Arecolin (BioDeep_00000868533)
Main id: BioDeep_00000002582
PANOMIX_OTCML-2023
代谢物信息卡片
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester
化学式: C8H13NO2 (155.0946238)
中文名称: 槟榔碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC=C(C1)C(=O)OC
InChI: InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
同义名列表
70 个代谢物同义名
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester; 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester; 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid methyl ester; 1-methyl-5,6-dihydro-2H-pyridine-3-carboxylic acid methyl ester; N-Methyltetrahydropyridine-.beta.-carboxylic acid methyl ester; InChI=1\C8H13NO2\c1-9-5-3-4-7(6-9)8(10)11-2\h4H,3,5-6H2,1-2H; N-Methyltetrahydropyridine-beta-carboxylic acid methyl ester; NICOTINIC ACID, 1,2,5,6-TETRAHYDRO-1-METHYL-, METHYL ESTER; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate; 1,2,5,6-Tetrahydro-1-methylnicotinic acid, methyl ester; 1-Methyl-delta(sup 3,4)tetrahydro-3-pyridinecarboxylate; N-Methyl-.delta.-tetrahydronicotinic acid methyl ester; methyl 1-methyl-5,6-dihydro-2H-pyridine-3-carboxylate; N-Methyltetrahydronicotinic acid, methyl ester; Methyl N-methyl-1,2,5,6-tetrahydronicotinate; 5-22-01-00322 (Beilstein Handbook Reference); Methyl 1,2,5,6-tetrahydro-1-methylnicotinate; Methyl N-methyltetrahydronicotinate; Arecaidine methyl ester; WLN: T6N CUTJ A1 CVO1; SDCCGMLS-0066647.P001; Prestwick1_000402; Prestwick2_000402; Prestwick0_000402; Prestwick3_000402; Spectrum4_000810; Spectrum5_001316; Spectrum3_001387; EINECS 200-565-5; Spectrum2_000051; NCGC00162053-02; Spectrum_000055; NCGC00015075-02; NCGC00015075-01; Methylarecaidin; Methylarecaiden; Arecoline base; MEGxp0_001891; KBioSS_000435; BSPBio_002974; BSPBio_000324; DivK1c_000810; Lopac0_000049; KBioGR_001299; BPBio1_000358; ACon1_002372; KBio3_002194; KBio2_000435; KBio2_003003; SPBio_000201; Lopac-A-6134; NINDS_000810; CAS-300-08-3; KBio1_000810; SPBio_002263; KBio2_005571; BRN 0123045; AIDS-002686; IDI1_000810; Arecholine; AIDS002686; CCRIS 7688; Arecaline; Arecoline; NSC 56321; Arecolin; NSC56321; Arekolin; 63-75-2; C10129
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:2814
- PubChem: 2230
- DrugBank: DB04365
- ChEMBL: CHEMBL7303
- MeSH: Arecoline
- CAS: 63-75-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 184783 - Areca catechu:
- 13217 - Piper betle: 10.1016/S0165-1161(96)90013-8
- 33090 - 槟榔: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mingyu Pan, Wenfeng Geng, Yuanxiao Wang, Makoto Tsunoda, Jiatong Liu, Yingxia Zhang, Haimei Yang, Lu-Shuang Li, Shiwen Song, Jinqiang Liang, Yanting Song. Simultaneous determination of five constituents of areca nut extract in rat plasma using UPLC-MS/MS and its application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2024 Aug; 245(?):116158. doi:
10.1016/j.jpba.2024.116158. [PMID: 38643703] - Sineenart Sanpinit, Julalak Chokpaisarn, Pinanong Na-Phatthalung, Dennapa Saeloh Sotthibandhu, Kanyatorn Yincharoen, Palika Wetchakul, Surasak Limsuwan, Sasitorn Chusri. Effectiveness of Ya-Samarn-Phlae in diabetic wound healing: Evidence from in vitro studies and a multicenter randomized controlled clinical trial.
Journal of ethnopharmacology.
2024 May; 326(?):117929. doi:
10.1016/j.jep.2024.117929. [PMID: 38373661] - Soumya Ranjan Mishra, Bishnu Prasad Behera, Vineet Kumar Singh, Kewal Kumar Mahapatra, Deepak Mundkinajeddu, Deeksha Bhat, Aruna Mukti Minz, Gautam Sethi, Thomas Efferth, Surajit Das, Sujit Kumar Bhutia. Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155157. doi:
10.1016/j.phymed.2023.155157. [PMID: 37951147] - Baile Ning, Zhifang Wang, Jiangshan He, Qian Wu, Qiyue Deng, Qing Yang, Jing Gao, Wen Fu, Ying Deng, Bingxin Wu, Xichang Huang, Jilin Mei, Fan Jiang, Wenbin Fu. The rapid antidepressant effect of acupuncture on two animal models of depression by inhibiting M1-Ach receptors regulates synaptic plasticity in the prefrontal cortex.
Brain research.
