(-)-Arctigenin (BioDeep_00000003670)

 

Secondary id: BioDeep_00000402837, BioDeep_00000859725

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity natural product


代谢物信息卡片


(3R,4R)-4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-2(3H)-FURANONE;2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R);(-)-ARCTIGENIN;ARCTIGENIN;ARCTIGENIN(P)

化学式: C21H24O6 (372.1573)
中文名称: 牛蒡甙元, 牛蒡苷元, 牛蒡子苷元
谱图信息: 最多检出来源 Viridiplantae(plant) 22.08%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
InChI: InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3

描述信息

(-)-Arctigenin is found in burdock. (-)-Arctigenin is isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD).Arctigenin is a lignan found in certain plants of the Asteraceae , including the Greater burdock (Arctium lappa) and Saussurea heteromalla. It has shown antiviral and anticancer effects. It is the aglycone of arctiin. (Wikipedia
(-)-Arctigenin is a lignan.
Arctigenin is a natural product found in Centaurea cineraria, Forsythia suspensa, and other organisms with data available.
See also: Arctium lappa Root (part of); Arctium lappa fruit (part of); Pumpkin Seed (part of) ... View More ...
Isolated from Cnicus benedictus, Forsythia viridissima, Arctium lappa, Ipomoea cairica and others (CCD)
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions[1][2][3].

同义名列表

36 个代谢物同义名

(3R,4R)-4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-2(3H)-FURANONE;2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R);(-)-ARCTIGENIN;ARCTIGENIN;ARCTIGENIN(P); (3R-trans)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy- 3-methoxyphenyl)methyl]-4,5-dihydrofuran-2(3H)-one; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-rel-; 2(3H)-furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R,4R)-; 2(3H)-Furanone, 4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-, (3R,4R)-; 4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R-trans)-2(3H)-Furanone; 2(3H)-Furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, trans-; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxy-phenyl)methyl]tetrahydrofuran-2-one; (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3- [(4-hydroxy-3-methoxyphenyl)methyl]-2-tetrahydrofuranone; 4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-(3R,4R)-2(3H)-Furanone; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-methoxy-4-oxidanyl-phenyl)methyl]oxolan-2-one; (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one; (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one; (-)-Arctigenin, >=95\\% (LC/MS-ELSD); Arctigenin, trans-((+/-)-; ARCTIGENIN, TRANS-(-)-; Arctigenin, (+/-)-; ARCTIGENIN [INCI]; ARCTIGENIN, (-)-; (+/-)-Arctigenin; UNII-2FD8L150E7; UNII-U76MR9VS6M; (-)-Arctigenin; MEGxp0_001799; ACon1_000416; Arctigenen; Arctigenin; U76MR9VS6M; 2FD8L150E7; CHEBI:79; C21H24O6; EQC; l-Arctigenin; Arctigenin



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

9 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(8)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

