Piperine (BioDeep_00000000394)

 

Secondary id: BioDeep_00000298279, BioDeep_00000420892

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

化学式: C17H19NO3 (285.1364864)
中文名称: 胡椒酰胺, 胡椒碱
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.36%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Piperine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/piperine (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000394). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CCN(CC1)C(=O)/C=C/C=C/c1ccc2c(c1)OCO2
InChI: InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+

描述信息

Piperine, also known as fema 2909, belongs to the class of organic compounds known as alkaloids and derivatives. These are naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and more rarely other elements such as chlorine, bromine, and phosphorus. Piperine is a pepper tasting compound. Piperine is found in the highest concentration within pepper (Piper nigrum) and many other Piper species. Piperine has also been detected, but not quantified, in dills and herbs and spices. Piperine is responsible for the hot taste of pepper. Piperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders. It is used to impart pungent taste to brandy.
Piperine is a N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. It has a role as a NF-kappaB inhibitor, a plant metabolite, a food component and a human blood serum metabolite. It is a member of benzodioxoles, a N-acylpiperidine, a piperidine alkaloid and a tertiary carboxamide. It is functionally related to an (E,E)-piperic acid.
Bioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders.
Piperine is a natural product found in Macropiper, Piper boehmeriifolium, and other organisms with data available.
See also: Black Pepper (part of) ... View More ...
Constituent of pepper (Piper nigrum) and many other Piper subspecies (Piperaceae). It is used to impart pungent taste to brandy. Responsible for the hot taste of pepper. Flavour ingredient. Piperine is found in dill, herbs and spices, and pepper (spice).
A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.

Piperine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=94-62-2 (retrieved 2024-07-01) (CAS RN: 94-62-2). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.

同义名列表

88 个代谢物同义名

InChI=1/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3; (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one; 2,4-Pentadien-1-one, 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-, (2E,4E)-; (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one; Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-; Piperidine, 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-; Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-; piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-; (2E,4E)-5-(1,3-dioxaindan-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one; (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one; (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(1-piperidyl)penta-2,4-dien-1-one; 1-(5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine, (E,E)-; 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine; 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine; Piperidine, 1-(5-(3,4-methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)-; 5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one; (E,E) 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine; 1-[(2E,4E)-5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine #; 1-(5-(3,4-Methylenedioxyphenyl)-1-oxo-2,4-pentadienyl)piperidine; 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-2,4-pentadienoyl)piperidine; 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl)piperidine; 1-[(2E,4E)-5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine; 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine; ((1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine; (1-(5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine; 5-(1,3-dioxaindan-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one; Piperidine,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-; 5-(1,3-benzodioxol-5-yl)-1-(1-piperidinyl)-1-penta-2,4-dienone; (E,E)-1-(5-(1,3-BENZODIOXOL-5-YL)-2,4-PENTADIENOYL)PIPERIDINE; Piperine, United States Pharmacopeia (USP) Reference Standard; Piperine, European Pharmacopoeia (EP) Reference Standard; 1-[5-(1,3-Benzodioxol-5-yl)-2,4-pentadienoyl]piperidine; 1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperidine; 1,3-Benzodioxol-5-yl-1-oxo-2,4-pentadienyl-piperine; PIPERINE (CONSTITUENT OF BLACK PEPPER) [DSC]; (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-; PIPERINE (CONSTITUENT OF BLACK PEPPER); (piperidin-1-yl)penta-2,4-dien-1-one; 1-trans,trans-piperinoyl-piperidine; Piperidine, 1-piperoyl-, (E,E)-; Piperine (1-Piperoylpiperidine); Bioperine;1-Piperoylpiperidine; Piperine, analytical standard; N-[(E,E)-Piperoyl]piperidine; 1-Piperoylpiperidine, (E,E)-; N-((E,E)-Piperoyl)piperidine; 1-PIPEROYL-(E,E)-PIPERIDINE; N-(E,E)-piperoyl-piperidine; (E,E)-1-piperoylpiperidine; N-EE-PIPEROYL-PIPERIDINE; Piperidine, 1-piperoyl-; piperine, (Z,Z)-isomer; piperine, (Z,E)-isomer; piperine, (E,Z)-isomer; piperine, (E,E)-isomer; 1-Piperoyl-piperidine; 1-piperoylpiperidine; Piperine (aliphatic); Piperine, >=97\\%, FG; 1-Piperylpiperidine; Piperidine, (E,E)-; Piperoylpiperidine; Prestwick3_000474; PIPERINE [WHO-DD]; PIPERINE [USP-RS]; PIPERINE (USP-RS); Prestwick2_000474; Spectrum5_001507; Piperine, >=97\\%; UNII-U71XL721QK; PIPERINE [FHFI]; PIPERINE [INCI]; Piperine [USP]; Piperine (USP); BPBio1_000670; PIPERINE [MI]; Piperine,(S); Tox21_201990; Tox21_302746; CAS-94-62-2; IDI1_000954; AI 3-01439; U71XL721QK; FEMA 2909; Bioperine; AI3-01439; Piperine; Piperin



