Hesperetin (BioDeep_00000398535)

Main id: BioDeep_00000000365

Secondary id: BioDeep_00000017486

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)- (9CI)

化学式: C16H14O6 (302.0790344)
中文名称: 橙皮甙, 橙皮素
谱图信息: 最多检出来源 Homo sapiens(feces) 0.68%

分子结构信息

SMILES: COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChI: InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3

描述信息

Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.958
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.957
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.955
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
(Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

同义名列表

60 个代谢物同义名

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)- (9CI); (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one; (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanone; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one; Flavanone, 3,5,7-trihydroxy-4-methoxy- (VAN) (8CI); 3′,5,7-Trihydroxy-4-methoxyflavanone; 3,5,7-trihydroxy-4-methoxyflavanone; SDCCGMLS-0066605.P001; Prestwick3_000124; Prestwick0_000124; Prestwick2_000124; Prestwick1_000124; EINECS 208-290-2; Spectrum3_001104; Spectrum2_001793; Spectrum5_000683; Spectrum4_001935; BCBcMAP01_000087; Spectrum_000181; NCGC00142415-01; NCGC00016482-01; NCGC00142415-02; NCGC00016482-02; (-)-hesperetin; SPECTRUM310012; BSPBio_002808; KBioSS_000661; DivK1c_001039; Oprea1_828704; BSPBio_000168; BPBio1_000186; Prestwick_908; KBioGR_002311; KBio2_005797; CAS-520-33-2; KBio2_000661; KBio2_003229; KBio3_002028; ZINC00039092; KBio1_001039; NINDS_001039; SPBio_001745; SPBio_002107; CHEBI:28230; H4125_SIGMA; IDI1_001039; SMP1_000148; AIDS-001413; Hesperetin; AIDS001413; NSC 57654; SBB005936; TNP00238; 520-33-2; C01709; YSO2; (Rac)-Hesperetin



