Thesal (BioDeep_00000864972)

Main id: BioDeep_00000398467

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


1H-purine-2,6-dione,3,7-dihydro-3,7- dimethyl- (9CI)

化学式: C7H8N4O2 (180.0647228)
中文名称: 可可碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C=NC2=C1C(=O)NC(=O)N2C
InChI: InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)9-7(13)11(5)2/h3H,1-2H3,(H,9,12,13)

描述信息

R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines
C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BD - Xanthine derivatives
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

81 个代谢物同义名

1H-purine-2,6-dione,3,7-dihydro-3,7- dimethyl- (9CI); 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-; 5-26-13-00553 (Beilstein Handbook Reference); 3,7-Dihydro-3,7-dimethyl-1H-purine-2,6-dione; 3,7-Dimethyl-3,7-dihydro-1H-purine-2,6-dione; 2,6-Dihydroxy-3,7-dimethyl-purine; 2,6-Dihydroxy-3,7-dimethylpurine; 3,7-dimethylpurine-2,6-dione; WLN: T56 BN DN FNVMVJ B1 F1; 5-26-13-00553 (Beilstein); Xanthine, 3,7-dimethyl-; SDCCGMLS-0002875.P003; Theobromine (natural); 3,7-Dimethylxanthine; Prestwick0_000874; Prestwick2_000874; Prestwick1_000874; Prestwick3_000874; Theobromine [BAN]; Spectrum5_001387; Spectrum2_000985; Spectrum3_000279; Spectrum4_000403; EINECS 201-494-2; NCGC00024123-05; NCGC00016023-02; NCGC00024123-08; SPECTRUM1500649; Spectrum_000053; NCGC00016023-01; NCGC00024123-04; Prestwick_1054; DivK1c_000611; Lopac0_001187; BPBio1_001043; KBioGR_000666; KBioSS_000433; BSPBio_000947; FEMA No. 3591; BSPBio_001758; Diurobromine; SPBio_002868; KBio1_000611; PDSP1_001017; KBio2_000433; ZINC00002151; MLS000028407; SPBio_001049; SMR000058357; KBio2_003001; NINDS_000611; Lopac-T-4500; KBio2_005569; PDSP2_001001; KBio3_001258; T4500_SIGMA; CHEBI:28946; AIDS-022717; IDI1_000611; theobromine; Theosalvose; BRN 0016464; CAS-83-67-0; CCRIS 2350; Theobromin; AIDS022717; EU-0101187; Thesodate; SBB012378; Theostene; Teobromin; Santheose; NSC 5039; SC 15090; LS-1828; NSC5039; 83-67-0; Thesal; C07480; c1095; 37T



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

37 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qifang Jin, Zhong Wang, Devinder Sandhu, Lan Chen, Chenyu Shao, Siyi Xie, Fanghuizi Shang, Shuai Wen, Ting Wu, Huiying Jin, Feiyi Huang, Guizhi Liu, Jinyu Hu, Qin Su, Mengdi Huang, Qian Zhu, Biao Zhou, Lihua Zhu, Lvwen Peng, Zhonghua Liu, Jianan Huang, Na Tian, Shuoqian Liu. miR828a-CsMYB114 Module Negatively Regulates the Biosynthesis of Theobromine in Camellia sinensis. Journal of agricultural and food chemistry. 2024 Feb; 72(8):4464-4475. doi: 10.1021/acs.jafc.3c07736. [PMID: 38376143]
  • Elham Sharifi-Zahabi, Nayebali Rezvani, Fatemeh Hajizadeh-Sharafabad, Fatemeh Sadat Hosseini-Baharanchi, Farzad Shidfar, Mehrali Rahimi. Theobromine supplementation in combination with a low-calorie diet improves cardiovascular risk factors in overweight and obese subjects with metabolic syndrome: a randomized controlled trial. Food & function. 2023 Aug; ?(?):. doi: 10.1039/d3fo00555k. [PMID: 37615657]