数据库引用编号

56 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Phanit Songvut, Tussapon Boonyarattanasoonthorn, Nitra Nuengchamnong, Thammaporn Junsai, Teetat Kongratanapasert, Kittitach Supannapan, Phisit Khemawoot. Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs. Pharmaceutical biology. 2024 Dec; 62(1):183-194. doi: 10.1080/13880209.2024.2311201. [PMID: 38351624]
  • Yifei Wu, Jiayu Zhang, Sha Du, Xiaochuan Wang, Jinrong Li, Yi Chen, Hongying Zhou, Su Gao, Yongrong Li, Xiuhong Liu. Combination of 308-nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR-328/SFRP1 axis. Photodermatology, photoimmunology & photomedicine. 2024 May; 40(3):e12970. doi: 10.1111/phpp.12970. [PMID: 38685665]
  • Kangyun Zhao, Siwei Zhang, Chunhong Piao, Fei Xu, Yutong Zhang, Xu Wang, Jiyue Zhang, Chunxia Zhao, Sang Guan You, Yanjun Zhang. Investigation of the formation mechanism of the pepper starch-piperine complex. International journal of biological macromolecules. 2024 May; 268(Pt 1):131777. doi: 10.1016/j.ijbiomac.2024.131777. [PMID: 38663710]
  • Bin Tang, Shangrong Hu, Yujia Luo, Dongmei Shi, Xiangyu Liu, Fan Zhong, Xinyi Jiang, Gao Hu, Can Li, Hongxia Duan, Yan Wu. Impact of Three Thiazolidinone Compounds with Piperine Skeletons on Trehalase Activity and Development of Spodoptera frugiperda Larvae. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8423-8433. doi: 10.1021/acs.jafc.3c08898. [PMID: 38565327]
  • Asmaa Badawy Darwish, Amira Mohamed Mohsen, Shaimaa ElShebiney, Rania Elgohary, Mostafa Mohamed Younis. Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats. Scientific reports. 2024 04; 14(1):8247. doi: 10.1038/s41598-024-58601-x. [PMID: 38589438]
  • Lan Yu, Xiaolu Hu, Rongrong Xu, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Xing Wang, Xiaoqing Chen, Yinying Ba, Zhikai Xing, Chongye Guo, Shuangli Mi, Xia Wu. Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117628. doi: 10.1016/j.jep.2023.117628. [PMID: 38158101]
  • Meghana N Kumar, Sreeram Peringattu Kalarikkal, Yashaswini Jayaram, Janakiraman Narayanan, Gopinath M Sundaram. Protocol to produce plant-based hybrid nanovesicles from fresh turmeric and pepper using polyethylene glycol. STAR protocols. 2024 Mar; 5(1):102924. doi: 10.1016/j.xpro.2024.102924. [PMID: 38430518]
  • Protha Biswas, Devendra Kumar Pandey, Mahipal S Shekhawat, Abhijit Dey, Tabarak Malik. Tissue-specific variations of piperine in ten populations of Piper longum L.: bioactivities and toxicological profile. Scientific reports. 2024 03; 14(1):5062. doi: 10.1038/s41598-024-52297-9. [PMID: 38424458]
  • Koniyan Shaheer, Br Swathi Prabhu, H Shabeer Ali, Divya Lakshmanan-M. Breast cancer cells are sensitized by piperine to radiotherapy through estrogen receptor-α mediated modulation of a key NHEJ repair protein- DNA-PK. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155126. doi: 10.1016/j.phymed.2023.155126. [PMID: 37913642]
  • Sakineh Rezaei, Hoda-Sadat Meftah, Yasamin Ebtehajpour, Hamid Reza Rahimi, Jamshidkhan Chamani. Investigation on the Effect of Fluorescence Quenching of Calf Thymus DNA by Piperine: Caspase Activation in the Human Breast Cancer Cell Line Studies. DNA and cell biology. 2024 Jan; 43(1):26-38. doi: 10.1089/dna.2023.0269. [PMID: 38079271]
  • Jin Han, Shaoyong Zhang, Jun He, Tianze Li. Piperine: Chemistry and Biology. Toxins. 2023 Dec; 15(12):. doi: 10.3390/toxins15120696. [PMID: 38133200]
  • Kosar Boshagh, Fariborz Khorvash, Amirhossein Sahebkar, Muhammed Majeed, Nimah Bahreini, Gholamreza Askari, Mohammad Bagherniya. The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial. Nutrition journal. 2023 Dec; 22(1):69. doi: 10.1186/s12937-023-00905-1. [PMID: 38082237]
