Phytoene (BioDeep_00000638838)

Main id: BioDeep_00000003690

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(6E,10E,14E,16E,18E,22E,26E)-2,6,10,14,19,23,27,31-Octamethyldotriaconta-2,6,10,14,16,18,22,26,30-nonaene

化学式: C40H64 (544.5008)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C(/C)=C/CC/C(/C)=C/CC/C(/C)=C/CC/C(/C)=C/C=C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C
InChI: InChI=1S/C40H64/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,19-22,27-30H,13-18,23-26,31-32H2,1-10H3/b12-11+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

123 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ARR3, CD36, FDPS, GGPS1, HPD, HPGDS, NDUFAF6, NQO1, SCARB1
Peripheral membrane protein 4 HPD, HSD17B6, PLOD2, PPOX
Endoplasmic reticulum membrane 5 FDFT1, HMGCR, HPD, PLOD1, PLOD2
Nucleus 3 GABPA, NDUFAF6, NQO1
cytosol 5 FDPS, GGPS1, HPD, HPGDS, NQO1
dendrite 1 NQO1
mitochondrial membrane 1 PPOX
phagocytic vesicle 2 CD36, STX8
trans-Golgi network 1 STX8
nucleoplasm 4 FDPS, GABPA, GGPS1, HPGDS
Cell membrane 3 CD36, SCARB1, SLC6A8
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 5 CD36, FDFT1, HMGCR, SCARB1, SLC6A8
Golgi apparatus membrane 1 HPD
Synapse 3 ARR3, NQO1, PPOX
cell surface 2 CD36, SCARB1
Golgi apparatus 1 CD36
Golgi membrane 1 HPD
lysosomal membrane 1 SCARB1
mitochondrial inner membrane 2 NDUFAF6, PPOX
neuronal cell body 1 NQO1
postsynapse 1 PPOX
synaptic vesicle 1 PPOX
Cytoplasm, cytosol 1 NQO1
Lysosome 1 SCARB1
endosome 1 STX8
plasma membrane 4 CD36, SCARB1, SLC6A8, STX8
Membrane 9 CD36, FDFT1, FDPS, HMGCR, NDUFAF6, NQO1, SCARB1, SLC6A8, STX8
apical plasma membrane 2 CD36, SLC6A8
caveola 2 CD36, SCARB1
extracellular exosome 4 HPD, PLOD1, PLOD2, SCARB1
Lumenal side 2 HSD17B6, PLOD2
endoplasmic reticulum 6 FDFT1, HMGCR, HSD17B6, PLOD1, PLOD2, STX8
extracellular space 2 CD36, FBN1
perinuclear region of cytoplasm 3 GGPS1, PPOX, STX8
mitochondrion 2 NDUFAF6, PPOX
intracellular membrane-bounded organelle 4 HPGDS, HSD17B6, NDUFAF6, SCARB1
Microsome membrane 1 HSD17B6
Secreted 2 FBN1, MATN1
extracellular region 3 FBN1, MATN1, PPOX
Single-pass membrane protein 1 STX8
mitochondrial matrix 1 FDPS
photoreceptor inner segment 1 ARR3
photoreceptor outer segment 1 ARR3
external side of plasma membrane 1 CD36
Secreted, extracellular space, extracellular matrix 1 FBN1
neuronal dense core vesicle lumen 1 PPOX
Z disc 1 GGPS1
cytoplasmic vesicle 1 PPOX
Early endosome 1 STX8
recycling endosome 1 STX8
vesicle 1 STX8
Apical cell membrane 2 CD36, SLC6A8
Cytoplasm, perinuclear region 1 GGPS1
Mitochondrion inner membrane 2 NDUFAF6, PPOX
Membrane raft 1 CD36
extracellular matrix 2 FBN1, MATN1
Peroxisome 1 FDPS
basement membrane 1 FBN1
collagen trimer 1 CD36
peroxisomal membrane 1 HMGCR
mitochondrial intermembrane space 1 PPOX
collagen-containing extracellular matrix 2 FBN1, MATN1
Late endosome 1 STX8
receptor complex 1 CD36
chromatin 1 GABPA
cell periphery 1 CD36
Cell projection, cilium, photoreceptor outer segment 1 ARR3
brush border membrane 1 CD36
Endomembrane system 1 STX8
Membrane, caveola 1 SCARB1
specific granule membrane 1 CD36
Peroxisome membrane 1 HMGCR
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
SNARE complex 1 STX8
endoplasmic reticulum lumen 1 FBN1
matrilin complex 1 MATN1
endocytic vesicle membrane 2 CD36, SCARB1
rough endoplasmic reticulum membrane 2 PLOD1, PLOD2
Single-pass type IV membrane protein 1 STX8
Rough endoplasmic reticulum 2 PLOD2, PPOX
Intermembrane side 1 PPOX
platelet alpha granule membrane 1 CD36
microfibril 1 FBN1
catalytic complex 1 PLOD1
[Fibrillin-1]: Secreted, extracellular space, extracellular matrix 1 FBN1
[Asprosin]: Secreted 1 FBN1


文献列表

  • Guillermo Sobrino-Mengual, Derry Alvarez, Richard M Twyman, Christopher Gerrish, Paul D Fraser, Teresa Capell, Paul Christou. Activation of the native PHYTOENE SYNTHASE 1 promoter by modifying near-miss cis-acting elements induces carotenoid biosynthesis in embryogenic rice callus. Plant cell reports. 2024 Apr; 43(5):118. doi: 10.1007/s00299-024-03199-7. [PMID: 38632121]
