7-Ethyl-10-hydroxycamptothecin (BioDeep_00000008528)

 

Secondary id: BioDeep_00000396396

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione

化学式: C22H20N2O5 (392.137215)
中文名称: 7-乙基-10-羟基喜树碱, 7-乙基-10羟基喜树碱, 4,11-二乙基-4,9-二羟基-1H-吡喃并[3’,4’:6,7]中氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮
谱图信息: 最多检出来源 Homo sapiens(blood) 2.24%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

7-Ethyl-10-hydroxycamptothecin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/7-ethyl-10-hydroxycamptothecin (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000008528). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCC1=C2C=C(O)C=CC2=NC2=C1CN1C2=CC2=C(COC(=O)[C@]2(O)CC)C1=O
InChI: InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3

描述信息

SN-38 is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an apoptosis inducer, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a drug metabolite and an antineoplastic agent. It is a pyranoindolizinoquinoline, a delta-lactone, a tertiary alcohol and a member of phenols.
7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.
7-Ethyl-10-hydroxycamptothecin is a natural product found in Apis cerana with data available.
A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
7-Ethyl-10-hydroxycamptothecin (SN38) is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor); it is 1000 times more active than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is metabolized via glucoronidation by UGT1A1. (Wikipedia) 7-Ethyl-10-hydroxycamptothecin (SN38), the active metabolite of irinotecan, exerts a 100-fold to 1000-fold higher effect than irinotecan itself against several tumor cell lines. (PMID: 23233044) Among five chemotherapeutic agents commonly used for breast cancer treatment, only an irinotecan metabolite SN38 showed additive antitumor activity with olaparib. (PMID: 22454224) Metabolism of irinotecan to SN38 is inefficient and subject to considerable patient-to-patient variability. One approach to more controlled administration of the anticancer agent is direct administration of the active SN38. (PMID: 23299391)
A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.


SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].
SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

