Imperatorin (BioDeep_00000000150)

 

Secondary id: BioDeep_00000358634, BioDeep_00000860997

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


InChI=1/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H

化学式: C16H14O4 (270.0892)
中文名称: 白芷乙素, 前胡内酯, 欧前胡素, 白茅苷, 前胡素, 欧芹属素乙, 主人草素
谱图信息: 最多检出来源 Viridiplantae(plant) 56.65%

分子结构信息

SMILES: CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C
InChI: InChI=1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3

描述信息

Imperatorin is a member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a metabolite.
Imperatorin is a natural product found in Allium wallichii, Ammi visnaga, and other organisms with data available.
Imperatorin is found in anise. Imperatorin is present in Aegle marmelos (bael fruit) and seeds of Pastinaca sativa (parsnip).Imperatorin is a furocoumarin and a phytochemical that has been isolated from Urena lobata L. (Malvaceae). It is biosynthesized from umbelliferone, a coumarin derivative.Imperatorin has been shown to exhibit anti-hypertrophic and anti-convulsant functions (A7784, A7785).Imperatorin belongs to the family of Furanocoumarins. These are polycyclic aromatic compounds containing a furan ring fused to a coumarin moeity.
See also: Angelica Dahurica Root (part of); Aegle marmelos fruit (part of); Ammi majus seed (part of) ... View More ...
Imperatorin is found in anise. Imperatorin is present in Aegle marmelos (bael fruit) and seeds of Pastinaca sativa (parsnip).Imperatorin is a furocoumarin and a phytochemical that has been isolated from Urena lobata L. (Malvaceae). It is biosynthesized from umbelliferone, a coumarin derivative
A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
Present in Aegle marmelos (bael fruit) and seeds of Pastinaca sativa (parsnip)
INTERNAL_ID 2244; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2244
Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.
Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.

同义名列表

75 个代谢物同义名

InChI=1/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H; 5-Benzofuranacrylic acid, 6-hydroxy-7-((3-methyl-2-butenyl)oxy)-, .delta.-lactone; 5-Benzofuranacrylic acid, 6-hydroxy-7-((3-methyl-2-butenyl)oxy)-, delta-lactone; 6-HYDROXY-7-(3-METHYL-2-BUTENYLOXY)-5-BENZOFURANACRYLIC ACID .GAMMA.-LACTONE; 6-Hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylic acid omega-lactone; 6-Hydroxy-7-(3-Methyl-2-Butenyloxy)-5-Benzofuranacrylic Acid Gamma-Lactone; 6-Hydroxy-7-(3-methyl-2butenyloxy)-5-benzofuranacrylic acid delta-lactone; (9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one); 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-buten-1-yl)oxy]-; 9-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one, 9CI; 9-[(3-METHYL-2-BUTEN-1-YL)OXY]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE; 7H-Furo[3,2-g][1]benzopyran-7-one, 9-((3-methyl-2-butenyl)oxy)-; 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((3-methyl-2-butenyl)oxy)-; 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]-; 9-[(3-Methylbut-2-enyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one; 9-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]-1-benzopyran-7-one; 9-((3-Methyl-2-butenyl)oxy)-7H-furo(3,2-g)(1)benzopyran-7-one; 9-((3-methyl-2-butenyl)oxy)-7H-furo(3,2-g)-1-benzopyran-7-one; Imperatorin, European Pharmacopoeia (EP) Reference Standard; 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one;Imperatorin; 9-((3-methylbut-2-en-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one; 9-[(3-methylbut-2-en-1-yl)oxy]-2H-furo[3,2-g]chromen-2-one; 9-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one; 9-((3-methylbut-2-en-1-yl)oxy)-7H-furo(3,2-g)chromen-7-one; 9-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one; 9-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g]chromen-7-one #; 9-(3-methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one; 9-(3-Methylbut-2-enyloxy)-7H-furo(3,2-g)chromen-7-one; 9-(3-Methyl-but-2-enyloxy)-furo[3,2-g]chromen-7-one; 9-(3-Methyl-2-butenyloxy)-7-oxofuro[3,2-g]chromene; 9-(3-Methylbut-2-enyloxy)furo[3,2-g]chromen-7-one; 9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one; 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one; 5-hydroxy-8-(1,1-dimethylallyl)psoralen; 7H-Furo[3, 9-[(3-methyl-2-butenyl)oxy]-; Imperatorin, >=98\\% (HPLC), powder; 9-(3-methylbut-2-enyloxy)-7H-furo; 8-(3-Methyl-2-butenyloxy)psoralen; Marmelosin, analytical standard; 8-Isopentenyloxypsoralene; 8-isoamylenoxypsoralen; [3,2-g]chromen-7-one; 8-Prenyloxypsoralen; MARMELOSIN (USP-RS); MARMELOSIN [USP-RS]; PENTOSALEN [WHO-DD]; PENTOSALEN [HSDB]; Spectrum4_001422; Spectrum2_000376; Spectrum5_000244; IMPERATORIN [MI]; Spectrum3_000145; Pentosalen [BAN]; Pentasalen, BAN; Imperatorin,(S); Tox21_113179_1; DivK1c_006851; MEGxp0_000089; Oprea1_407817; KBio3_001050; KBio2_003803; Tox21_113179; KBio2_001235; KBio2_006371; KBio1_001795; Tox21_500413; ACon1_001117; Imperatorin; Marmelosin; Pentosalen; AI3-61725; Marmelide; Ammidin; Imperatorin; Imperatorin



