Catalpol (BioDeep_00000007600)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2,3:4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

  化学式: C15H22O10 (362.1213)
中文名称: 梓醇
  谱图信息: 最多检出来源 Viridiplantae(plant) 25.37%

分子结构信息

SMILES: C1=COC(C2C1C(C3C2(O3)CO)O)OC4C(C(C(C(O4)CO)O)O)O
InChI: InChI=1S/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2


描述信息

Catalpol is an organic molecular entity. It has a role as a metabolite.
Catalpol is a natural product found in Verbascum lychnitis, Plantago atrata, and other organisms with data available.
See also: Rehmannia glutinosa Root (part of).
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects[1][2][3].
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects[1][2][3].

同义名列表

32 个代谢物同义名

(2S,3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2,3:4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (1S,5R,6R)-2-[(1S,1bS,2S,5aR,6S)-6-hydroxy-1a-((S)-hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydro-1,3-dioxa-cyclopropa[a]inden-2-yloxy]-6-((S)-hydroxymethyl)-tetrahydro-pyran-3,4,5-triol; beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy- 1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-; beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-; beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-; (1AS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl-beta-D-glucopyranoside; (2S,3R,4S,5S,6R)-2-{[(1S,2S,4S,5S,6R,10S)-5-HYDROXY-2-(HYDROXYMETHYL)-3,9-DIOXATRICYCLO[4.4.0.0(2),?]DEC-7-EN-10-YL]OXY}-6-(HYDROXYMETHYL)OXANE-3,4,5-TRIOL; (2S,3R,4S,5S,6R)-2-[[(1S,2S,4S,5S,6R,10S)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl beta-D-glucopyranoside; Catalposide, des-p-hydroxybenzoyl-; De(p-hydroxybenzoyl)catalposide; Catalpol, >=96\\% (HPLC); Digitalis purpurea L; UNII-JCX5L7JIC2; Catalpinoside; JCX5L7JIC2; Catalpol; Catapol; EINECS 219-324-0; NCGC00163523-01; LMPR01020108; 2415-24-9; C09773; 2-[[5-Hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; CID 53297354; Catalpol; (2S,3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 1ST000982; Catalpinoside;(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl- ?-D-glucopyranoside; Catalpol (Standard); Catalpol, >=96% (HPLC); LHDWRKICQLTVDL-PZYDOOQISA-N