同义名列表

59 个代谢物同义名

(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione; (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione; 7-Ethyl-10-hydroxycamptothecin ((S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione); (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione, AldrichCPR; (4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;SN-38; 1H-PYRANO(3,4:6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 4,11-DIETHYL-4,9-DIHYDROXY-, (4S)-; 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-; H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (S)-; 1H-Pyrano[3,7]indolizino[1,2-b]quinoline- 3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-; (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; (S)-4,11-Diethyl-4,9-di-OH-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; 7-Ethyl-10-hydroxycamptothecin, >=98\\% (HPLC), powder; 7-ethyl-10-hydroxy-20(s)-campthothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin; S-(+)-7-ETHYL-10-HYDROXYCAMPOTHECIN; (+)-7-ETHYL-10-HYDROXYCAMPTOTHECIN; CAMPTOTHECIN, 7-ETHYL-10-HYDROXY-; Captothecin, 7-ethyl-10-hydroxy-; 7-Ethyl-10-Hydroxy-Camptothecin; 10-hydroxy-7-ethyl-camptothecin; 10-hydroxy-7-ethyl camptothecin; 7-ethyl-10-hydroxycamptothecin; 10-Hydroxy-7-ethylcamptothecin; 12-Ethyl-9-hydroxycamptothecin; 7 Ethyl 10 hydroxycamptothecin; 7-Ethyl-10-hydroxy-20(S)-CPT; FJHBVJOVLFPMQE-QFIPXVFZSA-N; diethyl(dihydroxy)[?]dione; Irinotecan Hydrochloride; camptothecin-11; Camptothecin 11; UNII-0H43101T0J; NK012 Compound; SN 38 [WHO-DD]; SN-38(NK-012); SN 38 lactone; SN 38- Bio-X; NCI60_026056; Irrinotecan; C22H20N2O5; 0H43101T0J; Irinotecan; Camptosar; sn38 CPD; SN 38 11; SN-38-11; LE-SN38; CPT 11; CPT-11; CPT11; SN-38; SN 38; SN38; RS4; 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(2)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Miaomiao Sun, Honghong Zhan, Xiaoliang Long, Ali M Alsayed, Zhe Wang, Fancheng Meng, Guowei Wang, Jingxin Mao, Zhihua Liao, Min Chen. Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4/MD2 complex formation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155371. doi: 10.1016/j.phymed.2024.155371. [PMID: 38518649]
  • Supusson Pengnam, Watcharapa Jitkaroon, Roongtiwa Srisuphan, Pawaris Wongprayoon, Kanok-On Rayanil, Purin Charoensuksai. Furanocoumarin compounds isolated from Dorstenia foetida potentiate irinotecan anticancer activity against colorectal cancer cells. Acta pharmaceutica (Zagreb, Croatia). 2024 Mar; 74(1):67-79. doi: 10.2478/acph-2024-0004. [PMID: 38554381]
  • Jingya Wang, Jiangli Xu, Shuhui Yang, Liu He, Wenhuai Xu, Yan'e Liu, Baoshan Cao, Siwang Yu. SN-38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2-related factor 2 and enhances drug sensitivity of colorectal cancer cells. Molecular carcinogenesis. 2024 Jan; ?(?):. doi: 10.1002/mc.23685. [PMID: 38270247]
  • Huanyu Guan, Qian Wang, Yao Mei, Junyan Ran, Fanli Zeng, Haimin Cai, Daoping Wang, Shenggang Yang, Min Zhang, Yue Shi, Shanggao Liao, Pengfei Li. A multistep approach for exploring quality markers of Shengjiang Xiexin decoction by integrating plasma pharmacochemistry-pharmacokinetics-pharmacology. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 241(?):115999. doi: 10.1016/j.jpba.2024.115999. [PMID: 38306867]
  • Qing-Rui Qi, Huan Tian, Bao-Sen Yue, Bing-Tao Zhai, Feng Zhao. Research Progress of SN38 Drug Delivery System in Cancer Treatment. International journal of nanomedicine. 2024; 19(?):945-964. doi: 10.2147/ijn.s435407. [PMID: 38293612]
  • Jianzheng He, Shuzhen Han, Yixuan Wang, Qian Kang, Xiaoqian Wang, Yun Su, Yaling Li, Yongqi Liu, Hui Cai, Minghui Xiu. Irinotecan cause the side effects on development and adult physiology, and induces intestinal damage via innate immune response and oxidative damage in Drosophila. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115906. doi: 10.1016/j.biopha.2023.115906. [PMID: 37984304]
  • Cornelia Schmutz, Frank Will, Elisabeth Varga, Carola Jaunecker, Gudrun Pahlke, Walter Berger, Doris Marko. In Vitro Inhibitory Potential of Different Anthocyanin-Rich Berry Extracts in Murine CT26 Colon Cancer Cells. Molecules (Basel, Switzerland). 2023 Nov; 28(23):. doi: 10.3390/molecules28237684. [PMID: 38067418]
  • Wenxuan Li, Ya Zhang, Yuanyuan Wu, Guanghao Zhu, Xiaoyu Liu, Yunqing Song, Bo Ma, Sheng Lin, Guangbo Ge, Xiaozhen Jiao, Ping Xie. New bysspectin A derivatives as potent inhibitors of human carboxylesterase 2A. European journal of medicinal chemistry. 2023 Nov; 259(?):115708. doi: 10.1016/j.ejmech.2023.115708. [PMID: 37544184]
