Aerobactin (BioDeep_00000005864)

 

Secondary id: BioDeep_00001869178

human metabolite Endogenous


代谢物信息卡片


(2S)-2-[3-carboxy-3-({[(1S)-1-carboxy-5-(N-hydroxyacetamido)pentyl]carbamoyl}methyl)-3-hydroxypropanamido]-6-(N-hydroxyacetamido)hexanoic acid

化学式: C22H36N4O13 (564.2279)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(otcml) 16.82%

分子结构信息

SMILES: CC(=O)N(CCCCC(C(=O)O)NC(=O)CC(CC(=O)NC(CCCCN(C(=O)C)O)C(=O)O)(C(=O)O)O)O
InChI: InChI=1S/C22H36N4O13/c1-13(27)25(38)9-5-3-7-15(19(31)32)23-17(29)11-22(37,21(35)36)12-18(30)24-16(20(33)34)8-4-6-10-26(39)14(2)28/h15-16,37-39H,3-12H2,1-2H3,(H,23,29)(H,24,30)(H,31,32)(H,33,34)(H,35,36)/t15-,16-/m0/s1

描述信息

Aerobactin is a virulence factor for enteric bacteria found occasionally in humans, and is produced by bacteria such as Enterobacter cloacae. E. cloacae is part of the normal intestinal floras of many individuals and not a primary human pathogen but has been considered to be an important cause of nosocomial infections. Aerobactin secretion in vivo could be an important step in the stages of the infection cycle during which intestine-populating opportunistic bacteria effectively colonize the gut, penetrate the mucous layer covering the intestinal villi, translocate out of intestinal lumen through the epithelial cells, and finally spread to organs within which they may survive. (PMID: 9453621, 8752377) [HMDB]
Aerobactin is a virulence factor for enteric bacteria found occasionally in humans, and is produced by bacteria such as Enterobacter cloacae. E. cloacae is part of the normal intestinal floras of many individuals and not a primary human pathogen but has been considered to be an important cause of nosocomial infections. Aerobactin secretion in vivo could be an important step in the stages of the infection cycle during which intestine-populating opportunistic bacteria effectively colonize the gut, penetrate the mucous layer covering the intestinal villi, translocate out of intestinal lumen through the epithelial cells, and finally spread to organs within which they may survive. (PMID: 9453621, 8752377).
D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents

同义名列表

6 个代谢物同义名

(2S)-2-[3-carboxy-3-({[(1S)-1-carboxy-5-(N-hydroxyacetamido)pentyl]carbamoyl}methyl)-3-hydroxypropanamido]-6-(N-hydroxyacetamido)hexanoic acid; (8S,16S)-3,12,21-Trihydroxy-2,10,14,22-tetraoxo-3,9,15,21-tetraazatricosane-8,12,16-tricarboxylic acid; (8S,16S)-3,12,21-Trihydroxy-2,10,14,22-tetraoxo-3,9,15,21-tetraazatricosane-8,12,16-tricarboxylate; SCHEMBL17480163; Aerobactin; Aerobactin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ACO1, IREB2, WNT2
Peripheral membrane protein 2 ATP6V1D, CYP27A1
Endosome membrane 2 ATP6V1D, TF
Mitochondrion membrane 1 CYP27A1
Nucleus 1 CHD7
cytosol 4 ACO1, ATP6V1D, IREB2, STX1A
dendrite 1 PCDH8
centrosome 1 ATP6V1D
nucleoplasm 2 ATP6V1D, CHD7
Cell membrane 5 CD79A, NPHS1, PCDH8, RECK, STX1A
Cytoplasmic side 1 ATP6V1D
lamellipodium 1 STX2
cell surface 1 TF
glutamatergic synapse 2 C1QL3, PCDH8
Golgi apparatus 1 ACO1
Golgi membrane 1 ATP6V1D
lysosomal membrane 1 ATP6V1D
mitochondrial inner membrane 1 CYP27A1
presynaptic membrane 1 PCDH8
synaptic vesicle 2 STX1A, STX2
Cytoplasm, cytosol 1 ACO1
plasma membrane 10 ATP6V1D, CD79A, NPHS1, PCDH8, RECK, SERPINE1, ST14, STX1A, STX2, TF
synaptic vesicle membrane 1 STX1A
Membrane 4 ATP6V1D, RECK, ST14, STX2
apical plasma membrane 1 TF
axon 1 STX1A
basolateral plasma membrane 2 ST14, STX2
extracellular exosome 8 ACO1, ATP6V1D, HP, LCN2, NPHS1, SERPINE1, SPINK1, TF
endoplasmic reticulum 1 ACO1
extracellular space 8 HP, IL24, LCN2, SERPINE1, ST14, STX2, TF, WNT2
perinuclear region of cytoplasm 1 TF
Schaffer collateral - CA1 synapse 1 PCDH8
mitochondrion 3 ACO1, CYP27A1, IREB2
protein-containing complex 1 STX2
intracellular membrane-bounded organelle 1 STX2
Single-pass type I membrane protein 3 CD79A, NPHS1, PCDH8
Secreted 8 C1QL3, HP, IL24, LCN2, SERPINE1, SPINK1, TF, WNT2
extracellular region 8 HP, IL24, LCN2, RECK, SERPINE1, STX1A, TF, WNT2
basal part of cell 1 TF
hippocampal mossy fiber to CA3 synapse 1 C1QL3
[Isoform 2]: Secreted 1 STX1A
mitochondrial matrix 1 CYP27A1
Cytoplasmic vesicle lumen 1 LCN2
Cell projection, cilium 1 ATP6V1D
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ATP6V1D
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 STX1A
nuclear membrane 1 STX1A
external side of plasma membrane 2 CD79A, ST14
Secreted, extracellular space, extracellular matrix 1 WNT2
multivesicular body 1 CD79A
slit diaphragm 1 NPHS1
cytoplasmic vesicle 1 TF
nucleolus 1 CHD7
Wnt signalosome 2 RECK, WNT2
Cytoplasmic vesicle, clathrin-coated vesicle membrane 1 ATP6V1D
clathrin-coated vesicle membrane 1 ATP6V1D
Early endosome 1 TF
cell-cell junction 1 NPHS1
clathrin-coated pit 1 TF
recycling endosome 1 TF
Single-pass type II membrane protein 1 ST14
vesicle 1 TF
postsynaptic membrane 1 PCDH8
presynaptic active zone membrane 2 STX1A, STX2
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 CD79A
focal adhesion 1 NPHS1
collagen trimer 1 C1QL3
collagen-containing extracellular matrix 2 SERPINE1, WNT2
Late endosome 1 TF
neuron projection 1 STX1A
cilium 1 ATP6V1D
chromatin 1 CHD7
cell projection 1 NPHS1
blood microparticle 2 HP, TF
Lipid-anchor, GPI-anchor 1 RECK
Endomembrane system 2 STX1A, STX2
Cell projection, dendrite 1 PCDH8
specific granule membrane 1 ATP6V1D
side of membrane 1 RECK
basal plasma membrane 1 TF
SNARE complex 2 STX1A, STX2
secretory granule lumen 1 TF
HFE-transferrin receptor complex 1 TF
endoplasmic reticulum lumen 1 TF
platelet alpha granule lumen 1 SERPINE1
specific granule lumen 2 HP, LCN2
tertiary granule lumen 1 HP
endocytic vesicle 1 TF
extrinsic component of synaptic vesicle membrane 1 ATP6V1D
Single-pass type IV membrane protein 1 STX1A
clathrin-coated endocytic vesicle membrane 1 TF
[Isoform 1]: Nucleus 1 CHD7
Synapse, synaptosome 1 STX1A
synaptic cleft 1 C1QL3
serine protease inhibitor complex 1 SERPINE1
vacuolar proton-transporting V-type ATPase, V1 domain 1 ATP6V1D
proton-transporting V-type ATPase complex 1 ATP6V1D
vesicle coat 1 TF
endocytic vesicle lumen 1 HP
haptoglobin-hemoglobin complex 1 HP
peptidase inhibitor complex 1 SERPINE1
IgM B cell receptor complex 1 CD79A
B cell receptor complex 1 CD79A
synaptobrevin 2-SNAP-25-syntaxin-1a complex 1 STX1A
dense body 1 TF
Cytoplasmic granule lumen 1 LCN2
[Isoform 3]: Nucleus, nucleolus 1 CHD7


