3-Hydroxy-3-methylglutaric acid (BioDeep_00000407352)

Main id: BioDeep_00000001249

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


3-Hydroxy-3-methylglutaric acid

化学式: C6H10O5 (162.0528)
中文名称: 3-羟基-3-甲基戊二酸, 3-羟基-3-甲基谷氨酸
谱图信息: 最多检出来源 Homo sapiens(urine) 41.43%

分子结构信息

SMILES: CC(CC(=O)O)(CC(=O)O)O
InChI: InChI=1S/C6H10O5/c1-6(11,2-4(7)8)3-5(9)10/h11H,2-3H2,1H3,(H,7,8)(H,9,10)

描述信息

D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D009676 - Noxae > D000963 - Antimetabolites
Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, and serum beta-lipoproteins and phospholipids, and inhibits hydroxymethylglutaryl-CoA reductase activity, which is the rate-limiting enzyme in cholesterol biosynthesis.
Meglutol is an antilipidemic agent that lowers cholesterol, triglycerides, and serum beta-lipoproteins and phospholipids, and inhibits hydroxymethylglutaryl-CoA reductase activity, which is the rate-limiting enzyme in cholesterol biosynthesis.

同义名列表

5 个代谢物同义名

3-Hydroxy-3-methylglutaric acid; MEGLUTOL; Dicrotalic acid; 3-Hydroxy-3-methylglutarate; 3-Hydroxy-3-methylglutaric acid



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 CASP3, CAT, CCNB2, CDKN1A, E2F1, EGFR, HMGB1, HMGB2, HPD, TP53
Peripheral membrane protein 2 HMGB1, HPD
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 EGFR, HMGCR, HPD
Nucleus 12 CASP3, CCNB2, CDKN1A, E2F1, EGFR, HMGA1, HMGA2, HMGB1, HMGB2, MKI67, PPARGC1A, TP53
cytosol 10 CASP3, CAT, CCNB2, CDKN1A, HGD, HMGA1, HMGCL, HPD, PPARGC1A, TP53
nuclear body 2 CDKN1A, MKI67
centrosome 3 CCNB2, E2F1, TP53
nucleoplasm 10 CASP3, CDKN1A, E2F1, HMGA1, HMGA2, HMGB1, HMGB2, MKI67, PPARGC1A, TP53
RNA polymerase II transcription regulator complex 2 E2F1, HMGA1
Cell membrane 3 EGFR, HMGB1, TNF
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 HMGCR, MFN1, SYP
Golgi apparatus membrane 1 HPD
cell junction 1 EGFR
cell surface 3 EGFR, HMGB1, TNF
glutamatergic synapse 2 CASP3, EGFR
Golgi membrane 2 EGFR, HPD
neuromuscular junction 1 SYP
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 SYP
synaptic vesicle 1 SYP
endosome 2 EGFR, HMGB1
plasma membrane 3 EGFR, HMGB1, TNF
presynaptic active zone 1 SYP
synaptic vesicle membrane 1 SYP
terminal bouton 1 SYP
Membrane 8 CAT, CCNB2, EGFR, HMGCR, MFN1, MKI67, SYP, TP53
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 3 CAT, HGD, HPD
endoplasmic reticulum 3 HMGB1, HMGCR, TP53
extracellular space 4 EGFR, HMGB1, HMGB2, TNF
perinuclear region of cytoplasm 4 CDKN1A, EGFR, HMGB2, SYP
Schaffer collateral - CA1 synapse 1 SYP
mitochondrion 4 CAT, HMGCL, MFN1, TP53
protein-containing complex 7 CAT, CDKN1A, E2F1, EGFR, HMGB2, HMGCL, TP53
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 2 HMGB1, HMGB2
extracellular region 4 CAT, HMGB1, HMGB2, TNF
Mitochondrion outer membrane 1 MFN1
mitochondrial outer membrane 1 MFN1
excitatory synapse 1 SYP
Mitochondrion matrix 2 HMGCL, TP53
mitochondrial matrix 3 CAT, HMGCL, TP53
Extracellular side 1 HMGB1
transcription regulator complex 2 HMGA1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SYP
nuclear membrane 1 EGFR
external side of plasma membrane 1 TNF
microtubule cytoskeleton 1 CCNB2
nucleolus 4 CDKN1A, HMGB2, MKI67, TP53
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 EGFR, TNF
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 3 CAT, EGFR, HMGA1
Peroxisome 2 CAT, HMGCL
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, HMGCL
peroxisomal membrane 2 CAT, HMGCR
Nucleus, PML body 2 PPARGC1A, TP53
PML body 2 PPARGC1A, TP53
receptor complex 1 EGFR
neuron projection 1 SYP
chromatin 6 E2F1, HMGA1, HMGA2, HMGB2, PPARGC1A, TP53
phagocytic cup 1 TNF
Chromosome 4 HMGA1, HMGB1, HMGB2, MKI67
Nucleus, nucleolus 1 MKI67
nuclear chromosome 1 HMGA2
site of double-strand break 1 TP53
Endomembrane system 1 SYP
germ cell nucleus 1 TP53
replication fork 1 TP53
Peroxisome membrane 1 HMGCR
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 CAT, HMGB1
secretory granule lumen 2 CAT, HMGB1
nuclear matrix 1 TP53
transcription repressor complex 2 HMGB1, TP53
[Isoform 2]: Cytoplasm 1 MFN1
clathrin-coated endocytic vesicle membrane 1 EGFR
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
[Isoform 1]: Nucleus 2 PPARGC1A, TP53
Synapse, synaptosome 1 SYP
SMAD protein complex 1 HMGA2
protein-DNA complex 1 HMGA2
death-inducing signaling complex 1 CASP3
condensed chromosome 2 HMGB1, HMGB2
cyclin-dependent protein kinase holoenzyme complex 2 CCNB2, CDKN1A
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
Rb-E2F complex 1 E2F1
PCNA-p21 complex 1 CDKN1A
senescence-associated heterochromatin focus 2 HMGA1, HMGA2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
outer mitochondrial membrane protein complex 1 MFN1
[Isoform B4]: Nucleus 1 PPARGC1A
[Isoform B4-8a]: Cytoplasm 1 PPARGC1A
[Isoform B5]: Nucleus 1 PPARGC1A
[Isoform 9]: Nucleus 1 PPARGC1A


文献列表

  • Brian J Koos, Jeffrey A Gornbein. Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming. American journal of obstetrics and gynecology. 2021 02; 224(2):215.e1-215.e7. doi: 10.1016/j.ajog.2020.07.050. [PMID: 32739399]
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  • Camila Aguilar Delgado, Gilian Batista Balbueno Guerreiro, Carlos Eduardo Diaz Jacques, Daniella de Moura Coelho, Angela Sitta, Vanusa Manfredini, Moacir Wajner, Carmen Regla Vargas. Prevention by L-carnitine of DNA damage induced by 3-hydroxy-3-methylglutaric and 3-methylglutaric acids and experimental evidence of lipid and DNA damage in patients with 3-hydroxy-3-methylglutaric aciduria. Archives of biochemistry and biophysics. 2019 06; 668(?):16-22. doi: 10.1016/j.abb.2019.04.008. [PMID: 31047871]
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