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

473 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AKT1, BDNF, CASP3, CAT, GAP43, MAPK14, MTOR, NFE2L2, NLRP3, NOS3, PIK3C3, PIK3CA, PRKAA2, TLR4, VEGFA
Peripheral membrane protein 2 GAP43, MTOR
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 HMOX1, MTOR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 11 AKT1, CASP3, HMOX1, MAPK14, MTOR, NFE2L2, NLRP3, NOS3, PPARGC1A, PRKAA2, VEGFA
autophagosome 1 PIK3C3
cytosol 13 AKT1, CASP3, CAT, HMOX1, MAPK14, MTOR, NFE2L2, NLRP3, NOS3, PIK3C3, PIK3CA, PPARGC1A, PRKAA2
dendrite 4 BDNF, GAP43, MTOR, PRKAA2
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 NFE2L2
nucleoplasm 9 AKT1, CASP3, HMOX1, MAPK14, MTOR, NFE2L2, NOS3, PPARGC1A, PRKAA2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 AKT1, GAP43, TLR4, TNF
Cytoplasmic side 3 GAP43, HMOX1, MTOR
lamellipodium 2 AKT1, PIK3CA
Cell projection, axon 1 GAP43
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 1 GAP43
cell cortex 1 AKT1
cell surface 3 TLR4, TNF, VEGFA
glutamatergic synapse 4 AKT1, CASP3, MAPK14, PIK3C3
Golgi apparatus 4 NFE2L2, NOS3, PRKAA2, VEGFA
Golgi membrane 3 MTOR, NLRP3, NOS3
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
postsynapse 1 AKT1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 NFE2L2, NLRP3
Lysosome 1 MTOR
Presynapse 1 GAP43
endosome 1 PIK3C3
plasma membrane 7 AKT1, GAP43, NFE2L2, NOS3, PIK3CA, TLR4, TNF
Membrane 10 AKT1, BDNF, CAT, HMOX1, MTOR, NLRP3, PIK3C3, PRKAA2, TLR4, VEGFA
axon 2 BDNF, PRKAA2
caveola 1 NOS3
extracellular exosome 1 CAT
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 HMOX1, NLRP3, VEGFA
extracellular space 6 BDNF, CXCL8, HMOX1, IL6, TNF, VEGFA
perinuclear region of cytoplasm 5 BDNF, HMOX1, NOS3, PIK3CA, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 CAT, MAPK14, NLRP3
protein-containing complex 2 AKT1, CAT
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 MTOR
postsynaptic density 2 CASP3, GAP43
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 5 BDNF, CXCL8, IL6, NLRP3, VEGFA
extracellular region 8 BDNF, CAT, CXCL8, IL6, MAPK14, NLRP3, TNF, VEGFA
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 2 HMOX1, MTOR
mitochondrial matrix 1 CAT
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
perikaryon 1 GAP43
microtubule cytoskeleton 1 AKT1
midbody 1 PIK3C3
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 TLR4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
focal adhesion 1 CAT
spindle 1 AKT1
GABA-ergic synapse 2 GAP43, PIK3C3
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, PIK3C3
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, PPARGC1A
PML body 2 MTOR, PPARGC1A
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
axoneme 1 PIK3C3
nuclear speck 2 MAPK14, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Cell projection, ruffle 1 TLR4
Late endosome 1 PIK3C3
ruffle 1 TLR4
receptor complex 1 TLR4
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, PPARGC1A
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
phagocytic vesicle membrane 1 PIK3C3
cytoskeleton 1 NOS3
spindle pole 1 MAPK14
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
microtubule organizing center 1 NLRP3
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cell projection, dendrite 1 GAP43
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 2 NOS3, PRKAA2
filopodium membrane 1 GAP43
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 2 BDNF, IL6
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 NOS3
presynaptic endosome 1 PIK3C3
Single-pass type IV membrane protein 1 HMOX1
[Isoform 1]: Nucleus 1 PPARGC1A
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
Cell projection, filopodium membrane 1 GAP43
postsynaptic endosome 1 PIK3C3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Autolysosome 1 PIK3C3
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
Cell projection, growth cone membrane 1 GAP43
growth cone membrane 1 GAP43
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Mei-Feng Zhang, Jing-Hui Wang, Si Sun, Yi-Tong Xu, Dong Wan, Shan Feng, Zhen Tian, Hui-Feng Zhu. Catalpol attenuates ischemic stroke by promoting neurogenesis and angiogenesis via the SDF-1α/CXCR4 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155362. doi: 10.1016/j.phymed.2024.155362. [PMID: 38522312]
