Aucubin (BioDeep_00000000176)

 

Secondary id: BioDeep_00000327308

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-(((1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

化学式: C15H22O9 (346.1264)
中文名称: 珊瑚木苷, 杜仲苷, 珊瑚苷, 桃叶珊瑚苷
谱图信息: 最多检出来源 Viridiplantae(plant) 40.43%

分子结构信息

SMILES: C1=COC(C2C1C(C=C2CO)O)OC3C(C(C(C(O3)CO)O)O)O
InChI: InChI=1S/C15H22O9/c16-4-6-3-8(18)7-1-2-22-14(10(6)7)24-15-13(21)12(20)11(19)9(5-17)23-15/h1-3,7-21H,4-5H2

描述信息

Aucubin is found in common verbena. Aucubin is a monoterpenoid based compound. Aucubin, like all iridoids, has a cyclopentan-[C]-pyran skeleton. Iridoids can consist of ten, nine, or rarely eight carbons in which C11 is more frequently missing than C10. Aucubin has 10 carbons with the C11 carbon missing. The stereochemical configurations at C5 and C9 lead to cis fused rings, which are common to all iridoids containing carbocylclic- or seco-skeleton in non-rearranged form. Oxidative cleavage at C7-C8 bond affords secoiridoids. The last steps in the biosynthesis of iridoids usually consist of O-glycosylation and O-alkylation. Aucubin, a glycoside iridoid, has an O-linked glucose moiety. Aucubin is an iridoid glycoside. Iridoids are commonly found in plants and function as defensive compounds. Irioids decrease the growth rates of many generalist herbivores. Aucubin is found in the leaves of Aucuba japonica (Cornaceae), Eucommia ulmoides (Eucommiaceae), and Plantago asiatic (Plantaginaceae), etc, plants used in traditional Chinese and folk medicine. Aucubin was found to protect against liver damage induced by carbon tetrachloride or alpha-amanitin in mice and rats when 80 mg/kg was dosed intraperitoneally. Geranyl pyrophosphate is the precursor for iridoids. Geranyl phosphate is generated through the mevalonate pathway or the methylerythritol phosphate pathway. The initial steps of the pathway involve the fusion of three molecules of acetyl-CoA to produce the C6 compound 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). HMG-CoA is then reduced in two steps by the enzyme HMG-CoA reductase. The resulting mevalonate is then sequentially phosphorylated by two separate kinases, mevalonate kinase and phosphomevalonate kinase, to form 5-pyrophosphomevalonate. Phosphosphomevalonate decarboxylase through a concerted decarboxylation reaction affords isopentenyl pyrophosphate (IPP). IPP is the basic C5 building block that is added to prenyl phosphate cosubstrates to form longer chains. IPP is isomerized to the allylic ester dimethylallyl pyrophosphate (DMAPP) by IPP isomerase. Through a multistep process, including the dephosphorylation DMAPP, IPP and DMAPP are combinded to from the C10 compound geranyl pyrophosphate (GPP). Geranyl pyrophosphate is a major branch point for terpenoid synthesis. The cyclizaton reaction to form the iridoid pyrane ring may result from one of two routes: route 1 - a hydride nucleophillic attack on C1 will lead to 1-O-carbonyl atom attack on C3, yielding the lactone ring; route 2 - loss of proton from carbon 4 leads to the formation of a double bond C3-C4; consequently the 3-0-carbonyl atom will attach to C1
Aucubin is a monoterpenoid based compound. Aucubin, like all iridoids, has a cyclopentan-[C]-pyran skeleton. Iridoids can consist of ten, nine, or rarely eight carbons in which C11 is more frequently missing than C10. Aucubin has 10 carbons with the C11 carbon missing. The stereochemical configurations at C5 and C9 lead to cis fused rings, which are common to all iridoids containing carbocylclic- or seco-skeleton in non-rearranged form. Oxidative cleavage at C7-C8 bond affords secoiridoids. The last steps in the biosynthesis of iridoids usually consist of O-glycosylation and O-alkylation. Aucubin, a glycoside iridoid, has an O-linked glucose moiety.; Aucubin is an iridoid glycoside. Iridoids are commonly found in plants and function as defensive compounds. Irioids decrease the growth rates of many generalist herbivores. Aucubin is found in the leaves of Aucuba japonica (Cornaceae), Eucommia ulmoides (Eucommiaceae), and Plantago asiatic (Plantaginaceae), etc, plants used in traditional Chinese and folk medicine. Aucubin was found to protect against liver damage induced by carbon tetrachloride or alpha-amanitin in mice and rats when 80 mg/kg was dosed intraperitoneally.; Geranyl pyrophosphate is the precursor for iridoids. Geranyl phosphate is generated through the mevalonate pathway or the methylerythritol phosphate pathway. The initial steps of the pathway involve the fusion of three molecules of acetyl-CoA to produce the C6 compound 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). HMG-CoA is then reduced in two steps by the enzyme HMG-CoA reductase. The resulting mevalonate is then sequentially phosphorylated by two separate kinases, mevalonate kinase and phosphomevalonate kinase, to form 5-pyrophosphomevalonate. Phosphosphomevalonate decarboxylase through a concerted decarboxylation reaction affords isopentenyl pyrophosphate (IPP). IPP is the basic C5 building block that is added to prenyl phosphate cosubstrates to form longer chains. IPP is isomerized to the allylic ester dimethylallyl pyrophosphate (DMAPP) by IPP isomerase. Through a multistep process, including the dephosphorylation DMAPP, IPP and DMAPP are combinded to from the C10 compound geranyl pyrophosphate (GPP). Geranyl pyrophosphate is a major branch point for terpenoid synthesis.; The cyclizaton reaction to form the iridoid pyrane ring may result from one of two routes: route 1 - a hydride nucleophillic attack on C1 will lead to 1-O-carbonyl atom attack on C3, yielding the lactone ring; route 2 - loss of proton from carbon 4 leads to the formation of a double bond C3-C4; consequently the 3-0-carbonyl atom will attach to C1.
Aucubin is an organic molecular entity. It has a role as a metabolite.
Aucubin is a natural product found in Verbascum lychnitis, Plantago media, and other organisms with data available.
See also: Chaste tree fruit (part of); Rehmannia glutinosa Root (part of); Plantago ovata seed (part of).
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects[1][2][3].
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects[1][2][3].

