghua Shi, Xiao Yuan, Xinjiao Gao, Xing Liu, Jianye Zang, Wei Liu, Xuebiao Yao. Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism. The Journal of biological chemistry. 2021 08; 297(2):100929. doi: 10.1016/j.jbc.2021.100929. [PMID: 34216621]
  • Jun-Liang Pu, Zuo-Tian Huang, Yun-Hai Luo, Tong Mou, Ting-Ting Li, Zhong-Tang Li, Xu-Fu Wei, Zhong-Jun Wu. Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway. Hepatobiliary & pancreatic diseases international : HBPD INT. 2021 Aug; 20(4):352-360. doi: 10.1016/j.hbpd.2021.04.013. [PMID: 34024736]
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