2023 Sep; 1822(?):148609. doi:
10.1016/j.brainres.2023.148609. [PMID: 37783259] - Lin Zhang, Jin Tan, Yiping Liu, Mang Luo. Curcumin relieves arecoline-induced oral submucous fibrosis via inhibiting the LTBP2/NF-κB axis.
Oral diseases.
2023 Jun; ?(?):. doi:
10.1111/odi.14656. [PMID: 37382472] - Ming Li, Zhiyuan Deng, Changqin Xie, Juan Chen, Zhenying Yuan, Omar Rahhal, Zhangui Tang. Fibroblast activating protein promotes the proliferation, migration, and activation of fibroblasts in oral submucous fibrosis.
Oral diseases.
2023 Jun; ?(?):. doi:
10.1111/odi.14602. [PMID: 37357365] - Meng Xu, Shunyong Su, Shuaiming Jiang, Wanggao Li, Zeng Zhang, Jiachao Zhang, Xiaosong Hu. Short-term arecoline exposure affected the systemic health state of mice, in which gut microbes played an important role.
Ecotoxicology and environmental safety.
2023 May; 259(?):115055. doi:
10.1016/j.ecoenv.2023.115055. [PMID: 37224782] - Shuhan Yi, Keyu Chen, Kozue Sakao, Makoto Ikenaga, Yuanliang Wang, De-Xing Hou. Assessment of Areca Nut Bioactivities in Western Diet-Induced Mice NAFLD Model.
Nutrients.
2023 May; 15(10):. doi:
10.3390/nu15102403. [PMID: 37242285] - Pei-Feng Liu, Yung-Fu Chang. The Controversial Roles of Areca Nut: Medicine or Toxin?.
International journal of molecular sciences.
2023 May; 24(10):. doi:
10.3390/ijms24108996. [PMID: 37240342] - Sarita Pal, Disha Sharma, Narayan Prasad Yadav. Plant leads for mitigation of oral submucous fibrosis: Current scenario and future prospect.
Oral diseases.
2022 Dec; ?(?):. doi:
10.1111/odi.14485. [PMID: 36565439] - Dandan Kong, Gaofeng Wang, Yang Tang, Mengyue Guo, Zia Ul Haq Khan, Yifei Guo, Wei Gu, Yonggui Ma, Ming Sui, Jinping Li, Meihua Yang. Potential health risk of areca nut consumption: Hazardous effect of toxic alkaloids and aflatoxins on human digestive system.
Food research international (Ottawa, Ont.).
2022 12; 162(Pt A):112012. doi:
10.1016/j.foodres.2022.112012. [PMID: 36461237] - Feng-Mei Qi, Xiao-Yong Rao, Tong-Tong Han, Ling-Yun Zhong, Xiao-Jian Luo, Yan He, Rui-Lin Shen. [Water migration and kinetics of Arecae Semen during moistening process].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Apr; 47(7):1871-1880. doi:
10.19540/j.cnki.cjcmm.20211123.301. [PMID: 35534257] - Tsung-Jung Ho, Bruce Chi-Kang Tsai, Chia-Hua Kuo, Hsiang-Ning Luk, Cecilia Hsuan Day, Dennis Jine-Yuan Hsieh, Ray-Jade Chen, Wei-Wen Kuo, V Bharath Kumar, Chun-Hsu Yao, Chih-Yang Huang. Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague-Dawley rats.
Chemico-biological interactions.
2022 Feb; 354(?):109810. doi:
10.1016/j.cbi.2022.109810. [PMID: 34999050] - Pangzhen Zhang, Nathaniel Quan En Chua, Simon Dang, Ashleigh Davis, Kah Wee Chong, Stephen S Prime, Nicola Cirillo. Molecular Mechanisms of Malignant Transformation of Oral Submucous Fibrosis by Different Betel Quid Constituents-Does Fibroblast Senescence Play a Role?.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031637. [PMID: 35163557] - Jiao Wu, Chuang Cui, He Zhang, Dongjun Liu, Lukas Schreiber, Weiquan Qin, Yinglang Wan. Identifying new compounds with potential pharmaceutical and physiological activity in Areca catechu and Areca triandra via a non-targeted metabolomic approach.
Phytochemical analysis : PCA.
2021 Nov; 32(6):970-981. doi:
10.1002/pca.3039. [PMID: 33619832] - Wen-Yuan Lin, Bruce Chi-Kang Tsai, Cecilia Hsuan Day, Ping-Ling Chiu, Ray-Jade Chen, Michael Yu-Chih Chen, V Vijaya Padma, Hsiang-Ning Luk, Hsiang-Chen Lee, Chih-Yang Huang. Arecoline induces heart injure via Fas/Fas ligand apoptotic pathway in heart of Sprague-Dawley rat.
Environmental toxicology.
2021 Aug; 36(8):1567-1575. doi:
10.1002/tox.23153. [PMID: 33929070] - Q Chen, Z Jiang, J Zhang, L Cao, Z Chen. Arecoline hydrobromide enhances jejunum smooth muscle contractility via voltage-dependent potassium channels in W/Wv mice.
