15-Oxo-ETE (BioDeep_00001868669)

Main id: BioDeep_00000628860

 

natural product


代谢物信息卡片


15-Oxo-ETE

化学式: C20H30O3 (318.2195)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCC(=O)/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O
InChI: InChI=1S/C20H30O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)/b5-4-,10-8-,11-9-,17-14+

描述信息

An oxoicosatetraenoic acid having (5Z,8Z,11Z,13E) double bond stereochemistry, and an oxo group in position 15.

同义名列表

2 个代谢物同义名

15-Oxo-ETE; 15-OxoETE



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALOX15B, ALOX5, APOE, HPGD, KAT5, MAPK14, PTGR1, PTGS1, PTGS2
Peripheral membrane protein 5 ALOX15, ALOX15B, ALOX5, PTGS1, PTGS2
Endoplasmic reticulum membrane 4 ALOX5AP, PTGIS, PTGS1, PTGS2
Nucleus 5 ALOX15B, APOE, KAT5, MAPK14, PTGIS
cytosol 7 ALOX15, ALOX15B, ALOX5, HPGD, KAT5, KCNA1, MAPK14
dendrite 3 APOE, KCNA1, KCNB1
nucleoplasm 5 ALOX5, HPGD, KAT5, MAPK14, OLR1
Cell membrane 6 ALOX15, ALOX15B, KCNA1, KCNB1, OLR1, SELE
Lipid-anchor 1 OLR1
Cell projection, axon 2 KCNA1, KCNB1
Multi-pass membrane protein 4 ALOX5AP, F2RL1, KCNA1, KCNB1
Synapse 2 KCNA1, KCNB1
cell junction 1 KCNA1
cell surface 3 KCNA1, KCNB1, TPO
glutamatergic synapse 3 APOE, KCNA1, MAPK14
Golgi apparatus 3 APOE, F2RL1, PTGS1
neuronal cell body 2 APOE, KCNA1
presynaptic membrane 1 KCNA1
sarcolemma 1 KCNB1
Cytoplasm, cytosol 3 ALOX15, ALOX15B, ALOX5
Presynapse 1 KCNA1
plasma membrane 9 ALOX15, ALOX15B, APOE, F2RL1, KCNA1, KCNB1, OLR1, SELE, TPO
Membrane 9 ALOX15, ALOX15B, ALOX5AP, APOE, F2RL1, KCNA1, KCNB1, OLR1, TPO
apical plasma membrane 2 KCNA1, KCNB1
axon 1 KCNB1
basolateral plasma membrane 1 HPGD
caveola 3 PTGIS, PTGS2, SELE
extracellular exosome 5 ALOX15B, APOE, HPGD, PTGR1, PTGS1
endoplasmic reticulum 5 ALOX5AP, APOE, KCNA1, PTGIS, PTGS2
extracellular space 7 ALOX5, APOE, IL4, PTGIS, SELE, TG, TPO
perinuclear region of cytoplasm 4 ALOX5, KAT5, KCNB1, SELE
adherens junction 1 ALOX15B
mitochondrion 1 MAPK14
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 3 KAT5, OLR1, PTGS1
Microsome membrane 2 PTGS1, PTGS2
Single-pass type I membrane protein 2 SELE, TPO
Secreted 4 APOE, IL4, OLR1, TG
extracellular region 6 ALOX5, APOE, IL4, MAPK14, OLR1, TG
cytoplasmic side of plasma membrane 1 ALOX15
Single-pass membrane protein 1 PTGIS
neuronal cell body membrane 1 KCNB1
anchoring junction 1 KCNA1
transcription regulator complex 1 KAT5
photoreceptor outer segment 1 PTGS1
Nucleus membrane 2 ALOX5, ALOX5AP
nuclear membrane 2 ALOX5, ALOX5AP
external side of plasma membrane 1 SELE
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
perikaryon 2 KCNA1, KCNB1
cytoplasmic vesicle 1 KCNA1
nucleolus 1 KAT5
Early endosome 2 APOE, F2RL1
clathrin-coated pit 1 SELE
Single-pass type II membrane protein 1 OLR1