  • Ying Liu, Rui Zhu, Xinwei Liu, Dengzhou Li, Mengyu Guo, Bing Fei, Yanying Ren, Xiaojuan You, Yongwei Li. Effect of piperine on the inhibitory potential of MexAB-OprM efflux pump and imipenem resistance in carbapenem-resistant Pseudomonas aeruginosa. Microbial pathogenesis. 2023 Dec; 185(?):106397. doi: 10.1016/j.micpath.2023.106397. [PMID: 37852553]
  • Claudia Patricia Bravo-Chaucanés, Luis Carlos Chitiva, Yerly Vargas-Casanova, Valentina Diaz-Santoyo, Andrea Ximena Hernández, Geison M Costa, Claudia Marcela Parra-Giraldo. Exploring the Potential Mechanism of Action of Piperine against Candida albicans and Targeting Its Virulence Factors. Biomolecules. 2023 11; 13(12):. doi: 10.3390/biom13121729. [PMID: 38136600]
  • Maria D Octavia, Hasmiwati Hasmiwati, Gusti Revilla, Erizal Zaini. Effect of multicomponent crystal of piperine-nicotinic acid on antihyperlipidemic activity in rats. Pakistan journal of pharmaceutical sciences. 2023 Nov; 36(6):1777-1781. doi: . [PMID: 38124418]
  • Muhammed Majeed, Kalyanam Nagabhushanam, Avinash Murali, Devarajan T Vishwanathan, Ramamohan V Mamidala, Lakshmi Mundkur. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study. Journal of integrative and complementary medicine. 2023 Oct; ?(?):. doi: 10.1089/jicm.2023.0279. [PMID: 37878284]
  • Pu Jian, Takuto Kumano, Mio Kimura, Makoto Kurisaki, Yoshiteru Hashimoto, Michihiko Kobayashi. Biodegradation of the methylenedioxyphenyl group in piperine and its derivatives: discovery of a novel methylenetransferase in an actinomycete. Applied and environmental microbiology. 2023 Oct; ?(?):e0114523. doi: 10.1128/aem.01145-23. [PMID: 37874289]
  • Sohail Hussain, Abdulmajeed M Jali, Saeed Alshahrani, Khairat H M Khairat, Rahimullah Siddiqui, Mohammad Intakhab Alam, Raisuddin Ali, Manal Mohammed, Andleeb Khan, Hamad Al Shahi, Ali Hanbashi, Marwa Qadri, Mohammad Ashafaq. Hepatoprotective and Antioxidant Effects of Nanopiperine against Cypermethrin via Mitigation of Oxidative Stress, Inflammations and Gene Expression Using qRT-PCR. International journal of molecular sciences. 2023 Oct; 24(20):. doi: 10.3390/ijms242015361. [PMID: 37895045]
  • Rizal Subahar, Ayleen Huang, Rafaella Shiene Wijaya, Lia Savitri Eka Nur, Lisawati Susanto, Nurhadi Eko Firmansyah, Yulhasri Yulhasri, Gulshan Fahmi El Bayani, Surya Dwira. First report on evaluation of commercial eugenol and piperine against Aedes aegypti L (Diptera: Culicidae) larvae: Mortality, detoxifying enzyme, and histopathological changes in the midgut. Parasitology international. 2023 Oct; ?(?):102813. doi: 10.1016/j.parint.2023.102813. [PMID: 37793471]
  • Yuanyuan Lv, Jinjin Zhu, Sihui Huang, Xiaoli Xing, Shen Zhou, Hui Yao, Zhuang Yang, Ling Liu, Sishu Huang, Yuanyuan Miao, Xianqing Liu, Alisdair R Fernie, Yuanhao Ding, Jie Luo. Metabolome profiling and transcriptome analysis filling the early crucial missing steps of piperine biosynthesis in Piper nigrum L. The Plant journal : for cell and molecular biology. 2023 Sep; ?(?):. doi: 10.1111/tpj.16476. [PMID: 37753665]
  • Xuejiao Wang, Jiangbin Wang, Helin Li. Enhanced anticancer activity of piperine: Structural optimization and chitosan-based microgels with boosted drug delivery. International journal of biological macromolecules. 2023 Sep; 253(Pt 5):127019. doi: 10.1016/j.ijbiomac.2023.127019. [PMID: 37739282]
  • Sri-Arun Iamjan, Siriluk Veerasakul, Samur Thanoi, Waree Tiyaboonchai, Sutisa Nudmamud-Thanoi. A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain. Journal of complementary & integrative medicine. 2023 Sep; ?(?):. doi: 10.1515/jcim-2023-0043. [PMID: 37712769]
  • Ligang Yu, Xiaoyue Zhang, Wenyan Sun, Guang Shen, Yukun Yang, Maomao Zeng. The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems. Food chemistry. 2023 Sep; 420(?):136119. doi: 10.1016/j.foodchem.2023.136119. [PMID: 37060667]