同义名列表

31 个代谢物同义名

(2S,3R,4S,5S,6R)-2-(((1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-((1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-((1S,4aR,5R,7aS)-5-Hydroxy-7-hydroxymethyl-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-1-yloxy)-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-[[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-1-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; (2S,3R,4S,5S,6R)-2-{[(1S,4aR,5S,7aS)-5-hydroxy-7-(hydroxymethyl)-1H,4aH,5H,7aH-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (1S-(1alpha,4aalpha,5alpha,7aalpha))-1,4a,5,7a-Tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside; .beta.-D-Glucopyranoside, (1S,4aR,5S,7aS)-1,4a,5,7a-tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl; (1S,4AR,5S,7AS)-1,4A,5,7A-TETRAHYDRO-5-HYDROXY-7-(HYDROXYMETHYL)CYCLOPENTA(C)PYRAN-1-YL-.BETA.-D-GLUCOPYRANOSIDE; (1S,4aR,5S,7aS)-1,4a,5,7a-Tetrahydro-5-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-1-yl beta-D-glucopyranoside; (1S,4AR,5S,7AS)-1,4A,5,7A-TETRAHYDRO-5-HYDROXY-7-(HYDROXYMETHYL)CYCLOPENTA(C)PYRAN-1-YL-beta-D-GLUCOPYRANOSIDE; 2-{[5-hydroxy-7-(hydroxymethyl)-1H,4aH,5H,7aH-cyclopenta[c]pyran-1-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; B-D-GLUCOPYRANOSIDE, (1S,4AR,5S,7AS)-1,4A,5,7A-TETRAHYDRO-5-HYDROXY-7-(HYDROXYMETHYL)CYCLOPENTA[C]PYRAN-1-YL; 1,4a,5,7a-Tetrahydro-5-hydroxy-7-hydroxymethylcyclopenta(c)pyran-1-yl-beta-D-glucopyranoside; Aucubin, primary pharmaceutical reference standard; AUCUBIN (CONSTITUENT OF CHASTE TREE); Aucubin, analytical standard; RJWJHRPNHPHBRN-FKVJWERZSA-N; UNII-2G52GS8UML; MEGxp0_001729; ACon1_002452; AUCUBIN [MI]; aucubuside; rhinanthin; 2G52GS8UML; Aucuboside; NSC407293; Rhimantin; Aucubine; Aucubin; Aucubin



