(1R,3As,4S,6aS)-1,4-di(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan (BioDeep_00000171568)

Main id: BioDeep_00000230030

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


5-[4-(2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxole

化学式: C20H18O6 (354.1103)
中文名称: 芝麻素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6
InChI: InChI=1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2

描述信息

Constituent of sesame oil. (+)-Sesamin is found in many foods, some of which are ginkgo nuts, sesame, flaxseed, and fats and oils.
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D020011 - Protective Agents > D000975 - Antioxidants
D009676 - Noxae > D000963 - Antimetabolites
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
(-)-Asarinin is a extract lignan from Asarum sieboldii Miq., mainly produced in roots of this herb[1].
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2].

同义名列表

18 个代谢物同义名

5-[4-(2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxole; (1R,3As,4S,6aS)-1,4-di(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan; sesamin, (1R-(1alpha,3aalpha,4alpha,6aalpha))-isomer; sesamin, (1R-(1alpha,3aalpha,4beta,6aalpha))-isomer; PSEUDO CUBEBIN; D-(+)-Sesamin; epi-sesamin; (+)-Segamin; (+)-Sesamin; episesamin; d-Sesamin; asarinin; sesamin; Fagarol; Sezamin; DESAMIN; (-)-Asarinin; Sesamin



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

329 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CXCR3, CYP2C9, FOXP3, MAPK14, PPARG, TLR2, TLR4, TLR9
Peripheral membrane protein 1 CYP1B1
Endosome membrane 2 TLR4, TLR9
Endoplasmic reticulum membrane 4 CYP1B1, CYP2C9, CYP7A1, TLR9
Nucleus 6 FOXP3, MAPK14, NR1H4, PPARA, PPARG, TBX21
cytosol 3 FOXP3, MAPK14, PPARG
dendrite 1 CADM1
phagocytic vesicle 1 TLR9
nucleoplasm 5 FOXP3, MAPK14, NR1H4, PPARA, PPARG
RNA polymerase II transcription regulator complex 2 NR1H4, PPARG
Cell membrane 4 CADM1, CXCR3, TLR4, TNF
Early endosome membrane 1 TLR9
Multi-pass membrane protein 1 CXCR3
Golgi apparatus membrane 1 TLR9
Synapse 1 CADM1
cell surface 6 CXCR3, ITGAX, TLR2, TLR4, TNF, TNFRSF4
glutamatergic synapse 1 MAPK14
Golgi apparatus 1 TLR2
Golgi membrane 1 TLR9
neuronal cell body 2 TBX21, TNF
Lysosome 1 TLR9
endosome 1 TLR9
plasma membrane 12 CADM1, CXCR3, CYP2C9, F2, IFNLR1, ITGAX, TLR2, TLR4, TLR9, TNF, TNFRSF4, TNFSF9
Membrane 10 CADM1, CXCR3, CYP1B1, IFNLR1, ITGAX, TLR2, TLR4, TLR9, TNFRSF4, TNFSF9
apical plasma membrane 1 TLR9
basolateral plasma membrane 2 CADM1, TLR9
extracellular exosome 1 F2
endoplasmic reticulum 1 TLR9
extracellular space 3 F2, TNF, TNFSF9
perinuclear region of cytoplasm 2 PPARG, TLR4
mitochondrion 2 CYP1B1, MAPK14
protein-containing complex 1 FOXP3
intracellular membrane-bounded organelle 4 CYP1B1, CYP2C9, CYP7A1, PPARG
Microsome membrane 3 CYP1B1, CYP2C9, CYP7A1
postsynaptic density 1 CADM1
Single-pass type I membrane protein 6 CADM1, IFNLR1, ITGAX, TLR2, TLR4, TLR9
Secreted 1 F2
extracellular region 4 F2, MAPK14, TLR9, TNF
Single-pass membrane protein 2 CADM1, CYP7A1
external side of plasma membrane 5 CXCR3, ITGAX, TLR4, TNF, TNFRSF4
Early endosome 1 TLR4
cell-cell junction 1 CADM1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 TLR2, TNF
collagen-containing extracellular matrix 1 F2
nuclear speck 1 MAPK14
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 4 NR1H4, PPARG, TLR2, TLR4
neuron projection 1 CADM1
chromatin 5 FOXP3, NR1H4, PPARA, PPARG, TBX21
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 2 TLR4, TNF
phagocytic vesicle membrane 1 TLR2
[Isoform 3]: Nucleus 1 NR1H4
