Bergapten (BioDeep_00000000336)

 

Secondary id: BioDeep_00000398015, BioDeep_00000405730, BioDeep_00000861001

human metabolite PANOMIX_OTCML-2023 natural product Volatile Flavor Compounds


代谢物信息卡片


4-methoxyfuro[3,2-g]chromen-7-one

化学式: C12H8O4 (216.0422568)
中文名称: 佛手醇甲醚, 佛手苷内酯, 香柑内酯, 佛手烯, 5-甲氧基补骨脂素, 佛手柑内酯
谱图信息: 最多检出来源 Viridiplantae(plant) 0.23%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

Bergapten. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/bergapten (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000000336). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COc(c21)c(C=3)c(OC(=O)C3)cc(occ2)1
InChI: InChI=1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3

描述信息

Bergapten, also known as O-methylbergaptol or heraclin, belongs to the class of organic compounds known as 5-methoxypsoralens. These are psoralens containing a methoxy group attached at the C5 position of the psoralen group. Bergapten is found, on average, in the highest concentration within a few different foods, such as anises, figs, and parsnips and in a lower concentration in carrots, fennels, and celery stalks. Bergapten has also been detected, but not quantified, in several different foods, such as coconuts, pepper (c. frutescens), corianders, sesbania flowers, and cardamoms. This could make bergapten a potential biomarker for the consumption of these foods. It is also found in rose hip, sweet marjoram, greenthread tea, and tartary buckwheat. Bergapten is a potentially toxic compound. Bergapten is a major constituent of bergamot oil (Citrus bergamia). Present in celery, especially the outer leaves, and other common grocery vegetables. Implicated in photodermatitis among grocery workers. Bergapten was under investigation in clinical trial NCT00533195 "Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis".
Grayish-white microcrystalline powder or yellow fluffy solid. (NTP, 1992)
5-methoxypsoralen is a 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5. It has a role as a hepatoprotective agent and a plant metabolite. It is a member of psoralens, a 5-methoxyfurocoumarin and an organic heterotricyclic compound. It is functionally related to a psoralen.
Bergapten is under investigation in clinical trial NCT00533195 (Comparison of UVA1 Phototherapy Versus Photochemotherapy for Patients With Severe Generalized Atopic Dermatitis).
Bergapten is a natural product found in Ficus auriculata, Ficus virens, and other organisms with data available.
A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.
See also: Parsley (part of); Anise (part of); Angelica archangelica root (part of) ... View More ...
Bergapten is a major constituent of bergamot oil (Citrus bergamia). Present in celery, esp. the outer leaves, and other common grocery vegetables. Implicated in photodermatitis among grocery workers. It is also found in rose hip, sweet marjoram, greenthread tea, and tartary buckwheat.
D - Dermatologicals > D05 - Antipsoriatics > D05B - Antipsoriatics for systemic use > D05BA - Psoralens for systemic use
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
D000893 - Anti-Inflammatory Agents
D003879 - Dermatologic Agents
CONFIDENCE standard compound; INTERNAL_ID 1068; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8020; ORIGINAL_PRECURSOR_SCAN_NO 8017
CONFIDENCE standard compound; INTERNAL_ID 1068; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8002; ORIGINAL_PRECURSOR_SCAN_NO 8000
CONFIDENCE standard compound; INTERNAL_ID 1068; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7952; ORIGINAL_PRECURSOR_SCAN_NO 7950
CONFIDENCE standard compound; INTERNAL_ID 1068; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7968; ORIGINAL_PRECURSOR_SCAN_NO 7967
CONFIDENCE standard compound; INTERNAL_ID 1068; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8005; ORIGINAL_PRECURSOR_SCAN_NO 8002
CONFIDENCE standard compound; INTERNAL_ID 1068; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8376; ORIGINAL_PRECURSOR_SCAN_NO 8372
[Raw Data] CBA84_Bergapten_pos_20eV.txt
[Raw Data] CBA84_Bergapten_pos_10eV.txt
[Raw Data] CBA84_Bergapten_pos_30eV.txt
[Raw Data] CBA84_Bergapten_pos_40eV.txt
[Raw Data] CBA84_Bergapten_pos_50eV.txt
Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.
Bergapten is a natural anti-inflammatory and anti-tumor agent. Bergapten is inhibitory towards mouse and human CYP isoforms.