  • Ariadna Iglesias-Sanchez, Juan Navarro-Carcelen, Luca Morelli, Manuel Rodriguez-Concepcion. Arabidopsis FIBRILLIN6 influences carotenoid biosynthesis by directly promoting phytoene synthase activity. Plant physiology. 2023 Nov; ?(?):. doi: 10.1093/plphys/kiad613. [PMID: 37966976]
  • Miguel Ezquerro, Esteban Burbano-Erazo, Manuel Rodriguez-Concepcion. Overlapping and specialized roles of tomato phytoene synthases in carotenoid and abscisic acid production. Plant physiology. 2023 Jul; ?(?):. doi: 10.1093/plphys/kiad425. [PMID: 37474108]
  • Pedro Brivaldo Viana da Silva, Lívia Beatriz Brenelli, Lilian Regina Barros Mariutti. Waste and by-products as sources of lycopene, phytoene, and phytofluene - Integrative review with bibliometric analysis. Food research international (Ottawa, Ont.). 2023 07; 169(?):112838. doi: 10.1016/j.foodres.2023.112838. [PMID: 37254412]
  • Ming-Hua Liang, Shan-Rong Xie, Jv-Liang Dai, Hao-Hong Chen, Jian-Guo Jiang. Roles of Two Phytoene Synthases and Orange Protein in Carotenoid Metabolism of the β-Carotene-Accumulating Dunaliella salina. Microbiology spectrum. 2023 Apr; ?(?):e0006923. doi: 10.1128/spectrum.00069-23. [PMID: 37022233]
  • Yuto Oogo, Miho Takemura, Atsushi Sakamoto, Norihiko Misawa, Hiroshi Shimada. Orange protein, phytoene synthase regulator, has protein disulfide reductase activity. Plant signaling & behavior. 2022 12; 17(1):2072094. doi: 10.1080/15592324.2022.2072094. [PMID: 35699140]
  • Labodé Hospice Naitchede, Aggrey Bernard Nyende, Steven Runo. Transcript expression level analysis of phytoene synthase and phytoene desaturase associated with β-carotene content in selected Kenyan Bitter melon. Molecular biology reports. 2022 Dec; 49(12):12029-12037. doi: 10.1007/s11033-022-08020-w. [PMID: 36273337]
  • Micaela Cerletti, Agustín Rabino, Roberto A Paggi, Celeste Ferrari, Ansgar Poetsch, Harri Savilahti, Saija Kiljunen, Rosana E De Castro. The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii. The Biochemical journal. 2022 11; 479(22):2365-2377. doi: 10.1042/bcj20220403. [PMID: 36373632]
  • Xiongjie Zheng, Jianing Mi, Aparna Balakrishna, Kit Xi Liew, Abdugaffor Ablazov, Rachid Sougrat, Salim Al-Babili. Gardenia carotenoid cleavage dioxygenase 4a is an efficient tool for biotechnological production of crocins in green and non-green plant tissues. Plant biotechnology journal. 2022 11; 20(11):2202-2216. doi: 10.1111/pbi.13901. [PMID: 35997958]
  • Katja Frede, Susanne Baldermann. Accumulation of carotenoids in Brassica rapa ssp. chinensis by a high proportion of blue in the light spectrum. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2022 Nov; 21(11):1947-1959. doi: 10.1007/s43630-022-00270-8. [PMID: 35895283]
  • Yu Zhang, Huangying Shu, Muhammad Ali Mumtaz, Yuanyuan Hao, Lin Li, Yongjie He, Weiheng Jin, Caichao Li, Yan Zhou, Xu Lu, Huizhen Fu, Zhiwei Wang. Transcriptome and Metabolome Analysis of Color Changes during Fruit Development of Pepper (Capsicum baccatum). International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012524. [PMID: 36293402]
  • Fan Li, Xiaowei Gong, Yupeng Liang, Lijuan Peng, Xiulin Han, Mengliang Wen. Characteristics of a new carotenoid cleavage dioxygenase NtCCD10 derived from Nicotiana tabacum. Planta. 2022 Oct; 256(5):100. doi: 10.1007/s00425-022-04013-y. [PMID: 36251100]
  • Xufeng Fang, Peng Gao, Feishi Luan, Shi Liu. Identification and Characterization Roles of Phytoene Synthase (PSY) Genes in Watermelon Development. Genes. 2022 07; 13(7):. doi: 10.3390/genes13071189. [PMID: 35885972]
  • Prateek Gupta, Marta Rodriguez-Franco, Reddaiah Bodanapu, Yellamaraju Sreelakshmi, Rameshwar Sharma. Phytoene synthase 2 in tomato fruits remains functional and contributes to abscisic acid formation. Plant science : an international journal of experimental plant biology. 2022 Mar; 316(?):111177. doi: 10.1016/j.plantsci.2022.111177. [PMID: 35151443]
  • Sandra Rizk, Petra Henke, Carlos Santana-Molina, Gesa Martens, Marén Gnädig, Ngoc Anh Nguyen, Damien P Devos, Meina Neumann-Schaal, James P Saenz. Functional diversity of isoprenoid lipids in Methylobacterium extorquens PA1. Molecular microbiology. 2021 10; 116(4):1064-1078. doi: 10.1111/mmi.14794. [PMID: 34387371]
