Lovastatin (BioDeep_00000000231)

 

Secondary id: BioDeep_00000398731

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

化学式: C24H36O5 (404.2563)
中文名称: 洛伐司他汀, 洛伐他汀
谱图信息: 最多检出来源 Homo sapiens(blood) 12.02%

Reviewed

Last reviewed on 2024-10-09.

Cite this Page

Lovastatin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/lovastatin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000231). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C21
InChI: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

描述信息

Lovastatin is a fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). It has a role as an Aspergillus metabolite, a prodrug, an anticholesteremic drug and an antineoplastic agent. It is a polyketide, a statin (naturally occurring), a member of hexahydronaphthalenes, a delta-lactone and a fatty acid ester. It is functionally related to a (S)-2-methylbutyric acid and a mevastatin.
Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of Aspergillus terreus. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, which catalyzes the conversion of HMG-CoA to mevalonic acid and is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL). Prescribing of statin medications is considered standard practice following any cardiovascular events and for people with a moderate to high risk of development of CVD, such as those with Type 2 Diabetes. The clear evidence of the benefit of statin use coupled with very minimal side effects or long term effects has resulted in this class becoming one of the most widely prescribed medications in North America. Lovastatin and other drugs from the statin class of medications including [atorvastatin], [pravastatin], [rosuvastatin], [fluvastatin], and [simvastatin] are considered first-line options for the treatment of dyslipidemia. Increasing use of the statin class of drugs is largely due to the fact that cardiovascular disease (CVD), which includes heart attack, atherosclerosis, angina, peripheral artery disease, and stroke, has become a leading cause of death in high-income countries and a major cause of morbidity around the world. Elevated cholesterol levels, and in particular, elevated low-density lipoprotein (LDL) levels, are an important risk factor for the development of CVD. Use of statins to target and reduce LDL levels has been shown in a number of landmark studies to significantly reduce the risk of development of CVD and all-cause mortality. Statins are considered a cost-effective treatment option for CVD due to their evidence of reducing all-cause mortality including fatal and non-fatal CVD as well as the need for surgical revascularization or angioplasty following a heart attack. Evidence has shown that even for low-risk individuals (with <10\\\\% risk of a major vascular event occurring within 5 years) statins cause a 20\\\\%-22\\\\% relative reduction in major cardiovascular events (heart attack, stroke, coronary revascularization, and coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. While all statin medications are considered equally effective from a clinical standpoint, [rosuvastatin] is considered the most potent; doses of 10 to 40mg [rosuvastatin] per day were found in clinical studies to result in a 45.8\\\\% to 54.6\\\\% decrease in LDL cholesterol levels, while lovastatin has been found to have an average decrease in LDL-C of 25-40\\\\%. Potency is thought to correlate to tissue permeability as the more lipophilic statins such as lovastatin are thought to enter endothelial cells by passive diffusion, as opposed to hydrophilic statins such as [pravastatin] and [rosuvastatin] which are taken up into hepatocytes through OATP1B1 (org...
Lovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. It was the second agent of this class discovered. It was discovered by Alfred Alberts and his team at Merck in 1978 after screening only 18 compounds over 2 weeks. The agent, also known as mevinolin, was isolated from the fungi Aspergillus terreus. Research on this compound was suddenly shut down in 1980 and the drug was not approved until 1987. Interesting, Akira Endo at Sankyo Co. (Japan) patented lovastatin isolated from Monascus ruber four months before Merck. Lovastatin was found to be 2 times more potent than its predecessor, mevastatin, the first discovered statin. Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. Lovastatin is a competitive inhibitor of HMG-CoA reductase with a binding affinity 20,000 times greater than HMG-CoA. Lovastatin differs structurally from mevastatin by a single methyl group at the 6 position. Lovastatin is a prodrug that is activated by in vivo hydrolysis of the lactone ring. It, along with mevastatin, has served as one of the lead compounds for the development of the synthetic compounds used today.
A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AA - Hmg coa reductase inhibitors
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3139
CONFIDENCE standard compound; INTERNAL_ID 2212
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