数据库引用编号

75 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

118 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Álvaro Pérez-Valero, Juan Serna-Diestro, Albert Tafur Rangel, Simona Barbuto Ferraiuolo, Chiara Schiraldi, Eduard J Kerkhoven, Claudio J Villar, Felipe Lombó. Biosynthesis of Hesperetin, Homoeriodictyol, and Homohesperetin in a Transcriptomics-Driven Engineered Strain of Streptomyces albidoflavus. International journal of molecular sciences. 2024 Apr; 25(7):. doi: 10.3390/ijms25074053. [PMID: 38612864]
  • Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbosa. Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster. Neurotoxicology. 2024 Mar; 101(?):117-127. doi: 10.1016/j.neuro.2024.02.006. [PMID: 38423185]
  • Xianbin Yu, Zhixuan Liu, Yitian Yu, Chengjie Qian, Yuzhe Lin, Shuqing Jin, Long Wu, Shi Li. Hesperetin promotes diabetic wound healing by inhibiting ferroptosis through the activation of SIRT3. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8121. [PMID: 38234096]
  • Erik K R Hanko, João Correia, Caio S Souza, Alison Green, Jakub Chromy, Ruth Stoney, Cunyu Yan, Eriko Takano, Diana Lousa, Cláudio M Soares, Rainer Breitling. Microbial production of the plant flavanone hesperetin from caffeic acid. BMC research notes. 2023 Nov; 16(1):343. doi: 10.1186/s13104-023-06620-8. [PMID: 37978406]
  • Wenqian Wang, Lili Qu, Zhan Cui, Fuping Lu, Li Li, Fufeng Liu. Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16174-16183. doi: 10.1021/acs.jafc.3c06816. [PMID: 37870747]
  • Juan Liu, Zhiqiang Xiao, Siqi Zhang, Zhen Wang, Yun Chen, Yang Shan. Restricting Promiscuity of Plant Flavonoid 3'-Hydroxylase and 4'-O-Methyltransferase Improves the Biosynthesis of (2S)-Hesperetin in E. coli. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c02071. [PMID: 37310069]
  • Lukas Babylon, Julia Meißner, Gunter P Eckert. Combination of Secondary Plant Metabolites and Micronutrients Improves Mitochondrial Function in a Cell Model of Early Alzheimer's Disease. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210029. [PMID: 37373177]
  • Panpan Liu, Jian Chen, Jiaying Qi, Miaomiao Liu, Muqing Zhang, Yucong Xue, Li Li, Yanshuang Liu, Jing Shi, Yixin Zhang, Li Chu. Hesperetin ameliorates ischemia/hypoxia-induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca2+ homeostasis. Phytotherapy research : PTR. 2023 May; 37(5):1787-1805. doi: 10.1002/ptr.7693. [PMID: 36437582]
  • Yuri Doki, Yosuke Nakazawa, Naoki Morishita, Shin Endo, Noriaki Nagai, Naoki Yamamoto, Hiroomi Tamura, Megumi Funakoshi-Tago. Hesperetin treatment attenuates glycation of lens proteins and advanced‑glycation end products generation. Molecular medicine reports. 2023 05; 27(5):. doi: 10.3892/mmr.2023.12990. [PMID: 36999595]
  • Ah Young Yang, Hye Jin Choi, Kiryeong Kim, Jaechan Leem. Antioxidant, Antiapoptotic, and Anti-Inflammatory Effects of Hesperetin in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062759. [PMID: 36985731]
  • Kamil Wdowiak, Andrzej Miklaszewski, Robert Pietrzak, Judyta Cielecka-Piontek. Amorphous System of Hesperetin and Piperine-Improvement of Apparent Solubility, Permeability, and Biological Activities. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054859. [PMID: 36902286]
  • Lulu Shi, Mingzhe Zou, Xingxing Zhou, Songhua Wang, Wei Meng, Zhou Lan. Comparison of protective effects of hesperetin and pectolinarigenin on high-fat diet-induced hyperlipidemia and hepatic steatosis in Golden Syrian hamsters. Experimental animals. 2023 Feb; 72(1):123-131. doi: 10.1538/expanim.22-0115. [PMID: 36310057]