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

719 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 BCL2, CA1, CASP3, CAT, HMGB1, MTOR, NFE2L2, NLRP3, PRKAA2, PTGS1, PTGS2, STAT3, TLR4, VEGFA
Peripheral membrane protein 5 GORASP1, HMGB1, MTOR, PTGS1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 5 BCL2, HMOX1, MTOR, PTGS1, PTGS2
Nucleus 10 BCL2, CASP3, HMGB1, HMOX1, MTOR, NFE2L2, NLRP3, PRKAA2, STAT3, VEGFA
cytosol 10 BCL2, CA1, CASP3, CAT, HMOX1, MTOR, NFE2L2, NLRP3, PRKAA2, STAT3
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 1 NFE2L2
nucleoplasm 7 CASP3, HMGB1, HMOX1, MTOR, NFE2L2, PRKAA2, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 3 HMGB1, TLR4, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
Golgi apparatus membrane 3 GORASP1, MTOR, NLRP3
Synapse 1 ACAN
cell surface 4 HMGB1, TLR4, TNF, VEGFA
glutamatergic synapse 2 ACAN, CASP3
Golgi apparatus 5 GORASP1, NFE2L2, PRKAA2, PTGS1, VEGFA
Golgi membrane 3 GORASP1, MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
Cytoplasm, cytosol 2 NFE2L2, NLRP3
Lysosome 1 MTOR
endosome 1 HMGB1
plasma membrane 5 HMGB1, NFE2L2, STAT3, TLR4, TNF
Membrane 8 BCL2, CAT, HMOX1, MTOR, NLRP3, PRKAA2, TLR4, VEGFA
axon 2 CCK, PRKAA2
caveola 1 PTGS2
extracellular exosome 3 CA1, CAT, PTGS1
Lysosome membrane 1 MTOR
endoplasmic reticulum 6 BCL2, HMGB1, HMOX1, NLRP3, PTGS2, VEGFA
extracellular space 7 ACAN, CCK, HMGB1, HMOX1, IL6, TNF, VEGFA
lysosomal lumen 1 ACAN
perinuclear region of cytoplasm 2 HMOX1, TLR4
adherens junction 1 VEGFA
mitochondrion 3 BCL2, CAT, NLRP3
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, PTGS1
Microsome membrane 3 MTOR, PTGS1, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 5 CCK, HMGB1, IL6, NLRP3, VEGFA
extracellular region 8 ACAN, CAT, CCK, HMGB1, IL6, NLRP3, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
mitochondrial matrix 1 CAT
Extracellular side 1 HMGB1
transcription regulator complex 1 STAT3
photoreceptor outer segment 1 PTGS1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 2 ACAN, VEGFA
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
GABA-ergic synapse 1 ACAN
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACAN
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ACAN
secretory granule 1 VEGFA
nuclear speck 1 PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 2 PTGS1, PTGS2
chromatin 2 NFE2L2, STAT3
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
Chromosome 1 HMGB1
nuclear envelope 1 MTOR
Endomembrane system 3 MTOR, NLRP3, PTGS1
microtubule organizing center 1 NLRP3
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 2 CAT, HMGB1
secretory granule lumen 2 CAT, HMGB1
Golgi lumen 1 ACAN
endoplasmic reticulum lumen 2 IL6, PTGS2
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 1 VEGFA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
perineuronal net 1 ACAN
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
condensed chromosome 1 HMGB1
Cytoplasmic vesicle, phagosome 1 MTOR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
perisynaptic extracellular matrix 1 ACAN
