Tyrosol (BioDeep_00000000441)

 

Secondary id: BioDeep_00000861852, BioDeep_00000871956

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019 natural product


代谢物信息卡片


4-hydroxy-Benzeneethanol;4-Hydroxyphenylethanol;beta-(4-Hydroxyphenyl)ethanol

化学式: C8H10O2 (138.0681)
中文名称: 对羟基苯乙醇, 酪醇, 2-（4-羟基苯基）乙酸乙酯, 2-(4-羟苯基)乙醇, 2-（4-羟基苯基）乙醇
谱图信息: 最多检出来源 Homo sapiens(blood) 22.44%

分子结构信息

SMILES: C1=CC(=CC=C1CCO)O
InChI: InChI=1S/C8H10O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,9-10H,5-6H2

描述信息

Tyrosol is a phenolic compound present in two of the traditional components of the Mediterranean diet: wine and virgin olive oil. The presence of tyrosol has been described in red and white wines. Tyrosol is also present in vermouth and beer. Tyrosol has been shown to be able to exert antioxidant activity in vitro studies. Oxidation of low-density lipoprotein (LDL) appears to occur predominantly in arterial intimae in microdomains sequestered from antioxidants of plasma. The antioxidant content of the LDL particle is critical for its protection. The ability of tyrosol to bind human LDL has been reported. The bioavailability of tyrosol in humans from virgin olive oil in its natural form has been demonstrated. Urinary tyrosol increases, reaching a peak at 0-4 h after virgin olive oil administration. Men and women show a different pattern of urinary excretion of tyrosol. Moreover, tyrosol is absorbed in a dose-dependent manner after sustained and moderate doses of virgin olive oil. Tyrosol from wine or virgin olive oil could exert beneficial effects on human health in vivo if its biological properties are confirmed (PMID 15134375). Tyrosol is a microbial metabolite found in Bifidobacterium, Escherichia and Lactobacillus (PMID:28393285).
2-(4-hydroxyphenyl)ethanol is a phenol substituted at position 4 by a 2-hydroxyethyl group. It has a role as an anti-arrhythmia drug, an antioxidant, a cardiovascular drug, a protective agent, a fungal metabolite, a geroprotector and a plant metabolite. It is functionally related to a 2-phenylethanol.
2-(4-Hydroxyphenyl)ethanol is a natural product found in Thalictrum petaloideum, Casearia sylvestris, and other organisms with data available.
Tyrosol is a metabolite found in or produced by Saccharomyces cerevisiae.
See also: Sedum roseum root (part of); Rhodiola crenulata root (part of).
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
A phenol substituted at position 4 by a 2-hydroxyethyl group.
D020011 - Protective Agents > D000975 - Antioxidants
Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1].
Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1].

同义名列表

69 个代谢物同义名

4-hydroxy-Benzeneethanol;4-Hydroxyphenylethanol;beta-(4-Hydroxyphenyl)ethanol; InChI=1/C8H10O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,9-10H,5-6H; 2-(4-Hydroxyphenyl)ethanol, analytical standard; TYROSOL (CONSTITUENT OF RHODIOLA ROSEA) [DSC]; METOPROLOL SUCCINATE IMPURITY G [EP IMPURITY]; METOPROLOL SUCCINATE IMPURITY G (EP IMPURITY); METOPROLOL TARTRATE IMPURITY G (EP IMPURITY); METOPROLOL TARTRATE IMPURITY G [EP IMPURITY]; TYROSOL (CONSTITUENT OF RHODIOLA ROSEA); 2-(4-hydroxyphenyl)ethyl acetate; 2-(4-Hydroxyphenyl)ethyl Alcohol; 2-(4-Hydroxyphenyl)ethanol, 98\\%; .beta.-(p-Hydroxyphenyl)ethanol; .beta.-(4-Hydroxyphenyl)ethanol; 2-(3,4-dihydroxyphenyl)ethanol; beta-(p-Hydroxyphenyl)ethanol; beta-(4-hydroxyphenyl)ethanol; Ethanol, 2-(4-hydroxyphenyl)-; 2-(4-Hydroxyphenyl)-1-ethanol; Phenethyl alcohol, p-hydroxy-; 4-Hydroxyphenylmethylcarbinol; (4-Hydroxyphenethyl) alcohol; Ethanol, 2-(4-hydroxyphenyl); 4-Hydroxyphenylethyl alcohol; HYDROXYPHENETHYL ALCOHOL, P-; p-Hydroxyphenylethyl alcohol; 2-(4-hydroxyphenyl) ethanol; 2-(4-hydroxyphenyl)-ethanol; 2-(p-hydroxyphenyl) ethanol; β-(4-Hydroxyphenyl)ethanol; p-Hydroxyphenethyl alcohol; 4-Hydroxyphenethyl alcohol; Benzeneethanol, 4-hydroxy-; b-(4-Hydroxyphenyl)ethanol; β-(p-Hydroxyphenyl)ethanol; b-(p-Hydroxyphenyl)ethanol; 2-(4-Hydroxyphenyl)ethanol; 2-(P-HYDROXYPHENYL)ETHANOL; 4-(2-Hydroxy-ethyl)-phenol; 4-hydroxyphenethylalcohol; para-hydroxyphenylethanol; p-Hydroxy-benzeneethanol; p-(2-Hydroxyethyl)phenol; 4-hydroxy-Benzeneethanol; 4-(2-Hydroxyethyl)phenol; 4-Hydroxyphenyl ethanol; 4-hydroxybenzeneethanol; 4-Hydroxyphenyl alcohol; Metoprolol IMpurity 07; 4-hydroxybenzenethanol; 4-(Hydroxyethyl)phenol; 4-hydroxyphenylethanol; p-hydroxyphenylethanol; tyrosol acetate; UNII-1AK4MU3SNX; Tyrosol ,(S); TYROSOL [MI]; 1AK4MU3SNX; p-Thyrosol; 4-tyrosol; Tyrosol C; p-tyrosol; n-tyrosol; Tyrosol; p-HPEA; YRL; 2-(4-Hydroxyphenyl)ethanol; 4-Hydroxyphenylethanol; 2-(4-Hydroxyphenyl)ethyl acetate