  • Zehra Omeroglu Ulu, Nurdan Sena Degirmenci, Zeynep Busra Bolat, Fikrettin Sahin. Synergistic anti-cancer effect of sodium pentaborate pentahydrate, curcumin and piperine on hepatocellular carcinoma cells. Scientific reports. 2023 09; 13(1):14404. doi: 10.1038/s41598-023-40809-y. [PMID: 37658091]
  • Xiaolu Hu, Lan Yu, Yatong Li, Xiaoxi Li, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Qijun Chen, Xing Wang, Xiaoqing Chen, Yinying Ba, Yaonan Wang, Xia Wu. Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase. CNS neuroscience & therapeutics. 2023 Aug; ?(?):. doi: 10.1111/cns.14383. [PMID: 37528534]
  • Di Wu, Xia Hu, Zhangyu Cai, Jing Zhang, Fang Geng, Hui Li. Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin. Food & function. 2023 Jul; 14(14):6422-6431. doi: 10.1039/d3fo00617d. [PMID: 37395089]
  • Sharmistha Das, Ritwik Roy, Payel Paul, Poulomi Chakraborty, Sudipta Chatterjee, Moumita Malik, Sarita Sarkar, Anirban Das Gupta, Debasish Maiti, Prosun Tribedi. Piperine, a Plant Alkaloid, Exhibits Efficient Disintegration of the Pre-existing Biofilm of Staphylococcus aureus: a Step Towards Effective Management of Biofilm Threats. Applied biochemistry and biotechnology. 2023 Jun; ?(?):. doi: 10.1007/s12010-023-04610-x. [PMID: 37389724]
  • Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri. Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion. Journal of microencapsulation. 2023 Jun; 40(4):279-301. doi: 10.1080/02652048.2023.2194415. [PMID: 36948888]
  • Min Lv, Shaochen Li, Houpeng Wen, Yanyan Wang, Jiawei Du, Hui Xu. Expedient discovery of novel oxime ester derivatives of piperine/piperine analogs as potent pesticide candidates and their mode of action against Tetranychus cinnabarinus Boisduval. Pest management science. 2023 May; ?(?):. doi: 10.1002/ps.7521. [PMID: 37139821]
  • Niloofar Ghobadi, Ahmad Asoodeh. Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7794. [PMID: 36883534]
  • Kamil Wdowiak, Andrzej Miklaszewski, Robert Pietrzak, Judyta Cielecka-Piontek. Amorphous System of Hesperetin and Piperine-Improvement of Apparent Solubility, Permeability, and Biological Activities. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054859. [PMID: 36902286]
  • Shima Sharifi, Mohammad Bagherniya, Ziba Khoram, Amrollah Ebrahimi Varzaneh, Stephen L Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar, Gholamreza Askari. Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7764. [PMID: 36799355]
  • Hajar Heidari, Mohammad Bagherniya, Muhammed Majeed, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar. Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy research : PTR. 2023 Jan; ?(?):. doi: 10.1002/ptr.7737. [PMID: 36720711]
  • Lais Silva Morais, João Paulo Barreto Sousa, Carolina Melo Aguiar, Ciro Martins Gomes, Daniel Pecoraro Demarque, Lorena Carneiro Albernaz, Laila Salmen Espindola. Edible Plant Extracts against Aedes aegypti and Validation of a Piper nigrum L. Ethanolic Extract as a Natural Insecticide. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031264. [PMID: 36770931]
  • Hossein Hosseini, Farideh Ghavidel, Ghodratollah Panahi, Muhammed Majeed, Amirhossein Sahebkar. A systematic review and meta-analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders. Phytotherapy research : PTR. 2023 Jan; ?(?):. doi: 10.1002/ptr.7730. [PMID: 36649934]
  • Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang. Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid. Drug development and industrial pharmacy. 2023 Jan; 49(1):30-41. doi: 10.1080/03639045.2023.2182120. [PMID: 36803327]
  • Isha Gupta, Syeda Nashvia Adin, Mohd Aqil, Mohd Mujeeb, Yasmin Sultana. Quality by design-based development and validation of an HPLC method for simultaneous estimation of pregabalin and piperine in dual drug-loaded liposomes. Biomedical chromatography : BMC. 2023 Jan; 37(1):e5510. doi: 10.1002/bmc.5510. [PMID: 36100737]
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