  • Jingjing Yang, Lihua Zhang, Mengyue Zhang, Mingxuan Yang, Lin Zou, Ying Cui, Jing Yang, Xin Chai, Yuefei Wang. Exploration of the Dynamic Variations of the Characteristic Constituents and the Degradation Products of Catalpol during the Process of Radix Rehmanniae. Molecules (Basel, Switzerland). 2024 Feb; 29(3):. doi: 10.3390/molecules29030705. [PMID: 38338449]
  • Yuanjun Li, Xiaoru Zhai, Ligang Ma, Le Zhao, Na An, Weisheng Feng, Longyu Huang, Xiaoke Zheng. Transcriptome Analysis Provides Insights into Catalpol Biosynthesis in the Medicinal Plant Rehmannia glutinosa and the Functional Characterization of RgGES Genes. Genes. 2024 Jan; 15(2):. doi: 10.3390/genes15020155. [PMID: 38397145]
  • Yun Sun, Defen Zhu, Lu Qu, Manping Li, Wenxia Du, Mingming Wang, Yi Zhang, Guifang Chen, Gaoxiong Rao, Xiaoling Yu, Xiangnong Wu, Feng Huang, Xiaoyun Tong. Inhibitory effects of catalpol on DNCB-induced atopic dermatitis and IgE-mediated mast cells reaction. International immunopharmacology. 2024 Jan; 126(?):111274. doi: 10.1016/j.intimp.2023.111274. [PMID: 38041954]
  • Weiqing Hu, Li Zou, Ningxi Yu, Zhizhongbin Wu, Wei Yang, Tianyue Wu, Yulin Liu, Yu Pu, Yunbing Jiang, Jifeng Zhang, Huifeng Zhu, Fang Cheng, Shan Feng. Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-Κb-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice. Journal of ethnopharmacology. 2023 Nov; 319(Pt 3):117345. doi: 10.1016/j.jep.2023.117345. [PMID: 37926114]
  • Pengfei Zhou, Haihua Li, Yujin Lin, Yujun Zhou, Yinzi Chen, Yiheng Li, Xuan Li, Hui Yan, Weiming Lin, Beilu Xu, Huiting Deng, Xiaoqi Qiu. Omics analyses of Rehmannia glutinosa dedifferentiated and cambial meristematic cells reveal mechanisms of catalpol and indole alkaloid biosynthesis. BMC plant biology. 2023 Oct; 23(1):463. doi: 10.1186/s12870-023-04478-3. [PMID: 37794352]
  • Si Sun, Yitong Xu, Ningxi Yu, Meifeng Zhang, Jinghui Wang, Dong Wan, Zhen Tian, Huifeng Zhu. Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway. Molecular neurobiology. 2023 Jul; ?(?):. doi: 10.1007/s12035-023-03459-9. [PMID: 37439957]
  • Yuanfang Kong, Shuanglin Liu, Shaopei Wang, Bin Yang, Wei He, Hehe Li, Siqi Yang, Guoqing Wang, Chunhong Dong. Design, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives. Scientific reports. 2023 May; 13(1):7756. doi: 10.1038/s41598-023-33403-9. [PMID: 37173367]
  • Shengxi Meng, Huize Chen, Chunjun Deng, Zeyu Meng. Catalpol Mitigates Alzheimer's Disease Progression by Promoting the Expression of Neural Stem Cell Exosomes Released miR-138-5p. Neurotoxicity research. 2023 Feb; 41(1):41-56. doi: 10.1007/s12640-022-00626-z. [PMID: 36595161]
  • Samaneh Rahamouz-Haghighi, Khadijeh Bagheri, Ali Sharafi. In vitro elicitation and detection of apigenin, catalpol and gallic acid in hairy root culture of Plantago major L. and assessment of cytotoxicity and anti-bacterial activity of its methanolic extract. Natural product research. 2023 Feb; 37(4):633-637. doi: 10.1080/14786419.2022.2068543. [PMID: 35503010]
  • Chengkui Cai, Pengcheng Sun, Zhihui Chen, Chao Sun, Liying Tian. Catalpol protects mouse ATDC5 chondrocytes against interleukin-1β-induced catabolism. Histology and histopathology. 2022 Dec; ?(?):18575. doi: 10.14670/hh-18-575. [PMID: 36598130]
  • Yu Xia, Yun Wei Lu, Ren Juan Hao, Gu Ran Yu. Catalpol relieved angiotensin II-induced blood-brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells. Pharmaceutical biology. 2022 Dec; 60(1):2210-2218. doi: 10.1080/13880209.2022.2142801. [PMID: 36369944]
  • Jierong Liu, Jikun Du, Yuanhua Li, Fuwei Wang, Daibo Song, Jiantao Lin, Baohong Li, Li Li. Catalpol induces apoptosis in breast cancer in vitro and in vivo: Involvement of mitochondria apoptosis pathway and post-translational modifications. Toxicology and applied pharmacology. 2022 11; 454(?):116215. doi: 10.1016/j.taap.2022.116215. [PMID: 36067808]
  • Yuxin Xiao, Mengfei Tian, Qinglong Liu, Baoti Xu, Yang Peng, Chunjian Zhao, Chunying Li. A novel absorbent, HOF-3@PU: Preparation and application for sustainable and efficient purification of catalpol and ajugol from Rehmannia glutinosa leaves. Natural product research. 2022 Sep; ?(?):1-7. doi: 10.1080/14786419.2022.2119968. [PMID: 36070589]
  • Juan Zhao, Yong Tan, Zhe Feng, Yahong Zhou, Feihong Wang, Ge Zhou, Jing Yan, Xiaowei Nie. Catalpol attenuates polycystic ovarian syndrome by regulating sirtuin 1 mediated NF-κB signaling pathway. Reproductive biology. 2022 Sep; 22(3):100671. doi: 10.1016/j.repbio.2022.100671. [PMID: 35905692]
