Succinic acid (BioDeep_00000000439)

 

Secondary id: BioDeep_00000400032, BioDeep_00000400417, BioDeep_00000400475

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


butanedioic acid

化学式: C4H6O4 (118.0266076)
中文名称: 丁二酸, 琥珀酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.17%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Succinic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/succinic_acid (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000000439). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(=O)O)CC(=O)O
InChI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

描述信息

Succinic acid appears as white crystals or shiny white odorless crystalline powder. pH of 0.1 molar solution: 2.7. Very acid taste. (NTP, 1992)
Succinic acid is an alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle. It has a role as a nutraceutical, a radiation protective agent, an anti-ulcer drug, a micronutrient and a fundamental metabolite. It is an alpha,omega-dicarboxylic acid and a C4-dicarboxylic acid. It is a conjugate acid of a succinate(1-).
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawleys Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
Succinic acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Succinic acid is a dicarboxylic acid. The anion, succinate, is a component of the citric acid cycle capable of donating electrons to the electron transfer chain. Succinic acid is created as a byproduct of the fermentation of sugar. It lends to fermented beverages such as wine and beer a common taste that is a combination of saltiness, bitterness and acidity. Succinate is commonly used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. Succinate plays a role in the citric acid cycle, an energy-yielding process and is metabolized by succinate dehydrogenase to fumarate. Succinate dehydrogenase (SDH) plays an important role in the mitochondria, being both part of the respiratory chain and the Krebs cycle. SDH with a covalently attached FAD prosthetic group, binds enzyme substrates (succinate and fumarate) and physiological regulators (oxaloacetate and ATP). Oxidizing succinate links SDH to the fast-cycling Krebs cycle portion where it participates in the breakdown of acetyl-CoA throughout the whole Krebs cycle. Succinate can readily be imported into the mitochondrial matrix by the n-butylmalonate- (or phenylsuccinate-) sensitive dicarboxylate carrier in exchange with inorganic phosphate or another organic acid, e.g. malate. (A3509) Mutations in the four genes encoding the subunits of succinate dehydrogenase are associated with a wide spectrum of clinical presentations (i.e.: Huntingtons disease. (A3510). Succinate also acts as an oncometabolite. Succinate inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawleys Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
Succinic acid (succinate) is a dicarboxylic acid. It is an important component of the citric acid or TCA cycle and is capable of donating electrons to the electron transfer chain. Succinate is found in all living organisms ranging from bacteria to plants to mammals. In eukaryotes, succinate is generated in the mitochondria via the tricarboxylic acid cycle (TCA). Succinate can readily be imported into the mitochondrial matrix by the n-butylmalonate- (or phenylsuccinate-) sensitive dicarboxylate carrier in exchange with inorganic phosphate or another organic acid, e. g. malate (PMID 16143825). Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space. Succinate has multiple biological roles including roles as a metabolic intermediate and roles as a cell signalling molecule. Succinate can alter gene expression patterns, thereby modulating the epigenetic landscape or it can exhibit hormone-like signaling functions (PMID: 26971832). As such, succinate links cellular metabolism, especially ATP formation, to the regulation of cellular function. Succinate can be broken down or metabolized into fumarate by the enzyme succinate dehydrogenase (SDH), which is part of the electron transport chain involved in making ATP. Dysregulation of succinate synthesis, and therefore ATP synthesis, can happen in a number of genetic mitochondrial diseases, such as Leigh syndrome, and Melas syndrome. Succinate has been found to be associated with D-2-hydroxyglutaric aciduria, which is an inborn error of metabolism. Succinic acid has recently been identified as an oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes. In many tumours, oxygen availability becomes limited (hypoxia) very quickly due to rapid cell proliferation and limited blood vessel growth. The major regulator of the response to hypoxia is the HIF transcription factor (HIF-alpha). Under normal oxygen levels, protein levels of HIF-alpha are very low due to constant degradation, mediated by a series of post-translational modification events catalyzed by the prolyl hydroxylase domain-containing enzymes PHD1, 2 and 3, (also known as EglN2, 1 and 3) that hydroxylate HIF-alpha and lead to its degradation. All three of the PHD enzymes are inhibited by succinate. In humans, urinary succinic acid is produced by Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Enterobacter, Acinetobacter, Proteus mirabilis, Citrobacter frundii, Enterococcus faecalis (PMID: 22292465). Succinic acid is also found in Actinobacillus, Anaerobiospirillum, Mannheimia, Corynebacterium and Basfia (PMID: 22292465; PMID: 18191255; PMID: 26360870).
Succinic acid is widely distributed in higher plants and produced by microorganisms. It is found in cheeses and fresh meats. Succinic acid is a flavouring enhancer, pH control agent [DFC]. Succinic acid is also found in yellow wax bean, swamp cabbage, peanut, and abalone.
An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID S004
Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2].
Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries[1][2].