postsynaptic membrane 2 KCNA1, KCNB1
Cell membrane, sarcolemma 1 KCNB1
Cytoplasm, perinuclear region 2 ALOX5, KAT5
Membrane raft 2 OLR1, SELE
Cell junction, focal adhesion 1 ALOX15B
Cytoplasm, cytoskeleton 1 ALOX15B
focal adhesion 1 ALOX15B
Cell junction, adherens junction 1 ALOX15B
extracellular matrix 1 APOE
collagen-containing extracellular matrix 1 APOE
lateral plasma membrane 1 KCNB1
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 KCNB1
receptor complex 1 OLR1
neuron projection 2 PTGS1, PTGS2
chromatin 1 KAT5
Chromosome 1 KAT5
cytoskeleton 1 ALOX15B
Secreted, extracellular space 1 APOE
Nucleus, nucleolus 1 KAT5
spindle pole 1 MAPK14
blood microparticle 1 APOE
NuA4 histone acetyltransferase complex 1 KAT5
site of double-strand break 1 KAT5
Cytoplasm, cytoskeleton, spindle pole 1 KAT5
nuclear envelope 2 ALOX5, ALOX5AP
Nucleus envelope 1 ALOX5
Endomembrane system 1 PTGS1
Lipid droplet 1 ALOX15
Chromosome, centromere, kinetochore 1 KAT5
axon initial segment 1 KCNA1
Cell projection, dendrite 2 KCNA1, KCNB1
specific granule membrane 1 OLR1
tertiary granule membrane 1 OLR1
Melanosome 1 APOE
Presynaptic cell membrane 1 KCNA1
pseudopodium 1 F2RL1
voltage-gated potassium channel complex 2 KCNA1, KCNB1
ficolin-1-rich granule lumen 2 ALOX5, MAPK14
secretory granule lumen 2 ALOX5, MAPK14
endoplasmic reticulum lumen 2 APOE, PTGS2
nuclear matrix 1 ALOX5
axon terminus 1 KCNA1
kinetochore 1 KAT5
mitotic spindle pole 1 KAT5
paranode region of axon 1 KCNA1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
calyx of Held 1 KCNA1
clathrin-coated endocytic vesicle membrane 1 APOE
Synapse, synaptosome 1 KCNB1
synaptic cleft 1 APOE
Lateral cell membrane 1 KCNB1
[Isoform a]: Nucleus 1 ALOX15B
histone acetyltransferase complex 1 KAT5
postsynaptic specialization membrane 1 KCNB1
nucleosome 1 KAT5
Swr1 complex 1 KAT5
dendrite membrane 1 KCNB1
discoidal high-density lipoprotein particle 1 APOE
cholinergic synapse 1 KCNB1
endocytic vesicle lumen 1 APOE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
cortical cytoskeleton 1 SELE
Nucleus intermembrane space 1 ALOX5
proximal dendrite 1 KCNB1
juxtaparanode region of axon 1 KCNA1
piccolo histone acetyltransferase complex 1 KAT5


文献列表

  • Praveen Kumar Sugumaran, Shuang Wang, Shasha Song, Xiaowei Nie, Lei Zhang, Ye Feng, Wenchao Ma, Daling Zhu. 15-oxo-Eicosatetraenoic acid prevents serum deprivation-induced apoptosis of pulmonary arterial smooth muscle cells by activating pro-survival pathway. Prostaglandins, leukotrienes, and essential fatty acids. 2014 Apr; 90(4):89-98. doi: 10.1016/j.plefa.2014.01.006. [PMID: 24534136]
  • L M Landino, L J Marnett. Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. Biochemistry. 1996 Feb; 35(8):2637-43. doi: 10.1021/bi952546h. [PMID: 8611568]
  • . . . . doi: . [PMID: 17662651]