同义名列表

156 个代谢物同义名

BUTANOIC ACID, 2-METHYL-, 1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-(2-(TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL)ETHYL)-1-NAPHTHALENYL ESTER, (1S-(1.ALPHA.(R*),3.ALPHA.,7.BETA.,8.BETA.(2S*,4S*),8.ALPHA..BETA.))-; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-- oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-; (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-2-Methylbutanoic acid 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester; (S)-2-Methylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one; Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)-; (S)-2-Methylbutyric acid, 8-ester with (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one; butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-; (2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester; (2S)-2-METHYLBUTANOIC ACID (1S,3R,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-3,7-DIMETHYL-8-(2-((2R,4R)-TETRAHYDRO-4-HYDROXY-6-OXO-2H-PYRAN-2-YL)ETHYL)-1-NAPHTHALENYL ESTER; Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)-; (S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-[2-((3R,5R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl ester; (1S,3R,7S,8S,8AR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyric acid; (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate; (S)-((1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) 2-methylbutanoate; (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; [(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-[2-[(2R,4R)-4-oxidanyl-6-oxidanylidene-oxan-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate; (S)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate; (2S)-2-methylbutanoic acid [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-2-oxanyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] ester; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxo-tetrahydropyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate; [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; 1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-8-(2-((4R,6R)-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl)-3,7-dimethylnaphtyl(S)-2-methylbutyrat; 1,2,6,7,8,8a-Hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutyoxy)-1-naphthaleneheptanoic acid delta-lactone; 8-[2-(4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthale; 2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone; 2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinate lactone; 2Β,6α-dimethyl-8α-(2-methyl-1-oxobutoxy)-mevinic acid lactone; 2b,6a-Dimethyl-8a-(2-methyl-1-oxobutoxy)-mevinic acid lactone; 2b,6a-Dimethyl-8a-(2-methyl-1-oxobutoxy)-mevinate lactone; 2Β,6α-dimethyl-8α-(2-methyl-1-oxobutoxy)-mevinate lactone; Mevacor;Monacolin K;mevinolin;6-alpha-Methylcompactin; SIMVASTATIN IMPURITY, LOVASTATIN- [USP IMPURITY]; SIMVASTATIN IMPURITY, LOVASTATIN-(USP IMPURITY); Mevinolin from Aspergillus sp., >=98\\% (HPLC); Mevinolin from Aspergillus sp., powder; SIMVASTATIN IMPURITY E (EP IMPURITY); SIMVASTATIN IMPURITY E [EP IMPURITY]; Lovastatin for peak identification; Simvastatin impurity, lovastatin-; Lovastatin, (1 alpha(S*))-Isomer; LOVASTATIN COMPONENT OF ADVICOR; Mevinolin from Aspergillus sp.; Lovastatin [USAN:USP:INN:BAN]; Lovastatin (USAN:USP:INN:BAN); ADVICOR COMPONENT LOVASTATIN; PCZOHLXUXFIOCF-BXMDZJJMSA-N; Lovastatin, 1 alpha Isomer; LOVASTATIN (USP MONOGRAPH); alpha-Isomer Lovastatin, 1; LOVASTATIN [USP MONOGRAPH]; Lovastatin, 1 alpha-Isomer; LOVASTATIN [EP MONOGRAPH]; LOVASTATIN (EP MONOGRAPH); 1 alpha-Isomer Lovastatin; 6.alpha.-Methylcompactin; LOVASTATIN [ORANGE BOOK]; 6-alpha-Methylcompactin; 6 alpha-Methylcompactin; Mevinolin (lovastatin); 6alpha-Methylcompactin; Lovastatin & Primycin; Lovastatin (Standard); Lovastatina [Spanish]; Lovastatin (Mevacor); Lovastatin (USP/INN); Lovastatinum [Latin]; Lovastatine [French]; Lovastatinum (Latin); LOVASTATIN (USP-RS); LOVASTATIN [WHO-DD]; LOVASTATIN [USP-RS]; 6Α-methylcompactin; LOVASTATIN [VANDF]; LOVASTATIN (MART.); LOVASTATIN [MART.]; 6a-Methylcompactin; 6-Methylcompactin; Prestwick2_000516; Prestwick0_000516; LOVASTATIN [HSDB]; 6 Methylcompactin; Prestwick1_000516; Lovastatin [USAN]; Lovastatin- Bio-X; Prestwick3_000516; Spectrum3_001873; LOVASTATIN [INN]; Spectrum5_001294; LOVASTATIN [MI]; UNII-9LHU78OQFD; Tox21_110888_1; Lovastatin,(S); BPBio1_000519; MEGxm0_000398; (+)-mevinolin; DivK1c_001032; ACon1_000390; Tox21_201475; Tox21_300268; Lovastatinum; KBio1_001032; Tox21_110888; ACon0_000534; KBio3_002848; Mevacor (TN); Lovastatine; Monacolin K; IDI1_001032; Lovastatina; Monakolin K; Lovastatin; Hipovastin; 9LHU78OQFD; Lovasterol; mevinolin; Teroltrat; Closterol; Liposcler; Mevinacor; Cholestra; Lipofren; Lovastin; Lestatin; Tecnolip; Altoprev; Nergadan; Lovalord; Colevix; C10AA02; Rodatin; Rovacor; Mevacor; Hipolip; Altocor; Lozutin; Lipivas; ML-530b; Lovalip; Paschol; Belvas; Mevlor; Sivlor; Lipdip; Artein; Rextat; MK-803; Taucor; 1cqp; 2-methyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid; Lovastatin