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

401 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AKT1, BCL2, CASP3, CASP9, CAT, MAPK14, MAPK8, NFE2L2, PIK3CA, PTGS2, RELA, VEGFA
Peripheral membrane protein 3 ACHE, CYP1B1, PTGS2
Endoplasmic reticulum membrane 5 BCL2, CYP1A2, CYP1B1, HMOX1, PTGS2
Nucleus 11 ACHE, AKT1, BCL2, CASP3, CASP9, HMOX1, MAPK14, MAPK8, NFE2L2, RELA, VEGFA
cytosol 11 AKT1, BCL2, CASP3, CASP9, CAT, HMOX1, MAPK14, MAPK8, NFE2L2, PIK3CA, RELA
centrosome 1 NFE2L2
nucleoplasm 7 AKT1, CASP3, HMOX1, MAPK14, MAPK8, NFE2L2, RELA
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 ABCB1, ACHE, AKT1, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 ABCB1
Synapse 2 ACHE, MAPK8
cell cortex 1 AKT1
cell surface 4 ABCB1, ACHE, TNF, VEGFA
glutamatergic synapse 4 AKT1, CASP3, MAPK14, RELA
Golgi apparatus 3 ACHE, NFE2L2, VEGFA
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NFE2L2
plasma membrane 7 ABCB1, ACHE, AKT1, IGHE, NFE2L2, PIK3CA, TNF
Membrane 8 ABCB1, ACHE, AKT1, BCL2, CAT, CYP1B1, HMOX1, VEGFA
apical plasma membrane 1 ABCB1
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 2 ABCB1, CAT
endoplasmic reticulum 4 BCL2, HMOX1, PTGS2, VEGFA
extracellular space 6 ACHE, HMOX1, IGHE, IL6, TNF, VEGFA
perinuclear region of cytoplasm 3 ACHE, HMOX1, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, CAT, CYP1B1, MAPK14
protein-containing complex 5 AKT1, BCL2, CASP9, CAT, PTGS2
intracellular membrane-bounded organelle 3 CAT, CYP1A2, CYP1B1
Microsome membrane 3 CYP1A2, CYP1B1, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 IGHE
Secreted 3 ACHE, IL6, VEGFA
extracellular region 7 ACHE, CAT, IGHE, IL6, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
transcription regulator complex 1 RELA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, RELA
mediator complex 1 NFE2L2
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
spindle pole 1 MAPK14
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
NF-kappaB p50/p65 complex 1 RELA
[Isoform H]: Cell membrane 1 ACHE
NF-kappaB complex 1 RELA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fang Ren, Shiqiao Zhao, Xin He, Hanghong Lo, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Anguo Wu, Juan Zhang. Discovery and mechanistic study of Imperatorin that inhibits HBsAg expression and cccDNA transcription. Journal of medical virology. 2024 May; 96(5):e29669. doi: 10.1002/jmv.29669. [PMID: 38773784]
  • Junkyu Park, Sujin Shin, Youngmin Bu, Ho-Young Choi, Kyungjin Lee. Vasorelaxant and Blood Pressure-Lowering Effects of Cnidium monnieri Fruit Ethanol Extract in Sprague Dawley and Spontaneously Hypertensive Rats. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084223. [PMID: 38673809]
  • Li Liu, Lei Jiang, Jinglan Zhang, Yan Ma, Min Wan, Xueqing Hu, Lian Yang. Imperatorin inhibits oxidative stress injury and neuroinflammation via the PI3K/AKT signaling pathway in the MPTP-induced Parkinson's disease mouse. Neuroreport. 2024 Feb; 35(3):175-184. doi: 10.1097/wnr.0000000000001997. [PMID: 38305108]