同义名列表

74 个代谢物同义名

InChI=1/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H; 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, .gamma.-lactone; 6-Hydroxy-4-methoxy-5-benzofuranacrylic acid, gamma-lactone; 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy-; 7H-Furo[3,2-g][1]benzopyran-7-one, 4-methoxy-; 5-19-06-00004 (Beilstein Handbook Reference); 5-Methoxypsoralen with ultraviolet A therapy; 4-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one; 4-Methoxy-7H-furo[3,2-g]benzopyran-7-one; 4-Methoxy-7H-furo[3,2-g]chromen-7-one #; 5-methoxy-2H-furo[3,2-g]chromen-2-one; 4-Methoxyfuro[3,2-g]benzopyrane-7-one; 4-methoxy-7H-furo(3,2-g)chromen-7-one; 4-Methoxy-7H-furo[3,2-g]chromen-7-one; 4-Methoxyfuro[3,2-g]benzopyran-7-one; 5-methoxyfurano[3,2-g]chromen-2-one; 4-Methoxy-furo[3,2-g]chromen-7-one; 4-METHOXYFURO(3,2-G)CHROMEN-7-ONE; 4-methoxyfuro[3,2-g]chromen-7-one; Bergapten, analytical standard; 5-Methoxy-6,7-furanocoumarin; 5-Methoxypsoralen; Bergapten; 5-Methoxypsoralen (obsol.); 5-METHOXYPSORALEN [WHO-DD]; 5-Methoxypsoralen;Heraclin; 5-METHOXYPSORALEN [MART.]; 5-METHOXYPSORALEN (MART.); 5-METHOXYPSORALEN [IARC]; 5-METHOXYPSORALEN (IARC); 5-Methoxyfuranocoumarin; 5-Methoxypsoralen, 99\\%; 7H-Furo[3, 4-methoxy-; 5-methoxypsoralene; 5-Methoxy psoralen; 5 Methoxy Psoralen; 5-methoxy-psoralen; O-Methylbergaptol; 5-methoxypsoralen; 5 methoxypsoralen; Spectrum5_000155; Spectrum4_001478; Spectrum3_000663; Spectrum2_000534; Bergaptene (DCF); UNII-4FVK84C92X; Pentaderm (TN); BERGAPTEN [MI]; DivK1c_000529; MEGxp0_000990; Oprea1_562364; NCI60_042121; KBio2_001274; KBio2_003842; Tox21_303255; KBio2_006410; ACon1_001979; ACon0_000984; KBio1_000529; KBio3_001545; Tox21_202357; IDI1_000529; bergaptene; 4FVK84C92X; BERGAPTAN; Pentaderm; Bergapten; Psoraderm; Heraclin; Majudin; Geralen; 5-Mop; Bergapten; Bergapten



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

106 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

  • linear furanocoumarin biosynthesis: (+)-marmesin + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ H2O + acetone + an oxidized [NADPH-hemoprotein reductase] + psoralen

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(102)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