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

95 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(88)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

456 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, BCL2, CASP3, CAT, CYP2D6, MAPK14, MAPK8, NOS2, NOS3, PRKAA2, PTGS2, SIRT1, TH, TYR
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 4 BCL2, CYP2D6, HMOX1, PTGS2
Nucleus 11 AKT1, BCL2, CASP3, HMOX1, MAPK14, MAPK8, NOS2, NOS3, PRKAA2, SIRT1, TH
cytosol 13 AKT1, BCL2, CASP3, CAT, HMOX1, LIPE, MAPK14, MAPK8, NOS2, NOS3, PRKAA2, SIRT1, TH
dendrite 2 PRKAA2, TH
nucleoplasm 9 AKT1, CASP3, HMOX1, MAPK14, MAPK8, NOS2, NOS3, PRKAA2, SIRT1
Cell membrane 3 AKT1, LIPE, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 1 AKT1
Cell projection, axon 1 TH
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 2 NOS3, PRKAA2
Golgi membrane 2 INS, NOS3
lysosomal membrane 1 GAA
neuronal cell body 3 CASP3, PRKAA2, TNF
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Cytoplasm, cytosol 2 LIPE, NOS2
Lysosome 2 GAA, TYR
plasma membrane 5 AKT1, GAA, NOS2, NOS3, TNF
terminal bouton 1 TH
Membrane 8 AKT1, BCL2, CAT, CYP2D6, GAA, HMOX1, LIPE, PRKAA2
axon 3 MAPK8, PRKAA2, TH
caveola 3 LIPE, NOS3, PTGS2
extracellular exosome 2 CAT, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 4 BCL2, CYP2D6, HMOX1, PTGS2
extracellular space 4 HMOX1, IL6, INS, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 5 HMOX1, NOS2, NOS3, TH, TYR
mitochondrion 6 BCL2, CAT, CYP2D6, MAPK14, SIRT1, TH
protein-containing complex 4 AKT1, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 4 CAT, CYP2D6, GAA, TYR
Microsome membrane 2 CYP2D6, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 TYR
Secreted 3 GAA, IL6, INS
extracellular region 6 CAT, GAA, IL6, INS, MAPK14, TNF
cytoplasmic side of plasma membrane 1 TH
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, CYP2D6
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
perikaryon 1 TH
cytoplasmic vesicle 1 TH
microtubule cytoskeleton 1 AKT1
nucleolus 1 SIRT1
Melanosome membrane 2 TH, TYR
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cytoplasm, perinuclear region 2 NOS2, TH
heterochromatin 1 SIRT1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS2, TH
ciliary basal body 1 AKT1
chromatin 1 SIRT1
phagocytic cup 1 TNF
cytoskeleton 1 NOS3
spindle pole 1 MAPK14
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
Melanosome 1 TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 2 NOS3, PRKAA2
euchromatin 1 SIRT1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Daniela Gabbia, Katia Sayaf, Ilaria Zanotto, Martina Colognesi, Yahima Frion-Herrera, Maria Carrara, Francesco Paolo Russo, Sara De Martin. Tyrosol attenuates NASH features by reprogramming the hepatic immune milieu. European journal of pharmacology. 2024 Apr; 969(?):176453. doi: 10.1016/j.ejphar.2024.176453. [PMID: 38408597]
  • Yu Wang, Jihang Hou, Xiaoping Li, Pan Chen, Fang Chen, Yao Pan, Zeyuan Deng, Jing Li, Rong Liu, Ting Luo. Tyrosol regulates hepatic lipid metabolism in high-fat diet-induced NAFLD mice. Food & function. 2024 Apr; 15(7):3752-3764. doi: 10.1039/d3fo05345h. [PMID: 38506160]
  • Ágnes Jakab, Kinga Csillag, Károly Antal, Imre Boczonádi, Renátó Kovács, István Pócsi, Tamás Emri. Total transcriptome response for tyrosol exposure in Aspergillus nidulans. Fungal biology. 2024 04; 128(2):1664-1674. doi: 10.1016/j.funbio.2024.01.003. [PMID: 38575239]