  • A V Shchennikova, E A Dyachenko, G I Efremov, M A Filyushin, E Z Kochieva. Variability and Phylogeny of the Pepper Phytoene Synthase Paralogs PSY1 and PSY2 in Species of Various Capsicum Complexes. Doklady. Biochemistry and biophysics. 2020 Nov; 495(1):282-288. doi: 10.1134/s1607672920060137. [PMID: 33368035]
  • Briardo Llorente, Salvador Torres-Montilla, Luca Morelli, Igor Florez-Sarasa, José Tomás Matus, Miguel Ezquerro, Lucio D'Andrea, Fakhreddine Houhou, Eszter Majer, Belén Picó, Jaime Cebolla, Adrian Troncoso, Alisdair R Fernie, José-Antonio Daròs, Manuel Rodriguez-Concepcion. Synthetic conversion of leaf chloroplasts into carotenoid-rich plastids reveals mechanistic basis of natural chromoplast development. Proceedings of the National Academy of Sciences of the United States of America. 2020 09; 117(35):21796-21803. doi: 10.1073/pnas.2004405117. [PMID: 32817419]
  • Upasna Chettry, Nikhil K Chrungoo. A multifocal approach towards understanding the complexities of carotenoid biosynthesis and accumulation in rice grains. Briefings in functional genomics. 2020 07; 19(4):324-335. doi: 10.1093/bfgp/elaa007. [PMID: 32240289]
  • So-Jeong Jang, Hyo-Bong Jeong, Ayoung Jung, Min-Young Kang, Suna Kim, Sun-Hwa Ha, Jin-Kyung Kwon, Byoung-Cheorl Kang. Phytoene synthase 2 can compensate for the absence of PSY1 in the control of color in Capsicum fruit. Journal of experimental botany. 2020 06; 71(12):3417-3427. doi: 10.1093/jxb/eraa155. [PMID: 32219321]
  • Julian Koschmieder, Ralf Welsch. Quantification of Carotenoid Pathway Flux in Green and Nongreen Systems. Methods in molecular biology (Clifton, N.J.). 2020; 2083(?):279-291. doi: 10.1007/978-1-4939-9952-1_21. [PMID: 31745929]
  • Lulu Chen, Wenzhen Li, Yongpeng Li, Xuechao Feng, Keyu Du, Ge Wang, Lingxia Zhao. Identified trans-splicing of YELLOW-FRUITED TOMATO 2 encoding the PHYTOENE SYNTHASE 1 protein alters fruit color by map-based cloning, functional complementation and RACE. Plant molecular biology. 2019 Aug; 100(6):647-658. doi: 10.1007/s11103-019-00886-y. [PMID: 31154655]
  • Janja Kristl, Vilma Sem, Matjaž Kristl, Branko Kramberger, Mario Lešnik. Effects of integrated and organic pest management with copper and copper-free preparations on tomato (Lycopersicum esculentum Mill.) fruit yield, disease incidence and quality. Food chemistry. 2019 Apr; 278(?):342-349. doi: 10.1016/j.foodchem.2018.11.079. [PMID: 30583381]
  • Kelly Laje, Mark Seger, Barry Dungan, Peter Cooke, Juergen Polle, F Omar Holguin. Phytoene Accumulation in the Novel Microalga Chlorococcum sp. Using the Pigment Synthesis Inhibitor Fluridone. Marine drugs. 2019 Mar; 17(3):. doi: 10.3390/md17030187. [PMID: 30909380]
  • Maurizio Camagna, Alexander Grundmann, Cornelia Bär, Julian Koschmieder, Peter Beyer, Ralf Welsch. Enzyme Fusion Removes Competition for Geranylgeranyl Diphosphate in Carotenogenesis. Plant physiology. 2019 03; 179(3):1013-1027. doi: 10.1104/pp.18.01026. [PMID: 30309967]
  • Nancy E Moran, Jennifer M Thomas-Ahner, Jessica L Fleming, Joseph P McElroy, Rebecca Mehl, Elizabeth M Grainger, Ken M Riedl, Amanda E Toland, Steven J Schwartz, Steven K Clinton. Single Nucleotide Polymorphisms in β-Carotene Oxygenase 1 are Associated with Plasma Lycopene Responses to a Tomato-Soy Juice Intervention in Men with Prostate Cancer. The Journal of nutrition. 2019 03; 149(3):381-397. doi: 10.1093/jn/nxy304. [PMID: 30801647]
  • Paula Mapelli-Brahm, Charles Desmarchelier, Marielle Margier, Emmanuelle Reboul, Antonio J Meléndez Martínez, Patrick Borel. Phytoene and Phytofluene Isolated from a Tomato Extract are Readily Incorporated in Mixed Micelles and Absorbed by Caco-2 Cells, as Compared to Lycopene, and SR-BI is Involved in their Cellular Uptake. Molecular nutrition & food research. 2018 11; 62(22):e1800703. doi: 10.1002/mnfr.201800703. [PMID: 30192047]