  • Yogesh Chand Yadav, Satyanarayan Pattnaik. Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect. Drug development and industrial pharmacy. 2023 Feb; 49(2):240-247. doi: 10.1080/03639045.2023.2201625. [PMID: 37032647]
  • Parth Malik, Manju Bernela, Mahima Seth, Priya Kaushal, Tapan Kumar Mukherjee. Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic Actions and Synergistic Anticancer Efficacy. Current pharmaceutical design. 2023; 29(37):2954-2976. doi: 10.2174/0113816128253609231030070414. [PMID: 38173051]
  • Sai Zhu, Xin Chen, Si-Yu Chen, Ao Wang, Sha Wu, Yuan-Yuan Wu, Miao Cheng, Jin-Jin Xu, Xiao-Feng Li, Cheng Huang, Jun Li. Hesperetin derivative decreases CCl4 -induced hepatic fibrosis by Ptch1-dependent mechanisms. Journal of biochemical and molecular toxicology. 2022 Oct; 36(10):e23149. doi: 10.1002/jbt.23149. [PMID: 35712856]
  • Fatemeh Omidfar, Fatemeh Gheybi, Javid Davoodi, Mostafa Amirinejad, Ali Badiee. Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation. Biotechnology and applied biochemistry. 2022 Sep; ?(?):. doi: 10.1002/bab.2404. [PMID: 36112716]
  • Punnida Arjsri, Kamonwan Srisawad, Sariya Mapoung, Warathit Semmarath, Pilaiporn Thippraphan, Sonthaya Umsumarng, Supachai Yodkeeree, Pornngarm Dejkriengkraikul. Hesperetin from Root Extract of Clerodendrum petasites S. Moore Inhibits SARS-CoV-2 Spike Protein S1 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810346. [PMID: 36142258]
  • Alpa Shree, Johirul Islam, Vikas Yadav, Sarwat Sultana, Haider Ali Khan. Hesperetin alleviates DMH induced toxicity via suppressing oxidative stress and inflammation in the colon of Wistar rats. Environmental toxicology. 2022 Sep; 37(9):2153-2166. doi: 10.1002/tox.23558. [PMID: 35567572]
  • Lizha Mary Lazer, Yasodha Kesavan, Ravi Gor, Ilangovan Ramachandran, Surajit Pathak, Shoba Narayan, Muralidharan Anbalagan, Satish Ramalingam. Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles. Colloids and surfaces. B, Biointerfaces. 2022 Sep; 217(?):112612. doi: 10.1016/j.colsurfb.2022.112612. [PMID: 35738074]
  • Lateefat T Olumegbon, Akeem O Lawal, Dare M Oluyede, Monsurat O Adebimpe, Olusola O Elekofehinti, Haruna I Umar. Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats. Environmental science and pollution research international. 2022 Jul; 29(35):52574-52589. doi: 10.1007/s11356-022-19494-3. [PMID: 35262885]
  • Tatianny de Araújo Andrade, Luana Heimfarth, Danillo Menezes Dos Santos, Márcio Roberto Viana Dos Santos, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Agenor Gomes Dos Santos-Neto, Guilherme Rodolfo Souza de Araujo, Ana Amélia Moreira Lira, Saulo Santos Matos, Luiza Abrahão Frank, Thallita Kelly Rabelo, Lucindo José Quintans-Júnior, Jullyana de Souza Siqueira Quintans, Adriano Antunes de Souza Araujo, Mairim Russo Serafini. Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage. AAPS PharmSciTech. 2022 Jun; 23(6):170. doi: 10.1208/s12249-022-02323-8. [PMID: 35729366]
  • Yaseen Hussain, Haroon Khan, Thomas Efferth, Waqas Alam. Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 100(?):153985. doi: 10.1016/j.phymed.2022.153985. [PMID: 35358935]
  • Heba M Abdou, Fatma A Hamaad, Esraa Y Ali, Mamdooh H Ghoneum. Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112838. doi: 10.1016/j.biopha.2022.112838. [PMID: 35344738]
  • Juan-Juan Li, Xin-Yi Lu, Pengcheng Jia, Lin Zhu, Ao Wang, Fang-Tian Bu, Yi-Long Zhang, Cheng Huang, Jun Li. O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway. Toxicology. 2022 01; 466(?):153087. doi: 10.1016/j.tox.2021.153087. [PMID: 34974135]
  • Heba Mohamed Abdou, Heba-Tallah Abd Elrahim Abd Elkader. The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in male rats. Chemico-biological interactions. 2022 Jan; 352(?):109781. doi: 10.1016/j.cbi.2021.109781. [PMID: 34922902]