数据库引用编号

39 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, APOB, APOE, BCL2, CYP2C9, CYP3A4, EGFR, FNTA, MTOR, PIK3C3
Peripheral membrane protein 2 CYP1B1, MTOR
Endosome membrane 3 APOB, EGFR, LDLR
Endoplasmic reticulum membrane 9 APOB, BCL2, CYP1B1, CYP2C9, CYP3A4, EGFR, FDFT1, HMGCR, MTOR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 4 APOE, BCL2, EGFR, MTOR
autophagosome 1 PIK3C3
cytosol 7 APOA1, APOB, BCL2, FNTA, GPT, MTOR, PIK3C3
dendrite 2 APOE, MTOR
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 1 MTOR
Cell membrane 3 ABCB1, EGFR, LDLR
Cytoplasmic side 1 MTOR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 ABCB1, FDFT1, HMGCR
Golgi apparatus membrane 1 MTOR
cell junction 1 EGFR
cell surface 3 ABCB1, EGFR, LDLR
glutamatergic synapse 3 APOE, EGFR, PIK3C3
Golgi apparatus 2 APOE, LDLR
Golgi membrane 3 EGFR, INS, MTOR
lysosomal membrane 2 EGF, MTOR
neuronal cell body 2 APOB, APOE
smooth endoplasmic reticulum 1 APOB
Lysosome 2 LDLR, MTOR
endosome 2 EGFR, PIK3C3
plasma membrane 10 ABCB1, APOA1, APOB, APOE, CYP2C9, EGF, EGFR, FNTA, IFNLR1, LDLR
Membrane 13 ABCB1, APOE, BCL2, CYP1B1, CYP3A4, EGF, EGFR, FDFT1, HMGCR, IFNLR1, LDLR, MTOR, PIK3C3
apical plasma membrane 2 ABCB1, EGFR
basolateral plasma membrane 2 EGFR, LDLR
extracellular exosome 6 ABCB1, APOA1, APOB, APOE, EGF, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 APOE, BCL2, FDFT1, HMGCR
extracellular space 7 APOA1, APOB, APOE, CRP, EGF, EGFR, INS
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 1 EGFR
mitochondrion 2 BCL2, CYP1B1
protein-containing complex 2 BCL2, EGFR
intracellular membrane-bounded organelle 4 APOB, CYP1B1, CYP2C9, CYP3A4
Microsome membrane 4 CYP1B1, CYP2C9, CYP3A4, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 EGFR, IFNLR1, LDLR
Secreted 5 APOA1, APOB, APOE, CRP, INS
extracellular region 6 APOA1, APOB, APOE, CRP, EGF, INS
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 BCL2, LDLR
mitochondrial outer membrane 2 BCL2, MTOR
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 LDLR
Endosome, multivesicular body 1 APOE
Extracellular vesicle 2 APOA1, APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 3 APOA1, APOB, APOE
high-density lipoprotein particle 2 APOA1, APOE
low-density lipoprotein particle 4 APOA1, APOB, APOE, LDLR
multivesicular body 1 APOE
very-low-density lipoprotein particle 3 APOA1, APOB, APOE
cytoplasmic vesicle 1 APOA1
midbody 1 PIK3C3
Early endosome 4 APOA1, APOB, APOE, LDLR
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
clathrin-coated pit 1 LDLR
Apical cell membrane 1 ABCB1
Membrane raft 1 EGFR
pore complex 1 BCL2
focal adhesion 1 EGFR
GABA-ergic synapse 1 PIK3C3
extracellular matrix 1 APOE
Peroxisome 1 PIK3C3
intracellular vesicle 1 EGFR
peroxisomal membrane 1 HMGCR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 2 APOA1, APOE
axoneme 1 PIK3C3