  • David C Nieman, Courtney L Capps, Christopher R Capps, Zack L Shue, Jennifer E McBride. Effect of 4-Week Ingestion of Tomato-Based Carotenoids on Exercise-Induced Inflammation, Muscle Damage, and Oxidative Stress in Endurance Runners. International journal of sport nutrition and exercise metabolism. 2018 May; 28(3):266-273. doi: 10.1123/ijsnem.2017-0272. [PMID: 29091464]
  • Sheila McCormick. Surprise: The classic white seedling 3 mutant in maize lacks plastoquinone-9 but can still make carotenoids. The Plant journal : for cell and molecular biology. 2018 03; 93(5):797-798. doi: 10.1111/tpj.13862. [PMID: 29446173]
  • Patrick Schaub, Marta Rodriguez-Franco, Christopher Ian Cazzonelli, Daniel Álvarez, Florian Wüst, Ralf Welsch. Establishment of an Arabidopsis callus system to study the interrelations of biosynthesis, degradation and accumulation of carotenoids. PloS one. 2018; 13(2):e0192158. doi: 10.1371/journal.pone.0192158. [PMID: 29394270]
  • Paula Mapelli-Brahm, Joana Corte-Real, Antonio J Meléndez-Martínez, Torsten Bohn. Bioaccessibility of phytoene and phytofluene is superior to other carotenoids from selected fruit and vegetable juices. Food chemistry. 2017 Aug; 229(?):304-311. doi: 10.1016/j.foodchem.2017.02.074. [PMID: 28372178]
  • Anton Brausemann, Sandra Gemmecker, Julian Koschmieder, Sandro Ghisla, Peter Beyer, Oliver Einsle. Structure of Phytoene Desaturase Provides Insights into Herbicide Binding and Reaction Mechanisms Involved in Carotene Desaturation. Structure (London, England : 1993). 2017 08; 25(8):1222-1232.e3. doi: 10.1016/j.str.2017.06.002. [PMID: 28669634]
  • Shota Kato, Mika Soshino, Shinichi Takaichi, Takahiro Ishikawa, Noriko Nagata, Masashi Asahina, Tomoko Shinomura. Suppression of the phytoene synthase gene (EgcrtB) alters carotenoid content and intracellular structure of Euglena gracilis. BMC plant biology. 2017 07; 17(1):125. doi: 10.1186/s12870-017-1066-7. [PMID: 28716091]
  • Julian Koschmieder, Mirjam Fehling-Kaschek, Patrick Schaub, Sandro Ghisla, Anton Brausemann, Jens Timmer, Peter Beyer. Plant-type phytoene desaturase: Functional evaluation of structural implications. PloS one. 2017; 12(11):e0187628. doi: 10.1371/journal.pone.0187628. [PMID: 29176862]
  • Chureeporn Chitchumroonchokchai, Gianfranco Diretto, Bruno Parisi, Giovanni Giuliano, Mark L Failla. Potential of golden potatoes to improve vitamin A and vitamin E status in developing countries. PloS one. 2017; 12(11):e0187102. doi: 10.1371/journal.pone.0187102. [PMID: 29117188]
  • Noam Chayut, Hui Yuan, Shachar Ohali, Ayala Meir, Uzi Sa'ar, Galil Tzuri, Yi Zheng, Michael Mazourek, Shimon Gepstein, Xiangjun Zhou, Vitaly Portnoy, Efraim Lewinsohn, Arthur A Schaffer, Nurit Katzir, Zhangjun Fei, Ralf Welsch, Li Li, Joseph Burger, Yaakov Tadmor. Distinct Mechanisms of the ORANGE Protein in Controlling Carotenoid Flux. Plant physiology. 2017 01; 173(1):376-389. doi: 10.1104/pp.16.01256. [PMID: 27837090]
  • Sekhar Kambakam, Ujjal Bhattacharjee, Jacob Petrich, Steve Rodermel. PTOX Mediates Novel Pathways of Electron Transport in Etioplasts of Arabidopsis. Molecular plant. 2016 09; 9(9):1240-1259. doi: 10.1016/j.molp.2016.06.008. [PMID: 27353362]
  • Nancy E Moran, Janet A Novotny, Morgan J Cichon, Kenneth M Riedl, Randy B Rogers, Elizabeth M Grainger, Steven J Schwartz, John W Erdman, Steven K Clinton. Absorption and Distribution Kinetics of the 13C-Labeled Tomato Carotenoid Phytoene in Healthy Adults. The Journal of nutrition. 2016 Feb; 146(2):368-76. doi: 10.3945/jn.115.220525. [PMID: 26674763]
  • Shota Kato, Shinichi Takaichi, Takahiro Ishikawa, Masashi Asahina, Senji Takahashi, Tomoko Shinomura. Identification and functional analysis of the geranylgeranyl pyrophosphate synthase gene (crtE) and phytoene synthase gene (crtB) for carotenoid biosynthesis in Euglena gracilis. BMC plant biology. 2016 Jan; 16(?):4. doi: 10.1186/s12870-015-0698-8. [PMID: 26733341]
  • Kira Lätari, Florian Wüst, Michaela Hübner, Patrick Schaub, Kim Gabriele Beisel, Shizue Matsubara, Peter Beyer, Ralf Welsch. Tissue-Specific Apocarotenoid Glycosylation Contributes to Carotenoid Homeostasis in Arabidopsis Leaves. Plant physiology. 2015 Aug; 168(4):1550-62. doi: 10.1104/pp.15.00243. [PMID: 26134165]