  • Govindan Lakshmanan, Ammar B Altemimi, C Sivaraj, Jeyaperumal Selvakumari, L Karthik, K Saravanan, Vijay Viswanathan, Arjun Pandian, Francesco Cacciola, Marwa Rashad Ali, Mazin A A Najm, Tarek Gamal Abedelmaksoud. Imperatorin from the aerial parts of Cleome viscosa L.: a characterization study and evaluation of the antibacterial activity. Natural product research. 2024 Feb; 38(5):848-855. doi: 10.1080/14786419.2023.2190116. [PMID: 36987594]
  • Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu. Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgad127. [PMID: 38215001]
  • Xing Shen, Xiuxiu Liu, Xuemei Wang, Chaoyi Xue, Zhongping Chai, Maomao Zeng, Jie Chen. Effect of Angelica dahurica, Angelica dahurica polysaccharides, and imperatorin on free and bound heterocyclic amine generation in roasted beef patties and release profiles of bound heterocyclic amines during in vitro digestion. Food research international (Ottawa, Ont.). 2024 Jan; 175(?):113639. doi: 10.1016/j.foodres.2023.113639. [PMID: 38129016]
  • Emmanuel Kofi Kumatia, Felix Kwame Zoiku, Alex Asase, Nguyen Huu Tung. Anti-malarial activity of the alkaloid, heptaphylline, and the furanocoumarin, imperatorin, from Clausena anisata against human Plasmodium falciparum malaria parasites: ex vivo trophozoitocidal, schizonticidal and gametocytocidal approach. Malaria journal. 2023 Sep; 22(1):264. doi: 10.1186/s12936-023-04678-0. [PMID: 37689679]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
  • Mingming Zhang, Yuqing Wen, Peiwen Liang, Changsen Yang, Hongcheng Tu, Jingyi Wei, Junpei Du, Ting Zhan, Shangdong Liang, Guodong Li, Yun Gao. Imperatorin Improves Obesity-Induced Cardiac Sympathetic Nerve Injury Mediated by P2X4 Receptor in Stellate Sympathetic Ganglion. International journal of molecular sciences. 2023 Jan; 24(1):. doi: 10.3390/ijms24010783. [PMID: 36614227]
  • Gokay Albayrak, Serdar Demir, Halil Koyu, Sura Baykan. Anticholinesterase Compounds from Endemic Prangos uechtritzii. Chemistry & biodiversity. 2022 Nov; 19(11):e202200557. doi: 10.1002/cbdv.202200557. [PMID: 36201258]
  • Chia-Chen Hsieh, Yan-Yan Ng, Wei-Sung Li, Chung-Yuh Tzeng, Tsai-Yi Hsu, Wan-Hsiang Huang, Jen-Chieh Tsai. Ameliorative Effect of Imperatorin on Dermatophagoides pteronyssinus-Induced Allergic Asthma by Suppressing the Th2 Response in Mice. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27207028. [PMID: 36296620]
  • Yi-Fang Cui, Hong Wang, Jian Ruan, Wen-Wen Zhang, Hong-Yan Zhou, Ya-Nan Li, Long Dai, Jia-Yu Zhang. [Identification of metabolites of imperatorin in rats: based on UHPLC-Q-Exactive Orbitrap MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Aug; 47(15):4202-4213. doi: 10.19540/j.cnki.cjcmm.20220307.203. [PMID: 36046911]
  • Patoomporn Prasartthong, Poungrat Pakdeechote, Putcharawipa Maneesai, Sariya Meephat, Siwayu Rattanakanokchai, Chutamas Wunpathe, Kwanjit Apaijit, Sarawoot Bunbupha. Imperatorin attenuates cardiac remodelling and dysfunction in high-fat/high-fructose diet-fed rats by modulating oxidative stress, inflammation, and Nrf-2 expression. Tissue & cell. 2022 Apr; 75(?):101728. doi: 10.1016/j.tice.2021.101728. [PMID: 34998165]