Late endosome 2 LDLR, PIK3C3
receptor complex 2 EGFR, LDLR
microtubule associated complex 1 FNTA
phagocytic vesicle membrane 1 PIK3C3
Secreted, extracellular space 1 APOE
blood microparticle 2 APOA1, APOE
nuclear envelope 1 MTOR
Endomembrane system 2 LDLR, MTOR
endosome lumen 2 APOB, INS
sorting endosome 1 LDLR
Lipid droplet 1 APOB
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Melanosome 1 APOE
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 2 APOA1, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 APOA1, APOB, APOE, INS
platelet alpha granule lumen 1 EGF
endocytic vesicle 1 APOA1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
presynaptic endosome 1 PIK3C3
clathrin-coated endocytic vesicle membrane 5 APOB, APOE, EGF, EGFR, LDLR
synaptic cleft 1 APOE
external side of apical plasma membrane 1 ABCB1
endolysosome membrane 1 LDLR
somatodendritic compartment 1 LDLR
Cytoplasmic vesicle, phagosome 1 MTOR
postsynaptic endosome 1 PIK3C3
discoidal high-density lipoprotein particle 1 APOE
spherical high-density lipoprotein particle 1 APOA1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 3 APOA1, APOB, APOE
PCSK9-LDLR complex 1 LDLR
chylomicron remnant 2 APOB, APOE
intermediate-density lipoprotein particle 2 APOB, APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
Autolysosome 1 PIK3C3
mature chylomicron 1 APOB
BAD-BCL-2 complex 1 BCL2
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Fei Liu, Xinyi Qiao, Qin Li, Jiajun Zhou, Jie Gao, Feng He, Peng Wu, Chunmei Chen, Weiguang Sun, Hucheng Zhu, Yonghui Zhang. Aculeatiols A-G: Lovastatin Derivatives Extracted from Aspergillus aculeatus. Journal of natural products. 2024 Apr; 87(4):753-763. doi: 10.1021/acs.jnatprod.3c00872. [PMID: 38372239]
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  • Chanjuan Zheng, Hui Yao, Lu Lu, Hongqi Li, Lei Zhou, Xueyan He, Xi Xu, Hongzhuo Xia, Siyu Ding, Yiyuan Yang, Xinyu Wang, Muyao Wu, Lian Xue, Sisi Chen, Xiaojun Peng, Zhongyi Cheng, Yian Wang, Guangchun He, Shujun Fu, Evan T Keller, Suling Liu, Yi-Zhou Jiang, Xiyun Deng. Dysregulated Ribosome Biogenesis Is a Targetable Vulnerability in Triple-Negative Breast Cancer: MRPS27 as a Key Mediator of the Stemness-inhibitory Effect of Lovastatin. International journal of biological sciences. 2024; 20(6):2130-2148. doi: 10.7150/ijbs.94058. [PMID: 38617541]
  • Momoko Gyoten, Yi Luo, Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Shingo Kishi, Hiroki Kuniyasu. Lovastatin Treatment Inducing Apoptosis in Human Pancreatic Cancer Cells by Inhibiting Cholesterol Rafts in Plasma Membrane and Mitochondria. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316814. [PMID: 38069135]