  • Micaela Cerletti, Roberto A Paggi, Carina Ramallo Guevara, Ansgar Poetsch, Rosana E De Castro. Global role of the membrane protease LonB in Archaea: Potential protease targets revealed by quantitative proteome analysis of a lonB mutant in Haloferax volcanii. Journal of proteomics. 2015 May; 121(?):1-14. doi: 10.1016/j.jprot.2015.03.016. [PMID: 25829260]
  • Jessica L Cooperstone, Robin A Ralston, Ken M Riedl, Thomas C Haufe, Ralf M Schweiggert, Samantha A King, Cynthia D Timmers, David M Francis, Gregory B Lesinski, Steven K Clinton, Steven J Schwartz. Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. Molecular nutrition & food research. 2015 Apr; 59(4):658-69. doi: 10.1002/mnfr.201400658. [PMID: 25620547]
  • Cuihua Liu, Fuhua Yan, Huijun Gao, Min He, Zhuang Wang, Yunjiang Cheng, Xiuxin Deng, Juan Xu. Features of citrus terpenoid production as revealed by carotenoid, limonoid and aroma profiles of two pummelos (Citrus maxima) with different flesh color. Journal of the science of food and agriculture. 2015 Jan; 95(1):111-9. doi: 10.1002/jsfa.6689. [PMID: 24723118]
  • Antonio J Meléndez-Martínez, Margot Paulino, Carla M Stinco, Paula Mapelli-Brahm, Xiang-Dong Wang. Study of the time-course of cis/trans (Z/E) isomerization of lycopene, phytoene, and phytofluene from tomato. Journal of agricultural and food chemistry. 2014 Dec; 62(51):12399-406. doi: 10.1021/jf5041965. [PMID: 25426993]
  • Yongliang Liu, Shaohua Zeng, Wei Sun, Min Wu, Weiming Hu, Xiaofei Shen, Ying Wang. Comparative analysis of carotenoid accumulation in two goji (Lycium barbarum L. and L. ruthenicum Murr.) fruits. BMC plant biology. 2014 Dec; 14(?):269. doi: 10.1186/s12870-014-0269-4. [PMID: 25511605]
  • Zoran Jeknić, Stevan Jeknić, Slađana Jevremović, Angelina Subotić, Tony H H Chen. Alteration of flower color in Iris germanica L. 'Fire Bride' through ectopic expression of phytoene synthase gene (crtB) from Pantoea agglomerans. Plant cell reports. 2014 Aug; 33(8):1307-21. doi: 10.1007/s00299-014-1617-4. [PMID: 24801678]
  • Muluneh Tamiru, Akira Abe, Hiroe Utsushi, Kakoto Yoshida, Hiroki Takagi, Koki Fujisaki, Jerwin R Undan, Sujay Rakshit, Shinichi Takaichi, Yusuke Jikumaru, Takao Yokota, Matthew J Terry, Ryohei Terauchi. The tillering phenotype of the rice plastid terminal oxidase (PTOX) loss-of-function mutant is associated with strigolactone deficiency. The New phytologist. 2014 Apr; 202(1):116-131. doi: 10.1111/nph.12630. [PMID: 24350905]
  • M Águila Ruiz-Sola, Antía Rodríguez-Villalón, Manuel Rodríguez-Concepción. Light-sensitive Phytochrome-Interacting Factors (PIFs) are not required to regulate phytoene synthase gene expression in the root. Plant signaling & behavior. 2014; 9(8):e29248. doi: 10.4161/psb.29248. [PMID: 25763615]
  • Ada López-Emparán, Daniela Quezada-Martinez, Matías Zúñiga-Bustos, Víctor Cifuentes, Federico Iñiguez-Luy, María Laura Federico. Functional analysis of the Brassica napus L. phytoene synthase (PSY) gene family. PloS one. 2014; 9(12):e114878. doi: 10.1371/journal.pone.0114878. [PMID: 25506829]
  • Nancy Engelmann Moran, Steven K Clinton, John W Erdman. Differential bioavailability, clearance, and tissue distribution of the acyclic tomato carotenoids lycopene and phytoene in mongolian gerbils. The Journal of nutrition. 2013 Dec; 143(12):1920-6. doi: 10.3945/jn.113.181461. [PMID: 24108134]
  • Elio Fantini, Giulia Falcone, Sarah Frusciante, Leonardo Giliberto, Giovanni Giuliano. Dissection of tomato lycopene biosynthesis through virus-induced gene silencing. Plant physiology. 2013 Oct; 163(2):986-98. doi: 10.1104/pp.113.224733. [PMID: 24014574]
  • Thomas T Y Wang, Alison J Edwards, Beverly A Clevidence. Strong and weak plasma response to dietary carotenoids identified by cluster analysis and linked to beta-carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms. The Journal of nutritional biochemistry. 2013 Aug; 24(8):1538-46. doi: 10.1016/j.jnutbio.2013.01.001. [PMID: 23517913]
