Serotonin

3-(b-Aminoethyl)-5-hydroxyindole

C10H12N2O (176.095)


Serotonin or 5-hydroxytryptamine (5-HT) is a molecule that belongs to the class of compounds known as indoleamines. An indoleamine consists of an indole ring that bears an amino group or an alkyl amino group attached to the indole ring. Serotonin has an aminoethyl at position 2 and a hydroxyl group at position 5 of the indole ring. Serotonin exists in all living organisms, ranging from bacteria to plants to humans. In mammals, serotonin functions as a monoamine neurotransmitter, a biochemical messenger and regulator. It is synthesized from the essential amino acid L-Tryptophan. Approximately 90\\\\% of the human bodys total serotonin is located in the enterochromaffin cells in the GI tract, where it regulates intestinal movements. About 8\\\\% is found in platelets and 1–2\\\\% in the CNS. Serotonin in the nervous system acts as a local transmitter at synapses, and as a paracrine or hormonal modulator of circuits upon diffusion, allowing a wide variety of "state-dependent" behavioral responses to different stimuli. Serotonin is widely distributed in the nervous system of vertebrates and invertebrates and some of its behavioral effects have been preserved along evolution. Such is the case of aggressive behavior and rhythmic motor patterns, including those responsible for feeding. In vertebrates, which display a wider and much more sophisticated behavioral repertoire, serotonin also modulates sleep, the arousal state, sexual behavior, and others. Deficiencies of the serotonergic system causes disorders such as depression, obsessive-compulsive disorder, phobias, posttraumatic stress disorder, epilepsy, and generalized anxiety disorder. Serotonin has three different modes of action in the nervous system: as transmitter, acting locally at synaptic boutons; upon diffusion at a distance from its release sites, producing paracrine (also called volume) effects, and by circulating in the blood stream, producing hormonal effects. The three modes can affect a single neuronal circuit. (PMID: 16047543). Serotonin is also a microbial metabolite that can be found in the feces and urine of mammals. Urinary serotonin is produced by Candida, Streptococcus, Escherichia, and Enterococcus (PMID: 24621061). In plants, serotonin was first found and reported in a legume called Mucuna pruriens. The greatest concentration of serotonin in plants has been found in walnuts and hickory. In pineapples, banana, kiwi fruit, plums and tomatoes the concentration of serotonin is around 3 to 30 mg/kg. Isolated from bananas and other fruitsand is also from cotton (Gossypium hirsutum) [DFC]. Serotonin is found in many foods, some of which are common pea, eggplant, swiss chard, and dill. Serotonin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=50-67-9 (retrieved 2024-07-01) (CAS RN: 50-67-9). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

   

Perillic acid

4-(1-Methylethenyl)-1-cyclohexene-1-carboxylic acid

C10H14O2 (166.0994)


Perillic acid, also known as perillate, belongs to the class of organic compounds known as menthane monoterpenoids. These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes. Perillic acid is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Perillic acid is an intermediate in the Limonene and pinene degradation pathway. (KEGG); Its measurement in urine is used to monitor cancer patients receiving oral Limonene (a farnesyl transferase inhibitor that has shown antitumor properties)(PubMed ID 8723738 ). Perillic acid is found in cardamom. C471 - Enzyme Inhibitor > C2020 - Farnesyl Transferase Inhibitor

   

gamma-Carotene

2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E,19E)-3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaen-1-yl]-1,3,3-trimethylcyclohex-1-ene