Physiological research.
2021 07; 70(3):437-446. doi:
10.33549/physiolres.934557. [PMID: 33982580] - Hui Ren, Guoqin He, Zhiyuan Lu, Qianting He, Shuai Li, Zhexun Huang, Zheng Chen, Congyuan Cao, Anxun Wang. Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression.
Cancer science.
2021 Jun; 112(6):2173-2184. doi:
10.1111/cas.14866. [PMID: 33626219] - Sachin C Sarode, Gargi S Sarode. Comment on 'Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review'.
Archives of toxicology.
2021 05; 95(5):1859-1860. doi:
10.1007/s00204-021-03027-x. [PMID: 33738546] - Nuno G Oliveira, Daniela L Ramos, Ricardo Jorge Dinis-Oliveira. Reply to the commentary by Sarode and Sarode on 'Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review'.
Archives of toxicology.
2021 05; 95(5):1861-1862. doi:
10.1007/s00204-021-03039-7. [PMID: 33846819] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Xiaojian Yin, Yunxie Wei, Wei Song, He Zhang, Guoyin Liu, Yan Chen, Lan-Zhu Li, Raphael N Alolga, Gaoxiang Ma, Russel J Reiter, Jia Li, Haitao Shi. Melatonin as an inducer of arecoline and their coordinated roles in anti-oxidative activity and immune responses.
Food & function.
2020 Oct; 11(10):8788-8799. doi:
10.1039/d0fo01841d. [PMID: 32955540] - Yi-Hsien Hsieh, Ru-Jiang Syu, Chu-Che Lee, Shin-Huey Lin, Chien-Hsing Lee, Chun-Wen Cheng, Jen-Pi Tsai. Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway.
Environmental toxicology.
2020 Sep; 35(9):1007-1014. doi:
10.1002/tox.22937. [PMID: 32441858] - Romi Dasgupta, Indraneel Saha, Prajna Paramita Ray, Aniruddha Maity, Debajoyti Pradhan, Hari Prasad Sarkar, B R Maiti. Arecoline plays dual role on adrenal function and glucose-glycogen homeostasis under thermal stress in mice.
Archives of physiology and biochemistry.
2020 Jul; 126(3):214-224. doi:
10.1080/13813455.2018.1508238. [PMID: 30318934] - Mei-Chi Chang, Yu-Hwa Pan, Hsyueh-Liang Wu, Yi-Jie Lu, Wan-Chuen Liao, Chien-Yang Yeh, Jang-Jaer Lee, Jiiang-Huei Jeng. Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-β/Smad2-dependent and -independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin.
Aging.
2019 12; 11(23):11624-11639. doi:
10.18632/aging.102565. [PMID: 31831717] - Jeny Laskar, Mahuya Sengupta, Yashmin Choudhury. Treatment with the anti-diabetic drug metformin ameliorates betel-nut induced carcinogenesis in a murine model.
Pharmacological reports : PR.
2019 Dec; 71(6):1115-1124. doi:
10.1016/j.pharep.2019.06.011. [PMID: 31645006] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Jiao Wu, He Zhang, Shijie Wang, Langxing Yuan, Paul Grünhofer, Lukas Schreiber, Yinglang Wan. Tissue-specific and maturity-dependent distribution of pyridine alkaloids in Areca triandra.
Journal of plant research.
2019 Jul; 132(4):531-540. doi:
10.1007/s10265-019-01115-9. [PMID: 31127431] - Yu-Ping Hsieh, King-Jean Wu, Hsin-Ming Chen, Yi-Ting Deng. Arecoline activates latent transforming growth factor β1 via mitochondrial reactive oxygen species in buccal fibroblasts: Suppression by epigallocatechin-3-gallate.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2018 Jun; 117(6):527-534. doi:
10.1016/j.jfma.2017.07.003. [PMID: 28720506] - Hong Pan, Yi Li, Linyan Huang, Xumei Zhou, Yuanfu Lu, Fuguo Shi. Development and validation of a rapid LC-MS/MS method for simultaneous quantification of arecoline and its two active metabolites in rat plasma and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2018 May; 154(?):397-403. doi:
10.1016/j.jpba.2018.03.033. [PMID: 29573735] - Saeeda Baig, Zile Rubab, Wasfa Farooq. Molecular Pathogenesis of Chewable Tobacco.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2018 May; 28(5):381-385. doi:
10.29271/jcpsp.2018.05.381. [PMID: 29690969] - Lian Zheng, Zhen-Jie Guan, Wen-Ting Pan, Tian-Feng Du, Yu-Jia Zhai, Jia Guo. Tanshinone Suppresses Arecoline-Induced Epithelial-Mesenchymal Transition in Oral Submucous Fibrosis by Epigenetically Reactivating the p53 Pathway.
Oncology research.