  • Elham Sharifi-Zahabi, Fatemeh Hajizadeh-Sharafabad, Seyed Mostafa Nachvak, Soheila Mirzaian, Sahar Darbandi, Farzad Shidfar. A comprehensive insight into the molecular effect of theobromine on cardiovascular-related risk factors: A systematic review of in vitro and in vivo studies. Phytotherapy research : PTR. 2023 Jun; ?(?):. doi: 10.1002/ptr.7916. [PMID: 37309834]
  • Xu Wang, Xiuli Zeng, Chunyin Qin, Xiaomei Yan, Xuanqin Chen, Liang Zhang, Yu Zhou. Herbaspirillum sp. ZXN111 Colonization Characters to Different Tea Cultivars and the Effects on Tea Metabolites Profiling on Zijuan (Camellia sinensis var. assamica). Journal of agricultural and food chemistry. 2023 Apr; 71(13):5283-5292. doi: 10.1021/acs.jafc.3c00050. [PMID: 36946772]
  • Kiran Bharat Lokhande, Sarika Vishnu Pawar, Smriti Madkaiker, Ashish Shrivastava, Swamy K Venkateswara, Neelu Nawani, Minal Wani, Payel Ghosh, Ashutosh Singh. Screening of potential phytomolecules against MurG as drug target in nosocomial pathogen Pseudomonas aeruginosa: perceptions from computational campaign. Journal of biomolecular structure & dynamics. 2023 Mar; ?(?):1-14. doi: 10.1080/07391102.2023.2194005. [PMID: 36974974]
  • Zhen-Hong Wang, Guo-Qiang Zhang, Zi-Wei Zhang, Zheng-Hong Li. Target Metabolome and Transcriptome Analysis Reveal Molecular Mechanism Associated with Changes of Tea Quality at Different Development Stages. Molecular biotechnology. 2023 Jan; 65(1):52-60. doi: 10.1007/s12033-022-00525-w. [PMID: 35780278]
  • Dongqin Xu, Wenhao Zhao, Yiting Feng, Xiao Wen, Hanxiao Liu, Jie Ping. Pentoxifylline attenuates nonalcoholic fatty liver by inhibiting hepatic macrophage polarization to the M1 phenotype. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154368. doi: 10.1016/j.phymed.2022.154368. [PMID: 35994850]
  • Xiong Gao, Xiaorong Lin, Chi-Tang Ho, Yuanyuan Zhang, Bin Li, Zhongzheng Chen. Chemical composition and anti-inflammatory activity of water extract from black cocoa tea (Camellia ptilophylla). Food research international (Ottawa, Ont.). 2022 11; 161(?):111831. doi: 10.1016/j.foodres.2022.111831. [PMID: 36192963]
  • Francesca Julià, Antonia Costa-Bauza, Francisco Berga, Felix Grases. Effect of theobromine on dissolution of uric acid kidney stones. World journal of urology. 2022 Aug; 40(8):2105-2111. doi: 10.1007/s00345-022-04059-3. [PMID: 35689678]
  • Shoji Tanaka, Naotoshi Sugimoto, Takako Ohno-Shosaku, Sachiko Madokoro, Pleiades Tiharu Inaoka, Toshiaki Yamazaki. Effects of long-term treatment with dietary theobromine on rat skeletal muscles. Molecular biology reports. 2022 May; 49(5):3965-3973. doi: 10.1007/s11033-022-07248-w. [PMID: 35226259]
  • Alexandra C Purdue-Smithe, Keewan Kim, Karen C Schliep, Elizabeth A DeVilbiss, Stefanie N Hinkle, Aijun Ye, Neil J Perkins, Lindsey A Sjaarda, Robert M Silver, Enrique F Schisterman, Sunni L Mumford. Preconception caffeine metabolites, caffeinated beverage intake, and fecundability. The American journal of clinical nutrition. 2022 04; 115(4):1227-1236. doi: 10.1093/ajcn/nqab435. [PMID: 35030239]
  • Daniel Janitschke, Anna Andrea Lauer, Cornel Manuel Bachmann, Jakob Winkler, Lea Victoria Griebsch, Sabrina Melanie Pilz, Elena Leoni Theiss, Heike Sabine Grimm, Tobias Hartmann, Marcus Otto Walter Grimm. Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042295. [PMID: 35216410]