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  • Carlo Cervellati, Alessandro Trentini, Valentina Rosta, Giovanni Zuliani, Francesco Vieceli Dalla Sega, Francesca Fortini, Paola Rizzo, Paolo Cimaglia, Gianluca Campo. A Nutraceutical Compound Containing a Low Dose of Monacolin K, Polymethoxyflavones, Phenolic Acids, Flavonoids, and Hydroxytyrosol Improves HDL Functionality. Current vascular pharmacology. 2023 Feb; ?(?):. doi: 10.2174/1570161121666230221142131. [PMID: 36824007]
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  • Janani Balraj, Thandeeswaran Murugesan, Anand Raj Dhanapal, Vidhya Kalieswaran, Karunyadevi Jairaman, Govindaraju Archunan, Angayarkanni Jayaraman. Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity. Biotechnology and applied biochemistry. 2022 Dec; ?(?):. doi: 10.1002/bab.2429. [PMID: 36524308]
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  • Nan Sheng, Yun-Qiu Wang, Cun-Fu Wang, Meng-Qi Jia, Huan-Min Niu, Qi-Qi Lu, Ya-Nan Wang, Dan Feng, Xiao-Xue Zheng, Hui-Qing Yuan. AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin. Acta pharmacologica Sinica. 2022 Nov; 43(11):2905-2916. doi: 10.1038/s41401-022-00909-3. [PMID: 35459869]
  • Shi-You Jiang, Xinglin Yang, Zimo Yang, Jue-Wan Li, Meng-Qiang Xu, Yu-Xiu Qu, Jing-Jie Tang, Yun-Feng Li, Liguo Wang, Yi-Wen Shao, Xin-Yuan Meng, Huili Hu, Bao-Liang Song, Yu Rao, Wei Qi. Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis. Hepatology (Baltimore, Md.). 2022 11; 76(5):1466-1481. doi: 10.1002/hep.32381. [PMID: 35102596]
  • Antonio Cibelli, Eliana Scemes, David C Spray. Activity and Stability of Panx1 Channels in Astrocytes and Neuroblastoma Cells Are Enhanced by Cholesterol Depletion. Cells. 2022 10; 11(20):. doi: 10.3390/cells11203219. [PMID: 36291086]
  • Li-Juan Lang, Min Wang, Chang Lei, Yi Shen, Qi-Jie Zhu, Hong-Mei Diao, Hao Chen, Lei Shen, Xiang Dong, Bei Jiang, Chao-Jiang Xiao. Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity. Planta medica. 2022 Oct; 88(13):1190-1198. doi: 10.1055/a-1716-0958. [PMID: 34875697]
  • Liwei Zhang, Yan Shi, Mingzhu Yan, Guangping Zhang. Modulatory action of withaferin-A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high cholesterol-induced atherosclerosis in experimental rats. Journal of biochemical and molecular toxicology. 2022 Oct; 36(10):e23154. doi: 10.1002/jbt.23154. [PMID: 35734936]
  • Xianchen Geng, Chun Zhang, Lida Wei, Kai Lin, Zeng-Fu Xu. Genome-Wide Identification and Expression Analysis of Cytokinin Response Regulator (RR) Genes in the Woody Plant Jatropha curcas and Functional Analysis of JcRR12 in Arabidopsis. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911388. [PMID: 36232689]
  • Maciej Banach, Alberico L Catapano, Arrigo F G Cicero, Carlos Escobar, Bernhard Foger, Niki Katsiki, Gustavs Latkovskis, Michal Rakowski, Zeljko Reiner, Amirhossein Sahebkar, Geeta Sikand, Peter E Penson, On Behalf Of The International Lipid Expert Panel Ilep. Red yeast rice for dyslipidaemias and cardiovascular risk reduction: A position paper of the International Lipid Expert Panel. Pharmacological research. 2022 09; 183(?):106370. doi: 10.1016/j.phrs.2022.106370. [PMID: 35901940]