  • Guosi Li, Wei Wang, Heng Guo, Shanyong Yi, Fang Wang, Shiping Huang, Nan Hu, Qilin Xu, Yongjun Zang, Bangxing Han, Xinjian Yin. Mutability landscape guided engineering of a promiscuous microbial glycosyltransferase for regioselective synthesis of salidroside and icariside D2. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130229. doi: 10.1016/j.ijbiomac.2024.130229. [PMID: 38378110]
  • Fazheng Yu, Xueyu Hu, HongLin Ren, Xiaoxu Wang, Ruoran Shi, Jian Guo, Jiang Chang, Xiaoshi Zhou, Yuanyuan Jin, Yansong Li, Zengshan Liu, Pan Hu. Protective effect of synbiotic combination of Lactobacillus plantarum SC-5 and olive oil extract tyrosol in a murine model of ulcerative colitis. Journal of translational medicine. 2024 Mar; 22(1):308. doi: 10.1186/s12967-024-05026-9. [PMID: 38528541]
  • Anabel González-Acedo, Rebeca Illescas-Montes, Elvira de Luna-Bertos, Concepción Ruiz, Javier Ramos-Torrecillas, Olga García-Martínez, Lucía Melguizo-Rodríguez. Extra Virgin Olive Oil Phenolic Compounds Modulate the Gene Expression of Biomarkers Involved in Fibroblast Proliferation and Differentiation. Genes. 2024 Jan; 15(2):. doi: 10.3390/genes15020173. [PMID: 38397163]
  • Michalis K Stefanakis, Olga St Tsiftsoglou, Pavle Z Mašković, Diamanto Lazari, Haralambos E Katerinopoulos. Chemical Constituents and Anticancer Activities of the Extracts from Phlomis × commixta Rech. f. (P. cretica × P. lanata). International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020816. [PMID: 38255889]
  • Guosi Li, Qilin Xu, Nan Hu, Xinyang Liu, Yiqi Jiang, Hailong Xue, Yongjun Zang, Fucheng Zhu. Highly efficient biosynthesis of salidroside by a UDP-glucosyltransferase-catalyzed cascade reaction. Biotechnology letters. 2024 Jan; ?(?):. doi: 10.1007/s10529-023-03453-0. [PMID: 38184486]
  • Yuping Shen, Ziwei Zhou, Xi He, Leyi Yin, Chunlan He, Zujiao Zhang. [Dynamic regulation using a quorum-sensing circuit enhances the production of tyrosol by Escherichia coli]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2023 Aug; 39(8):3379-3393. doi: 10.13345/j.cjb.230136. [PMID: 37622367]
  • Jurga Bernatoniene, Valdas Jakstas, Dalia M Kopustinskiene. Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241512293. [PMID: 37569669]
  • Yushiro Fuji, Kai Uchida, Tomoyoshi Akashi, Takashi Ohtsuki, Hiroshi Matsufuji, Masami Yokota Hirai. Molecular Identification of UDP-Sugar Dependent Glycosyltransferase and Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis Induced by Methyl Jasmonate in Sesamum indicum L. Plant & cell physiology. 2023 May; ?(?):. doi: 10.1093/pcp/pcad053. [PMID: 37233612]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Joana Madureira, Bianca Albuquerque, Maria Inês Dias, José Pinela, Ricardo C Calhelha, Celestino Santos-Buelga, Fernanda M A Margaça, Isabel C F R Ferreira, Sandra Cabo Verde, Lillian Barros. Ultrasound-assisted extraction of hydroxytyrosol and tyrosol from olive pomace treated by gamma radiation: process optimization and bioactivity assessment. Food & function. 2023 Apr; 14(7):3038-3050. doi: 10.1039/d2fo03607j. [PMID: 36896737]