  • Lauren E Conlon, Ryan D King, Nancy E Moran, John W Erdman. Coconut oil enhances tomato carotenoid tissue accumulation compared to safflower oil in the Mongolian gerbil ( Meriones unguiculatus ). Journal of agricultural and food chemistry. 2012 Aug; 60(34):8386-94. doi: 10.1021/jf301902k. [PMID: 22866697]
  • B Y Hsu, Y S Pu, B Stephen Inbaraj, B H Chen. An improved high performance liquid chromatography-diode array detection-mass spectrometry method for determination of carotenoids and their precursors phytoene and phytofluene in human serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jun; 899(?):36-45. doi: 10.1016/j.jchromb.2012.04.034. [PMID: 22622065]
  • Phoi T Tran, Marina N Sharifi, Subhajit Poddar, Rachel M Dent, Krishna K Niyogi. Intragenic enhancers and suppressors of phytoene desaturase mutations in Chlamydomonas reinhardtii. PloS one. 2012; 7(8):e42196. doi: 10.1371/journal.pone.0042196. [PMID: 22912689]
  • Kim Gabriele Beisel, Ulrich Schurr, Shizue Matsubara. Altered turnover of β-carotene and Chl a in Arabidopsis leaves treated with lincomycin or norflurazon. Plant & cell physiology. 2011 Jul; 52(7):1193-203. doi: 10.1093/pcp/pcr069. [PMID: 21632655]
  • Xiangjun Zhou, Ryan McQuinn, Zhangjun Fei, Anne-Marie A Wolters, Joyce VAN Eck, Charles Brown, James J Giovannoni, L I Li. Regulatory control of high levels of carotenoid accumulation in potato tubers. Plant, cell & environment. 2011 Jun; 34(6):1020-1030. doi: 10.1111/j.1365-3040.2011.02301.x. [PMID: 21388418]
  • Nancy J Engelmann, Steven K Clinton, John W Erdman. Nutritional aspects of phytoene and phytofluene, carotenoid precursors to lycopene. Advances in nutrition (Bethesda, Md.). 2011 Jan; 2(1):51-61. doi: 10.3945/an.110.000075. [PMID: 22211189]
  • Ayhan Dogukan, Mehmet Tuzcu, Can Ali Agca, Hasan Gencoglu, Nurhan Sahin, Muhittin Onderci, Ibrahim Hanifi Ozercan, Necip Ilhan, Omer Kucuk, Kazim Sahin. A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression. Nutrition and cancer. 2011; 63(3):427-34. doi: 10.1080/01635581.2011.535958. [PMID: 21391123]
  • Jiancheng Zhang, Nengguo Tao, Qiang Xu, Wenjing Zhou, Hongbo Cao, Juan Xu, Xiuxin Deng. Functional characterization of Citrus PSY gene in Hongkong kumquat (Fortunella hindsii Swingle). Plant cell reports. 2009 Nov; 28(11):1737-46. doi: 10.1007/s00299-009-0774-3. [PMID: 19813015]
  • Aviv Shaish, Ayelet Harari, Yehuda Kamari, Etienne Soudant, Dror Harats, Ami Ben-Amotz. A carotenoid algal preparation containing phytoene and phytofluene inhibited LDL oxidation in vitro. Plant foods for human nutrition (Dordrecht, Netherlands). 2008 Jun; 63(2):83-6. doi: 10.1007/s11130-008-0075-y. [PMID: 18443908]
  • Peter Lorenz, Melanie Berger, Julia Bertrams, Kristian Wende, Kristin Wenzel, Ulrike Lindequist, Ulrich Meyer, Florian C Stintzing. Natural wax constituents of a supercritical fluid CO(2) extract from quince (Cydonia oblonga Mill.) pomace. Analytical and bioanalytical chemistry. 2008 May; 391(2):633-46. doi: 10.1007/s00216-008-2000-5. [PMID: 18418588]
  • Paul D Fraser, Eugenia M A Enfissi, John M Halket, Mark R Truesdale, Dongmei Yu, Christopher Gerrish, Peter M Bramley. Manipulation of phytoene levels in tomato fruit: effects on isoprenoids, plastids, and intermediary metabolism. The Plant cell. 2007 Oct; 19(10):3194-211. doi: 10.1105/tpc.106.049817. [PMID: 17933904]
  • Jens Steinbrenner, Gerhard Sandmann. Transformation of the green alga Haematococcus pluvialis with a phytoene desaturase for accelerated astaxanthin biosynthesis. Applied and environmental microbiology. 2006 Dec; 72(12):7477-84. doi: 10.1128/aem.01461-06. [PMID: 17012596]
  • Silvia Travella, Theres E Klimm, Beat Keller. RNA interference-based gene silencing as an efficient tool for functional genomics in hexaploid bread wheat. Plant physiology. 2006 Sep; 142(1):6-20. doi: 10.1104/pp.106.084517. [PMID: 16861570]
  • Lutz Schäfer, Manuela Sandmann, Sonja Woitsch, Gerhard Sandmann. Coordinate up-regulation of carotenoid biosynthesis as a response to light stress in Synechococcus PCC7942. Plant, cell & environment. 2006 Jul; 29(7):1349-56. doi: 10.1111/j.1365-3040.2006.01515.x. [PMID: 17080956]
