Axillarin (BioDeep_00000007757)

Main id: BioDeep_00000269973

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one

化学式: C17H14O8 (346.0689)
中文名称: 槲皮万寿菊素-3,6-二甲醚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(c(c2=O)OC)c1ccc(c(c1)O)O)O)OC)O
InChI: InChI=1S/C17H14O8/c1-23-16-10(20)6-11-12(13(16)21)14(22)17(24-2)15(25-11)7-3-4-8(18)9(19)5-7/h3-6,18-21H,1-2H3

描述信息

同义名列表

5 个代谢物同义名

2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one; 3,6-Dimethoxy-5,7,3,4-tetrahydroxyflavone; Quercetagetin 3,6-dimethyl ether; Axillarin; Axillarin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

215 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AXIN2, BCL2, CASP3, CAT, GAMT, MAPK14, MAPK8, PSAT1, PTGS2, SNCAIP, TFDP3, TYR
Peripheral membrane protein 2 ACHE, PTGS2
Endoplasmic reticulum membrane 3 BCL2, PTGS2, SLC7A11
Nucleus 10 ACHE, AXIN2, BCL2, CASP3, GAMT, MAPK14, MAPK8, MYB, OGA, TFDP3
cytosol 11 AXIN2, BCL2, CASP3, CAT, GAMT, MAPK14, MAPK8, MYB, OGA, PSAT1, SNCAIP
centrosome 1 AXIN2
nucleoplasm 5 CASP3, MAPK14, MAPK8, MYB, SNCAIP
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 3 ACHE, SLC7A11, TNF
Multi-pass membrane protein 1 SLC7A11
Synapse 2 ACHE, MAPK8
cell surface 3 ACHE, SLC7A11, TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 2 ACHE, ATRN
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 3 CASP3, SNCAIP, TNF
presynaptic membrane 1 SNCAIP
synaptic vesicle 1 SNCAIP
Lysosome 2 GAA, TYR
plasma membrane 6 ACHE, ATRN, AXIN2, GAA, SLC7A11, TNF
Membrane 7 ACHE, BCL2, CAT, GAA, MYB, OGA, SLC7A11
axon 1 MAPK8
basolateral plasma membrane 1 SLC7A11
caveola 1 PTGS2
extracellular exosome 4 ATRN, CAT, GAA, PSAT1
Lysosome membrane 1 GAA
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 4 ACHE, ATRN, IL10, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ACHE, TYR
mitochondrion 3 BCL2, CAT, MAPK14
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 3 CAT, GAA, TYR
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 ATRN, SLC7A11, TYR
Secreted 3 ACHE, GAA, IL10
extracellular region 6 ACHE, CAT, GAA, IL10, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
transcription regulator complex 1 TFDP3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
beta-catenin destruction complex 1 AXIN2
Melanosome membrane 1 TYR
apical part of cell 1 SLC7A11
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 SLC7A11
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 1 TFDP3
phagocytic cup 1 TNF
[Isoform 3]: Nucleus 1 OGA
cytoplasmic ribonucleoprotein granule 1 SNCAIP
brush border membrane 1 SLC7A11
spindle pole 1 MAPK14
Basolateral cell membrane 1 SLC7A11
Lipid-anchor, GPI-anchor 1 ACHE
Cell projection, microvillus membrane 1 SLC7A11
microvillus membrane 1 SLC7A11
[Isoform 3]: Secreted 1 ATRN
tertiary granule membrane 1 GAA
Melanosome 1 TYR
side of membrane 1 ACHE
myelin sheath 1 BCL2
[Isoform 1]: Cytoplasm 1 OGA
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 1 MYB
azurophil granule membrane 1 GAA
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ATRN
astrocyte projection 1 SLC7A11
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Katarzyna Gaweł-Bęben, Marcelina Strzępek-Gomółka, Marcin Czop, Zuriyadda Sakipova, Kazimierz Głowniak, Wirginia Kukula-Koch. Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts-Bioactive Ingredients for Cosmetic Use. Molecules (Basel, Switzerland). 2020 Jul; 25(15):. doi: 10.3390/molecules25153368. [PMID: 32722270]
  • Ayumi Uehara, Tsukasa Iwashina. Flavonoids from the Japanese monotypic genus, Nipponanthemum. Natural product communications. 2012 Aug; 7(8):1005-6. doi: . [PMID: 22978216]
  • Peter Forgo, István Zupkó, Judit Molnár, Andrea Vasas, György Dombi, Judit Hohmann. Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. Fitoterapia. 2012 Jul; 83(5):921-5. doi: 10.1016/j.fitote.2012.04.006. [PMID: 22537643]
  • Malindra Juan-Badaturuge, Solomon Habtemariam, Caroline Jackson, Michael J K Thomas. Antioxidant principles of Tanacetum vulgare L. aerial parts. Natural product communications. 2009 Nov; 4(11):1561-4. doi: ". [PMID: 19967991]
  • Valeria Moscatelli, Oksana Hnatyszyn, Cristina Acevedo, Javier Megías, María José Alcaraz, Graciela Ferraro. Flavonoids from Artemisia copa with anti-inflammatory activity. Planta medica. 2006 Jan; 72(1):72-4. doi: 10.1055/s-2005-873177. [PMID: 16450301]
  • Guillermo Schmeda-Hirschmann, Alejandro Tapia, Cristina Theoduloz, Jaime Rodríguez, Susana López, Gabriela Egly Feresin. Free radical scavengers and antioxidants from Tagetes mendocina. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2004 May; 59(5-6):345-53. doi: 10.1515/znc-2004-5-610. [PMID: 18998399]
  • So Ra Kim, Mi Jung Park, Mi Kyeong Lee, Sang Hyun Sung, Eun Jung Park, Jinwoong Kim, Sun Yeou Kim, Tae H Oh, George J Markelonis, Young Choong Kim. Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate. Free radical biology & medicine. 2002 Apr; 32(7):596-604. doi: 10.1016/s0891-5849(02)00751-7. [PMID: 11909694]
  • J C Meng, Y F Hu, J H Chen, R X Tan. Antifungal highly oxygenated guaianolides and other constituents from Ajania fruticulosa. Phytochemistry. 2001 Dec; 58(7):1141-5. doi: 10.1016/s0031-9422(01)00389-2. [PMID: 11730880]
  • Li, Meng, Cheng, Higa, Tanaka, Tan. New guaianolides and xanthine oxidase inhibitory flavonols from ajania fruticulosa. Journal of natural products. 1999 Jul; 62(7):1053-5. doi: 10.1021/np990009i. [PMID: 10425142]
  • M A al-Yahya, A M el-Sayed, J S Mossa, J F Kozlowski, M D Antoun, M Ferin, W M Baird, J M Cassady. Potential cancer chemopreventive and cytotoxic agents from Pulicaria crispa. Journal of natural products. 1988 May; 51(3):621-4. doi: 10.1021/np50057a038. [PMID: 3404160]