Scutellarein (BioDeep_00000003711)

Main id: BioDeep_00000229882

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


6-hydroxyapigenin

化学式: C15H10O6 (286.0477)
中文名称: 高黄芩素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1ccc(cc1)O)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H

描述信息

Scutellarein is a natural flavonoid compound with anti-inflammatory effects.
Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

同义名列表

5 个代谢物同义名

6-hydroxyapigenin; Isocarthamidin; Scutellarein; 4',5,6,7-Tetrahydroxyflavone; Scutellarein



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

158 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, ANXA5, BCL2, CA1, CASP3, CYP1A1, PIK3CA, PTEN, PTGS2, VEGFA
Peripheral membrane protein 5 ACHE, ANXA5, CYP1A1, CYP1B1, PTGS2
Endoplasmic reticulum membrane 7 BCL2, CYP1A1, CYP1B1, PTGS2, UGT1A1, UGT1A3, UGT1A9
Nucleus 6 ACHE, AKT1, BCL2, CASP3, PTEN, VEGFA
cytosol 7 AKT1, ANXA5, BCL2, CA1, CASP3, PIK3CA, PTEN
nucleoplasm 3 AKT1, CASP3, PTEN
Cell membrane 3 ACHE, AKT1, TNF
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 SLC15A1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 2 ACHE, VEGFA
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Lysosome 1 GAA
plasma membrane 9 ACHE, AKT1, F2, GAA, PIK3CA, PTEN, SLC15A1, TNF, UGT1A1
Membrane 11 ACHE, AKT1, ANXA5, BCL2, CYP1B1, GAA, SLC15A1, UGT1A1, UGT1A3, UGT1A9, VEGFA
apical plasma membrane 2 PTEN, SLC15A1
brush border 1 SLC15A1
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CA1, F2, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 6 BCL2, PTGS2, UGT1A1, UGT1A3, UGT1A9, VEGFA
extracellular space 5 ACHE, F2, IL6, TNF, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 ACHE, PIK3CA, UGT1A1
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CYP1A1, CYP1B1
protein-containing complex 3 AKT1, BCL2, PTGS2
intracellular membrane-bounded organelle 3 CYP1A1, CYP1B1, GAA
Microsome membrane 3 CYP1A1, CYP1B1, PTGS2
postsynaptic density 2 CASP3, PTEN
Secreted 5 ACHE, F2, GAA, IL6, VEGFA
extracellular region 8 ACHE, ANXA5, F2, GAA, IL6, PTEN, TNF, VEGFA
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 4 BCL2, UGT1A1, UGT1A3, UGT1A9
mitochondrial outer membrane 1 BCL2
Extracellular side 1 ACHE
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
dendritic spine 1 PTEN
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 SLC15A1
Cytoplasm, perinuclear region 1 UGT1A1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
spindle 1 AKT1
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ANXA5, F2
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, neuron projection 1 PTEN
Zymogen granule membrane 1 ANXA5
neuron projection 2 PTEN, PTGS2
ciliary basal body 1 AKT1
cell projection 1 PTEN
phagocytic cup 1 TNF
blood microparticle 1 F2
Lipid-anchor, GPI-anchor 1 ACHE
tertiary granule membrane 1 GAA
side of membrane 1 ACHE
myelin sheath 1 BCL2
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, IL6, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 GAA
Schmidt-Lanterman incisure 1 PTEN
vesicle membrane 1 ANXA5
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 UGT1A1
myelin sheath adaxonal region 1 PTEN
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
cytochrome complex 1 UGT1A1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Guangjun Yu, Yichun Shi, Shiqin Cong, Chengxun Wu, Jing Liu, Yanghui Zhang, Hongyan Liu, Xiuxiu Liu, Haixing Deng, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of butylphthalide-scutellarein hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2024 Feb; 265(?):116099. doi: 10.1016/j.ejmech.2023.116099. [PMID: 38160618]
  • Lu Liu, Yunsen Zhang, Lun Wang, Yue Liu, Hongqing Chen, Qiongying Hu, Chunguang Xie, Xianli Meng, Xiaofei Shen. Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase. Phytotherapy research : PTR. 2023 Oct; 37(10):4587-4606. doi: 10.1002/ptr.7928. [PMID: 37353982]
  • Yujing Wang, Liaoxi Tan, Kejun Jiao, Chu Xue, Qinglian Tang, Shan Jiang, Younan Ren, Hao Chen, Tarek Mohamed Abd El-Aziz, Khalid N M Abdelazeem, Ye Yu, Fang Zhao, Michael X Zhu, Zhengyu Cao. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. British journal of pharmacology. 2022 10; 179(20):4792-4808. doi: 10.1111/bph.15913. [PMID: 35771623]
  • Min Yeong Park, Sang Eun Ha, Hun Hwan Kim, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Se Hyo Jeong, Joon-Suk Park, Jeong Doo Heo, Gon Sup Kim. Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123782. [PMID: 35744907]
  • Ivana M P Violante, Carlos A Carollo, Larissa I Silva, Adna Q C Oliveira, Flavia C Pardinho, Walmir Silva Garcez, Fernanda R Garcez, Ruberlei Godinho de Oliveira, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins. Cytotoxicity and antibacterial activity of scutellarein and carajurone-enriched fraction obtained from the hydroethanolic extract of the leaves of Fridericia chica (Bonpl.) L.G. Lohmann. Natural product research. 2021 Dec; 35(23):5287-5293. doi: 10.1080/14786419.2020.1753050. [PMID: 32290696]