176 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 BCL2, CASP3, CDH1, CDH2, CTNNB1, MAPK14, MAPK8, MTOR, NLRP3, NOS2, PIK3CA, PRKAA2, PTGS2, STAT3, TLR4, VEGFA
Peripheral membrane protein 3 GORASP1, MTOR, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Nucleus 12 BCL2, CASP3, CDH1, CTNNB1, MAPK14, MAPK8, MTOR, NLRP3, NOS2, PRKAA2, STAT3, VEGFA
cytosol 12 BCL2, CASP3, CDH1, CTNNB1, MAPK14, MAPK8, MTOR, NLRP3, NOS2, PIK3CA, PRKAA2, STAT3
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
trans-Golgi network 1 CDH1
centrosome 1 CTNNB1
nucleoplasm 9 CASP3, CDH1, CTNNB1, MAPK14, MAPK8, MTOR, NOS2, PRKAA2, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 5 CDH1, CDH2, CTNNB1, TLR4, TNF
Cytoplasmic side 2 GORASP1, MTOR
lamellipodium 4 CDH1, CDH2, CTNNB1, PIK3CA
Golgi apparatus membrane 3 GORASP1, MTOR, NLRP3
Synapse 2 CTNNB1, MAPK8
cell cortex 1 CTNNB1
cell junction 3 CDH1, CDH2, CTNNB1
cell surface 4 CDH2, TLR4, TNF, VEGFA
glutamatergic synapse 4 CASP3, CDH1, CTNNB1, MAPK14
Golgi apparatus 4 CDH1, GORASP1, PRKAA2, VEGFA
Golgi membrane 3 GORASP1, MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
postsynapse 1 CDH1
presynaptic membrane 1 CTNNB1
sarcolemma 1 CDH2
Cytoplasm, cytosol 2 NLRP3, NOS2
Lysosome 1 MTOR
endosome 1 CDH1
plasma membrane 8 CDH1, CDH2, CTNNB1, NOS2, PIK3CA, STAT3, TLR4, TNF
Membrane 9 BCL2, CDH1, CDH2, CTNNB1, MTOR, NLRP3, PRKAA2, TLR4, VEGFA
apical plasma membrane 1 CDH2
axon 3 CCK, MAPK8, PRKAA2
basolateral plasma membrane 2 CDH2, CTNNB1
caveola 1 PTGS2
extracellular exosome 2 CDH1, CTNNB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, NLRP3, PTGS2, VEGFA
extracellular space 4 CCK, IL6, TNF, VEGFA
perinuclear region of cytoplasm 5 CDH1, CTNNB1, NOS2, PIK3CA, TLR4
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 4 CDH1, CDH2, CTNNB1, VEGFA
apicolateral plasma membrane 2 CDH2, CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 2 CDH2, PIK3CA
mitochondrion 3 BCL2, MAPK14, NLRP3
protein-containing complex 3 BCL2, CTNNB1, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 2 CASP3, CDH2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 CDH1, CDH2, TLR4
Secreted 4 CCK, IL6, NLRP3, VEGFA
extracellular region 7 CCK, CDH1, IL6, MAPK14, NLRP3, TNF, VEGFA
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
transcription regulator complex 2 CTNNB1, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDH1
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 CDH1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
apical part of cell 2 CDH2, CTNNB1
cell-cell junction 2 CDH2, CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
presynaptic active zone membrane 1 CDH2
Cell membrane, sarcolemma 1 CDH2
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CDH2, CTNNB1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 3 CDH1, CDH2, CTNNB1
flotillin complex 2 CDH1, CTNNB1
extracellular matrix 1 VEGFA
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 CDH2
secretory granule 1 VEGFA
fascia adherens 2 CDH2, CTNNB1
lateral plasma membrane 2 CDH1, CTNNB1
nuclear speck 2 MAPK14, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 2 CDH2, PTGS2
chromatin 1 STAT3
phagocytic cup 2 TLR4, TNF
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 2 CTNNB1, MAPK14
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Endomembrane system 3 CTNNB1, MTOR, NLRP3
microtubule organizing center 1 NLRP3
cytoplasmic stress granule 1 PRKAA2
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
plasma membrane raft 1 CDH2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 3 CDH2, IL6, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
beta-catenin-TCF complex 1 CTNNB1
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
presynaptic active zone cytoplasmic component 1 CTNNB1
[Isoform 2]: Nucleus 1 CDH1
protein-DNA complex 1 CTNNB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 CDH2
apical junction complex 1 CDH1
nucleotide-activated protein kinase complex 1 PRKAA2
Cell junction, desmosome 2 CDH1, CDH2
desmosome 2 CDH1, CDH2