spindle pole 1 MAPK14
blood microparticle 1 F2
[Isoform 2]: Cell membrane 1 CXCR3
tertiary granule membrane 1 ITGAX
euchromatin 1 NR1H4
cell body 1 TLR2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 2 ITGAX, TLR2
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 1 NR1H4
ficolin-1-rich granule membrane 1 ITGAX
endolysosome membrane 1 TLR9
[Isoform 1]: Cell membrane 1 CXCR3
early phagosome 1 TLR9
Cytoplasmic vesicle, phagosome 1 TLR9
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
integrin complex 1 ITGAX
[Isoform 4]: Nucleus 1 NR1H4
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
integrin alphaX-beta2 complex 1 ITGAX
endolysosome 1 TLR9
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Ya-Ping Bai, Teng Zhang, Zheng-Yan Hu, Yan Zhang, De-Guo Wang, Meng-Yun Zhou, Ying Zhang, Fang Zhang, Xiang Kong. Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo. Biochemical pharmacology. 2024 Jun; 224(?):116240. doi: 10.1016/j.bcp.2024.116240. [PMID: 38679210]
  • Mengyun Dong, Tianliang Zhang, Xueli Liang, Xinyi Cheng, Fuyan Shi, Hang Yuan, Fengxiang Zhang, Qiqi Jiang, Xia Wang. Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells. Biochemical and biophysical research communications. 2024 May; 708(?):149815. doi: 10.1016/j.bbrc.2024.149815. [PMID: 38531220]
  • Maoyuan Zhao, Yueqiang Wen, Yi Yang, Huafeng Pan, Shunkai Xie, Caifei Shen, Wenhao Liao, Nianzhi Chen, Qiao Zheng, Gang Zhang, Yuchen Li, Daoyin Gong, Jianyuan Tang, Ziyi Zhao, Jinhao Zeng. (-)-Asarinin alleviates gastric precancerous lesions by promoting mitochondrial ROS accumulation and inhibiting the STAT3 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155348. doi: 10.1016/j.phymed.2024.155348. [PMID: 38335913]
  • Baining Zhang, Zhiwei He, Jialin Guo, Feng Li, Zhi Huang, Wenkai Zheng, Wenhua Xing, Manglai Li, Yong Zhu, Xuejun Yang. Sesamin-mediated high expression of BECN2 ameliorates cartilage endplate degeneration by reducing autophagy and inflammation. Aging. 2024 Jan; 16(2):1145-1160. doi: 10.18632/aging.205386. [PMID: 38284902]
  • Shahab Ghaderi, Masome Rashno, Alireza Sarkaki, Seyed Esmaeil Khoshnam. Sesamin mitigates lead-induced behavioral deficits in male rats: The role of oxidative stress. Brain research bulletin. 2024 Jan; 206(?):110852. doi: 10.1016/j.brainresbull.2023.110852. [PMID: 38141790]
  • Nelma Nyvonne Tiqu Gina, Jui-Ling Kuo, Mei-Li Wu, Show-Mei Chuang. Sesamin and sesamolin potentially inhibit adipogenesis through downregulating the peroxisome proliferator-activated receptor γ protein expression and activity in 3T3-L1 cells. Nutrition research (New York, N.Y.). 2023 Dec; 123(?):4-17. doi: 10.1016/j.nutres.2023.12.011. [PMID: 38228077]
  • Shu-Ming Huang, Cheng-Hung Chuang, Christine Joyce F Rejano, Lemmuel L Tayo, Cheng-Yang Hsieh, Steven Kuan-Hua Huang, Po-Wei Tsai. Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes. Molecules (Basel, Switzerland). 2023 Oct; 28(21):. doi: 10.3390/molecules28217255. [PMID: 37959677]
  • Qian Zeng, Ting-Ting Zhou, Wen-Jie Huang, Xiao-Ting Huang, Lei Huang, Xiao-Hua Zhang, Xiao-Xue Sang, Yu-Yang Luo, Yu-Mei Tian, Bin Wu, Lin Liu, Zi-Qiang Luo, Bin He, Wei Liu, Si-Yuan Tang. Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ. Scientific reports. 2023 09; 13(1):14706. doi: 10.1038/s41598-023-41933-5. [PMID: 37679587]
  • Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Chul Yung Choi, Gil-Saeng Jeong, Sang Ki Lee, Hyung Sik Kim, Hye Gwang Jeong. Sesamin ameliorates lipotoxicity and lipid accumulation through the activation of the estrogen receptor alpha signaling pathway. Biochemical pharmacology. 2023 Aug; 216(?):115768. doi: 10.1016/j.bcp.2023.115768. [PMID: 37652106]