  • Li Li, Shan Lu, Kelly M Cosman, Elizabeth D Earle, David F Garvin, Jennifer O'Neill. beta-Carotene accumulation induced by the cauliflower Or gene is not due to an increased capacity of biosynthesis. Phytochemistry. 2006 Jun; 67(12):1177-84. doi: 10.1016/j.phytochem.2006.05.013. [PMID: 16790254]
  • Da-Qi Fu, Ben-Zhong Zhu, Hong-Liang Zhu, Hong-Xing Zhang, Yuan-Hong Xie, Wei-Bo Jiang, Xiao-Dan Zhao, Kun-Bo Luo. Enhancement of virus-induced gene silencing in tomato by low temperature and low humidity. Molecules and cells. 2006 Feb; 21(1):153-60. doi: . [PMID: 16511359]
  • Jessica K Campbell, Randy B Rogers, Mary Ann Lila, John W Erdman. Biosynthesis of 14C-phytoene from tomato cell suspension cultures (Lycopersicon esculentum) for utilization in prostate cancer cell culture studies. Journal of agricultural and food chemistry. 2006 Feb; 54(3):747-55. doi: 10.1021/jf0581269. [PMID: 16448178]
  • Patrizia Riso, Antonella Brusamolino, Antonia Martinetti, Marisa Porrini. Effect of a tomato drink intervention on insulin-like growth factor (IGF)-1 serum levels in healthy subjects. Nutrition and cancer. 2006; 55(2):157-62. doi: 10.1207/s15327914nc5502_6. [PMID: 17044770]
  • Thomas C Koch, Irwin L Goldman. Relationship of carotenoids and tocopherols in a sample of carrot root-color accessions and carrot germplasm carrying Rp and rp alleles. Journal of agricultural and food chemistry. 2005 Jan; 53(2):325-31. doi: 10.1021/jf048272z. [PMID: 15656668]
  • Olivier Aust, Wilhelm Stahl, Helmut Sies, Hagen Tronnier, Ulrike Heinrich. Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2005 Jan; 75(1):54-60. doi: 10.1024/0300-9831.75.1.54. [PMID: 15830922]
  • Niels-Ulrik Frigaard, Julia A Maresca, Colleen E Yunker, A Daniel Jones, Donald A Bryant. Genetic manipulation of carotenoid biosynthesis in the green sulfur bacterium Chlorobium tepidum. Journal of bacteriology. 2004 Aug; 186(16):5210-20. doi: 10.1128/jb.186.16.5210-5220.2004. [PMID: 15292122]
  • Paul D Fraser, Peter M Bramley. The biosynthesis and nutritional uses of carotenoids. Progress in lipid research. 2004 May; 43(3):228-65. doi: 10.1016/j.plipres.2003.10.002. [PMID: 15003396]
  • Thomas Fester, Diana Schmidt, Swanhild Lohse, Michael H Walter, Giovanni Giuliano, Peter M Bramley, Paul D Fraser, Bettina Hause, Dieter Strack. Stimulation of carotenoid metabolism in arbuscular mycorrhizal roots. Planta. 2002 Nov; 216(1):148-54. doi: 10.1007/s00425-002-0917-z. [PMID: 12430024]
  • V G Ladygin. [Current state of carotenoid biosynthesis in chloroplasts of eucaryotes]. Zhurnal obshchei biologii. 2002 Jul; 63(4):299-325. doi: . [PMID: 12298179]
  • Steve Holzberg, Paul Brosio, Cynthia Gross, Gregory P Pogue. Barley stripe mosaic virus-induced gene silencing in a monocot plant. The Plant journal : for cell and molecular biology. 2002 May; 30(3):315-27. doi: 10.1046/j.1365-313x.2002.01291.x. [PMID: 12000679]
  • Hyoungshin Park, Sarah S Kreunen, Abby J Cuttriss, Dean DellaPenna, Barry J Pogson. Identification of the carotenoid isomerase provides insight into carotenoid biosynthesis, prolamellar body formation, and photomorphogenesis. The Plant cell. 2002 Feb; 14(2):321-32. doi: 10.1105/tpc.010302. [PMID: 11884677]
  • Nancy A Eckardt. Tangerine dreams: cloning of carotenoid isomerase from Arabidopsis and tomato. The Plant cell. 2002 Feb; 14(2):289-92. doi: 10.1105/tpc.140210. [PMID: 11884674]
  • P D Fraser, P Bramley, G B Seymour. Effect of the Cnr mutation on carotenoid formation during tomato fruit ripening. Phytochemistry. 2001 Sep; 58(1):75-9. doi: 10.1016/s0031-9422(01)00175-3. [PMID: 11524116]
  • H Ogawa, I Yamada, K Arai, K Hirase, K Moriyasu, C Schneider, G Sandmann, P Böger, K Wakabayashi. Mode of bleaching phytotoxicity of herbicidal diphenylpyrrolidinones. Pest management science. 2001 Jan; 57(1):33-40. doi: 10.1002/1526-4998(200101)57:1<33::aid-ps243>3.0.co;2-h. [PMID: 11455630]
  • E T Wurtzel, R B Luo, O Yatou. A simple approach to identify the first rice mutants blocked in carotenoid biosynthesis. Journal of experimental botany. 2001 Jan; 52(354):161-6. doi: 10.1093/jexbot/52.354.161. [PMID: 11181725]