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 3 CDH1, CDH2, CTNNB1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Mengjia Lv, Shiyi Chen, Mengwen Shan, Yuan Si, Chenggang Huang, Jing Chen, Likun Gong. Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice. European journal of pharmacology. 2024 Jul; 974(?):176629. doi: 10.1016/j.ejphar.2024.176629. [PMID: 38679116]
  • Zhuoqun Li, Lixing Cao, Kai Han, Lihong Fan, Chong Zhao, Shutao Yin, Hongbo Hu. Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis. Biochemical and biophysical research communications. 2024 May; 710(?):149895. doi: 10.1016/j.bbrc.2024.149895. [PMID: 38593620]
  • Xueling Li, Jue Wang, Jiayi Yan, John Cijiang He, Yi Li, Yifei Zhong. Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 171(?):116107. doi: 10.1016/j.biopha.2023.116107. [PMID: 38215692]
  • Shunfang Liu, Yaozhen He, Minding Feng, Yongtong Huang, Wenhao Wu, Jiu Wang. Targeted Delivery of Arctigenin Using Sialic Acid Conjugate-Modified Liposomes for the Treatment of Breast Cancer. Molecules (Basel, Switzerland). 2024 Jan; 29(1):. doi: 10.3390/molecules29010278. [PMID: 38202860]
  • Zekrayat J H Medras, Yasser M Mostafa, Amal A M Ahmed, Norhan M El-Sayed. Arctigenin improves neuropathy via ameliorating apoptosis and modulating autophagy in streptozotocin-induced diabetic mice. CNS neuroscience & therapeutics. 2023 May; ?(?):. doi: 10.1111/cns.14249. [PMID: 37170684]
  • Yi-Fan Chen, Run-Zhi Liu, Wen-Wen Ying, Yue-Ning Yang, Sen-Feng Xiang, Xue-Jing Shao, Ji Cao, Yan-Qi Zhang, Bo Yang, Qiao-Jun He, Mei-Dan Ying. Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells. Acta pharmacologica Sinica. 2023 Mar; 44(3):661-669. doi: 10.1038/s41401-022-00992-6. [PMID: 36138144]
  • Peter Kiplangʼat Koech, Gergely Jócsák, Imre Boldizsár, Kinga Moldován, Sándor Borbély, Ildikó Világi, Arpád Dobolyi, Petra Varró. Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin - An ex vivo Study on Rat Brain Slices. Planta medica. 2023 Feb; ?(?):. doi: 10.1055/a-2005-5497. [PMID: 36592636]
  • Xingyue Jin, Suyi Liu, Shujing Chen, Lirong Wang, Yan Cui, Jun He, Shiming Fang, Jin Li, Yanxu Chang. A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit. Journal of ethnopharmacology. 2023 Feb; ?(?):116223. doi: 10.1016/j.jep.2023.116223. [PMID: 36781057]
  • Guanming Wang, Li Ge, Tongyu Liu, Zhihui Zheng, Lijun Chen. The therapeutic potential of arctigenin against multiple human diseases: A mechanistic review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 110(?):154647. doi: 10.1016/j.phymed.2023.154647. [PMID: 36628833]
  • Yuyan Zhou, Lina Liu, Ruoxuan Xiang, Xiaoyang Bu, Guozheng Qin, Jiajia Dai, Zhigang Zhao, Xue Fang, Shuo Yang, Jun Han, Guodong Wang. Arctigenin mitigates insulin resistance by modulating the IRS2/GLUT4 pathway via TLR4 in type 2 diabetes mellitus mice. International immunopharmacology. 2023 Jan; 114(?):109529. doi: 10.1016/j.intimp.2022.109529. [PMID: 36481528]
  • Quan Yuan, Yiran Wu, Gang Wang, Xiang Zhou, Xiaohui Dong, Zihan Lou, Sanqiang Li, Dongmei Wang. Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice. Metabolic brain disease. 2022 08; 37(6):2039-2052. doi: 10.1007/s11011-022-01031-3. [PMID: 35731324]
  • Yu Tao, Si-Miao Qiao, Chang-Jun Lv, Xin-Ming Yun, Meng-Fan Yue, Yu-Lai Fang, Zhi-Feng Wei, Yue Dai, Yu-Feng Xia. Phytoestrogen arctigenin preserves the mucus barrier in inflammatory bowel diseases by inhibiting goblet cell apoptosis via the ERβ/TRIM21/PHB1 pathway. Phytotherapy research : PTR. 2022 Aug; 36(8):3248-3264. doi: 10.1002/ptr.7495. [PMID: 35599350]
  • Jia-Cheng Qin, Bo-Yang Li, Yu-Feng Shen, Tao Wang, Gao-Xue Wang. In vitro and in vivo inhibition of a novel arctigenin derivative on aquatic rhabdovirus. Virus research. 2022 07; 316(?):198798. doi: 10.1016/j.virusres.2022.198798. [PMID: 35562080]
  • Nguyen Duy Phan, Ashraf M Omar, Sijia Sun, Juthamart Maneenet, Dya Fita Dibwe, Mao Sato, Surya Kant Kalauni, Naoki Toyooka, Tsutomu Fujii, Suresh Awale. Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line. Bioorganic & medicinal chemistry letters. 2022 06; 66(?):128723. doi: 10.1016/j.bmcl.2022.128723. [PMID: 35395369]
