Harrisonin (BioDeep_00000006964)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Harrisonin

化学式: C27H32O10 (516.1995)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 82.26%

分子结构信息

SMILES: CC1(C(=O)C2(C(C3CCC4(C(OC(=O)C5C4(C3(C2(O1)O)C)O5)C6=COC=C6)C)(C)C=CC(=O)OC)O)C
InChI: InChI=1S/C27H32O10/c1-21(2)20(30)25(31)22(3,11-8-16(28)33-6)15-7-10-23(4)17(14-9-12-34-13-14)35-19(29)18-26(23,36-18)24(15,5)27(25,32)37-21/h8-9,11-13,15,17-18,31-32H,7,10H2,1-6H3/b11-8-/t15-,17+,18-,22-,23+,24-,25+,26-,27+/m1/s1

描述信息

同义名列表

2 个代谢物同义名

Harrisonin; Harrisonin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 BCL2, BCL2L1, BIRC5, CCND1, CDK5, CYP3A4, FES, MAPK1, RIGI, TYR
Peripheral membrane protein 1 ACHE
Endosome membrane 1 BACE1
Endoplasmic reticulum membrane 4 BCL2, CYP3A4, CYP3A5, CYP3A7
Mitochondrion membrane 1 BCL2L1
Nucleus 7 ACHE, BCL2, BIRC5, CCND1, CDK5, MAPK1, TRIM33
cytosol 9 AACS, BCL2, BCL2L1, BIRC5, CCND1, CDK5, FES, MAPK1, RIGI
dendrite 2 BACE1, CDK5
trans-Golgi network 1 BACE1
centrosome 3 BCL2L1, CCND1, MAPK1
nucleoplasm 5 BIRC5, CCND1, CDK5, MAPK1, TRIM33
Cell membrane 4 ACHE, BACE1, CDK5, TNF
Cytoplasmic side 1 BCL2L1
lamellipodium 1 CDK5
ruffle membrane 1 RIGI
Cell projection, axon 1 BACE1
Cell projection, growth cone 1 CDK5
Synapse 3 ACHE, CDK5, MAPK1
cell junction 1 CDK5
cell surface 3 ACHE, BACE1, TNF
Golgi apparatus 4 ACHE, BACE1, FES, MAPK1
growth cone 1 CDK5
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 BCL2L1
neuromuscular junction 2 ACHE, CDK5
neuronal cell body 3 BACE1, CDK5, TNF
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 2 AACS, BCL2L1
Lysosome 3 BACE1, GAA, TYR
Presynapse 1 CDK5
endosome 1 BACE1
plasma membrane 7 ACHE, BACE1, CDK5, FES, GAA, MAPK1, TNF
synaptic vesicle membrane 1 BCL2L1
Membrane 8 ACHE, BACE1, BCL2, CDK5, CYP3A4, CYP3A5, FES, GAA
axon 2 BACE1, CDK5
caveola 1 MAPK1
extracellular exosome 1 GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 3 BACE1, BCL2, BCL2L1
extracellular space 3 ACHE, IL17A, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ACHE, TYR
bicellular tight junction 2 CCND1, RIGI
mitochondrion 4 ALKBH7, BCL2, BCL2L1, MAPK1
protein-containing complex 2 BCL2, BIRC5
intracellular membrane-bounded organelle 4 CYP3A4, CYP3A5, GAA, TYR
Microsome membrane 3 CYP3A4, CYP3A5, CYP3A7
filopodium 1 CDK5
postsynaptic density 1 CDK5
protein kinase 5 complex 1 CDK5
Single-pass type I membrane protein 2 BACE1, TYR
Secreted 3 ACHE, GAA, IL17A
extracellular region 5 ACHE, GAA, IL17A, MAPK1, TNF
cytoplasmic side of plasma membrane 1 FES
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 2 BCL2, BCL2L1
hippocampal mossy fiber to CA3 synapse 1 BACE1
Mitochondrion matrix 2 ALKBH7, BCL2L1
mitochondrial matrix 2 ALKBH7, BCL2L1
Extracellular side 1 ACHE
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BCL2L1, MAPK1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CCND1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, CCND1
external side of plasma membrane 2 IL17A, TNF
multivesicular body 1 BACE1
actin cytoskeleton 1 RIGI
perikaryon 1 CDK5
cytoplasmic vesicle 1 FES
microtubule cytoskeleton 2 BIRC5, FES
Melanosome membrane 1 TYR
midbody 1 BIRC5
Early endosome 2 BACE1, MAPK1
Golgi-associated vesicle 1 TYR
recycling endosome 2 BACE1, TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 CDK5
Membrane raft 2 BACE1, TNF
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 FES
Cytoplasm, cytoskeleton, spindle 2 BIRC5, MAPK1
focal adhesion 2 FES, MAPK1
microtubule 1 BIRC5
spindle 2 BIRC5, MAPK1
basement membrane 1 ACHE
interphase microtubule organizing center 1 BIRC5
Late endosome 2 BACE1, MAPK1
neuron projection 1 CDK5
chromatin 1 TRIM33
phagocytic cup 1 TNF
mitotic spindle 1 MAPK1
Chromosome 1 BIRC5
cytoskeleton 2 FES, MAPK1
centriole 1 BIRC5
Golgi apparatus, trans-Golgi network 1 BACE1
nuclear chromosome 1 BIRC5
Lipid-anchor, GPI-anchor 1 ACHE
Endomembrane system 1 BACE1
Membrane, caveola 1 MAPK1
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
tertiary granule membrane 1 GAA
Melanosome 1 TYR
side of membrane 1 ACHE
myelin sheath 1 BCL2
pseudopodium 1 MAPK1
[Isoform 1]: Cytoplasm 1 CDK5
ficolin-1-rich granule lumen 1 MAPK1
endoplasmic reticulum lumen 2 BACE1, MAPK1
transcription repressor complex 1 CCND1
kinetochore 1 BIRC5
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MAPK1
chromosome, centromeric region 1 BIRC5
chromosome passenger complex 1 BIRC5
ribonucleoprotein complex 1 RIGI
cytoplasmic microtubule 1 BIRC5
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDK5
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
Golgi-associated vesicle lumen 1 BACE1
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • J K Rugutt, K J Rugutt, D K Berner. Limonoids from Nigerian Harrisonia abyssinica and their stimulatory activity against Striga hermonthica seeds. Journal of natural products. 2001 Nov; 64(11):1434-8. doi: 10.1021/np0100183. [PMID: 11720527]