同义名列表

125 个代谢物同义名

Succinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture; Succinic Acid, Pharmaceutical Secondary Standard; Certified Reference Material; Succinic acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.0\\%; Succinic acid, matrix substance for MALDI-MS, >=99.5\\% (T), Ultra pure; Succinic acid, United States Pharmacopeia (USP) Reference Standard; Succinic acid, certified reference material, TraceCERT(R); Succinic acid, puriss. p.a., ACS reagent, >=99.5\\% (T); InChI=1/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8; Succinic acid, Vetec(TM) reagent grade, 98\\%; 4-02-00-01908 (Beilstein Handbook Reference); Succinic acid, SAJ special grade, >=99.5\\%; Succinic acid, SAJ first grade, >=99.0\\%; Succinic acid, p.a., ACS reagent, 99.0\\%; Succinic acid, purum p.a., >=99.0\\% (T); Succinic acid, ReagentPlus(R), >=99.0\\%; SuccinicAcid(IndustrialGrade&FoodGrade); ADIPIC ACID IMPURITY B (EP IMPURITY); ADIPIC ACID IMPURITY B [EP IMPURITY]; 37E8FFFB-70DA-4399-B724-476BD8715EF0; 1,4-BUTANEDIOIC ACID (SUCCINIC ACID); Succinic acid, ACS reagent, >=99.0\\%; Succinic acid, BioXtra, >=99.0\\%; Butanedioic acid diammonium salt; Succinic acid (Butanedioic acid); Succinic Acid; Butanedioic acid; Succinic acid, >=99\\%, FCC, FG; 2-Acetamido-2-deoxy-D-glucose; 2 Acetamido 2 deoxy D glucose; SUCCINIC ACID (USP IMPURITY); SUCCINIC ACID [USP IMPURITY]; 1,2 Ethanedicarboxylic Acid; 1,2-Ethanedicarboxylic acid; Ethylene dicarboxylic acid; 2 Acetamido 2 deoxyglucose; Kyselina jantarova [Czech]; 2-Acetamido-2-deoxyglucose; Butanedioic acid-1,4-13C2; SUCCINICUM ACIDUM [HPUS]; Succinic acid, ACS grade; Bernsteinsaure [German]; 1,2-Ethanedicarboxylate; Ethanedicarboxylic acid; SUCCINIC ACID [WHO-DD]; Butanedioic acid (9CI); Succinic acid, natural; Ethylene succinic acid; N-Acetyl-D-glucosamine; SUCCINIC ACID [USP-RS]; N Acetyl D glucosamine; ethylenesuccinic acid; Butanedioic acid-13C4; SUCCINIC ACID (MART.); SUCCINIC ACID [VANDF]; SUCCINIC ACID [MART.]; SUCCINIC ACID [HSDB]; 1,4 Butanedioic Acid; Succinate, Potassium; 1,4-Butanedioic acid; SUCCINIC ACID [INCI]; N-Acetylchitosamine; Succinate, Ammonium; SUCCINIC ACID [FCC]; Succinic acid, 99\\%; Dihydrofumaric acid; Succinic acid (8CI); 1,4-Butandioic Acid; Potassium Succinate; acide butanedioique; Kyselina jantarova; SUCCINIC ACID (II); SUCCINIC ACID [MI]; Succinic acid, FCC; SUCCINIC ACID [II]; Succinic Acide,(S); Ammonium Succinate; Succinic acid [NF]; Ethylenesuccinate; Acidum succinicum; HOOC-CH2-CH2-COOH; Succinicum acidum; Butanedionic acid; Acetylglucosamine; 1,4-Butanedioate; butanedioic acid; acide succinique; Succinic acid, 6; UNII-AB6MNQ6J6L; Dihydrofumarate; Bernsteinsaeure; Spirit OF amber; Bernsteinsaure; Tox21_111612_1; succinic-acid; Wormwood acid; Butandisaeure; Butanedionate; Succinic acid; Butane diacid; Tox21_201918; Tox21_111612; Tox21_303247; Succinellite; succinate, 9; butandisaure; Succinicate; Sal succini; Katasuccin; AB6MNQ6J6L; Amber acid; WLN: QV2VQ; AI3-06297; Succinate; FA 4:1;O2; Wormwood; D-GlcNAc; Asuccin; succ; e363; 4lh2; 1cze; suc; SIN; Succinic acid; Succinate; Succinic acid