  • Kristen J Polinski, Alexandra Purdue-Smithe, Sonia L Robinson, Sifang Kathy Zhao, Karen C Schliep, Robert M Silver, Weihua Guan, Enrique F Schisterman, Sunni L Mumford, Edwina H Yeung. Maternal caffeine intake and DNA methylation in newborn cord blood. The American journal of clinical nutrition. 2022 02; 115(2):482-491. doi: 10.1093/ajcn/nqab348. [PMID: 34669932]
  • Emi Tanaka, Takakazu Mitani, Momona Nakashima, Eito Yonemoto, Hiroshi Fujii, Hitoshi Ashida. Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner. The Journal of nutritional biochemistry. 2022 02; 100(?):108898. doi: 10.1016/j.jnutbio.2021.108898. [PMID: 34748921]
  • Martin Kertys, Nela Žideková, Kristián Pršo, Katarína Maráková, Katarína Kmeťová, Juraj Mokrý. Simultaneous determination of caffeine and its metabolites in rat plasma by UHPLC-MS/MS. Journal of separation science. 2021 Dec; 44(23):4274-4283. doi: 10.1002/jssc.202100604. [PMID: 34626085]
  • Dusan Petrovic, Menno Pruijm, Belén Ponte, Nasser A Dhayat, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Bruno Vogt, Pierre-Yves Martin, Silvia Stringhini, Sandrine Estoppey-Younès, Lutgarde Thijs, Zhenyu Zhang, Jesus D Melgarejo, Chin B Eap, Jan A Staessen, Murielle Bochud, Idris Guessous. Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies. Mayo Clinic proceedings. 2021 12; 96(12):3071-3085. doi: 10.1016/j.mayocp.2021.05.030. [PMID: 34579945]
  • Julia Brunmair, Mathias Gotsmy, Laura Niederstaetter, Benjamin Neuditschko, Andrea Bileck, Astrid Slany, Max Lennart Feuerstein, Clemens Langbauer, Lukas Janker, Jürgen Zanghellini, Samuel M Meier-Menches, Christopher Gerner. Finger sweat analysis enables short interval metabolic biomonitoring in humans. Nature communications. 2021 10; 12(1):5993. doi: 10.1038/s41467-021-26245-4. [PMID: 34645808]
  • Javeed Ahmad Bhat, Sushma Gupta, Manish Kumar. Neuroprotective effects of theobromine in transient global cerebral ischemia-reperfusion rat model. Biochemical and biophysical research communications. 2021 09; 571(?):74-80. doi: 10.1016/j.bbrc.2021.07.051. [PMID: 34303966]
  • Kamilla Nunes Machado, Antony de Paula Barbosa, Aline Alves de Freitas, Luana Farah Alvarenga, Rodrigo Maia de Pádua, André Augusto Gomes Faraco, Fernão Castro Braga, Cristina Duarte Vianna-Soares, Rachel Oliveira Castilho. TNF-α inhibition, antioxidant effects and chemical analysis of extracts and fraction from Brazilian guaraná seed powder. Food chemistry. 2021 Sep; 355(?):129563. doi: 10.1016/j.foodchem.2021.129563. [PMID: 33799249]
  • Jader B Ruchel, Viviane M Bernardes, Josiane B S Braun, Alessandra G Manzoni, Daniela F Passos, Lívia G Castilhos, Fátima H Abdalla, Juliana S de Oliveira, Cinthia M de Andrade, Emerson A Casali, Ivana B M da Cruz, Daniela B R Leal. Lipotoxicity-associated inflammation is prevented by guarana (Paullinia cupana) in a model of hyperlipidemia. Drug and chemical toxicology. 