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Weili Li, Jing Cao, Yawen Zhang, Guanjing Ling, Nannan Tan, Yan Wei, Yuqin Zhang, Xiaoping Wang, Weina Qian, Jinchi Jiang, Jingmei Zhang, Wei Wang, Yong Wang. Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 May; 127(?):155473. doi: 10.1016/j.phymed.2024.155473. [PMID: 38422972]
  • Xuejuan Liang, Dan Wan, Lei Tan, Hao Liu. Dynamic changes of endophytic bacteria in the bark and leaves of medicinal plant Eucommia ulmoides in different seasons. Microbiological research. 2024 Mar; 280(?):127567. doi: 10.1016/j.micres.2023.127567. [PMID: 38103467]
  • Chunbo Dong, Qiuyu Shao, Qingsong Ran, Xu Li, Yanfeng Han. Interactions of rhizosphere microbiota-environmental factors-pharmacological active ingredients of Eucommia ulmoides. Planta. 2024 Feb; 259(3):59. doi: 10.1007/s00425-024-04338-w. [PMID: 38311641]
  • Elizabeth Rubio-Rodríguez, Ileana Vera-Reyes, Aída Araceli Rodríguez-Hernández, Alma Rosa López-Laredo, Ana C Ramos-Valdivia, Gabriela Trejo-Tapia. Mixed elicitation with salicylic acid and hydrogen peroxide modulates the phenolic and iridoid pathways in Castilleja tenuiflora plants. Planta. 2023 Jun; 258(1):20. doi: 10.1007/s00425-023-04177-1. [PMID: 37326881]
  • Serpil Demirci, Cemalettin Alp, Hüseyin Akşit, Yakup Ulutaş, Ahmet Altay, Esma Yeniçeri, Ekrem Köksal, Nurettin Yaylı. Isolation, characterization and anticancer activity of secondary metabolites from Verbascum speciosum. Chemical biology & drug design. 2023 Feb; ?(?):. doi: 10.1111/cbdd.14211. [PMID: 36756721]
  • Ping Yang, Qiaoyue Zhang, Hengyan Shen, Xinyu Bai, Ping Liu, Tao Zhang. Research progress on the protective effects of aucubin in neurological diseases. Pharmaceutical biology. 2022 Dec; 60(1):1088-1094. doi: 10.1080/13880209.2022.2074057. [PMID: 35634723]
  • Zhen Xu, Hang Yang, Xiaoqin Li, Xiaoying Xu, Hongxin Tan, Xiangjun Leng. Dietary effects of aucubin on growth and flesh quality of grass carp (Ctenopharyngodon idellus) based on metabolomics. Journal of animal science. 2022 Oct; 100(10):. doi: 10.1093/jas/skac273. [PMID: 35985277]
  • Han Huang, Yuan-Hang Chang, Jian Xu, Hai-Yan Ni, Heng Zhao, Bo-Wen Zhai, Thomas Efferth, Cheng-Bo Gu, Yu-Jie Fu. Aucubin as a natural potential anti-acute hepatitis candidate: Inhibitory potency and hepatoprotective mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154170. doi: 10.1016/j.phymed.2022.154170. [PMID: 35609387]
  • Yan Zhang, Li-Dong Tang, Jian-Ying Wang, Hao Wang, Xiao-Yun Chen, Lei Zhang, Ying Yuan. Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis. Chinese journal of natural medicines. 2022 Jun; 20(6):458-472. doi: 10.1016/s1875-5364(22)60182-1. [PMID: 35750385]
  • Carlos E Rodríguez-López, Yindi Jiang, Mohamed O Kamileen, Benjamin R Lichman, Benke Hong, Brieanne Vaillancourt, C Robin Buell, Sarah E O'Connor. Phylogeny-Aware Chemoinformatic Analysis of Chemical Diversity in Lamiaceae Enables Iridoid Pathway Assembly and Discovery of Aucubin Synthase. Molecular biology and evolution. 2022 04; 39(4):. doi: 10.1093/molbev/msac057. [PMID: 35298643]