  • I Neuman, H Nahum, A Ben-Amotz. Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy. 2000 Dec; 55(12):1184-9. doi: 10.1034/j.1398-9995.2000.00748.x. [PMID: 11117277]
  • P D Fraser, J W Kiano, M R Truesdale, W Schuch, P M Bramley. Phytoene synthase-2 enzyme activity in tomato does not contribute to carotenoid synthesis in ripening fruit. Plant molecular biology. 1999 Jul; 40(4):687-98. doi: 10.1023/a:1006256302570. [PMID: 10480392]
  • P Carol, D Stevenson, C Bisanz, J Breitenbach, G Sandmann, R Mache, G Coupland, M Kuntz. Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation. The Plant cell. 1999 Jan; 11(1):57-68. doi: 10.1105/tpc.11.1.57. [PMID: 9878632]
  • W E Hable, K K Oishi, K S Schumaker. Viviparous-5 encodes phytoene desaturase, an enzyme essential for abscisic acid (ABA) accumulation and seed development in maize. Molecular & general genetics : MGG. 1998 Jan; 257(2):167-76. doi: 10.1007/s004380050636. [PMID: 9491075]
  • H Nishino. [Bio-chemoprevention of cancer]. Gan to kagaku ryoho. Cancer & chemotherapy. 1997 Jul; 24(9):1047-52. doi: . [PMID: 9239155]
  • S Kajiwara, P D Fraser, K Kondo, N Misawa. Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli. The Biochemical journal. 1997 Jun; 324 ( Pt 2)(?):421-6. doi: 10.1042/bj3240421. [PMID: 9182699]
  • P K Burkhardt, P Beyer, J Wünn, A Klöti, G A Armstrong, M Schledz, J von Lintig, I Potrykus. Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis. The Plant journal : for cell and molecular biology. 1997 May; 11(5):1071-8. doi: 10.1046/j.1365-313x.1997.11051071.x. [PMID: 9193076]
  • G A Armstrong, J E Hearst. Carotenoids 2: Genetics and molecular biology of carotenoid pigment biosynthesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1996 Feb; 10(2):228-37. doi: 10.1096/fasebj.10.2.8641556. [PMID: 8641556]
  • S R Norris, T R Barrette, D DellaPenna. Genetic dissection of carotenoid synthesis in arabidopsis defines plastoquinone as an essential component of phytoene desaturation. The Plant cell. 1995 Dec; 7(12):2139-49. doi: 10.1105/tpc.7.12.2139. [PMID: 8718624]
  • N Misawa, S Yamano, H Linden, M R de Felipe, M Lucas, H Ikenaga, G Sandmann. Functional expression of the Erwinia uredovora carotenoid biosynthesis gene crtl in transgenic plants showing an increase of beta-carotene biosynthesis activity and resistance to the bleaching herbicide norflurazon. The Plant journal : for cell and molecular biology. 1993 Nov; 4(5):833-40. doi: 10.1046/j.1365-313x.1993.04050833.x. [PMID: 8275101]
  • I Pecker, D Chamovitz, H Linden, G Sandmann, J Hirschberg. A single polypeptide catalyzing the conversion of phytoene to zeta-carotene is transcriptionally regulated during tomato fruit ripening. Proceedings of the National Academy of Sciences of the United States of America. 1992 Jun; 89(11):4962-6. doi: 10.1073/pnas.89.11.4962. [PMID: 1594600]
  • J Ray, P Moureau, C Bird, A Bird, D Grierson, M Maunders, M Truesdale, P Bramley, W Schuch. Cloning and characterization of a gene involved in phytoene synthesis from tomato. Plant molecular biology. 1992 Jun; 19(3):401-4. doi: 10.1007/bf00023387. [PMID: 1623189]
  • D A BEELER, J W PORTER. The enzymatic conversion of phytoene to phytofluene. Biochemical and biophysical research communications. 1962 Aug; 8(?):367-71. doi: 10.1016/0006-291x(62)90009-8. [PMID: 13866515]
  • D G ANDERSON, J W PORTER. The biosynthesis of phytoene and other carotenes by enzymes of isolated higher plant plastids. Archives of biochemistry and biophysics. 1962 Jun; 97(?):509-19. doi: 10.1016/0003-9861(62)90115-7. [PMID: 13861207]
  • G SUZUE. Separation of a phytoene-accumulating mutant of Staphylococcus. Archives of biochemistry and biophysics. 1960 May; 88(?):180-1. doi: 10.1016/0003-9861(60)90217-4. [PMID: 13835866]
  • W J RABOURN, F W QUACKENBUSH. The occurrence of phytoene in various plant materials. Archives of biochemistry and biophysics. 1953 May; 44(1):159-64. doi: 10.1016/0003-9861(53)90019-8. [PMID: 13058364]
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