2021 Sep; 44(5):524-532. doi: 10.1080/01480545.2019.1624767. [PMID: 31195840]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Nathalie Raharimalala, Stephane Rombauts, Andrew McCarthy, Andréa Garavito, Simon Orozco-Arias, Laurence Bellanger, Alexa Yadira Morales-Correa, Solène Froger, Stéphane Michaux, Victoria Berry, Sylviane Metairon, Coralie Fournier, Maud Lepelley, Lukas Mueller, Emmanuel Couturon, Perla Hamon, Jean-Jacques Rakotomalala, Patrick Descombes, Romain Guyot, Dominique Crouzillat. The absence of the caffeine synthase gene is involved in the naturally decaffeinated status of Coffea humblotiana, a wild species from Comoro archipelago. Scientific reports. 2021 04; 11(1):8119. doi: 10.1038/s41598-021-87419-0. [PMID: 33854089]
  • Carlotta Ciaramelli, Alessandro Palmioli, Ada De Luigi, Laura Colombo, Gessica Sala, Mario Salmona, Cristina Airoldi. NMR-based Lavado cocoa chemical characterization and comparison with fermented cocoa varieties: Insights on cocoa's anti-amyloidogenic activity. Food chemistry. 2021 Mar; 341(Pt 2):128249. doi: 10.1016/j.foodchem.2020.128249. [PMID: 33038804]
  • Daniel Janitschke, Anna A Lauer, Cornel M Bachmann, Heike S Grimm, Tobias Hartmann, Marcus O W Grimm. Methylxanthines and Neurodegenerative Diseases: An Update. Nutrients. 2021 Feb; 13(3):. doi: 10.3390/nu13030803. [PMID: 33671099]
  • Caroline Belló, Ana Paula Prestes, Josiane Aparecida Schemberger, Ana Carolina Mendes Hacke, Romaiana Picada Pereira, Francine Alessandra Manente, Iracilda Zeppone Carlos, Cleverton Roberto de Andrade, Daniel Fernandes, Ivana Beatrice Manica da Cruz, Taís Cristina Unfer, José Carlos Rebuglio Vellosa. Aqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen. Journal of food biochemistry. 2021 01; 45(1):e13560. doi: 10.1111/jfbc.13560. [PMID: 33270240]
  • Myeong Hwan Jang, Sulagna Mukherjee, Min Ji Choi, Nam Hyeon Kang, Huong Giang Pham, Jong Won Yun. Theobromine alleviates diet-induced obesity in mice via phosphodiesterase-4 inhibition. European journal of nutrition. 2020 Dec; 59(8):3503-3516. doi: 10.1007/s00394-020-02184-6. [PMID: 31965293]
  • Daniel Janitschke, Anna A Lauer, Cornel M Bachmann, Martin Seyfried, Heike S Grimm, Tobias Hartmann, Marcus O W Grimm. Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells. International journal of molecular sciences. 2020 Nov; 21(23):. doi: 10.3390/ijms21239015. [PMID: 33260941]
  • Agnieszka Viapiana, Filippo Maggi, Mateusz Kaszuba, Pawel Konieczynski, Marek Wesolowski. Quality assessment of Coffea arabica commercial samples. Natural product research. 2020 Nov; 34(21):3154-3157. doi: 10.1080/14786419.2019.1610750. [PMID: 31088303]
  • Shou En Wu, Wei-Liang Chen. Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study. Nutrients. 2020 Sep; 12(9):. doi: 10.3390/nu12092803. [PMID: 32933151]
  • Binxing Zhou, Cunqiang Ma, Chengqin Zheng, Tao Xia, Bingsong Ma, Xiaohui Liu. 3-Methylxanthine production through biodegradation of theobromine by Aspergillus sydowii PT-2. BMC microbiology. 2020 08; 20(1):269. doi: 10.1186/s12866-020-01951-z. [PMID: 32854634]
