Ergocornin (BioDeep_00000002617)

描述信息

Ergocornine is ergotaman bearing a hydroxy group at the 12' position, isopropyl groups at the 2' and 5'alpha positions, and oxo groups at positions 3', 6', and 18. It is a natural ergot alkaloid. It derives from a hydride of an ergotaman.Ergocornine has been reported in Festuca rubra and Claviceps purpurea

Ergocornine is an alkaloid of the ergoline family. Like other ergoline alkaloids, it occurs in various species of vines of the Convolvulaceae (morning glory) family and in some species of lower fungi. Ergocornine is one of 3 similar peptides referred to as ergotoxine alkaloids, the other two being ergocryptine and ergocristine. Ergotoxines prepared into their hihydroergotoxine mesylates, commonly known as ergoloid mesylates, are used in the symptomatic therapy of age-related dementia. Long term exposure to some ergoline alkaloids can cause ergotism, a disease causing convulsive and gangrenous symptoms. (L1918, A2915)

Ergocornin is a compound that belongs to the ergot alkaloid family, which are a group of compounds produced by certain fungi, particularly those of the genus Claviceps. Ergocornin itself is a derivative of the more well-known ergot alkaloid, ergotamine. The biological functions and effects of ergocornin can be complex and multifaceted, and they include the following:
Vasoconstriction: Ergocornin has the ability to constrict blood vessels. This effect can be useful in the treatment of conditions such as migraines, where it helps to reduce the inflammation and vasodilation that can contribute to the pain associated with migraines.
Central Nervous System Effects: Ergocornin can affect the central nervous system, potentially leading to alterations in perception, mood, and consciousness. Due to these effects, it has been studied for its potential use in psychiatric conditions, although its use in this context is not common.
Inhibition of Serotonin Reuptake: Ergocornin can inhibit the reuptake of serotonin, a neurotransmitter that plays a key role in mood regulation, among other functions. This can lead to increased serotonin levels in the synaptic cleft, which may contribute to its therapeutic effects in certain conditions.
4.Abortifacient Properties: Some ergot alkaloids, including ergocornin, have historically been used as abortifacients to terminate pregnancies. However, due to the risks associated with these compounds, this use is highly regulated and not commonly employed in modern medicine.
Antimicrobial Activity: Ergot alkaloids, including ergocornin, have been found to possess antimicrobial properties, which could potentially be harnessed for the development of new antimicrobial agents.
It is important to note that while ergocornin and other ergot alkaloids have various biological functions and potential therapeutic uses, they also come with a range of side effects and risks. Ergot alkaloids can be toxic at high doses and may cause ergotism, a condition characterized by symptoms such as hallucinations, gangrene, and other severe effects. Due to these risks, the use of ergocornin and related compounds is carefully controlled and typically requires medical supervision.

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