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  • Ines Villano, Marco La Marra, Salvatore Allocca, Ciro Rosario Ilardi, Rita Polito, Chiara Porro, Sergio Chieffi, Giovanni Messina, Vincenzo Monda, Girolamo Di Maio, Antonietta Messina. The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy. Biomolecules. 2022 08; 12(8):. doi: 10.3390/biom12081118. [PMID: 36009012]
  • Olga Protic, Raffaele Di Pillo, Alberto Montesanto, Roberta Galeazzi, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Felicia Gurău, Andrea Silvestrini, Fabiola Olivieri, Roberto Antonicelli, Anna Rita Bonfigli. Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia. Nutrients. 2022 Jul; 14(14):. doi: 10.3390/nu14142812. [PMID: 35889769]
  • Jia Chen, Qi Zheng, Zhenxing Zheng, Yirou Li, Hailang Liao, Hui Zhao, Dale Guo, Yuntong Ma. Analysis of the differences in the chemical composition of monascus rice and highland barley monascus. Food & function. 2022 Jul; 13(13):7000-7019. doi: 10.1039/d2fo00402j. [PMID: 35723016]
  • K S Abdelkawy, Fathalla Belal, AbdelazizE Abdelaziz, H A Elmekawy, M Y Abdelgaied, N M El-Khodary. Statins Increase the Bioavailability of Fixed-Dose Combination of Sofosbuvir/Ledipasvir by Inhibition of P-glycoprotein. Drug research. 2022 Jul; 72(6):319-326. doi: 10.1055/a-1835-1690. [PMID: 35724670]
  • Anan Liu, Amanda Juan Chen, Bingyu Liu, Qian Wei, Jian Bai, Youcai Hu. Investigation of citrinin and monacolin K gene clusters variation among pigment producer Monascus species. Fungal genetics and biology : FG & B. 2022 05; 160(?):103687. doi: 10.1016/j.fgb.2022.103687. [PMID: 35315337]
  • Dinesh Suram, Kishan Veerabrahma. Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug Dissolution and In vivo Effects-a Pharmacokinetic and Pharmacodynamic Assessment. AAPS PharmSciTech. 2022 Apr; 23(5):123. doi: 10.1208/s12249-022-02272-2. [PMID: 35460060]
  • Joanna Niedbalska-Tarnowska, Katarzyna Ochenkowska, Marta Migocka-Patrzałek, Magda Dubińska-Magiera. Assessment of the Preventive Effect of L-carnitine on Post-statin Muscle Damage in a Zebrafish Model. Cells. 2022 04; 11(8):. doi: 10.3390/cells11081297. [PMID: 35455976]
  • Chen Benjian, Huang Xiaodan, Peng Huiting, L I Yishi, Cao Yongtao, W U Huanlin, X U Danping. Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 04; 42(2):264-271. doi: 10.19852/j.cnki.jtcm.2022.02.007. [PMID: 35473348]
  • Andy Wijaya, Yi Wang, Dan Tang, Yuan Zhong, Boyan Liu, Meng Yan, Quhui Jiu, Wei Wu, Guixue Wang. A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression. Journal of materials chemistry. B. 2022 01; 10(4):607-624. doi: 10.1039/d1tb01455b. [PMID: 34994373]
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