文献列表

  • Okhee Choi, Jaeyeong Cho, Byeongsam Kang, Yeyeong Lee, Jinwoo Kim. Negatively Regulated Aerobactin and Desferrioxamine E by Fur in Pantoea ananatis Are Required for Full Siderophore Production and Antibacterial Activity, but Not for Virulence. Applied and environmental microbiology. 2022 03; 88(6):e0240521. doi: 10.1128/aem.02405-21. [PMID: 35108090]
  • Dan-Dan Wei, Xiao-Shun Xiong, Yan-Fang Mei, Fang-Ling Du, La-Gen Wan, Yang Liu. Microbiological and Clinical Characteristics of Klebsiella pneumoniae Isolates of K57 Capsular Serotype in China. Microbial drug resistance (Larchmont, N.Y.). 2021 Mar; 27(3):391-400. doi: 10.1089/mdr.2018.0456. [PMID: 32762612]
  • Mathieu Genuini, Philippe Bidet, Jean-François Benoist, Dimitri Schlemmer, Chloé Lemaitre, André Birgy, Stéphane Bonacorsi. ShiF acts as an auxiliary factor of aerobactin secretion in meningitis Escherichia coli strain S88. BMC microbiology. 2019 12; 19(1):298. doi: 10.1186/s12866-019-1677-2. [PMID: 31847813]
  • Guili Li, Shuhong Sun, Zhong Yuan Zhao, Yunfang Sun. The pathogenicity of rmpA or aerobactin-positive Klebsiella pneumoniae in infected mice. The Journal of international medical research. 2019 Sep; 47(9):4344-4352. doi: 10.1177/0300060519863544. [PMID: 31328596]
  • Zhou Liu, Yi Gu, Xin Li, Yanyan Liu, Ying Ye, Shihe Guan, Jiabin Li. Identification and Characterization of NDM-1-producing Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae in China. Annals of laboratory medicine. 2019 Mar; 39(2):167-175. doi: 10.3343/alm.2019.39.2.167. [PMID: 30430779]
  • Thomas A Russo, Ruth Olson, Ulrike MacDonald, Janet Beanan, Bruce A Davidson. Aerobactin, but not yersiniabactin, salmochelin, or enterobactin, enables the growth/survival of hypervirulent (hypermucoviscous) Klebsiella pneumoniae ex vivo and in vivo. Infection and immunity. 2015 Aug; 83(8):3325-33. doi: 10.1128/iai.00430-15. [PMID: 26056379]
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  • Jielu Ling, Haizhu Pan, Qingqing Gao, Liping Xiong, Yefei Zhou, Debao Zhang, Song Gao, Xiufan Liu. Aerobactin synthesis genes iucA and iucC contribute to the pathogenicity of avian pathogenic Escherichia coli O2 strain E058. PloS one. 2013; 8(2):e57794. doi: 10.1371/journal.pone.0057794. [PMID: 23460907]
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