  • Ahmet Tektemur, Nalan Kaya Tektemur, Elif Erdem Güzel. The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1). Toxicology and applied pharmacology. 2022 01; 435(?):115833. doi: 10.1016/j.taap.2021.115833. [PMID: 34933056]
  • Bahare Salehi, Natália Cruz-Martins, Monica Butnariu, Ioan Sarac, Iulia-Cristina Bagiu, Shahira M Ezzat, Jinfan Wang, Aaron Koay, Helen Sheridan, Charles Oluwaseun Adetunji, Prabhakar Semwal, Mauricio Schoebitz, Miquel Martorell, Javad Sharifi-Rad. Hesperetin's health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations. Critical reviews in food science and nutrition. 2022; 62(16):4449-4464. doi: 10.1080/10408398.2021.1875979. [PMID: 33491467]
  • Qian Lu, Yongwei Lai, Hong Zhang, Kuang Ren, Wei Liu, Ying An, Jiahong Yao, Hongyan Fan. Hesperetin Inhibits TGF-β1-Induced Migration and Invasion of Triple Negative Breast Cancer MDA-MB-231 Cells via Suppressing Fyn/Paxillin/RhoA Pathway. Integrative cancer therapies. 2022 Jan; 21(?):15347354221086900. doi: 10.1177/15347354221086900. [PMID: 35297710]
  • Yi-Shaun Sheen, Hsin-Yi Huang, Yi-Hua Liao. The efficacy and safety of an antiaging topical serum containing hesperetin and sodium cyclic lysophosphatidic acid: A single-center clinical trial. Journal of cosmetic dermatology. 2021 Dec; 20(12):3960-3967. doi: 10.1111/jocd.14063. [PMID: 33690913]
  • Zhen Wang, Xu Huang, Juan Liu, Feiyao Xiao, Miaomiao Tian, Shenghua Ding, Yang Shan. Screening and heterologous expression of flavone synthase and flavonol synthase to catalyze hesperetin to diosmetin. Biotechnology letters. 2021 Nov; 43(11):2161-2183. doi: 10.1007/s10529-021-03184-0. [PMID: 34514540]
  • Shun Katada, Sachiko Oishi, Kiyotaka Yanagawa, Shunsuke Ishii, Mamoru Oki, Yuji Matsui, Noriko Osaki, Kazuhiko Takano, Masanobu Hibi. Concomitant use of tea catechins affects absorption and serum triglyceride-lowering effects of monoglucosyl hesperidin. Food & function. 2021 Oct; 12(19):9339-9346. doi: 10.1039/d1fo01917a. [PMID: 34606551]
  • Fedora Grande, Maria Antonietta Occhiuzzi, Maria Rosaria Perri, Giuseppina Ioele, Bruno Rizzuti, Giancarlo Statti, Antonio Garofalo. Polyphenols from Citrus Tacle® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy. Molecules (Basel, Switzerland). 2021 Sep; 26(18):. doi: 10.3390/molecules26185718. [PMID: 34577189]
  • Shang-Ta Wang, Jou-An Chen, Chen Hsu, Nan-Wei Su. Microbial Phosphorylation Product of Hesperetin by Bacillus subtilis BCRC 80517 Improves Oral Bioavailability in Rats. Journal of agricultural and food chemistry. 2021 Sep; 69(35):10184-10193. doi: 10.1021/acs.jafc.1c04298. [PMID: 34449206]
  • Fang-Ju Cheng, Thanh-Kieu Huynh, Chia-Shin Yang, Dai-Wei Hu, Yi-Cheng Shen, Chih-Yen Tu, Yang-Chang Wu, Chih-Hsin Tang, Wei-Chien Huang, Yeh Chen, Chien-Yi Ho. Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection. Nutrients. 2021 Aug; 13(8):. doi: 10.3390/nu13082800. [PMID: 34444960]
  • Halil Ibrahim Guler, Gizem Tatar, Oktay Yildiz, Ali Osman Belduz, Sevgi Kolayli. Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study. Archives of microbiology. 2021 Aug; 203(6):3557-3564. doi: 10.1007/s00203-021-02351-1. [PMID: 33950349]
  • Naila Rabbani, Mingzhan Xue, Martin O Weickert, Paul J Thornalley. Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation. Nutrients. 2021 Jul; 13(7):. doi: 10.3390/nu13072374. [PMID: 34371884]
  • Panpan Liu, Jinghan Li, Miaomiao Liu, Muqing Zhang, Yucong Xue, Yuanyuan Zhang, Xue Han, Xuan Jing, Li Chu. Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111552. doi: 10.1016/j.biopha.2021.111552. [PMID: 33839495]