2018 Apr; 26(3):483-494. doi:
10.3727/096504017x14941825760362. [PMID: 28550687] - Ghulam Abbas, Muhammad Kashif, - Mudassar, Taseer Ahmed Khan, Huma Aslam Bhatti, Sayedul Haque, Sabira Naqvi, Ahsana Dar Farooq. Cytotoxic, embryotoxic, insecticidal and anti-microbial activities of standardized Areca catechu nut.
Pakistan journal of pharmaceutical sciences.
2018 Mar; 31(2):385-392. doi:
". [PMID: 29618425] - Hong Pan, Linyan Huang, Yi Li, Xumei Zhou, Yuanfu Lu, Fuguo Shi. Liquid chromatography-tandem mass spectrometric assay for determination of unstable arecoline in rat plasma and its application.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Dec; 1070(?):112-116. doi:
10.1016/j.jchromb.2017.10.026. [PMID: 29107731] - Pooja Narain Adtani, Malathi Narasimhan, Alan M Punnoose, Himavanth Reddy Kambalachenu. Antifibrotic effect of Centella asiatica Linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts.
Journal of investigative and clinical dentistry.
2017 May; 8(2):. doi:
10.1111/jicd.12208. [PMID: 26840561] - Hong-Yan Ling, Juan He, Si-Si Yang, Kai-Fang Zhang, Jian-Qin He, Ze-Mei Zhu, Shui-Dong Feng. [The effects of arecoline on the lipid metabolism of 3T3-L1 adipocytes].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2017 Jan; 33(1):22-25. doi:
10.12047/j.cjap.5448.2017.005. [PMID: 29926602] - Wei Peng, Yu-Jie Liu, Mei-Bian Hu, Dan Yan, Yong-Xiang Gao, Chun-Jie Wu. Using the "target constituent removal combined with bioactivity assay" strategy to investigate the optimum arecoline content in charred areca nut.
Scientific reports.
2017 01; 7(?):40278. doi:
10.1038/srep40278. [PMID: 28054652] - I-Chen Wu, Yu-Kuei Chen, Chun-Chieh Wu, Yu-Jen Cheng, Wei-Chung Chen, Huey-Jiun Ko, Yu-Peng Liu, Chee-Yin Chai, Hung-Shun Lin, Deng-Chyang Wu, Ming-Tsang Wu. Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Oncotarget.
2016 Dec; 7(51):85244-85258. doi:
10.18632/oncotarget.13267. [PMID: 27845894] - Yu-Jie Liu, Wei Peng, Mei-Bian Hu, Min Xu, Chun-Jie Wu. The pharmacology, toxicology and potential applications of arecoline: a review.
Pharmaceutical biology.
2016 Nov; 54(11):2753-2760. doi:
10.3109/13880209.2016.1160251. [PMID: 27046150] - Adrian A Franke, Xingnan Li, Jennifer F Lai. Pilot study of the pharmacokinetics of betel nut and betel quid biomarkers in saliva, urine, and hair of betel consumers.
Drug testing and analysis.
2016 Oct; 8(10):1095-1099. doi:
10.1002/dta.1912. [PMID: 26619803] - Hongli Yu, Lijuan Tang, Hao Wu, Kuilong Wang, Baochang Cai, Xingde Zhang, Chengchao Zhang, Yunzhi Yin. Determination of contents of four alkaloids in Pericarpium arecae by quantitative analysis of multi-components by single-marker.
Pakistan journal of pharmaceutical sciences.
2016 Jul; 29(4):1269-74. doi:
". [PMID: 27393441] - Sheng-Hsuan Lin, Shean-Jaw Chiou, Wan-Ting Ho, Chao-Tang Chuang, Lea-Yea Chuang, Jinn-Yuh Guh. Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase.
Toxicology.
2016 Feb; 344-346(?):53-60. doi:
10.1016/j.tox.2016.02.004. [PMID: 26908192] - Imran Khan, Ila Pant, Sivakrishna Narra, Rekha Radhesh, Kannan Ranganathan, Somanahalli Girish Rao, Paturu Kondaiah. Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut.
Journal of cellular and molecular medicine.
2015 Oct; 19(10):2397-412. doi:
10.1111/jcmm.12622. [PMID: 26248978] - Tzer-Min Kuo, Shun-Yuan Luo, Shang-Lun Chiang, Kun-Tu Yeh, Hui-Ting Hsu, Cheng-Tien Wu, Chi-Yu Lu, Ming-Hsui Tsai, Jan-Gowth Chang, Ying-Chin Ko. Fibrotic Effects of Arecoline N-Oxide in Oral Potentially Malignant Disorders.
Journal of agricultural and food chemistry.
2015 Jun; 63(24):5787-94. doi:
10.1021/acs.jafc.5b01351. [PMID: 26061808] - Indraneel Saha, Joydeep Das, Biswaranjan Maiti, Urmi Chatterji. A protective role of arecoline hydrobromide in experimentally induced male diabetic rats.
BioMed research international.