C40H56 (536.4382)


gamma-Carotene is a cyclic carotene obtained by the cyclization of lycopene. It is found in human serum and breast milk (PMID: 9164160). Carotenoids are isoprenoid molecules that are widespread in nature and are typically seen as pigments in fruits, flowers, birds, and crustacea. Animals are unable to synthesize carotenoids de novo and rely upon the diet as a source of these compounds. Over recent years there has been considerable interest in dietary carotenoids with respect to their potential in alleviating age-related diseases in humans. This attention has been mirrored by significant advances in cloning most of the carotenoid genes and in the genetic manipulation of crop plants with the intention of increasing levels in the diet. Studies have shown an inverse relationship between the consumption of certain fruits and vegetables and the risk of epithelial cancer. Since carotenoids are among the micronutrients found in cancer-preventive foods, detailed qualitative and quantitative determination of these compounds, particularly in fruits and vegetables and in human plasma, have recently become increasingly important (PMID: 1416048, 15003396). Gamma-carotene, also known as γ-carotene, is a member of the class of compounds known as carotenes. Carotenes are a type of unsaturated hydrocarbons containing eight consecutive isoprene units. They are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Gamma-carotene can be found in a number of food items such as corn, yellow bell pepper, fig, and papaya, which makes gamma-carotene a potential biomarker for the consumption of these food products.

   

Juvenile hormone III acid

9-(3,3-dimethyloxiran-2-yl)-3,7-dimethylnona-2,6-dienoic acid

C15H24O3 (252.1725)


A member of the juvenile hormone family of compounds obtained by formal hydrolysis of the methyl ester group of juvenile hormone III.

   

10,11-epoxy-3,11-dimethyl-7-ethyl-2,6-tridecadienoic acid

(2E,6E)-7-ethyl-9-[(2R,3S)-3-ethyl-3-methyloxiran-2-yl]-3-methylnona-2,6-dienoic acid

C17H28O3 (280.2038)


   

2-(3,7,12,16,20,24-Hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaenyl)-1,3,3-trimethylcyclohexene

2-(3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaen-1-yl)-1,3,3-trimethylcyclohex-1-ene

C40H56 (536.4382)


   

Serotonin

5-Hydroxytryptamine

C10H12N2O (176.095)


D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists

   

hexadec-9-enal

hexadec-9-enal

C16H30O (238.2297)


   

hexadec-11-enal

hexadec-11-enal

C16H30O (238.2297)


   

15-Phenylpentadecanoic acid

15-Phenylpentadecanoic acid

C21H34O2 (318.2559)


   

13-phenyltridecanoic Acid

13-phenyltridecanoic Acid

C19H30O2 (290.2246)


   

Serotonin

5-Hydroxytryptamine

C10H12N2O (176.095)


D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists A primary amino compound that is the 5-hydroxy derivative of tryptamine. MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; QZAYGJVTTNCVMB_STSL_0135_Serotonin_8000fmol_180506_S2_LC02_MS02_147; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I. MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I. relative retention time with respect to 9-anthracene Carboxylic Acid is 0.054 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.053

   

Perillic acid

4-prop-1-en-2-ylcyclohexene-1-carboxylic acid

C10H14O2 (166.0994)


C471 - Enzyme Inhibitor > C2020 - Farnesyl Transferase Inhibitor

   

gamma-Carotene

beta,psi-Carotene

C40H56 (536.4382)


A cyclic carotene obtained by the cyclisation of lycopene. Window width to select the precursor ion was 3 Da.; CONE_VOLTAGE is 10 V.; This record was created by the financial support of MEXT/JSPS KAKENHI Grant Number 19HP8024 to the Mass Spectrometry Society of Japan.

   

4-[4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol

4-[4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol

C21H28O4 (344.1987)


   

11-hexadecenal

11-hexadecenal

C16H30O (238.2297)


   

Thesal

1H-purine-2,6-dione,3,7-dihydro-3,7- dimethyl- (9CI)

C7H8N4O2 (180.0647)


R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BD - Xanthine derivatives D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

   

hexadecanal

1-hexadecanal

C16H32O (240.2453)


COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS Hexadecanal (Palmitaldehyde) is a free fatty aldehyde present in animals[1]. Hexadecanal (Palmitaldehyde) is a free fatty aldehyde present in animals[1].