  • Jingda Li, Tianqi Wang, Panpan Liu, Fuyuan Yang, Xudong Wang, Weilong Zheng, Wenlong Sun. Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. Food & function. 2021 May; 12(9):3898-3918. doi: 10.1039/d0fo02736g. [PMID: 33977953]
  • Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production. Journal of natural products. 2021 03; 84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121. [PMID: 33667099]
  • Ling Liu, Jie Zheng, YaZhen Yang, Lingjuan Ni, Hongyu Chen, Dongrong Yu. Hesperetin alleviated glucocorticoid-induced inhibition of osteogenic differentiation of BMSCs through regulating the ERK signaling pathway. Medical molecular morphology. 2021 Mar; 54(1):1-7. doi: 10.1007/s00795-020-00251-9. [PMID: 32253606]
  • Fang Wu, Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Chuan Chen, Xuehang Zhu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Jinlin Zhou, Yujing Lu, Limin Zhang. Short-Term Intake of Hesperetin-7-O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice. Journal of agricultural and food chemistry. 2021 Feb; 69(5):1478-1486. doi: 10.1021/acs.jafc.0c05921. [PMID: 33351610]
  • Theresa Saenger, Florian Hübner, Viktoria Lindemann, Kristina Ganswind, Hans-Ulrich Humpf. Urinary Biomarkers for Orange Juice Consumption. Molecular nutrition & food research. 2021 01; 65(2):e2000781. doi: 10.1002/mnfr.202000781. [PMID: 33216459]
  • Raphael J Eberle, Danilo S Olivier, Carolina C Pacca, Clarita M S Avilla, Mauricio L Nogueira, Marcos S Amaral, Dieter Willbold, Raghuvir K Arni, Monika A Coronado. In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases. PloS one. 2021; 16(3):e0246319. doi: 10.1371/journal.pone.0246319. [PMID: 33661906]
  • Kexin Li, Li Wei, Zhigang Han, Huarong Xiong, Fengmei Zhang, Xuwei Liu, Dezhang Zhao, Yongquan Pan, Wenli Han. Comparative Pharmacokinetic Study of Hesperetin after Oral Administration in Normal and Hyperuricemia Rats by UPLC-MS/MS. Current reviews in clinical and experimental pharmacology. 2021; 16(2):155-161. doi: 10.2174/1574884715666200702120521. [PMID: 32614750]
  • Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zifeng Yang, Jianxin Chen. Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Journal of medicinal chemistry. 2020 11; 63(22):13205-13227. doi: 10.1021/acs.jmedchem.0c00626. [PMID: 32845145]
  • Gopalsamy Rajiv Gandhi, Alan Bruno Silva Vasconcelos, Ding-Tao Wu, Hua-Bin Li, Poovathumkal James Antony, Hang Li, Fang Geng, Ricardo Queiroz Gurgel, Narendra Narain, Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020 Sep; 12(10):. doi: 10.3390/nu12102907. [PMID: 32977511]
  • Egeria Scoditti. Neuroinflammation and Neurodegeneration: The Promising Protective Role of the Citrus Flavanone Hesperetin. Nutrients. 2020 Aug; 12(8):. doi: 10.3390/nu12082336. [PMID: 32764233]
  • Dabin Choi, Cho-Long Kim, Jae Eun Kim, Jung-Soon Mo, Han-Sol Jeong. Hesperetin inhibit EMT in TGF-β treated podocyte by regulation of mTOR pathway. Biochemical and biophysical research communications. 2020 07; 528(1):154-159. doi: 10.1016/j.bbrc.2020.05.087. [PMID: 32451085]
  • Marina Marques Bonomo, João Batista Fernandes, Rose Maria Carlos, Marisa Narciso Fernandes. Biochemical and genotoxic biomarkers and cell cycle assessment in the zebrafish liver (ZF-L) cell line exposed to the novel metal-insecticide magnesium-hespiridin complex. Chemosphere. 2020 Jul; 250(?):126416. doi: 10.1016/j.chemosphere.2020.126416. [PMID: 32380589]
  • Jingyuan Wan, Ge Kuang, Li Zhang, Rong Jiang, Yongtao Chen, Zhen He, Duyun Ye. Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. International immunopharmacology. 2020 Jun; 83(?):106435. doi: 10.1016/j.intimp.2020.106435. [PMID: 32222641]
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