  • Ke Li, Kun Xu, Shaopeng Liu, Ye He, Meijun Tan, Yulan Mao, Yulu Yang, Jing Wu, Qian Feng, Zhong Luo, Kaiyong Cai. All-in-One Engineering Multifunctional Nanoplatforms for Sensitizing Tumor Low-Temperature Photothermal Therapy In Vivo. ACS nano. 2023 10; 17(20):20218-20236. doi: 10.1021/acsnano.3c05991. [PMID: 37838975]
  • Jingbo Pei, Yuanyuan Zou, Wenying Zhou, Yakun Wang. Baicalein, a component of banxia xiexin decoction, alleviates CPT-11-induced gastrointestinal dysfunction by inhibiting ALOX15-mediated ferroptosis. Chemical biology & drug design. 2023 Sep; ?(?):. doi: 10.1111/cbdd.14349. [PMID: 37735740]
  • Xiao-Qin Yang, Shu-Yang Wu, Min Li, Jia-Mei Chen, Yan-Fen Cheng, Yi-Tao Wang, Yi-Han Wu, Jin-Ming Zhang. [Q-marker prediction of resin ethanol extract of Gegen Qinlian Decoction based on characteristic spectrum and network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Sep; 48(18):4993-5002. doi: 10.19540/j.cnki.cjcmm.20230518.303. [PMID: 37802841]
  • XiaoLi Lin, Yu Fang, Yuan Cheng, QiaoLing Wang. Chinese herbal medicine for irinotecan-induced diarrhea: A systematic review and meta-analysis. Explore (New York, N.Y.). 2023 Aug; ?(?):. doi: 10.1016/j.explore.2023.08.003. [PMID: 37640591]
  • Caiyan Wang, Xiaojun Teng, Chuang Wang, Binjie Liu, Runze Zhou, Xueyu Xu, Huawei Qiu, Yu Fu, Rongjin Sun, Zuhui Liang, Rong Zhang, Zhongqiu Liu, Lin Zhang, Lijun Zhu. Insight into the mechanism of Xiao-Chai-Hu-Tang alleviates irinotecan-induced diarrhea based on regulating the gut microbiota and inhibiting Gut β-GUS. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 120(?):155040. doi: 10.1016/j.phymed.2023.155040. [PMID: 37683587]
  • Anna Radajewska, Helena Moreira, Dorota Bęben, Oliwia Siwiela, Anna Szyjka, Katarzyna Gębczak, Paulina Nowak, Jakub Frąszczak, Fathi Emhemmed, Christian D Muller, Ewa Barg. Combination of Irinotecan and Melatonin with the Natural Compounds Wogonin and Celastrol for Colon Cancer Treatment. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119544. [PMID: 37298495]
  • Changpei Gan, Jing Wang, Yaogeng Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Maria C Lebre, Els Wagenaar, Hilde Rosing, Sjoerd Klarenbeek, Onno B Bleijerveld, Ji-Ying Song, Maarten Altelaar, Jos H Beijnen, Alfred H Schinkel. Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 164(?):114956. doi: 10.1016/j.biopha.2023.114956. [PMID: 37267638]
  • Congjian Shi, Zhenghong Zhang, Renfeng Xu, Yan Zhang, Zhengchao Wang. Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury. Scientific reports. 2023 04; 13(1):6528. doi: 10.1038/s41598-023-33848-y. [PMID: 37085612]
  • Youngjoo Lee, Soo-Hyun Lee, Geon Kook Lee, Eun Jin Lim, Ji-Youn Han. A randomized Phase II Study of Irinotecan Plus Cisplatin with or without Simvastatin in ever Smokers with Extended Disease Small Cell Lung Cancer. Cancer research and treatment. 2023 Mar; ?(?):. doi: 10.4143/crt.2023.283. [PMID: 36960628]
  • Aranka Brockmueller, Samson Mathews Samuel, Alena Mazurakova, Dietrich Büsselberg, Peter Kubatka, Mehdi Shakibaei. Curcumin, calebin A and chemosensitization: How are they linked to colorectal cancer?. Life sciences. 2023 Feb; 318(?):121504. doi: 10.1016/j.lfs.2023.121504. [PMID: 36813082]
  • Md Monirujjaman, Leila Baghersad Renani, Peter Isesele, Abha R Dunichand-Hoedl, Vera C Mazurak. Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043547. [PMID: 36834959]
  • Annamaria Di Turi, Marina Antonacci, Jacopo Raffaele Dibenedetto, Fatima Maqoud, Francesco Leonetti, Gerardo Centoducati, Nicola Colonna, Domenico Tricarico. Molecular Composition and Biological Activity of a Novel Acetonitrile-Water Extract of Lens Culinaris Medik in Murine Native Cells and Cell Lines Exposed to Different Chemotherapeutics Using Mass Spectrometry. Cells. 2023 Feb; 12(4):. doi: 10.3390/cells12040575. [PMID: 36831242]
  • Tao Zhou, Yushi Liu, Kelu Lei, Junjing Liu, Minghao Hu, Li Guo, Yiping Guo, Qiang Ye. A 'Trojan Horse' Strategy: The Preparation of Bile Acid-Modifying Irinotecan Hydrochloride Nanoliposomes for Liver-Targeted Anticancer Drug Delivery System Study. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041577. [PMID: 36838565]
  • Yi Ding, Sizhe Chen, Feng Zhang, Wenda Li, Guangbo Ge, Tian Liu, Qing Yang. Chitinase is a Potent Insecticidal Molecular Target of Camptothecin and Its Derivatives. Journal of agricultural and food chemistry. 2023 Feb; 71(4):1845-1851. doi: 10.1021/acs.jafc.2c06607. [PMID: 36655791]