2015; 2015(?):136738. doi:
10.1155/2015/136738. [PMID: 25695047] - Jing-Hong Zhou, Zhi-Yuan Pan, Yan-Fang Zhang, Wen-Yu Cui, Chao-Liang Long, Hai Wang. Stimulation of endothelial non-neuronal muscarinic receptor attenuates the progression of atherosclerosis via inhibiting endothelial cells activation.
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2014 Nov; 30(6):549-59. doi:
. [PMID: 26016366] - Bing Li, Xu-Zheng Zhou, Jian-Yong Li, Ya-Jun Yang, Jian-Rong Niu, Xiao-Juan Wei, Xi-Wang Liu, Jin-Shan Li, Ji-Yu Zhang. Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Oct; 969(?):12-8. doi:
10.1016/j.jchromb.2014.07.043. [PMID: 25140901] - Jia-Sin Yang, Mu-Kuan Chen, Shun-Fa Yang, Yu-Chao Chang, Shih-Chi Su, Hui-Ling Chiou, Ming-Hsien Chien, Chiao-Wen Lin. Increased expression of carbonic anhydrase IX in oral submucous fibrosis and oral squamous cell carcinoma.
Clinical chemistry and laboratory medicine.
2014 Sep; 52(9):1367-77. doi:
10.1515/cclm-2014-0129. [PMID: 24695043] - Xiao Run-mei, Wang Jun-jun, Chen Jing-ya, Sun Li-juan, Chen Yong. Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress.
The Journal of toxicological sciences.
2014 Aug; 39(4):609-14. doi:
10.2131/jts.39.609. [PMID: 25056785] - Federica De Angelis, Sara Marinelli, Bernard Fioretti, Luigi Catacuzzeno, Fabio Franciolini, Flaminia Pavone, Ada Maria Tata. M2 receptors exert analgesic action on DRG sensory neurons by negatively modulating VR1 activity.
Journal of cellular physiology.
2014 Jun; 229(6):783-90. doi:
10.1002/jcp.24499. [PMID: 24166293] - Hong-Yan Ling, Qi-Xin Yao, Zhu-Qing Qi, Si-Si Yang, Jian-Qin He, Kai-Fang Zhang, Bi Hu. [The role of arecoline on hepatic insulin resistance in type 2 diabetes rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2014 May; 30(3):208-12. doi:
. [PMID: 25244782] - Tsu-Nai Wang, Ming-Shyan Huang, Meng-Chih Lin, Tsai-Hui Duh, Chih-Hung Lee, Chin-Chou Wang, Ping-Ho Chen, Shang-Lun Chiang, Chau-Chyun Sheu, Vincent Chin-Hung Chen, Chao-Chien Wu, Cleusa P Ferri, Robert Stewart, Ying-Chin Ko. Betel chewing and arecoline affects eotaxin-1, asthma and lung function.
PloS one.
2014; 9(3):e91889. doi:
10.1371/journal.pone.0091889. [PMID: 24658613] - Mei-Chi Chang, Chiu-Po Chan, Wei-Ting Wang, Bei-En Chang, Jang-Jaer Lee, Shuei-Kuen Tseng, Sin-Yuet Yeung, Liang-Jiunn Hahn, Jiiang-Huei Jeng. Toxicity of areca nut ingredients: activation of CHK1/CHK2, induction of cell cycle arrest, and regulation of MMP-9 and TIMPs production in SAS epithelial cells.
Head & neck.
2013 Sep; 35(9):1295-302. doi:
10.1002/hed.23119. [PMID: 22907745] - Yogita V Chavan, Rekha S Singhal. Separation of polyphenols and arecoline from areca nut (Areca catechu L.) by solvent extraction, its antioxidant activity, and identification of polyphenols.
Journal of the science of food and agriculture.
2013 Aug; 93(10):2580-9. doi:
10.1002/jsfa.6081. [PMID: 23494978] - Mei-Chi Chang, Li-Deh Lin, Hui-Lin Wu, Yuan-Soon Ho, Hsiang-Chi Hsien, Tong-Mei Wang, Po-Yuan Jeng, Ru-Hsiu Cheng, Liang-Jiunn Hahn, Jiiang-Huei Jeng. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
Carcinogenesis.
2013 May; 34(5):1096-104. doi:
10.1093/carcin/bgt012. [PMID: 23349021] - Tung-Sheng Chen, Mu-Hsin Chang, Wei-Wen Kuo, Yueh-Min Lin, Yu-Lan Yeh, Cecilia Hsuan Day, Chien-Chung Lin, Fuu-Jen Tsai, Chang-Hai Tsai, Chih-Yang Huang. MALDI-TOF mass spectrometry analysis of small molecular weight compounds (under 10 KDa) as biomarkers of rat hearts undergoing arecoline challenge.
Pharmaceutical biology.
2013 Apr; 51(4):488-91. doi:
10.3109/13880209.2012.742117. [PMID: 23336293] - Qian Xiang, Ying Gao, Bingyan Han, Jing Li, Yunhong Xu, Jianyuan Yin. Determination of arecoline in areca nut based on field amplification in capillary electrophoresis coupled with electrochemiluminescence detection.