  • Daniel Oduro-Mensah, Augustine Ocloo, Thomas Nortey, Stephen Antwi, Laud K Okine, Naa A Adamafio. Nutritional value and safety of animal feed supplemented with Talaromyces verruculosus-treated cocoa pod husks. Scientific reports. 2020 08; 10(1):13163. doi: 10.1038/s41598-020-69763-9. [PMID: 32753579]
  • Yumaira Hernandez, Antonia Costa-Bauza, Paula Calvó, Joan Benejam, Pilar Sanchis, Felix Grases. Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine. Nutrients. 2020 Jul; 12(7):. doi: 10.3390/nu12072012. [PMID: 32645831]
  • Jie Teng, Changyu Yan, Wen Zeng, Yuqian Zhang, Zhen Zeng, Yahui Huang. Purification and characterization of theobromine synthase in a Theobromine-Enriched wild tea plant (Camellia gymnogyna Chang) from Dayao Mountain, China. Food chemistry. 2020 May; 311(?):125875. doi: 10.1016/j.foodchem.2019.125875. [PMID: 31753680]
  • Ana Clara da Costa Pinaffi, Geni Rodrigues Sampaio, Maiara Jurema Soares, Fereidoon Shahidi, Adriano Costa de Camargo, Elizabeth A F S Torres. Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile. Molecules (Basel, Switzerland). 2020 Feb; 25(3):. doi: 10.3390/molecules25030679. [PMID: 32033416]
  • Patrick B Kyle, Jaswinder Kaur. Evaluating Novel Markers for Specimen Validity Testing. Archives of pathology & laboratory medicine. 2020 02; 144(2):168-171. doi: 10.5858/arpa.2019-0197-oa. [PMID: 31755779]
  • H D Ponce-Rodríguez, A A García-Robles, P Sáenz-González, J Verdú-Andrés, P Campíns-Falcó. On-line in-tube solid phase microextraction coupled to capillary liquid chromatography-diode array detection for the analysis of caffeine and its metabolites in small amounts of biological samples. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 178(?):112914. doi: 10.1016/j.jpba.2019.112914. [PMID: 31610396]
  • Krishna Gopal Chattaraj, Sandip Paul. Inclusion of Theobromine Modifies Uric Acid Aggregation with Possible Changes in Melamine-Uric Acid Clusters Responsible for Kidney Stones. The journal of physical chemistry. B. 2019 12; 123(49):10483-10504. doi: 10.1021/acs.jpcb.9b08487. [PMID: 31715106]
  • Eri Sumiyoshi, Kentaro Matsuzaki, Naotoshi Sugimoto, Yoko Tanabe, Toshiko Hara, Masanori Katakura, Mayumi Miyamoto, Seiji Mishima, Osamu Shido. Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial. Nutrients. 2019 Nov; 11(11):. doi: 10.3390/nu11112800. [PMID: 31744119]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Marluci P Silva, Marcelo Thomazini, Augusto T Holkem, Lorena S Pinho, Maria I Genovese, Carmen S Fávaro-Trindade. Production and characterization of solid lipid microparticles loaded with guaraná (Paullinia cupana) seed extract. Food research international (Ottawa, Ont.). 2019 09; 123(?):144-152. doi: 10.1016/j.foodres.2019.04.055. [PMID: 31284962]
  • Vera M Mendes, Margarida Coelho, Angelo R Tomé, Rodrigo A Cunha, Bruno Manadas. Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve. Molecules (Basel, Switzerland). 2019 Aug; 24(16):. doi: 10.3390/molecules24162863. [PMID: 31394755]
  • Ádina L Santana, Gabriela A Macedo. Effects of hydroalcoholic and enzyme-assisted extraction processes on the recovery of catechins and methylxanthines from crude and waste seeds of guarana (Paullinia cupana). Food chemistry. 2019 May; 281(?):222-230. doi: 10.1016/j.foodchem.2018.12.091. [PMID: 30658751]
  • Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Eri Sumiyoshi, Akihiro Yachie, Osamu Shido. Chronic administration of theobromine inhibits mTOR signal in rats. Basic & clinical pharmacology & toxicology. 2019 May; 124(5):575-581. doi: 10.1111/bcpt.13175. [PMID: 30451374]
  • María Ángeles Ávila-Gálvez, Rocío García-Villalba, Francisco Martínez-Díaz, Beatriz Ocaña-Castillo, Tamara Monedero-Saiz, Adela Torrecillas-Sánchez, Beatriz Abellán, Antonio González-Sarrías, Juan Carlos Espín. Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients. Molecular nutrition & food research. 2019 05; 63(9):e1801239. doi: 10.1002/mnfr.201801239. [PMID: 30690879]
  • Rafiad Islam, Kentaro Matsuzaki, Eri Sumiyoshi, Md Emon Hossain, Michio Hashimoto, Masanori Katakura, Naotoshi Sugimoto, Osamu Shido. Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats. Nutrients. 2019 Apr; 11(4):. doi: 10.3390/nu11040888. [PMID: 31010016]
  • Mariona Camps-Bossacoma, Mar Garcia-Aloy, Sandra Saldaña-Ruiz, Trinitat Cambras, Raúl González-Domínguez, Àngels Franch, Francisco J Pérez-Cano, Cristina Andres-Lacueva, Margarida Castell. Role of Theobromine in Cocoa's Metabolic Properties in Healthy Rats. Journal of agricultural and food chemistry. 2019 Apr; 67(13):3605-3614. doi: 10.1021/acs.jafc.8b07248. [PMID: 30855143]
  • María de la Luz Cádiz-Gurrea, Vicente Micol, Jorge Joven, Antonio Segura-Carretero, Salvador Fernández-Arroyo. Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells. Food research international (Ottawa, Ont.). 2019 04; 118(?):96-100. doi: 10.1016/j.foodres.2018.02.027. [PMID: 30898358]
  • Lotte Smolders, Ronald P Mensink, Jose J van den Driessche, Peter J Joris, Jogchum Plat. Theobromine consumption does not improve fasting and postprandial vascular function in overweight and obese subjects. European journal of nutrition. 2019 Apr; 58(3):981-987. doi: 10.1007/s00394-018-1612-6. [PMID: 29330660]
  • Emma R Collings, M Carmen Alamar, Sally Redfern, Katherine Cools, Leon A Terry. Spatial changes in leaf biochemical profile of two tea cultivars following cold storage under two different vapour pressure deficit (VPD) conditions. Food chemistry. 2019 Mar; 277(?):179-185. doi: 10.1016/j.foodchem.2018.10.095. [PMID: 30502133]
  • Biying Zhu, Lin-Bo Chen, Mengqian Lu, Jing Zhang, Jieyun Han, Wei-Wei Deng, Zheng-Zhu Zhang. Caffeine Content and Related Gene Expression: Novel Insight into Caffeine Metabolism in Camellia Plants Containing Low, Normal, and High Caffeine Concentrations. Journal of agricultural and food chemistry. 2019 Mar; 67(12):3400-3411. doi: 10.1021/acs.jafc.9b00240. [PMID: 30830771]
  • Yen K T Dang, Ha V H Nguyen. Effects of Maturity at Harvest and Fermentation Conditions on Bioactive Compounds of Cocoa Beans. Plant foods for human nutrition (Dordrecht, Netherlands). 2019 Mar; 74(1):54-60. doi: 10.1007/s11130-018-0700-3. [PMID: 30368643]
  • Elie Dolgin. Genomic focus brings tea research to the boil. Nature. 2019 02; 566(7742):S12-S13. doi: 10.1038/d41586-019-00400-w. [PMID: 30728517]
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