665 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tianshu Xu, Jiyuan Yin, Xuan Dai, Tianyuan Liu, Hanfen Shi, Yueyi Zhang, Shan Wang, Gaiyue Yue, Yanfei Zhang, Dandan Zhao, Sihua Gao, Marc Prentki, Lili Wang, Dongwei Zhang. Cnidii Fructus: A traditional Chinese medicine herb and source of antiosteoporotic drugs. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155375. doi: 10.1016/j.phymed.2024.155375. [PMID: 38507853]
  • Chong Gao, Zhong-He Hu, Zhen-Yu Cui, Yu-Chen Jiang, Jia-Yi Dou, Zhao-Xu Li, Li-Hua Lian, Ji-Xing Nan, Yan-Ling Wu. Angelica dahurica extract and its effective component bergapten alleviated hepatic fibrosis by activating FXR signaling pathway. Journal of natural medicines. 2024 Mar; 78(2):427-438. doi: 10.1007/s11418-024-01780-8. [PMID: 38334900]
  • Tong Luo, Xin Jia, Wan-di Feng, Jin-Yong Wang, Fang Xie, Ling-Dong Kong, Xue-Jiao Wang, Rui Lian, Xia Liu, Ying-Jie Chu, Yao Wang, An-Long Xu. Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy. Acta pharmacologica Sinica. 2023 May; ?(?):. doi: 10.1038/s41401-023-01094-7. [PMID: 37142684]
  • Magdalena Bartnik. Efficient Separation of the Methoxyfuranocoumarins Peucedanin, 8-Methoxypeucedanin, and Bergapten by Centrifugal Partition Chromatography (CPC). Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041923. [PMID: 36838916]
  • Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
  • Noura S Dosoky, Prabodh Satyal, William N Setzer. Authentication of Citrus spp. Cold-Pressed Essential Oils by Their Oxygenated Heterocyclic Components. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196277. [PMID: 36234812]
  • Kriti Juneja, Till Beuerle, Debabrata Sircar. Enhanced Accumulation of Biologically Active Coumarin and Furanocoumarins in Callus Culture and Field-grown Plants of Ruta chalepensis Through LED Light-treatment. Photochemistry and photobiology. 2022 09; 98(5):1100-1109. doi: 10.1111/php.13610. [PMID: 35191044]
  • Yanni Yang, Juanping Han, Renju G Lilly, Qin Yang, Yanjie Guo. Bergapten mediated inflammatory and apoptosis through AMPK/eNOS/AKT signaling pathway of isoproterenol-induced myocardial infarction in Wistar rats. Journal of biochemical and molecular toxicology. 2022 Sep; 36(9):e23143. doi: 10.1002/jbt.23143. [PMID: 35815753]
  • Muhammad Faheem, Arif-Ullah Khan, Muhammad Waqas Saleem, Fawad Ali Shah, Fawad Ali, Abdul Waheed Khan, Shupeng Li. Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain. Molecules (Basel, Switzerland). 2022 Aug; 27(15):. doi: 10.3390/molecules27154926. [PMID: 35956877]
  • Huan Shi, Ya-Qing Chang, Xie Feng, Gui-Ya Yang, Yu-Guang Zheng, Qian Zheng, Lan-Lan Zhang, Dan Zhang, Long Guo. Chemical comparison and discrimination of two plant sources of Angelicae dahuricae Radix, Angelica dahurica and Angelica dahurica var. formosana, by HPLC-Q/TOF-MS and quantitative analysis of multiple components by a single marker. Phytochemical analysis : PCA. 2022 Jul; 33(5):776-791. doi: 10.1002/pca.3129. [PMID: 35470493]
  • Maria Magdalena Quetglas-Llabrés, Cristina Quispe, Jesús Herrera-Bravo, Marcelo D Catarino, Olívia R Pereira, Susana M Cardoso, Kamal Dua, Dinesh Kumar Chellappan, Kavita Pabreja, Saurabh Satija, Meenu Mehta, Antoni Sureda, Miquel Martorell, Dinara Satmbekova, Balakyz Yeskaliyeva, Javad Sharifi-Rad, Naeem Rasool, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu, Daniela Calina, William C Cho. Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects. Oxidative medicine and cellular longevity. 2022; 2022(?):8615242. doi: 10.1155/2022/8615242. [PMID: 35509838]