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(6)

PlantCyc(0)

代谢反应

1043 个相关的代谢反应过程信息。

Reactome(87)

BioCyc(66)

WikiPathways(3)

Plant Reactome(606)

INOH(11)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(270)

PharmGKB(0)

443 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nikhil Dnyaneshwar Patil, Aarti Bains, Sawinder Kaur, Rahul Yadav, Gulden Goksen, Nemat Ali, Abdullah F AlAsmari, Prince Chawla. Effect of dual modifications with ultrasonication and succinylation on Cicer arietinum protein-iron complexes: Characterization, digestibility, in-vitro cellular mineral uptake and preparation of fortified smoothie. Food research international (Ottawa, Ont.). 2024 Jun; 186(?):114344. doi: 10.1016/j.foodres.2024.114344. [PMID: 38729696]
  • Yiwen Li, Tan Dai, Yidong Tang, Yan Wang, Xixi Wang, Zhongqiao Huang, Feng Li, Liang Lu, Jianqiang Miao, Xili Liu. Inhibitory activity to Fusarium spp. and control potential for wheat Fusarium crown rot of a novel succinate dehydrogenase inhibitor cyclobutrifluram. Pest management science. 2024 Apr; 80(4):2001-2010. doi: 10.1002/ps.7935. [PMID: 38096203]
  • Jing Wu, Yilian Li, Jinbao Yin, Chen Wang, Xuejin Qi, Yujie Zhou, Hongjuan Liu, Pengfei Wu, Jianan Zhang. Mutation breeding of high-stress resistant strains for succinic acid production from corn straw. Applied microbiology and biotechnology. 2024 Apr; 108(1):278. doi: 10.1007/s00253-024-13112-7. [PMID: 38558151]
  • Ningbo Wang, Zeming Zhang, Yinan Wang, Liuquan Zhang, Aili Sun, Hua Liu, Xizhi Shi. Comparative antioxidant and metabolomic analysis for the identification of differential response of mussel (Mytilus coruscus) to four succinate dehydrogenase inhibitor fungicides. Environmental science and pollution research international. 2024 Mar; 31(11):16819-16831. doi: 10.1007/s11356-024-32309-x. [PMID: 38324158]
  • Mei-Yu Zhang, Xin-Ru Xu, Ru-Ping Zhao, Chao Huang, Yuan-Da Song, Zi-Tong Zhao, Yu-Bin Zhao, Xiao-Jie Ren, Xin-He Zhao. Mechanism of enhanced microalgal biomass and lipid accumulation through symbiosis between a highly succinic acid-producing strain of Escherichia coli SUC and Aurantiochytrium sp. SW1. Bioresource technology. 2024 Feb; 394(?):130232. doi: 10.1016/j.biortech.2023.130232. [PMID: 38141881]
  • Shuying Gu, Taju Wu, Junqi Zhao, Tao Sun, Zhen Zhao, Lu Zhang, Jingen Li, Chaoguang Tian. Rewiring metabolic flux to simultaneously improve malate production and eliminate by-product succinate accumulation by Myceliophthora thermophila. Microbial biotechnology. 2024 Jan; ?(?):e14410. doi: 10.1111/1751-7915.14410. [PMID: 38298109]
  • Monique Marcondes Krauskopf, Chimenes Darlan Leal de Araújo, Priscila R Dos Santos-Donado, Mariana Damiames Baccarin Dargelio, João Antônio Santos Manzi, Anna Cecilia Venturini, Júlio César de Carvalho Balieiro, Eduardo Francisquine Delgado, Carmen Josefina Contreras Castillo. The effect of succinate on color stability of Bos indicus bull meat: pH-dependent effects during the 14-day aging period. Food research international (Ottawa, Ont.). 2024 Jan; 175(?):113688. doi: 10.1016/j.foodres.2023.113688. [PMID: 38129031]