  • Dong Liu, Cuijie Zhang, Min Hu, Kangle Su. Scutellarein relieves the death and inflammation of tubular epithelial cells in ischemic kidney injury by degradation of COX-2 protein. International immunopharmacology. 2021 Dec; 101(Pt A):108193. doi: 10.1016/j.intimp.2021.108193. [PMID: 34619498]
  • Dongni Ji, Jianhua Li, Fanglin Xu, Yuhong Ren, Yong Wang. Improve the Biosynthesis of Baicalein and Scutellarein via Manufacturing Self-Assembly Enzyme Reactor In Vivo. ACS synthetic biology. 2021 05; 10(5):1087-1094. doi: 10.1021/acssynbio.0c00606. [PMID: 33880917]
  • Venu Venkatarame Gowda Saralamma, Preethi Vetrivel, Ho Jeong Lee, Seong Min Kim, Sang Eun Ha, Rajeswari Murugesan, Eun Hee Kim, Jeong Doo Heo, Gon Sup Kim. Comparative proteomic analysis uncovers potential biomarkers involved in the anticancer effect of Scutellarein in human gastric cancer cells. Oncology reports. 2020 09; 44(3):939-958. doi: 10.3892/or.2020.7677. [PMID: 32705238]
  • Yuanzhi Li, Jundong Wang, Sen Zhong, Jun Li, Weiliang Du. Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination. International journal of molecular medicine. 2020 Apr; 45(4):1059-1072. doi: 10.3892/ijmm.2020.4496. [PMID: 32124957]
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  • Jianhua Li, Chenfei Tian, Yuhui Xia, Ishmael Mutanda, Kaibo Wang, Yong Wang. Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine. Metabolic engineering. 2019 03; 52(?):124-133. doi: 10.1016/j.ymben.2018.11.008. [PMID: 30496827]
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  • Lin You, Hong Zhu, Chun Wang, Fang Wang, Yongjun Li, Yan Li, Yonglin Wang, Bin He. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. Bioorganic & medicinal chemistry letters. 2017 12; 27(24):5404-5408. doi: 10.1016/j.bmcl.2017.11.011. [PMID: 29157862]
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  • Xiaoxuan Tian, Lianying Chang, Guangyin Ma, Taiyi Wang, Ming Lv, Zhilong Wang, Liping Chen, Yuefei Wang, Xiumei Gao, Yan Zhu. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. Biological & pharmaceutical bulletin. 2016; 39(2):181-91. doi: 10.1248/bpb.b15-00511. [PMID: 26581323]
  • Hao Tang, Zhi-Hao Shi, Nian-Guang Li, Yu-Ping Tang, Qian-Ping Shi, Ze-Xi Dong, Peng-Xuan Zhang, Jin-Ao Duan. Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. Archives of pharmacal research. 2015 Oct; 38(10):1789-801. doi: 10.1007/s12272-014-0541-z. [PMID: 25577334]
  • Yearam Jung, Soon Young Shin, Yeonjoong Yong, Hyeryoung Jung, Seunghyun Ahn, Young Han Lee, Yoongho Lim. Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. Chemical biology & drug design. 2015 May; 85(5):574-85. doi: 10.1111/cbdd.12445. [PMID: 25298094]
  • Zhipei Sang, Xiaoming Qiang, Yan Li, Wen Yuan, Qiang Liu, Yikun Shi, Wei Ang, Youfu Luo, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2015 Apr; 94(?):348-66. doi: 10.1016/j.ejmech.2015.02.063. [PMID: 25778991]
  • Hao Tang, Yuping Tang, Nian-Guang Li, Hang Lin, Weixia Li, Qianping Shi, Wei Zhang, Pengxuan Zhang, Zexi Dong, Minzhe Shen, Ting Gu, Jin-Ao Duan. Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. PloS one. 2015; 10(7):e0131569. doi: 10.1371/journal.pone.0131569. [PMID: 26147971]
  • Kasumi Nakamura, Jia-Hua Yang, Eiji Sato, Naoyuki Miura, Yi-Xin Wu. Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. Biological & pharmaceutical bulletin. 2015; 38(6):935-40. doi: 10.1248/bpb.b15-00018. [PMID: 25810454]
  • Xiao Yang, Xiaoqing Miao, Fangrui Cao, Shang Li, Nana Ai, Qi Chang, Simon M Y Lee, Ying Zheng. Nanosuspension development of scutellarein as an active and rapid orally absorbed precursor of its BCS class IV glycoside scutellarin. Journal of pharmaceutical sciences. 2014 Nov; 103(11):3576-3584. doi: 10.1002/jps.24149. [PMID: 25187229]
  • Xin Wang, Hongjun Xia, Youping Liu, Feng Qiu, Xin Di. Simultaneous determination of three glucuronide conjugates of scutellarein in rat plasma by LC-MS/MS for pharmacokinetic study of breviscapine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):79-84. doi: 10.1016/j.jchromb.2014.06.013. [PMID: 24999248]
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  • Guang-You Ma, Yun-Feng Cao, Cui-Min Hu, Zhong-Ze Fang, Xiao-Yu Sun, Mo Hong, Zhi-Tu Zhu. Comparison of inhibition capability of scutellarein and scutellarin towards important liver UDP-glucuronosyltransferase (UGT) isoforms. Phytotherapy research : PTR. 2014 Mar; 28(3):382-6. doi: 10.1002/ptr.4990. [PMID: 23620377]
  • Z Shu-Yao, J Hong, L Chao-Xian, Z Zhi-Wei, Xin Dai-Shan, C Lei. In vitro evidence of possible influence of scutellarein towards bile acids' metabolism. African health sciences. 2013 Sep; 13(3):556-9. doi: 10.4314/ahs.v13i3.4. [PMID: 24250288]
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