  • Christina L Burnett, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Lillian J Gill, Bart Heldreth. Safety Assessment of Citrus Plant- and Seed-Derived Ingredients as Used in Cosmetics. International journal of toxicology. 2021 12; 40(3_suppl):39S-52S. doi: 10.1177/10915818211040027. [PMID: 34406100]
  • Youdan Liang, Long Xie, Kai Liu, Yi Cao, Xiaolin Dai, Xian Wang, Jing Lu, Xumin Zhang, Xiaofang Li. Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity. Phytotherapy research : PTR. 2021 Nov; 35(11):6131-6147. doi: 10.1002/ptr.7221. [PMID: 34347307]
  • Komal Latif, Arif-Ullah Khan, Muhammad Izhar Ul Haque, Komal Naeem. Bergapten Attenuates Nitroglycerin-Induced Migraine Headaches through Inhibition of Oxidative Stress and Inflammatory Mediators. ACS chemical neuroscience. 2021 09; 12(18):3303-3313. doi: 10.1021/acschemneuro.1c00146. [PMID: 34455773]
  • Shumaila Arshad, Maqsoodur Rehman, Juwairiya Zulfiqar, Saima Najam, Mulazim Hussain Asim, Farah Abid. Compatibility analysis of bergapten with different pharmaceutical excipients used in nanostructured lipid carriers. Pakistan journal of pharmaceutical sciences. 2019 Nov; 32(6(Supplementary)):2879-2885. doi: ". [PMID: 32024628]
  • Unwoo Kang, Ah-Reum Han, Yangkang So, Chang Hyun Jin, Seung Mok Ryu, Dongho Lee, Eun Kyoung Seo. Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation. Journal of natural products. 2019 09; 82(9):2601-2607. doi: 10.1021/acs.jnatprod.9b00547. [PMID: 31464439]
  • Christina L Burnett, Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Lillian J Gill, Bart Heldreth. Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics. International journal of toxicology. 2019 Sep; 38(2_suppl):33S-59S. doi: 10.1177/1091581819862504. [PMID: 31522650]
  • Gurjit Singh, Anudeep Kaur, Jashanpreet Kaur, Manpreet S Bhatti, Palwinder Singh, Rajbir Bhatti. Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines. Inflammopharmacology. 2019 Aug; 27(4):749-760. doi: 10.1007/s10787-019-00585-6. [PMID: 30953227]
  • Gurjit Singh, Amritpal Singh, Palwinder Singh, Rajbir Bhatti. Bergapten Ameliorates Vincristine-Induced Peripheral Neuropathy by Inhibition of Inflammatory Cytokines and NFκB Signaling. ACS chemical neuroscience. 2019 06; 10(6):3008-3017. doi: 10.1021/acschemneuro.9b00206. [PMID: 31064179]
  • Yi He, Zeng Zisan, Zhenhui Lu, Li Zheng, Jinmin Zhao. Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway. FEBS open bio. 2019 06; 9(6):1144-1152. doi: 10.1002/2211-5463.12648. [PMID: 31037830]
  • Guiping Chen, Qiang Xu, Min Dai, Xuqiang Liu. Bergapten suppresses RANKL-induced osteoclastogenesis and ovariectomy-induced osteoporosis via suppression of NF-κB and JNK signaling pathways. Biochemical and biophysical research communications. 2019 02; 509(2):329-334. doi: 10.1016/j.bbrc.2018.12.112. [PMID: 30579598]
  • Md Moshfekus Saleh-E-In, Ayan Roy, Muhammad Abdullah Al-Mansur, Choudhury Mahmood Hasan, Md Matiur Rahim, Nasim Sultana, Shamim Ahmed, Md Rabiul Islam, Johannes van Staden. Isolation and in silico prediction of potential drug-like compounds from Anethum sowa L. root extracts targeted towards cancer therapy. Computational biology and chemistry. 2019 Feb; 78(?):242-259. doi: 10.1016/j.compbiolchem.2018.11.025. [PMID: 30584950]
  • Shakti Prasad Pattanayak, Pritha Bose, Priyashree Sunita, Mohd Usman Mohd Siddique, Antonio Lapenna. Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Dec; 108(?):297-308. doi: 10.1016/j.biopha.2018.08.145. [PMID: 30227322]
  • Man Liao, Gengshen Song, Xiaoye Cheng, Xinpeng Diao, Yupeng Sun, Lantong Zhang. Simultaneous Determination of Six Coumarins in Rat Plasma and Metabolites Identification of Bergapten in Vitro and in Vivo. Journal of agricultural and food chemistry. 2018 May; 66(18):4602-4613. doi: 10.1021/acs.jafc.7b05637. [PMID: 29663811]