  • Haiyan Sun, Shiyan Cai, Yuanyu Deng, Shulin Cao, Xiaoyue Yang, Yanteng Lu, Wei Li, Huaigu Chen. Efficacy of cyclobutrifluram in controlling Fusarium crown rot of wheat and resistance risk of three Fusarium species to cyclobutrifluram. Pesticide biochemistry and physiology. 2024 Jan; 198(?):105723. doi: 10.1016/j.pestbp.2023.105723. [PMID: 38225078]
  • Xin Jin, Hangyi Wu, Jie Yu, Yanni Cao, Lanyi Zhang, Zhenhai Zhang, Huixia Lv. Glutamate affects self-assembly, protein corona, and anti-4 T1 tumor effects of melittin/vitamin E-succinic acid-(glutamate)n nanoparticles. Journal of controlled release : official journal of the Controlled Release Society. 2024 Jan; 365(?):802-817. doi: 10.1016/j.jconrel.2023.12.013. [PMID: 38092255]
  • Keke Luo, Haiyu Zhao, Mengxiao Wang, Mengyao Tian, Nan Si, Wen Xia, Jianfang Song, Yunqin Chen, Linna Wang, Yan Zhang, Xiaolu Wei, Xing Li, Guangyuan Qin, Jiaying Yang, Hongjie Wang, Baolin Bian, Yanyan Zhou. Huanglian Jiedu Wan intervened with 'Shi-Re Shanghuo' syndrome through regulating immune balance mediated by biomarker succinate. Clinical immunology (Orlando, Fla.). 2024 01; 258(?):109861. doi: 10.1016/j.clim.2023.109861. [PMID: 38065370]
  • Chao Ma, Chunran Zhu, Yajun Zhang, Mei Yu, Yizhi Song, Yulong Chong, Yan Yang, Chan Zhu, Yucui Jiang, Changming Wang, Shuo Cheng, Keke Jia, Guang Yu, Jia Li, Zongxiang Tang. Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Dec; 125(?):155266. doi: 10.1016/j.phymed.2023.155266. [PMID: 38241917]
  • Yurong Qiu, Yaling Meng, Wenxu Lian, Shasha Jian, Yannan Du, Meng Wang, Ye Yang, Xiaoyu Liang, Yu Zhang. Polymorphisms at amino acid positions 85 and 86 in succinate dehydrogenase subunit C of Colletotrichum siamense: Implications for fitness and intrinsic sensitivity to SDHI fungicides. Fungal genetics and biology : FG & B. 2023 Dec; 169(?):103844. doi: 10.1016/j.fgb.2023.103844. [PMID: 37989450]
  • Shiyong Li, Chaodong Song, Hongyan Zhang, Yan Qin, Mingguo Jiang, Naikun Shen. Comparative Transcriptome Analysis Reveals the Molecular Mechanisms of Acetic Acid Reduction by Adding NaHSO3 in Actinobacillus succinogenes GXAS137. Polish journal of microbiology. 2023 Dec; 72(4):399-411. doi: 10.33073/pjm-2023-036. [PMID: 38000010]
  • Seo Hyun Hwang, Chaw Ei Htwe Maung, Jun Su Noh, Jeong-Yong Cho, Kil Yong Kim. Butyl succinate-mediated control of Bacillus velezensis  ce 100 for apple anthracnose caused by Colletotrichum gloeosporioides. Journal of applied microbiology. 2023 Nov; 134(11):. doi: 10.1093/jambio/lxad247. [PMID: 37903743]
  • Yan-Ming Yin, Zong-Yue Sun, Da-Wei Wang, Zhen Xi. Discovery of Benzothiazolylpyrazole-4-Carboxamides as Potent Succinate Dehydrogenase Inhibitors through Active Fragment Exchange and Link Approach. Journal of agricultural and food chemistry. 2023 Oct; 71(40):14471-14482. doi: 10.1021/acs.jafc.3c03646. [PMID: 37775473]