   

(2E,6E)-7-ethyl-9-[(2R,3S)-3-ethyl-3-methyloxiran-2-yl]-3-methylnona-2,6-dienoic acid

(2E,6E)-7-ethyl-9-[(2R,3S)-3-ethyl-3-methyloxiran-2-yl]-3-methylnona-2,6-dienoic acid

C17H28O3 (280.2038)


   

juvenile hormone I acid

juvenile hormone I acid

C17H28O3 (280.2038)


A member of the juvenile hormone family of compounds obtained by formal hydrolysis of the methyl ester group of juvenile hormone I.

   

(2s)-2-{[(9z,12z,15z,17r)-1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene]amino}-4-(c-hydroxycarbonimidoyl)butanoic acid

(2s)-2-{[(9z,12z,15z,17r)-1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene]amino}-4-(c-hydroxycarbonimidoyl)butanoic acid

C23H38N2O5 (422.2781)


   

(2e,6e)-9-[(2r)-3,3-dimethyloxiran-2-yl]-7-ethyl-3-methylnona-2,6-dienoic acid

(2e,6e)-9-[(2r)-3,3-dimethyloxiran-2-yl]-7-ethyl-3-methylnona-2,6-dienoic acid

C16H26O3 (266.1882)


   

11-hexadecen-1-ol (z)

11-hexadecen-1-ol (z)

C16H32O (240.2453)


   

methyl (2e,6e)-9-[(2s)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate

methyl (2e,6e)-9-[(2s)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate

C16H26O3 (266.1882)


   

4-[(2r,3s)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol

4-[(2r,3s)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol

C21H28O4 (344.1987)


   

(2r)-2-[(1r)-4-methylcyclohex-3-en-1-yl]propane-1,2-diol

(2r)-2-[(1r)-4-methylcyclohex-3-en-1-yl]propane-1,2-diol

C10H18O2 (170.1307)


   

(2e,6e)-9-[(2s,3s)-3-ethyl-3-methyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoic acid

(2e,6e)-9-[(2s,3s)-3-ethyl-3-methyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoic acid

C16H26O3 (266.1882)


   

(2s)-2-{[(2e,4e,6e,8e)-1-hydroxy-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ylidene]amino}propanoic acid

(2s)-2-{[(2e,4e,6e,8e)-1-hydroxy-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ylidene]amino}propanoic acid

C23H33NO3 (371.246)


   

2-{[(9z,12z,15z)-1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene]amino}-4-(c-hydroxycarbonimidoyl)butanoic acid

2-{[(9z,12z,15z)-1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene]amino}-4-(c-hydroxycarbonimidoyl)butanoic acid

C23H38N2O5 (422.2781)


   

hexadec-11-en-1-ol

hexadec-11-en-1-ol

C16H32O (240.2453)


   

1,4-dimethyl 2-[(3,4-dimethoxyphenyl)methylidene]-3-[(4-hydroxy-3-methoxyphenyl)methylidene]butanedioate

1,4-dimethyl 2-[(3,4-dimethoxyphenyl)methylidene]-3-[(4-hydroxy-3-methoxyphenyl)methylidene]butanedioate

C23H24O8 (428.1471)


   

(2r)-2-[(1s)-4-methylcyclohex-3-en-1-yl]propane-1,2-diol

(2r)-2-[(1s)-4-methylcyclohex-3-en-1-yl]propane-1,2-diol

C10H18O2 (170.1307)


   

(11z)-11-hexadecenyl acetate

(11z)-11-hexadecenyl acetate

C18H34O2 (282.2559)


   

2-[(1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene)amino]-4-(c-hydroxycarbonimidoyl)butanoic acid

2-[(1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene)amino]-4-(c-hydroxycarbonimidoyl)butanoic acid

C23H38N2O5 (422.2781)


   

9-(3,3-dimethyloxiran-2-yl)-7-ethyl-3-methylnona-2,6-dienoic acid

9-(3,3-dimethyloxiran-2-yl)-7-ethyl-3-methylnona-2,6-dienoic acid

C16H26O3 (266.1882)