  • Elham Ramazani, Faeze Ebrahimpour, Seyed Ahmad Emami, Abolfazl Shakeri, Behjat Javadi, Amirhossein Sahebkar, Zahra Tayarani-Najaran. Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells. Recent advances in food, nutrition & agriculture. 2023 Aug; ?(?):. doi: 10.2174/2772574x14666230804151124. [PMID: 37539928]
  • Zhao-Jie Wang, Yi-Chi Chen, Feng-Cai Zou, Yan Qin, Yan-Yan Zhu, Xia Xiao, Tian-Zhen Xie, Ying-Jie He, Yun-Li Zhao, Xiao-Dong Luo. Phytochemical Analysis and Anti-Ascaris suum Activity of Different Zanthoxylum Species In Vitro and In Vivo. Journal of agricultural and food chemistry. 2023 Apr; 71(13):5219-5229. doi: 10.1021/acs.jafc.2c08949. [PMID: 36971186]
  • Chao Liang, Chi Ndi, Louise Kjaerulff, Susan Semple, Bevan Buirchell, Sonia Coriani, Birger Lindberg Møller, Dan Staerk. Characterization of Serrulatane Diterpenoids in Eremophila phyllopoda subsp. phyllopoda by Triple High-Resolution α-Glucosidase/PTP1B/Radical Scavenging Profiling, NMR Spectroscopy, DFT-GIAO NMR, and Electronic Circular Dichroism Calculations. Journal of natural products. 2023 Mar; ?(?):. doi: 10.1021/acs.jnatprod.2c00692. [PMID: 36880726]
  • Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu, Jingyuan Wan. Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice. Journal of immunology research. 2023; 2023(?):1116841. doi: 10.1155/2023/1116841. [PMID: 37663051]
  • Satoshi Morita, Hideyuki Sasaki, Yoshihisa Kaneda, Tomohiro Rogi, Takayuki Izumo, Masaaki Nakai. Effects of Combining Docosahexaenoic Acid and Eicosapentaenoic Acid with Sesame Lignan on Vascular Endothelial Function. Journal of nutritional science and vitaminology. 2023; 69(5):370-376. doi: 10.3177/jnsv.69.370. [PMID: 37940577]
  • Jun Yamada, Shoichiro Maeda, Mariko Soya, Hidefumi Nishida, Kyoko M Iinuma, Shozo Jinno. Alleviation of cognitive deficits via upregulation of chondroitin sulfate biosynthesis by lignan sesamin in a mouse model of neuroinflammation. The Journal of nutritional biochemistry. 2022 10; 108(?):109093. doi: 10.1016/j.jnutbio.2022.109093. [PMID: 35724814]
  • Longkai Shi, Emad Karrar, Ruijie Liu, Ming Chang, Xingguo Wang. Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells. Journal of food biochemistry. 2022 08; 46(8):e14180. doi: 10.1111/jfbc.14180. [PMID: 35396857]
  • Qiaoyun Bai, Zhiguang Wang, Yihua Piao, Xiao Zhou, Qinji Piao, Jingzhi Jiang, Hanye Liu, Hongmei Piao, Liangchang Li, Yilan Song, Guanghai Yan. Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis. Journal of agricultural and food chemistry. 2022 Apr; 70(16):4921-4933. doi: 10.1021/acs.jafc.1c07877. [PMID: 35420033]
  • Daiki Oikawa, Satoshi Yamashita, Seiji Takahashi, Toshiyuki Waki, Koichi Kikuchi, Takaaki Abe, Takane Katayama, Toru Nakayama. (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis. Biochemical and biophysical research communications. 2022 01; 590(?):158-162. doi: 10.1016/j.bbrc.2021.12.088. [PMID: 34974305]
  • Sayeh Mottaghi, Hassan Abbaszadeh. A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives. Critical reviews in food science and nutrition. 2022; 62(26):7301-7318. doi: 10.1080/10408398.2021.1913568. [PMID: 33905270]
  • Yiting Sun, Jingyi Ren, Siqi Zhu, Zhenao Zhang, Zihao Guo, Jiaqi An, Bowen Yin, Yuxia Ma. The Effects of Sesamin Supplementation on Obesity, Blood Pressure, and Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in endocrinology. 2022; 13(?):842152. doi: 10.3389/fendo.2022.842152. [PMID: 35311241]