  • Xin Zhang, Mengjun Zou, Yue Liang, Yonghong Yang, Lina Jing, Minghui Sun, Zhilin Dong, Xinyuan Zhang, Huabao Xiong, Guanjun Dong. Arctigenin inhibits abnormal germinal center reactions and attenuates murine lupus by inhibiting IFN-I pathway. European journal of pharmacology. 2022 Mar; 919(?):174808. doi: 10.1016/j.ejphar.2022.174808. [PMID: 35151645]
  • Lijun Wu, Jie Chen, Danna Zhou, Runshan Chen, Xiabing Chen, Zhiyong Shao, Wenhai Yang, Bin He. Anti-inflammatory activity of arctigenin against PCV2 infection in a mouse model. Veterinary medicine and science. 2022 03; 8(2):700-709. doi: 10.1002/vms3.693. [PMID: 34914190]
  • Mingzhuo Cao, Changda Liu, Kamal D Srivastava, Adora Lin, Christopher Lazarski, Lu Wang, Anish Maskey, Ying Song, Xiaoke Chen, Nan Yang, Linda Zambrano, Renna Bushko, Anna Nowak-Wegrzyn, Amanda Cox, Zhigang Liu, Weihua Huang, David Dunkin, Mingsan Miao, Xiu-Min Li. Anti-IgE effect of small-molecule-compound arctigenin on food allergy in association with a distinct transcriptome profile. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2022 02; 52(2):250-264. doi: 10.1111/cea.14048. [PMID: 34757674]
  • Sayeh Mottaghi, Hassan Abbaszadeh. A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives. Critical reviews in food science and nutrition. 2022; 62(26):7301-7318. doi: 10.1080/10408398.2021.1913568. [PMID: 33905270]
  • Samir A Salama, Ahmed M Mohamadin, Mohamed S Abdel-Bakky. Arctigenin alleviates cadmium-induced nephrotoxicity: Targeting endoplasmic reticulum stress, Nrf2 signaling, and the associated inflammatory response. Life sciences. 2021 Dec; 287(?):120121. doi: 10.1016/j.lfs.2021.120121. [PMID: 34742745]
  • Arezoo Gowhari Shabgah, Wanich Suksatan, Muhammad Harun Achmad, Dmitry O Bokov, Walid Kamal Abdelbasset, Fatemeh Ezzatifar, Sasan Hemmati, Hamed Mohammadi, Davood Soleimani, Farhad Jadidi-Niaragh, Majid Ahmadi, Jamshid Gholizadeh Navashenaq. Arctigenin, an anti-tumor agent; a cutting-edge topic and up-to-the-minute approach in cancer treatment. European journal of pharmacology. 2021 Oct; 909(?):174419. doi: 10.1016/j.ejphar.2021.174419. [PMID: 34391770]
  • Ashraf M Omar, Sijia Sun, Min Jo Kim, Nguyen Duy Phan, Ahmed M Tawila, Suresh Awale. Benzophenones from Betula alnoides with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line. Journal of natural products. 2021 05; 84(5):1607-1616. doi: 10.1021/acs.jnatprod.1c00150. [PMID: 34008971]
  • Yosuke Suzuki, Michiko Sato, Takuya Awazuhara, Yusuke Nukui, Airi Yoshida, Tomoka Terashima, Keita Watanabe, Rumi Fujioka, Katsuya Tsuchihara, Satoshi Kishino, Keiko Ohno. Simultaneous quantification of arctigenin and its glucuronide conjugate in mouse plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry. Journal of separation science. 2021 Apr; 44(7):1299-1306. doi: 10.1002/jssc.202001078. [PMID: 33387366]
  • Shaimaa Fayez, Alessia Cacciatore, Sijia Sun, Minjo Kim, Laurent Aké Assi, Doris Feineis, Suresh Awale, Gerhard Bringmann. Ancistrobrevidines A-C and related naphthylisoquinoline alkaloids with cytotoxic activities against HeLa and pancreatic cancer cells, from the liana Ancistrocladus abbreviatus. Bioorganic & medicinal chemistry. 2021 01; 30(?):115950. doi: 10.1016/j.bmc.2020.115950. [PMID: 33383442]
  • Xueying Liu, Jian Wang, Peiyuan Dou, Xu Zhang, Xiaoku Ran, Linlin Liu, Deqiang Dou. The Ameliorative Effects of Arctiin and Arctigenin on the Oxidative Injury of Lung Induced by Silica via TLR-4/NLRP3/TGF-β Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):5598980. doi: 10.1155/2021/5598980. [PMID: 34336106]
  • Liangpeng Wei, Zhenyi Xue, Baihui Lan, Shiyang Yuan, Yuanyuan Li, Cunle Guo, Rongxin Zhang, Ran Ding, Hui Shen. Arctigenin Exerts Neuroprotective Effect by Ameliorating Cortical Activities in Experimental Autoimmune Encephalomyelitis In Vivo. Frontiers in immunology. 2021; 12(?):691590. doi: 10.3389/fimmu.2021.691590. [PMID: 34349758]
  • Eman Al-Sayed, Tzu-Yi Ke, Tsong-Long Hwang, Shu-Rong Chen, Michal Korinek, Shu-Li Chen, Yuan-Bin Cheng. Cytotoxic and anti-inflammatory effects of lignans and diterpenes from Cupressus macrocarpa. Bioorganic & medicinal chemistry letters. 2020 05; 30(10):127127. doi: 10.1016/j.bmcl.2020.127127. [PMID: 32223924]
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