   

n-[2-(5-methoxy-1h-indol-3-yl)ethyl]ethanimidic acid

n-[2-(5-methoxy-1h-indol-3-yl)ethyl]ethanimidic acid

C13H16N2O2 (232.1212)


   

(9z)-9-hexadecenal

(9z)-9-hexadecenal

C16H30O (238.2297)


   

(11z)-11-hexadecenal

(11z)-11-hexadecenal

C16H30O (238.2297)


   

(2s)-2-{[(9z,12z,15z,17s)-1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene]amino}-4-(c-hydroxycarbonimidoyl)butanoic acid

(2s)-2-{[(9z,12z,15z,17s)-1,17-dihydroxyoctadeca-9,12,15-trien-1-ylidene]amino}-4-(c-hydroxycarbonimidoyl)butanoic acid

C23H38N2O5 (422.2781)


   

(2s)-3-hydroxy-2-{[(2e,4e,6e,8e)-1-hydroxy-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ylidene]amino}propanoic acid

(2s)-3-hydroxy-2-{[(2e,4e,6e,8e)-1-hydroxy-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ylidene]amino}propanoic acid

C23H33NO4 (387.2409)


   

(4r)-4-(prop-1-en-2-yl)cyclohex-1-ene-1-carboxylic acid

(4r)-4-(prop-1-en-2-yl)cyclohex-1-ene-1-carboxylic acid

C10H14O2 (166.0994)


   

tetradec-9-en-1-yl acetate

tetradec-9-en-1-yl acetate

C16H30O2 (254.2246)


   

hexadec-11-en-1-yl acetate

hexadec-11-en-1-yl acetate

C18H34O2 (282.2559)


   

tetradec-7-en-1-yl acetate

tetradec-7-en-1-yl acetate

C16H30O2 (254.2246)


   

2-(4-methylcyclohex-3-en-1-yl)propane-1,2-diol

2-(4-methylcyclohex-3-en-1-yl)propane-1,2-diol

C10H18O2 (170.1307)


   

(4s)-4-(prop-1-en-2-yl)cyclohex-1-ene-1-carboxylic acid

(4s)-4-(prop-1-en-2-yl)cyclohex-1-ene-1-carboxylic acid

C10H14O2 (166.0994)


   

methyl (2e,6e)-9-[(2s,3s)-3-ethyl-3-methyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate

methyl (2e,6e)-9-[(2s,3s)-3-ethyl-3-methyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoate

C17H28O3 (280.2038)


   

1,4-dimethyl (2z,3z)-2-[(3,4-dimethoxyphenyl)methylidene]-3-[(4-hydroxy-3-methoxyphenyl)methylidene]butanedioate

1,4-dimethyl (2z,3z)-2-[(3,4-dimethoxyphenyl)methylidene]-3-[(4-hydroxy-3-methoxyphenyl)methylidene]butanedioate

C23H24O8 (428.1471)


   

7-ethyl-9-(3-ethyl-3-methyloxiran-2-yl)-3-methylnona-2,6-dienoic acid

7-ethyl-9-(3-ethyl-3-methyloxiran-2-yl)-3-methylnona-2,6-dienoic acid

C17H28O3 (280.2038)


   

(2e,6e)-9-[(2s)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoic acid

(2e,6e)-9-[(2s)-3,3-dimethyloxiran-2-yl]-3,7-dimethylnona-2,6-dienoic acid

C15H24O3 (252.1725)


   

methyl 9-(3-ethyl-3-methyloxiran-2-yl)-3,7-dimethylnona-2,6-dienoate

methyl 9-(3-ethyl-3-methyloxiran-2-yl)-3,7-dimethylnona-2,6-dienoate

C17H28O3 (280.2038)


   

(7z)-tetradec-7-en-1-yl acetate

(7z)-tetradec-7-en-1-yl acetate

C16H30O2 (254.2246)