  • Yang Xie, Ling-Yun Zhong, Xiao Xue, Zhuo Wang, Jin-Ju Song, Jia-Qing Li, Qing Zhang, Yi-Bin Wang, Yan Zeng. [Optimization of processing technology of braised Rehmanniae Radix based on multiple indexes and response surface technology and correlation between components and color]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):4927-4937. doi: 10.19540/j.cnki.cjcmm.20220128.306. [PMID: 36164902]
  • Jikun Du, Jierong Liu, Xiaoman Huang, Yuanhua Li, Daibo Song, Qin Li, Jiantao Lin, Baohong Li, Li Li. Catalpol Ameliorates Neurotoxicity in N2a/APP695swe Cells and APP/PS1 Transgenic Mice. Neurotoxicity research. 2022 Aug; 40(4):961-972. doi: 10.1007/s12640-022-00524-4. [PMID: 35699892]
  • Xin Xiao, Wen-Hua Xu, Xiao-Qing Zhang, Jun-Feng Ding, Yue Jiang, Jun Tu. [Anti-oxidative and anti-apoptotic effects and molecular mechanisms of catalpol against H_2O_2-induced oxidative damage in pancreatic β cells (INS-1 cells)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Aug; 47(16):4403-4410. doi: 10.19540/j.cnki.cjcmm.20220119.402. [PMID: 36046869]
  • Hong-Jin Wang, Hai-Feng Ran, Yue Yin, Xiao-Gang Xu, Bao-Xiang Jiang, Shi-Qi Yu, Yi-Jin Chen, Hui-Jing Ren, Shan Feng, Ji-Fen Zhang, Yi Chen, Qiang Xue, Xiao-Yu Xu. Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling. Acta pharmacologica Sinica. 2022 Jul; 43(7):1670-1685. doi: 10.1038/s41401-021-00803-4. [PMID: 34795412]
  • Dan Chen, Jing Guo, Longguang Li. Catalpol promotes mitochondrial biogenesis in chondrocytes. Archives of physiology and biochemistry. 2022 Jun; 128(3):802-808. doi: 10.1080/13813455.2020.1727927. [PMID: 32096418]
  • Linluo Zhang, Changqing Li, Ling Fu, Zhichao Yu, Gengrui Xu, Jie Zhou, Meiyu Shen, Zhe Feng, Huaxu Zhu, Tong Xie, Lingling Zhou, Xueping Zhou. Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway. PeerJ. 2022; 10(?):e12759. doi: 10.7717/peerj.12759. [PMID: 35036109]
  • Yuting Huang, Hirokazu Ando, Mai Tsujino, Kazuki Yoshihara, Li Zhang, Yohei Sasaki. Study on Catalpol Content in Rehmannia glutinosa Root, an Important Ingredient in Kampo Prescriptions. Biological & pharmaceutical bulletin. 2022; 45(7):955-961. doi: 10.1248/bpb.b21-01095. [PMID: 35786603]
  • Cong Cong, Xiaohong Yuan, Ying Hu, Wenjing Chen, Yong Wang, Lei Tao. Catalpol Alleviates Ang II-Induced Renal Injury Through NF-κB Pathway and TGF-β1/Smads Pathway. Journal of cardiovascular pharmacology. 2022 01; 79(1):e116-e121. doi: 10.1097/fjc.0000000000001148. [PMID: 34654783]
  • Yuxi Di, Mingfei Zhang, Yichang Chen, Ruonan Sun, Meiyu Shen, Fengxiang Tian, Pei Yang, Feiya Qian, Lingling Zhou. Catalpol Inhibits Tregs-to-Th17 Cell Transdifferentiation by Up-Regulating Let-7g-5p to Reduce STAT3 Protein Levels. Yonsei medical journal. 2022 Jan; 63(1):56-65. doi: 10.3349/ymj.2022.63.1.56. [PMID: 34913284]
  • Lingling Song, Xiaohui Wu, Junming Wang, Yuechen Guan, Yueyue Zhang, Mingzhu Gong, Yanmei Wang, Bingyin Li. Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-κB and Nrf2. Brain research bulletin. 2021 12; 177(?):81-91. doi: 10.1016/j.brainresbull.2021.09.002. [PMID: 34500039]
  • Aimin Liu, Buxin Zhang, Wei Zhao, Yuanhui Tu, Qingxing Wang, Jing Li. Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways. Bioengineered. 2021 12; 12(1):183-195. doi: 10.1080/21655979.2020.1863015. [PMID: 33323018]
  • Sara Muhammad El-Hanboshy, Maged Wasfy Helmy, Mohammad Mahmoud Abd-Alhaseeb. Catalpol synergistically potentiates the anti-tumour effects of regorafenib against hepatocellular carcinoma via dual inhibition of PI3K/Akt/mTOR/NF-κB and VEGF/VEGFR2 signaling pathways. Molecular biology reports. 2021 Nov; 48(11):7233-7242. doi: 10.1007/s11033-021-06715-0. [PMID: 34596810]
  • Junming Wang, Rongxing Chen, Chen Liu, Xiaohui Wu, Yueyue Zhang. Antidepressant mechanism of catalpol: Involvement of the PI3K/Akt/Nrf2/HO-1 signaling pathway in rat hippocampus. European journal of pharmacology. 2021 Oct; 909(?):174396. doi: 10.1016/j.ejphar.2021.174396. [PMID: 34332921]
  • Anmei Shu, Qiu Du, Jing Chen, Yuyan Gao, Yihui Zhu, Gaohong Lv, Jinfu Lu, Yuping Chen, Huiqin Xu. Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE/RhoA/ROCK signaling pathway. Chemico-biological interactions. 2021 Oct; 348(?):109625. doi: 10.1016/j.cbi.2021.109625. [PMID: 34416245]
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