  • Yi Yang, Kangdi Zheng, Wenjie Mei, Yandong Wang, Chuqin Yu, Bangwei Yu, Shanbin Deng, Jinhua Hu. Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model. Biochemical and biophysical research communications. 2018 02; 496(2):763-769. doi: 10.1016/j.bbrc.2018.01.071. [PMID: 29337062]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
  • Camilo Soto-Argel, Diego Hidalgo, Javier Palazon, Purificación Corchete. Extracellular chromone derivatives in cell cultures of Pimpinella anisum. Influence of elicitation with methyl jasmonate and 2β-methyl cyclodextrins. Biotechnology letters. 2018 Feb; 40(2):413-418. doi: 10.1007/s10529-017-2482-3. [PMID: 29185164]
  • Vincenzo Sicari. Optimization of the Supercritical Carbon Dioxide Separation of Bergapten from Bergamot Essential Oil. Journal of AOAC International. 2018 Jan; 101(1):293-297. doi: 10.5740/jaoacint.17-0190. [PMID: 28762330]
  • Sony George, Ramaswamy Venkataraman, Sabulal Baby. Melicodenine I, a new quinolinone alkaloid from Melicope denhamii leaves. Natural product research. 2017 Apr; 31(8):890-895. doi: 10.1080/14786419.2016.1253075. [PMID: 27817202]
  • Qunqun Guo, Guicai Du, Hongwei He, Hongkai Xu, Daosen Guo, Ronggui Li. Two nematicidal furocoumarins from Ficus carica L. leaves and their physiological effects on pine wood nematode (Bursaphelenchus xylophilus). Natural product research. 2016 Sep; 30(17):1969-73. doi: 10.1080/14786419.2015.1094804. [PMID: 26479900]
  • Marta Santoro, Carmela Guido, Francesca De Amicis, Diego Sisci, Erika Cione, Dolce Vincenza, Ada Donà, Maria Luisa Panno, Saveria Aquila. Bergapten induces metabolic reprogramming in breast cancer cells. Oncology reports. 2016 Jan; 35(1):568-76. doi: 10.3892/or.2015.4327. [PMID: 26459431]
  • Krystyna Skalicka-Woźniak, Marta Mendel, Magdalena Chłopecka, Natalia Dziekan. Isolation and evaluation of the myorelaxant effect of bergapten on isolated rat jejunum. Pharmaceutical biology. 2016; 54(1):48-54. doi: 10.3109/13880209.2015.1014570. [PMID: 25885935]
  • Giuseppe Mancuso, Gigliola Borgonovo, Leonardo Scaglioni, Angela Bassoli. Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception. Molecules (Basel, Switzerland). 2015 Oct; 20(10):18907-22. doi: 10.3390/molecules201018907. [PMID: 26501253]
  • Jin-Long Li, Li-Xin Gao, Fan-Wang Meng, Chun-Lan Tang, Ru-Jun Zhang, Jing-Ya Li, Cheng Luo, Jia Li, Wei-Min Zhao. PTP1B inhibitors from stems of Angelica keiskei (Ashitaba). Bioorganic & medicinal chemistry letters. 2015; 25(10):2028-32. doi: 10.1016/j.bmcl.2015.04.003. [PMID: 25891102]
  • Jing Li, Bo Ma, Qi Zhang, Xiaojing Yang, Jingjing Sun, Bowen Tang, Guangbo Cui, Di Yao, Lei Liu, Guiying Gu, Jianwei Zhu, Ping Wei, Pingkai Ouyang. Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Nov; 970(?):77-85. doi: 10.1016/j.jchromb.2014.06.014. [PMID: 25240925]
  • Sidney J Stohs, Howard Miller, Felice Romano. Absence of furanocoumarins in Advantra Z® (Citrus aurantium, bitter orange) extracts. Journal of dietary supplements. 2014 Sep; 11(3):288-93. doi: 10.3109/19390211.2014.937047. [PMID: 25026202]
  • Cheryl E Ainslie-Waldman, Scott W Simpkins, Pramod Upadhyaya, Steven G Carmella, Stephen S Hecht, Sabrina P Trudo. Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Dec; 62(?):188-93. doi: 10.1016/j.fct.2013.08.055. [PMID: 23994708]
  • Christian Celia, Elena Trapasso, Marcello Locatelli, Michele Navarra, Cinzia Anna Ventura, Joy Wolfram, Maria Carafa, Valeria Maria Morittu, Domenico Britti, Luisa Di Marzio, Donatella Paolino. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids and surfaces. B, Biointerfaces. 2013 Dec; 112(?):548-53. doi: 10.1016/j.colsurfb.2013.09.017. [PMID: 24099646]
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