  • Pragya Paramita Pal, Ahil Sajeli Begum, S Ameer Basha, Hiroshi Araya, Yoshinori Fujimoto. New natural pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) and iNOS inhibitors identified from Penicillium polonicum through in vitro and in vivo studies. International immunopharmacology. 2023 Apr; 117(?):109940. doi: 10.1016/j.intimp.2023.109940. [PMID: 37012863]
  • Fazheng Yu, Jian Guo, Hong Lin Ren, Shiying Lu, Zhaoqi He, Jiang Chang, Xueyu Hu, Ruoran Shi, Yuanyuan Jin, Yansong Li, Zengshan Liu, Xiaoxu Wang, Pan Hu. Tyrosol inhibits NF-κB pathway in the treatment of enterotoxigenic Escherichia coli-induced diarrhea in mice. Microbial pathogenesis. 2023 Mar; 176(?):105944. doi: 10.1016/j.micpath.2022.105944. [PMID: 36526033]
  • Pragya Paramita Pal, Sajeli A Begum, Ameer S Basha, Hiroshi Araya, Yoshinori Fujimoto. A New Lignan (Polonilignan) and Inhibitors of Nitric Oxide Production from Penicillium polonicum, an Endophytic Fungi of Piper nigrum. Chemistry & biodiversity. 2023 Mar; 20(3):e202200840. doi: 10.1002/cbdv.202200840. [PMID: 36662670]
  • Rana Mohammad Qasaymeh, Dino Rotondo, Veronique Seidel. Phytochemical study and immunomodulatory activity of Fraxinus excelsior L. The Journal of pharmacy and pharmacology. 2023 Jan; 75(1):117-128. doi: 10.1093/jpp/rgac076. [PMID: 36332078]
  • Hanna Nikolaichuk, Marek Studziński, Marek Stankevič, Irena M Choma. Qualitative and Quantitative Evaluation of Rosavin, Salidroside, and p-Tyrosol in Artic Root Products via TLC-Screening, HPLC-DAD, and NMR Spectroscopy. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238299. [PMID: 36500392]
  • Bruna Colombari, Davide Tagliazucchi, Alessandra Odorici, Eva Pericolini, Ismaela Foltran, Diego Pinetti, Aida Meto, Samuele Peppoloni, Elisabetta Blasi. Pomegranate Extract Affects Fungal Biofilm Production: Consumption of Phenolic Compounds and Alteration of Fungal Autoinducers Release. International journal of environmental research and public health. 2022 10; 19(21):. doi: 10.3390/ijerph192114146. [PMID: 36361021]
  • Yingjie Liu, Dong Song, Haitao Hu, Ruijin Yang, Xiaomei Lyu. De Novo Production of Hydroxytyrosol by Saccharomyces cerevisiae-Escherichia coli Coculture Engineering. ACS synthetic biology. 2022 09; 11(9):3067-3077. doi: 10.1021/acssynbio.2c00300. [PMID: 35952699]
  • Mi-Jin Kwon, Ju-Woon Lee, Kwan-Soo Kim, Hao Chen, Cheng-Bi Cui, Gye Won Lee, Young Ho Cho. The Influence of Tyrosol-Enriched Rhodiola sachalinensis Extracts Bioconverted by the Mycelium of Bovista plumbe on Scopolamine-Induced Cognitive, Behavioral, and Physiological Responses in Mice. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144455. [PMID: 35889329]
  • Xinmiao Wang, Kefan Chen, Jin Qiu, Yuanyuan Hu, Fawen Yin, Xiaoyang Liu, Dayong Zhou. Gastrointestinal Distribution of Tyrosol Acyl Esters in Orally Infected Mice and Their Hydrolysis by Lactobacillus Species Isolated from the Feces of Mice. Journal of agricultural and food chemistry. 2022 Feb; 70(4):1316-1326. doi: 10.1021/acs.jafc.1c07432. [PMID: 35068150]
  • Parikshit Kumar, S C Sati. Chemical composition, antioxidant and antimicrobial activities of Himalayan Fraxinus micrantha Lingelsh leaf extract. Natural product research. 2021 Oct; 35(20):3519-3523. doi: 10.1080/14786419.2019.1710706. [PMID: 31920103]
  • Mustafa Cellat, Müslüm Kuzu, Cafer Tayer İşler, Muhammed Etyemez, Nursel Dikmen, Ahmet Uyar, İshak Gökçek, Erdinç Türk, Mehmet Güvenç. Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation. Naunyn-Schmiedeberg's archives of pharmacology. 2021 10; 394(10):2061-2075. doi: 10.1007/s00210-021-02117-y. [PMID: 34287677]