  • Kuei-Yen Tsai, Po-Li Wei, Mohamed Azarkan, Nasiha M'Rabet, Precious Takondwa Makondi, Hsin-An Chen, Chien-Yu Huang, Yu-Jia Chang. Cytotoxic properties of unfractionated and fractionated bromelain alone or in combination with chemotherapeutic agents in colorectal cancer cells. PloS one. 2023; 18(6):e0285970. doi: 10.1371/journal.pone.0285970. [PMID: 37262048]
  • Bin Huang, Mengxuan Gui, Zhuona Ni, Yanbin He, Jinyan Zhao, Jun Peng, Jiumao Lin. Chemotherapeutic Drugs Induce Different Gut Microbiota Disorder Pattern and NOD/RIP2/NF-κB Signaling Pathway Activation That Lead to Different Degrees of Intestinal Injury. Microbiology spectrum. 2022 12; 10(6):e0167722. doi: 10.1128/spectrum.01677-22. [PMID: 36222691]
  • Youqiang Liu, Hongxin Zhang, Haijing Cui, Futong Zhang, Liyan Zhao, Yibing Liu, Qingju Meng. Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers. Drug delivery. 2022 Dec; 29(1):342-350. doi: 10.1080/10717544.2022.2027573. [PMID: 35049388]
  • Wei Li, Yin-Nan Chen, Yue-Yue Chen, Zhe Wang, Zhen Wang, Li-Li Jiang, Hong-Can Shi, Yong Liu. Inhibition of UGT1A1*1 and UGT1A1*6 catalyzed glucuronidation of SN-38 by silybins. Chemico-biological interactions. 2022 Dec; 368(?):110248. doi: 10.1016/j.cbi.2022.110248. [PMID: 36343684]
  • Bohao Liu, Cong Ding, Wenbin Tang, Chen Zhang, Yiying Gu, Zhiqiang Wang, Tingzi Yu, Zhuan Li. Hepatic ROS Mediated Macrophage Activation Is Responsible for Irinotecan Induced Liver Injury. Cells. 2022 Nov; 11(23):. doi: 10.3390/cells11233791. [PMID: 36497051]
  • Amanda J Stolarz, Bijay P Chhetri, Michael J Borrelli, Samir V Jenkins, Azemat Jamshidi-Parsian, Joshua H Phillips, Daniel Fologea, Jay Gandy, Robert J Griffin. Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911662. [PMID: 36232973]
  • Siqi Ma, Zhaoqing Cong, Jiaxing Wei, Weiya Chen, Di Ge, Feifei Yang, Yonghong Liao. Pulmonary delivery of size-transformable nanoparticles improves tumor accumulation and penetration for chemo-sonodynamic combination therapy. Journal of controlled release : official journal of the Controlled Release Society. 2022 10; 350(?):132-145. doi: 10.1016/j.jconrel.2022.08.003. [PMID: 35940360]
  • Marina Antonacci, Jacopo Raffaele Dibenedetto, Fatima Maqoud, Gerardo Centoducati, Nicola Colonna, Francesco Leonetti, Domenico Tricarico. Counteractions of a Novel Hydroalcoholic Extract from Lens Culinaria against the Dexamethasone-Induced Osteoblast Loss of Native Murine Cells. Cells. 2022 09; 11(19):. doi: 10.3390/cells11192936. [PMID: 36230898]
  • Luana David do Carmo, Gisele de Fátima Pinheiro Rangel, Liviane Maria Alves Rabelo, Tamiris de Fátima Goebel de Souza, Roberto César Pereira Lima Júnior, Deysi Viviana Tenazoa Wong, Renata Ferreira de Carvalho Leitão, Alfredo Augusto Vasconcelos da Silva, Pedro Jorge Caldas Magalhães, Andréa Santos Costa, Dyély de Carvalho Oliveira Campos, Nylane Maria Nunes de Alencar, Hermógenes David de Oliveira. Therapeutic effects of a lipid transfer protein isolated from Morinda citrifolia L. (noni) seeds on irinotecan-induced intestinal mucositis in mice. Naunyn-Schmiedeberg's archives of pharmacology. 2022 09; 395(9):1097-1107. doi: 10.1007/s00210-022-02267-7. [PMID: 35776167]
  • Zhiren Wang, Wenpan Li, Jonghan Park, Karina Marie Gonzalez, Aaron James Scott, Jianqin Lu. Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade. Journal of controlled release : official journal of the Controlled Release Society. 2022 09; 349(?):929-939. doi: 10.1016/j.jconrel.2022.07.042. [PMID: 35926754]
  • Lijia Luo, Xiang Wang, Yu-Pei Liao, Chong Hyun Chang, Andre E Nel. Nanocarrier Co-formulation for Delivery of a TLR7 Agonist plus an Immunogenic Cell Death Stimulus Triggers Effective Pancreatic Cancer Chemo-immunotherapy. ACS nano. 2022 08; 16(8):13168-13182. doi: 10.1021/acsnano.2c06300. [PMID: 35920660]
  • Matthew Ng, Sylvia Chen, Whee Sze Ong, Akhila Balachander, Amanda Seet, Joe Yeong, Natalia Sutiman, Tony Kiat Hon Lim, Bernett Lee, Yu Amanda Guo, Wai Fook Leong, Sze Sing Lee, Justina Lam, Su Pin Choo, Anders Jacobsen Skanderup, Subhra Kumar Biswas, David Tai, Balram Chowbay. A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects. International journal of cancer. 2022 08; 151(3):435-449. doi: 10.1002/ijc.34021. [PMID: 35415893]
  • Gérard Milano, Federico Innocenti, Hironobu Minami. Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs. Cancer science. 2022 Jul; 113(7):2224-2231. doi: 10.1111/cas.15377. [PMID: 35445479]
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