  • Haiping He, Tonghua Yang, Fan Li, Lihua Zhang, Xiaosui Ling. A novel study on the immunomodulatory effect of umbilical cord derived mesenchymal stem cells pretreated with traditional Chinese medicine Asarinin. International immunopharmacology. 2021 Nov; 100(?):108054. doi: 10.1016/j.intimp.2021.108054. [PMID: 34492537]
  • Chen Chen, Xinwei Shi, Tao Zhou, Weimin Li, Sifeng Li, Guoqing Bai. Full-length transcriptome analysis and identification of genes involved in asarinin and aristolochic acid biosynthesis in medicinal plant Asarum sieboldii. Genome. 2021 Jun; 64(6):639-653. doi: 10.1139/gen-2020-0095. [PMID: 33320770]
  • Zhao-Yue Dong, Lin Wei, Hui-Qiang Lu, Qing-Hong Zeng, Fan-Cheng Meng, Guo-Wei Wang, Xiao-Zhong Lan, Zhi-Hua Liao, Min Chen. Ptehoosines A and B: Two new sesamin-type sesquilignans with antiangiogenic activity from Pterocephalus hookeri (C.B. Clarke) Höeck. Fitoterapia. 2021 Jun; 151(?):104886. doi: 10.1016/j.fitote.2021.104886. [PMID: 33757847]
  • Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee. Simultaneous determination of asarinin, β-eudesmol, and wogonin in rats using ultraperformance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies following administration of standards and Gumiganghwal-tang. Biomedical chromatography : BMC. 2021 Apr; 35(4):e5021. doi: 10.1002/bmc.5021. [PMID: 33169364]
  • Mengxi Wang, Pan Liu, Lingyan Kong, Na Xu, Hong Lei. Promotive effects of sesamin on proliferation and adhesion of intestinal probiotics and its mechanism of action. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Mar; 149(?):112049. doi: 10.1016/j.fct.2021.112049. [PMID: 33561518]
  • Yilin Wang, Jin Wen, Marwan Almoiliqy, Yaojia Wang, Zhihao Liu, Xiaobo Yang, Xiaolong Lu, Qiang Meng, Jinyong Peng, Yuan Lin, Pengyuan Sun. Sesamin Protects against and Ameliorates Rat Intestinal Ischemia/Reperfusion Injury with Involvement of Activating Nrf2/HO-1/NQO1 Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):5147069. doi: 10.1155/2021/5147069. [PMID: 34630849]
  • Tianyang Wang, Song Lin, Hua Li, Ran Liu, Zihan Liu, Huarong Xu, Qing Li, Kaishun Bi. A stepwise integrated multi-system to screen quality markers of Chinese classic prescription Qingzao Jiufei decoction on the treatment of acute lung injury by combining 'network pharmacology-metabolomics-PK/PD modeling'. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153313. doi: 10.1016/j.phymed.2020.153313. [PMID: 32866904]
  • Jinling Cao, Cuiping Feng, Lingtian Xie, Lijuan Li, Jianjie Chen, Shaojun Yun, Wenjing Guo, Tianyu Wang, Yijie Wu, Rui Meng, Guodong Wang, Xinjing He, Yongju Luo. Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride. Fish & shellfish immunology. 2020 Nov; 106(?):715-723. doi: 10.1016/j.fsi.2020.08.039. [PMID: 32860904]
  • Ren-Ai Xu, Wei Sun, Ruimin Chen, Naihua Liu, Chengke Huang. Inhibitory effect of sesamin on ivabradine metabolism in rats. Pakistan journal of pharmaceutical sciences. 2020 Nov; 33(6):2543-2546. doi: NULL. [PMID: 33867328]
  • Erisa Harada, Jun Murata, Eiichiro Ono, Hiromi Toyonaga, Akira Shiraishi, Kosuke Hideshima, Masayuki P Yamamoto, Manabu Horikawa. (+)-Sesamin-oxidising CYP92B14 shapes specialised lignan metabolism in sesame. The Plant journal : for cell and molecular biology. 2020 11; 104(4):1117-1128. doi: 10.1111/tpj.14989. [PMID: 32955771]
  • Amin F Majdalawieh, Sarah Dalibalta, Sarah M Yousef. Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review. European journal of pharmacology. 2020 Oct; 885(?):173417. doi: 10.1016/j.ejphar.2020.173417. [PMID: 32750369]