  • Yung-Fong Tsai, Chun-Yu Chen, I-Wen Lin, Yann-Lii Leu, Shun-Chin Yang, Yu-Ting Syu, Po-Jen Chen, Tsong-Long Hwang. Imperatorin Alleviates Psoriasiform Dermatitis by Blocking Neutrophil Respiratory Burst, Adhesion, and Chemotaxis Through Selective Phosphodiesterase 4 Inhibition. Antioxidants & redox signaling. 2021 10; 35(11):885-903. doi: 10.1089/ars.2019.7835. [PMID: 33107318]
  • Tengyun Ma, Panwang Liu, Jiangping Wei, Meihuan Zhao, Xingxing Yao, Xiaohong Luo, Shijun Xu. Imperatorin alleviated endometriosis by inhibiting the activation of PI3K/Akt/NF-κB pathway in rats. Life sciences. 2021 Jun; 274(?):119291. doi: 10.1016/j.lfs.2021.119291. [PMID: 33667515]
  • Sarawoot Bunbupha, Patoomporn Prasarttong, Anuson Poasakate, Putcharawipa Maneesai, Poungrat Pakdeechote. Imperatorin alleviates metabolic and vascular alterations in high-fat/high-fructose diet-fed rats by modulating adiponectin receptor 1, eNOS, and p47phox expression. European journal of pharmacology. 2021 May; 899(?):174010. doi: 10.1016/j.ejphar.2021.174010. [PMID: 33711309]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yijia Xu, Yue Yu, Qi Wang, Wenwen Li, Suli Zhang, Xiaoyuan Liao, Yanfeng Liu, Yang Su, Mingyi Zhao, Jinghai Zhang. Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7. Journal of ethnopharmacology. 2021 Apr; 269(?):113736. doi: 10.1016/j.jep.2020.113736. [PMID: 33359917]
  • Javad Mottaghipisheh, Norbert Kúsz, Judit Hohmann, Yu-Chi Tsai, Dezső Csupor. Isolation of secondary metabolites from the Iranian medicinal plant Eremurus persicus. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2021 Jan; 76(1-2):43-47. doi: 10.1515/znc-2020-0059. [PMID: 32681789]
  • Changqiong Xu, Ran Li, Jie Wu. Effects of Yuanhu- Zhitong tablets on alcohol-induced conditioned place preference in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan; 133(?):110962. doi: 10.1016/j.biopha.2020.110962. [PMID: 33166765]
  • Wenqi Li, Jinjin Yu, Xin Xiao, Lulu Zang, Yajie Yang, Jiabao Yu, Qiuxia Huang, Xiaofeng Niu, Weifeng Li. Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro. International immunopharmacology. 2021 Jan; 90(?):107170. doi: 10.1016/j.intimp.2020.107170. [PMID: 33218940]
  • Xing X Zheng, Kai Y Zhang, Ying C Li, Yi W Chen, Yi S Yue, Si Z Xia, Yang Li, Huan H Deng, Hui L Jing, Yan J Cao. Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring. Phytotherapy research : PTR. 2020 Sep; 34(9):2408-2418. doi: 10.1002/ptr.6692. [PMID: 32281712]
  • Qingqing Guo, Li Li, Kang Zheng, Guang Zheng, Haiyang Shu, Yingjie Shi, Cheng Lu, Jun Shu, Daogang Guan, Aiping Lu, Xiaojuan He. Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis. Journal of leukocyte biology. 2020 08; 108(2):509-517. doi: 10.1002/jlb.3ma0320-440rr. [PMID: 32392637]
  • Linlin Chen, Weiheng Xu, Quanjun Yang, Hong Zhang, Lili Wan, Bo Xin, Junping Zhang, Cheng Guo. Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3. Pharmacological research. 2020 08; 158(?):104871. doi: 10.1016/j.phrs.2020.104871. [PMID: 32413482]
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