  • Antonella Maria Aresta, Nicolella De Vietro, Maria Lisa Clodoveo, Riccardo Amirante, Filomena Corbo, Francesco Paolo Schena, Carlo Zambonin. Determination of hydroxytyrosol and tyrosol in human urine after intake of extra virgin olive oil produced with an ultrasounds-based technology. Journal of pharmaceutical and biomedical analysis. 2021 Sep; 203(?):114204. doi: 10.1016/j.jpba.2021.114204. [PMID: 34130008]
  • Ramasamy Chandramohan, Leelavinothan Pari. Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats. Toxicology mechanisms and methods. 2021 Sep; 31(7):507-516. doi: 10.1080/15376516.2021.1926030. [PMID: 33942700]
  • Aurélia Malapert, Emmanuelle Reboul, Olivier Dangles, Alain Thiéry, N'nabinty Sylla, Valérie Tomao. One-Step Extraction of Olive Phenols from Aqueous Solution Using β-Cyclodextrin in the Solid State, a Simple Eco-Friendly Method Providing Photochemical Stability to the Extracts. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154463. [PMID: 34361616]
  • Camila Macaúbas-Silva, Maysa D G Félix, Ana Karoline S de Aquino, Paulo G Pereira-Júnior, Emmily Vieira de O Brito, Abrahão A de Oliveira-Filho, John O Igoli, David G Watson, Yanna C F Teles. Araçain, a tyrosol derivative and other phytochemicals from Psidium guineense Sw. Natural product research. 2021 Jul; 35(14):2424-2428. doi: 10.1080/14786419.2019.1672683. [PMID: 31581838]
  • Zelin Yang, Xin Huang, Wenfang Lai, Yuheng Tang, Junjie Liu, Yingzheng Wang, Kedan Chu, John Brown, Guizhu Hong. Synthesis and identification of a novel derivative of salidroside as a selective, competitive inhibitor of monoamine oxidase B with enhanced neuroprotective properties. European journal of medicinal chemistry. 2021 Jan; 209(?):112935. doi: 10.1016/j.ejmech.2020.112935. [PMID: 33097301]
  • Evangelia Kritikou, Natasa P Kalogiouri, Lydia Kolyvira, Nikolaos S Thomaidis. Target and Suspect HRMS Metabolomics for the Determination of Functional Ingredients in 13 Varieties of Olive Leaves and Drupes from Greece. Molecules (Basel, Switzerland). 2020 Oct; 25(21):. doi: 10.3390/molecules25214889. [PMID: 33105803]
  • Sara Fernandes, Catarina Ribeiro, Fátima Paiva-Martins, Cristina Catarino, Alice Santos-Silva. Protective effect of olive oil polyphenol phase II sulfate conjugates on erythrocyte oxidative-induced hemolysis. Food & function. 2020 Oct; 11(10):8670-8679. doi: 10.1039/d0fo01690j. [PMID: 32939526]
  • Antonio Francioso, Rodolfo Federico, Anna Maggiore, Mario Fontana, Alberto Boffi, Maria D'Erme, Luciana Mosca. Green Route for the Isolation and Purification of Hyrdoxytyrosol, Tyrosol, Oleacein and Oleocanthal from Extra Virgin Olive Oil. Molecules (Basel, Switzerland). 2020 Aug; 25(16):. doi: 10.3390/molecules25163654. [PMID: 32796621]
  • Tatsuya Hayakawa, Miran Yanagawa, Atsushi Yamamoto, Sen-Ichi Aizawa, Atsushi Taga, Naoki Mochizuki, Yutaka Itabashi, Hajime Uchida, Yoshimi Ishihara, Shuji Kodama. A Simple Screening Method for Extra Virgin Olive Oil Adulteration by Determining Squalene and Tyrosol. Journal of oleo science. 2020 Jul; 69(7):677-684. doi: 10.5650/jos.ess20033. [PMID: 32522947]
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