2,5-Dihydroxybenzoic acid (BioDeep_00000398226)

Main id: BioDeep_00000000115

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


"2,5-Dihydroxybenzoic acid"

化学式: C7H6O4 (154.0266)
中文名称: 2,5-二羟基苯甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1O)C(=O)O)O
InChI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)

描述信息

D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
Profile spectrum of this record is given as a JPEG file.; [Profile] MCH00007.jpg
Profile spectrum of this record is given as a JPEG file.; [Profile] MCH00006.jpg
Profile spectrum of this record is given as a JPEG file.; [Profile] MCH00002.jpg
2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.
2,5-Dihydroxybenzoic acid is a derivative of benzoic and a powerful inhibitor of fibroblast growth factors.

同义名列表

6 个代谢物同义名

"2,5-Dihydroxybenzoic acid"; 2,5-Dihydroxybenzoic acid; "2,5-DIHYDROXYBENZOATE"; 2,5-Dihydroxy benzoic acid; 2,5-Dihydroxybenzoate; Gentisic acid



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

317 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, BDH2, CAT, HELB, HPGDS, KEAP1, PTGS2, TYR
Peripheral membrane protein 2 FDXR, PTGS2
Endoplasmic reticulum membrane 2 CYBB, PTGS2
Nucleus 5 ALB, GABPA, HELB, KEAP1, MPO
cytosol 8 ALB, BDH2, CAT, GPT, HELB, HPGDS, KEAP1, MB
dendrite 1 CYBB
nuclear body 1 HELB
phagocytic vesicle 1 CYBB
centrosome 1 ALB
nucleoplasm 5 GABPA, HELB, HPGDS, KEAP1, MPO
Cell membrane 2 CYBB, TNF
Multi-pass membrane protein 1 CYBB
cell surface 1 TNF
Golgi apparatus 1 ALB
Golgi membrane 1 INS
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 FDXR
neuronal cell body 2 CYBB, TNF
Lysosome 3 GAA, MPO, TYR
plasma membrane 4 CYBB, GAA, KNG1, TNF
Membrane 3 CAT, CYBB, GAA
caveola 1 PTGS2
extracellular exosome 9 ALB, BDH2, CAT, GAA, GPT, KNG1, LCN2, MB, MPO
Lysosome membrane 1 GAA
endoplasmic reticulum 3 ALB, KEAP1, PTGS2
extracellular space 7 ALB, CCL26, INS, KNG1, LCN2, MPO, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 TYR
mitochondrion 3 CAT, FDXR, HELB
protein-containing complex 3 ALB, CAT, PTGS2
intracellular membrane-bounded organelle 5 CAT, GAA, HPGDS, MPO, TYR
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 TYR
Secreted 5 ALB, CCL26, GAA, INS, LCN2
extracellular region 8 ALB, CAT, GAA, INS, KNG1, LCN2, MPO, TNF
mitochondrial matrix 2 CAT, FDXR
Cytoplasmic vesicle lumen 1 LCN2
anchoring junction 1 ALB
centriolar satellite 1 KEAP1
external side of plasma membrane 1 TNF
Melanosome membrane 1 TYR
midbody 1 KEAP1
sarcoplasm 1 MB
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 FDXR
Membrane raft 1 TNF
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 MPO
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 1 GABPA
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 CYBB
Chromosome 1 HELB
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
actin filament 1 KEAP1
blood microparticle 2 ALB, KNG1
site of double-strand break 1 HELB
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 1 CYBB
endosome lumen 1 INS
monoatomic ion channel complex 1 CYBB
specific granule membrane 1 CYBB
tertiary granule membrane 2 CYBB, GAA
Melanosome 1 TYR
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, INS, KNG1, PTGS2
platelet alpha granule lumen 2 ALB, KNG1
specific granule lumen 1 LCN2
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
perinuclear endoplasmic reticulum 1 CYBB
phagocytic vesicle lumen 1 MPO
ficolin-1-rich granule membrane 1 GAA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Cytoplasm, sarcoplasm 1 MB
catalase complex 1 CAT
inclusion body 1 KEAP1
NADPH oxidase complex 1 CYBB
autolysosome lumen 1 GAA
ciliary transition fiber 1 ALB
Cytoplasmic granule lumen 1 LCN2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Morteza Saeedavi, Mehdi Goudarzi, Iman Fatemi, Zahra Basir, Seyyed Mohammad Ali Noori, Saeed Mehrzadi. Gentisic acid mitigates gentamicin-induced nephrotoxicity in rats. Tissue & cell. 2023 Aug; 84(?):102191. doi: 10.1016/j.tice.2023.102191. [PMID: 37556917]
  • Reza Noei Razliqi, Akram Ahangarpour, Seyyed Ali Mard, Layasadat Khorsandi. Gentisic acid ameliorates type 2 diabetes induced by Nicotinamide-Streptozotocin in male mice by attenuating pancreatic oxidative stress and inflammation through modulation of Nrf2 and NF-кB pathways. Life sciences. 2023 Jul; 325(?):121770. doi: 10.1016/j.lfs.2023.121770. [PMID: 37192699]
  • Dou Ding, Qi Zhang, Fu-Jia Zeng, Ming-Xing Cai, Yuan Gan, Xiao-Jun Dong. Mechanism of Gentisic Acid on Rheumatoid Arthritis Based on miR-19b-3p/RAF1 Axis. Chinese journal of integrative medicine. 2023 Jun; 29(6):508-516. doi: 10.1007/s11655-022-3723-4. [PMID: 36251141]
  • C Payá, S Minguillón, M Hernández, S M Miguel, L Campos, I Rodrigo, J M Bellés, M P López-Gresa, P Lisón. SlS5H silencing reveals specific pathogen-triggered salicylic acid metabolism in tomato. BMC plant biology. 2022 Nov; 22(1):549. doi: 10.1186/s12870-022-03939-5. [PMID: 36443652]
  • Hui Li, Yanxiong Pan, Chun Li, Zhongyu Yang, Jiajia Rao, Bingcan Chen. Design, synthesis and characterization of lysozyme-gentisic acid dual-functional conjugates with antibacterial/antioxidant activities. Food chemistry. 2022 Feb; 370(?):131032. doi: 10.1016/j.foodchem.2021.131032. [PMID: 34500294]
  • Poulami Gupta, Bratati De. Influence of calcium channel modulators on the production of serotonin, gentisic acid, and a few other biosynthetically related phenolic metabolites in seedling leaves of salt tolerant rice variety Nonabokra. Plant signaling & behavior. 2021 10; 16(10):1929732. doi: 10.1080/15592324.2021.1929732. [PMID: 34024248]
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  • Daniela Paula de Toledo Thomazella, Kyungyong Seong, Rebecca Mackelprang, Douglas Dahlbeck, Yu Geng, Upinder S Gill, Tiancong Qi, Julie Pham, Priscila Giuseppe, Clara Youngna Lee, Arturo Ortega, Myeong-Je Cho, Samuel F Hutton, Brian Staskawicz. Loss of function of a DMR6 ortholog in tomato confers broad-spectrum disease resistance. Proceedings of the National Academy of Sciences of the United States of America. 2021 07; 118(27):. doi: 10.1073/pnas.2026152118. [PMID: 34215692]
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