  • Yutong Sui, Shiyou Li, Yahui Zhao, Qing Liu, Yanjiang Qiao, Li Feng, Sheng Li. Identification of a natural compound, sesamin, as a novel TRPM8 antagonist with inhibitory effects on prostate adenocarcinoma. Fitoterapia. 2020 Sep; 145(?):104631. doi: 10.1016/j.fitote.2020.104631. [PMID: 32439453]
  • Miharu Fujii, Kaori Yasuda, Toshiyuki Sakaki. Inhibitory effects of sesamin on CYP2C9-dependent 7-hydroxylation of S-warfarin. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):368-373. doi: 10.1016/j.dmpk.2020.05.002. [PMID: 32601017]
  • Maurizio D'Auria, Marisabel Mecca, Luigi Todaro. High temperature treatment allows the detection of episesamin in paulownia wood extractives. Natural product research. 2020 May; 34(9):1326-1330. doi: 10.1080/14786419.2018.1560289. [PMID: 30663367]
  • S Shimoyoshi, D Takemoto, Y Kishimoto, A Amano, A Sato, Y Ono, T Rogi, H Shibata, A Ishigami. Sesame lignans suppress age-related disorders of the kidney in mice. European review for medical and pharmacological sciences. 2020 05; 24(9):5140-5147. doi: 10.26355/eurrev_202005_21208. [PMID: 32432778]
  • Yazhen Chen, Hetong Lin, Mengshi Lin, Yongzhan Zheng, Jicheng Chen. Effect of roasting and in vitro digestion on phenolic profiles and antioxidant activity of water-soluble extracts from sesame. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 May; 139(?):111239. doi: 10.1016/j.fct.2020.111239. [PMID: 32145351]
  • Norifumi Tateishi, Satoshi Morita, Izumi Yamazaki, Hitoshi Okumura, Masaru Kominami, Sota Akazawa, Ayuta Funaki, Namino Tomimori, Tomohiro Rogi, Hiroshi Shibata, Shigenobu Shibata. Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats. Chronobiology international. 2020 04; 37(4):493-509. doi: 10.1080/07420528.2019.1700998. [PMID: 31833423]
  • Lu Jin, Michael Schmiech, Menna El Gaafary, Xinlei Zhang, Tatiana Syrovets, Thomas Simmet. A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153181. doi: 10.1016/j.phymed.2020.153181. [PMID: 32065954]
  • Eiichiro Ono, Toshiyuki Waki, Daiki Oikawa, Jun Murata, Akira Shiraishi, Hiromi Toyonaga, Masako Kato, Naoki Ogata, Seiji Takahashi, Masa-Atsu Yamaguchi, Manabu Horikawa, Toru Nakayama. Glycoside-specific glycosyltransferases catalyze regio-selective sequential glucosylations for a sesame lignan, sesaminol triglucoside. The Plant journal : for cell and molecular biology. 2020 03; 101(5):1221-1233. doi: 10.1111/tpj.14586. [PMID: 31654577]
  • Weiran Dai, Yue Sun, Guoqiang Zhong. A Network Pharmacology Approach to Estimate the Active Ingredients and Potential Targets of Cuscutae semen in the Treatment of Osteoporosis. Medical science monitor : international medical journal of experimental and clinical research. 2020 Feb; 26(?):e920485. doi: 10.12659/msm.920485. [PMID: 32081843]
  • B H Ali, S Al Salam, Y Al Suleimani, M Al Za'abi, M Ashique, P Manoj, M Sudhadevi, M Al Tobi, A Nemmar. Ameliorative effect of sesamin in cisplatin-induced nephrotoxicity in rats by suppressing inflammation, oxidative/nitrosative stress, and cellular damage. Physiological research. 2020 02; 69(1):61-72. doi: 10.33549/physiolres.934142. [PMID: 31852200]
  • Yueming Chen, Huachao Li, Weinan Zhang, Wanchen Qi, Changpeng Lu, Huiliang Huang, Zhicheng Yang, Bing Liu, Luyong Zhang. Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway. Toxicology and applied pharmacology. 2020 01; 387(?):114848. doi: 10.1016/j.taap.2019.114848. [PMID: 31809756]
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