Luminescence : the journal of biological and chemical luminescence.
2013 Jan; 28(1):50-5. doi:
10.1002/bio.2335. [PMID: 22298421] - Shiuan-Shinn Lee, Chung-Hung Tsai, Cheng-Chia Yu, Yu-Chao Chang. Elevated snail expression mediates tumor progression in areca quid chewing-associated oral squamous cell carcinoma via reactive oxygen species.
PloS one.
2013; 8(7):e67985. doi:
10.1371/journal.pone.0067985. [PMID: 23874481] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Chi-Hsien Chou, Lea-Yea Chuang, Wei-Lung Tseng, Chi-Yu Lu. Characterization of protein adducts formed by toxic alkaloids by nano-scale liquid chromatography with mass spectrometry.
Journal of mass spectrometry : JMS.
2012 Oct; 47(10):1303-12. doi:
10.1002/jms.3083. [PMID: 23019161] - Hong-yan Ling, Guang Wang, Wei Zhang, Xing Li, Shou-hong Zhou, Bi Hu. Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathionine-γ-lyase expression and activating K(ATP) channels.
Acta pharmacologica Sinica.
2012 Aug; 33(8):1023-9. doi:
10.1038/aps.2012.63. [PMID: 22820911] - Ping-Ho Chen, Hung-Pin Tu, Shu-Jung Wang, Albert Min-Shan Ko, Chi-Pin Lee, Tai-An Chiang, Yi-Shan Tsai, Chien-Hung Lee, Tien-Yu Shieh, Chih-Hung Ko, Shang-Lun Chiang, Ying-Chin Ko. Monoamine oxidase A variants are associated with heavy betel quid use.
Addiction biology.
2012 Jul; 17(4):786-97. doi:
10.1111/j.1369-1600.2011.00331.x. [PMID: 21521428] - Maurizio Coppola, Raffaella Mondola. Potential action of betel alkaloids on positive and negative symptoms of schizophrenia: a review.
Nordic journal of psychiatry.
2012 Apr; 66(2):73-8. doi:
10.3109/08039488.2011.605172. [PMID: 21859398] - Jingsong Yuan, Dajian Yang, Yonghong Liang, Wenping Gao, Zhipeng Ren, Wei Zeng, Baorong Wang, Jian Han, Dean Guo. Alkaloids from areca (betel) nuts and their effects on human sperm motility in vitro.
Journal of food science.
2012 Apr; 77(4):T70-8. doi:
10.1111/j.1750-3841.2012.02653.x. [PMID: 22515256] - Imran Khan, Neeraj Kumar, Ila Pant, Sivakrishna Narra, Paturu Kondaiah. Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis.
PloS one.
2012; 7(12):e51806. doi:
10.1371/journal.pone.0051806. [PMID: 23284772] - Danijela Markovic, Jonathan Holdich, Suleiman Al-Sabah, Rajendra Mistry, Cornelius Krasel, Martyn P Mahaut-Smith, R A John Challiss. FRET-based detection of M1 muscarinic acetylcholine receptor activation by orthosteric and allosteric agonists.
PloS one.
2012; 7(1):e29946. doi:
10.1371/journal.pone.0029946. [PMID: 22272263] - Tusty-Jiuan Hsieh, Pei-Chen Hsieh, Ming-Tsang Wu, Wei-Chiao Chang, Pi-Jung Hsiao, Kun-Der Lin, Pong-Chun Chou, Shyi-Jang Shin. Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes.
Cell biology and toxicology.
2011 Dec; 27(6):397-411. doi:
10.1007/s10565-011-9195-5. [PMID: 21786209] - Chia-Chi Wang, Hung-Li Lin, Hong-Jen Liang, Tong-Rong Jan. Areca nut extracts enhance the development of CD11b(+) Gr-1(+) cells with the characteristics of myeloid-derived suppressor cells in antigen-stimulated mice.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2011 Nov; 40(10):769-77. doi:
10.1111/j.1600-0714.2011.01043.x. [PMID: 21481006] - Yi-Shan Tsai, Chang-Shen Lin, Shang-Lun Chiang, Chien-Hung Lee, Ka-Wo Lee, Ying-Chin Ko. Areca nut induces miR-23a and inhibits repair of DNA double-strand breaks by targeting FANCG.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Oct; 123(2):480-90. doi:
10.1093/toxsci/kfr182. [PMID: 21750350] - Indraneel Saha, Aniruddha Chatterjee, Anushree Mondal, Bishwa Ranjan Maiti, Urmi Chatterji. Arecoline augments cellular proliferation in the prostate gland of male Wistar rats.
Toxicology and applied pharmacology.
2011 Sep; 255(2):160-8. doi:
10.1016/j.taap.2011.06.010. [PMID: 21741983] - Yi-Ting Deng, Jenny Zwei-Chieng Chang, Cheng-Chang Yeh, Shih-Jung Cheng, Mark Yen-Ping Kuo. Arecoline stimulated Cyr61 production in human gingival epithelial cells: inhibition by lovastatin.