  • Bingxue Sun, Rongjia Zhou, Guangxue Zhu, Xuewen Xie, Ali Chai, Lei Li, Tengfei Fan, Jingjing Shi, Baoju Li, Yanxia Shi. A Rapid Molecular Detection System for Sdh Mutations Conferring Differential Succinate Dehydrogenase Inhibitor Resistance in Corynespora cassiicola. Plant disease. 2023 Jul; 107(7):2153-2159. doi: 10.1094/pdis-11-22-2626-re. [PMID: 36548917]
  • Jun Liu, Jiaxuan Wu, Peiyuan Jin, Jian Hu, Kurt Lamour, Zhimin Yang. Activity of a succinate dehydrogenase inhibitor fungicide benzovindiflupyr against Clarireedia spp. Plant disease. 2023 Jun; ?(?):. doi: 10.1094/pdis-02-23-0201-re. [PMID: 37340553]
  • Sarah Abdullah, Michael Ghio, Aaron Cotton-Betteridge, Aditya Vinjamuri, Robert Drury, Jacob Packer, Oguz Aras, Jessica Friedman, Mardeen Karim, David Engelhardt, Emma Kosowski, Kelby Duong, Farhana Shaheen, Patrick R McGrew, Charles T Harris, Robert Reily, Mimi Sammarco, Partha K Chandra, Derek Pociask, Jay Kolls, Prasad V Katakam, Alison Smith, Sharven Taghavi, Juan Duchesne, Olan Jackson-Weaver. Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage. Science advances. 2023 06; 9(24):eadf6600. doi: 10.1126/sciadv.adf6600. [PMID: 37315138]
  • Shengfang Zhou, Yingli Zhang, Zhiwen Wei, Sunghoon Park. Recent advances in metabolic engineering of microorganisms for the production of monomeric C3 and C4 chemical compounds. Bioresource technology. 2023 Jun; 377(?):128973. doi: 10.1016/j.biortech.2023.128973. [PMID: 36972803]
  • Jingwen Xu, Zhenhua Tian, Zhe Li, Xiaoshi Du, Yansong Cui, Jiangrong Wang, Mei Gao, Yinglong Hou. Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis. Journal of ethnopharmacology. 2023 May; ?(?):116675. doi: 10.1016/j.jep.2023.116675. [PMID: 37257708]
  • Tamieka Pearce, Jason Scott, Calum R Wilson, David H Gent. Evolution of the genetic structure of the Didymella tanaceti population during development of succinate dehydrogenase inhibitor resistance. Phytopathology. 2023 May; ?(?):. doi: 10.1094/phyto-10-22-0385-r. [PMID: 37129263]
  • Salvatore Nesci, Cristina Algieri, Fabiana Trombetti, Micaela Fabbri, Giorgio Lenaz. Two separate pathways underlie NADH and succinate oxidation in swine heart mitochondria: Kinetic evidence on the mobile electron carriers. Biochimica et biophysica acta. Bioenergetics. 2023 Apr; 1864(3):148977. doi: 10.1016/j.bbabio.2023.148977. [PMID: 37059413]
  • Mathias Brouillard, Rémi Kinet, Marie Joyeux, Benjamin Dehay, Sylvie Crauste-Manciet, Valérie Desvergnes. Modulating Lysosomal pH through Innovative Multimerized Succinic Acid-Based Nucleolipid Derivatives. Bioconjugate chemistry. 2023 03; 34(3):572-580. doi: 10.1021/acs.bioconjchem.3c00041. [PMID: 36853958]
  • Jinhang Li, Peng Wei, Juan Qin, Kaiyang Feng, Guangmao Shen, Wei Dou, Youjun Zhang, Peng Cao, Zhiguang Yuchi, Thomas Van Leeuwen, Lin He. Molecular Basis for the Selectivity of the Succinate Dehydrogenase Inhibitor Cyflumetofen between Pest and Predatory Mites. Journal of agricultural and food chemistry. 2023 Mar; 71(8):3658-3669. doi: 10.1021/acs.jafc.2c06149. [PMID: 36787109]