  • Yongfeng Zhang, Xin Liu, Yangyang Li, Minkai Song, Yutong Li, Anhui Yang, Yaqin Zhang, Di Wang, Min Hu. Aucubin slows the development of osteoporosis by inhibiting osteoclast differentiation via the nuclear factor erythroid 2-related factor 2-mediated antioxidation pathway. Pharmaceutical biology. 2021 Dec; 59(1):1556-1565. doi: 10.1080/13880209.2021.1996614. [PMID: 34757891]
  • Ying Chun Li, Jin Cheng Hao, Bo Shang, Cheng Zhao, Li Juan Wang, Kai Lin Yang, Xiao Zhou He, Qian Qian Tian, Zhao Liang Wang, Hui Ling Jing, Yang Li, Yan Jun Cao. Neuroprotective effects of aucubin on hydrogen peroxide-induced toxicity in human neuroblastoma SH-SY5Y cells via the Nrf2/HO-1 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 87(?):153577. doi: 10.1016/j.phymed.2021.153577. [PMID: 33994055]
  • Marta Dąbrowska, Eliana B Souto, Izabela Nowak. Lipid Nanoparticles Loaded with Iridoid Glycosides: Development and Optimization Using Experimental Factorial Design. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113161. [PMID: 34070620]
  • Iva Potočnjak, Jelena Marinić, Lara Batičić, Lidija Šimić, Dalibor Broznić, Robert Domitrović. Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Aug; 142(?):111472. doi: 10.1016/j.fct.2020.111472. [PMID: 32504734]
  • Xianhui Lian, Ning Wang, Lin Ma, Hui Jiang, Dong Bai, Hongyu Xue, Qiang Ma. Determination of aucubin by supramolecular solvent-based dispersive liquid-liquid microextraction and UPLC-MS/MS: Application to a pharmacokinetic study in rats with type 1 diabetes. Journal of pharmaceutical and biomedical analysis. 2020 Jul; 186(?):113301. doi: 10.1016/j.jpba.2020.113301. [PMID: 32353680]
  • Xiangchang Zeng, Fei Guo, Dongsheng Ouyang. A review of the pharmacology and toxicology of aucubin. Fitoterapia. 2020 Jan; 140(?):104443. doi: 10.1016/j.fitote.2019.104443. [PMID: 31790767]
  • Eunsoo Jung, Su-Bin Park, Woo Kwon Jung, Hyung Rae Kim, Junghyun Kim. Aucubin, An Active Ingredient in Aucuba japonica, Prevents N-methyl-N-nitrosourea-induced Retinal Degeneration in Mice. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244437. [PMID: 31817154]
  • Eunsoo Jung, Su-Bin Park, Woo Kwon Jung, Hyung Rae Kim, Junghyun Kim. Antiglycation Activity of Aucubin In Vitro and in Exogenous Methylglyoxal Injected Rats. Molecules (Basel, Switzerland). 2019 Oct; 24(20):. doi: 10.3390/molecules24203653. [PMID: 31658696]
  • Kazufumi Toume, Zhiyan Hou, Huanhuan Yu, Mitsuru Kato, Miki Maesaka, Yanjing Bai, Shiho Hanazawa, Yuewei Ge, Tsugunobu Andoh, Katsuko Komatsu. Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula "Goshajinkigan". Journal of natural medicines. 2019 Sep; 73(4):761-768. doi: 10.1007/s11418-019-01327-2. [PMID: 31190267]
  • Shaofeng Yang, Linghui Li, Liguo Zhu, Chao Zhang, Zhaoyong Li, Yantao Guo, Ying Nie, Zhenhua Luo. Aucubin inhibits IL-1β- or TNF-α-induced extracellular matrix degradation in nucleus pulposus cell through blocking the miR-140-5p/CREB1 axis. Journal of cellular physiology. 2019 08; 234(8):13639-13648. doi: 10.1002/jcp.28044. [PMID: 30637726]
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