Oral oncology.
2011 Apr; 47(4):256-61. doi:
10.1016/j.oraloncology.2011.01.005. [PMID: 21317023] - Nai Wen Chang, Ming-Hsui Tsai, Chingju Lin, Hui Ting Hsu, Pei-Yi Chu, Chung-Min Yeh, Chang-Fang Chiu, Kun-Tu Yeh. Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model.
Biochimica et biophysica acta.
2011 Apr; 1812(4):558-64. doi:
10.1016/j.bbadis.2010.11.002. [PMID: 21081159] - Pranav Kumar Prabhakar, Mukesh Doble. Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Feb; 18(4):285-91. doi:
10.1016/j.phymed.2010.06.016. [PMID: 20724125] - Igor N Iezhitsa, Alexander A Spasov, Maria V Kharitonova, Maria S Kravchenko. Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
Nutritional neuroscience.
2011 Jan; 14(1):10-24. doi:
10.1179/174313211x12966635733277. [PMID: 21535917] - Pei-Chin Lin, Wen-Hsin Chang, Yung-Hsiu Chen, Chien-Chih Lee, Yi-Hsiung Lin, Jan-Gowth Chang. Cytotoxic effects produced by arecoline correlated to epigenetic regulation in human K-562 cells.
Journal of toxicology and environmental health. Part A.
2011; 74(11):737-45. doi:
10.1080/15287394.2011.539123. [PMID: 21480048] - Mireille Basselin, Angelo O Rosa, Epolia Ramadan, Yewon Cheon, Lisa Chang, Mei Chen, Deanna Greenstein, Mary Wohltmann, John Turk, Stanley I Rapoport. Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA(2)β (VIA)-deficient mice.
Journal of lipid research.
2010 Nov; 51(11):3166-73. doi:
10.1194/jlr.m008334. [PMID: 20686114] - Chiung-Wen Hu, Yan-Zin Chang, Hsiao-Wen Wang, Mu-Rong Chao. High-throughput simultaneous analysis of five urinary metabolites of areca nut and tobacco alkaloids by isotope-dilution liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2010 Oct; 19(10):2570-81. doi:
10.1158/1055-9965.epi-10-0483. [PMID: 20713654] - N B Pierangeli, S V Soriano, I Roccia, H F J Bergagna, L E Lazzarini, A Celescinco, A V Kossman, M S Saiz, J A Basualdo. Usefulness and validation of a coproantigen test for dog echinococcosis screening in the consolidation phase of hydatid control in Neuquén, Argentina.
Parasitology international.
2010 Sep; 59(3):394-9. doi:
10.1016/j.parint.2010.05.004. [PMID: 20546931] - I-Chen Wu, Ping-Ho Chen, Chien-Jen Wang, Deng-Chyang Wu, Shih-Meng Tsai, Mu-Rong Chao, Bai-Hsiun Chen, Hei-Hwa Lee, Chien-Hung Lee, Ying-Chin Ko. Quantification of blood betel quid alkaloids and urinary 8-hydroxydeoxyguanosine in humans and their association with betel chewing habits.
Journal of analytical toxicology.
2010 Jul; 34(6):325-31. doi:
10.1093/jat/34.6.325. [PMID: 20663285] - Romi Dasgupta, Urmi Chatterji, T C Nag, Santasri Chaudhuri-Sengupta, Debabrata Nag, B R Maiti. Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice.
Molecular and cellular endocrinology.
2010 May; 319(1-2):1-7. doi:
10.1016/j.mce.2010.01.005. [PMID: 20085799] - Chia-Hsien Feng, Chi-Yu Lu. A new matrix for analyzing low molecular mass compounds and its application for determination of carcinogenic areca alkaloids by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
Analytica chimica acta.
2009 Sep; 649(2):230-5. doi:
10.1016/j.aca.2009.07.039. [PMID: 19699399] - Bennett J D Datu, Alex Loukas, Cinzia Cantacessi, Peter O'Donoghue, Robin B Gasser. Investigation of the regulation of transcriptional changes in Ancylostoma caninum larvae following serum activation, with a focus on the insulin-like signalling pathway.
Veterinary parasitology.
2009 Feb; 159(2):139-48. doi:
10.1016/j.vetpar.2008.10.026. [PMID: 19054616] - Mei-Huei Lin, Shyun-Yeu Liu, Young-Chau Liu. Autophagy induction by a natural ingredient of areca nut.
Autophagy.
2008 Oct; 4(7):967-8. doi:
10.4161/auto.6821. [PMID: 18758233] - Shyi-Wu Wang, Guey-Shyang Hwang, Te-Jung Chen, Paulus S Wang. Effects of arecoline on testosterone release in rats.
American journal of physiology. Endocrinology and metabolism.
2008 Aug; 295(2):E497-504. doi:
10.1152/ajpendo.00045.2008. [PMID: 18559981] - I-Min Liu, Cheng Kuei Chang, Shiow-Wen Juang, Dai-Huang Kou, Yat-Ching Tong, Kai-Chun Cheng, Juei-Tang Cheng. Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats.