  • Chang-Shun Liu, Yin-Xia Hu, Zhen-Ye Luo, Chuan-Wei Qiu, Xiang-Hua Deng, Fei-Long Chen. Xianglian pill modulates gut microbial production of succinate and induces regulatory T cells to alleviate ulcerative colitis in rats. Journal of ethnopharmacology. 2023 Mar; 303(?):116007. doi: 10.1016/j.jep.2022.116007. [PMID: 36473618]
  • Naikun Shen, Shiyong Li, Shuyan Li, Yibing Wang, Hongyan Zhang, Mingguo Jiang. Reduced acetic acid formation using NaHSO3 as a steering agent by Actinobacillus succinogenes GXAS137. Journal of bioscience and bioengineering. 2023 Mar; 135(3):203-209. doi: 10.1016/j.jbiosc.2022.12.007. [PMID: 36628842]
  • Zhaolin Xue, Shan Zhong, Jinghuan Shen, Ye Sun, Xuheng Gao, Xiangyang Wang, Feng Li, Liang Lu, Xili Liu. Multiple Mutations in SDHB and SDHC2 Subunits Confer Resistance to the Succinate Dehydrogenase Inhibitor Cyclobutrifluram in Fusarium fujikuroi. Journal of agricultural and food chemistry. 2023 Mar; 71(8):3694-3704. doi: 10.1021/acs.jafc.2c08023. [PMID: 36802617]
  • Yu-Hao Zhang, Shan-Shan Yang, Qi Zhang, Tian-Tian Zhang, Tian-Yi Zhang, Bo-Hang Zhou, Le Zhou. Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi. Journal of agricultural and food chemistry. 2023 Feb; ?(?):. doi: 10.1021/acs.jafc.2c07712. [PMID: 36790098]
  • Trinita K Barboza, Leonardo Susta, Alex Zur Linden, Sara Gardhouse, Hugues Beaufrère. Association of plasma metabolites and diagnostic imaging findings with hepatic lipidosis in bearded dragons (Pogona vitticeps) and effects of gemfibrozil therapy. PloS one. 2023; 18(2):e0274060. doi: 10.1371/journal.pone.0274060. [PMID: 36735707]
  • Haoran Zhao, Minmin Li, Xiaowei Liu, Jiajie Yang, Xueyao Li, Jieyin Chen, Xiaofeng Dai, Jesus Simal-Gandara, Zhiqiang Kong, Zhizhong Li. Simultaneous determination of succinate-dehydrogenase-inhibitor fungicide traces in cereals by QuEChERS preparation and UPLC-MS/MS analysis. Food chemistry. 2022 Dec; 396(?):133708. doi: 10.1016/j.foodchem.2022.133708. [PMID: 35878445]
  • Xuan Li, Yuting Ren, Guowen Huang, Ruofan Zhang, Yanan Zhang, Weiyun Zhu, Kaifan Yu. Succinate communicates pro-inflammatory signals to the host and regulates bile acid enterohepatic metabolism in a pig model. Food & function. 2022 Oct; 13(21):11070-11082. doi: 10.1039/d2fo01958b. [PMID: 36197400]
  • Hao Liu, Hairong Zhang, Xiaoyu Zhang, Qian Chen, Lei Xia. Role of succinic acid in the regulation of sepsis. International immunopharmacology. 2022 Sep; 110(?):109065. doi: 10.1016/j.intimp.2022.109065. [PMID: 35853278]
  • Jing Li, Huyi Zhou, Wei Zuo, Wenjin An, Yaohai Zhang, Qiyang Zhao. Simultaneous enantioselective determination of two succinate- dehydrogenase-inhibitor fungicides in plant-origin foods by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2022 Aug; 1677(?):463325. doi: 10.1016/j.chroma.2022.463325. [PMID: 35853420]
  • Nadezhda Fedotcheva, Natalia Beloborodova. Influence of Microbial Metabolites and Itaconic Acid Involved in Bacterial Inflammation on the Activity of Mitochondrial Enzymes and the Protective Role of Alkalization. International journal of molecular sciences. 2022 Aug; 23(16):. doi: 10.3390/ijms23169069. [PMID: 36012366]
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