International journal of experimental pathology.
2008 Aug; 89(4):292-300. doi:
10.1111/j.1365-2613.2008.00595.x. [PMID: 18715473] - A A Spasov, I N Iezhitsa, M S Kravchenko, M V Kharitonova. [The characterization of central neuromediation in rats fed with magnesium-deprived diet before and after magnesium replenishment].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.
2008 Jul; 94(7):822-33. doi:
. [PMID: 18767395] - Mireille Basselin, Nelly E Villacreses, Ho-Joo Lee, Jane M Bell, Stanley I Rapoport. Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats.
Neurochemical research.
2007 Nov; 32(11):1857-67. doi:
10.1007/s11064-007-9372-3. [PMID: 17562170] - Indraneel Saha, Urmi Chatterji, Santasri Chaudhuri-Sengupta, Tapas C Nag, Debabrata Nag, Samir Banerjee, B R Maiti. Ultrastructural and hormonal changes in the pineal-testicular axis following arecoline administration in rats.
Journal of experimental zoology. Part A, Ecological genetics and physiology.
2007 Apr; 307(4):187-98. doi:
10.1002/jez.354. [PMID: 17436329] - Selma Lahmar, Samia Lahmar, Belgees Boufana, Helen Bradshaw, P S Craig. Screening for Echinococcus granulosus in dogs: Comparison between arecoline purgation, coproELISA and coproPCR with necropsy in pre-patent infections.
Veterinary parasitology.
2007 Mar; 144(3-4):287-92. doi:
10.1016/j.vetpar.2006.10.016. [PMID: 17125928] - Sarbani Giri, Kristopher W Krausz, Jeffrey R Idle, Frank J Gonzalez. The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases.
Biochemical pharmacology.
2007 Feb; 73(4):561-73. doi:
10.1016/j.bcp.2006.10.017. [PMID: 17123469] - Y-L Lai, J-C Lin, S-F Yang, T-Y Liu, S-L Hung. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes.
Journal of periodontal research.
2007 Feb; 42(1):69-76. doi:
10.1111/j.1600-0765.2006.00917.x. [PMID: 17214642] - Gao Nannan, Yang Runmei, Lin Fusheng, Zhang Shoulan, Lei Guangqing. Effects of AIT-082, a purine derivative, on tremor induced by arecoline or oxotremorine in mice.
Pharmacology.
2007; 80(1):21-6. doi:
10.1159/000102601. [PMID: 17496436] - Xiao-ming Wen, Ying-li Zhang, Xin-min Liu, Shun-Xing Guo, Hai Wang. Immune responses in mice to arecoline mediated by lymphocyte muscarinic acetylcholine receptor.
Cell biology international.
2006 Dec; 30(12):1048-53. doi:
10.1016/j.cellbi.2006.09.015. [PMID: 17084646] - Romi Dasgupta, Indraneel Saha, Suman Pal, Arindam Bhattacharyya, Gaurisankar Sa, Tapas C Nag, Tania Das, B R Maiti. Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice.
Toxicology.
2006 Oct; 227(1-2):94-104. doi:
10.1016/j.tox.2006.07.016. [PMID: 16945459] - Kuo-Chu Lai, Te-Chang Lee. Genetic damage in cultured human keratinocytes stressed by long-term exposure to areca nut extracts.
Mutation research.
2006 Jul; 599(1-2):66-75. doi:
10.1016/j.mrfmmm.2006.01.005. [PMID: 16488451] - Sarbani Giri, Jeffrey R Idle, Chi Chen, T Mark Zabriskie, Kristopher W Krausz, Frank J Gonzalez. A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse.
Chemical research in toxicology.
2006 Jun; 19(6):818-27. doi:
10.1021/tx0600402. [PMID: 16780361] - A D van Eyk, P van der Biijl. Comparative permeability of fresh and frozen/thawed porcine buccal mucosa towards various chemical markers.
SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging.
2006 Jun; 61(5):200-3. doi:
". [PMID: 16892714] - Po-Hsuen Lee, Mei-Chi Chang, Wen-Hui Chang, Tong-Mei Wang, Ying-Jen Wang, Liang-Jiunn Hahn, Yuan-Soon Ho, Chuan-Yu Lin, Jiiang-Huei Jeng. Prolonged exposure to arecoline arrested human KB epithelial cell growth: regulatory mechanisms of cell cycle and apoptosis.
Toxicology.
2006 Mar; 220(2-3):81-9. doi:
10.1016/j.tox.2005.07.026. [PMID: 16413651] - Mireille Basselin, Nelly E Villacreses, Robert Langenbach, Kaizong Ma, Jane M Bell, Stanley I Rapoport. Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse.
Journal of neurochemistry.
2006 Feb; 96(3):669-79. doi:
10.1111/j.1471-4159.2005.03612.x. [PMID: 16405503]