malonic acid (BioDeep_00000405337)

Main id: BioDeep_00000002855

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


Propanedioic acid

化学式: C3H4O4 (104.011)
中文名称: 丙二酸, 丙二酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(=O)O)C(=O)O
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)

描述信息

An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.

同义名列表

5 个代谢物同义名

malonic acid; Propanedioic acid; FA 3:1;O2; Malonate; Malonic acid



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

96 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CAT, DCTD, FH, GLUL, HTT, MLYCD, PC, SRR
Peripheral membrane protein 1 HSD17B6
Endosome membrane 1 HTT
Nucleus 5 FH, GLUL, HTT, SLC25A10, SLC25A11
autophagosome 1 HTT
cytosol 8 CAT, DCTD, FH, GLUL, HTT, MLYCD, PC, SRR
dendrite 1 HTT
nucleoplasm 5 ACSF3, ATP2B1, CD2, HTT, SLC25A10
Cell membrane 5 ATP2B1, CD2, GLUL, HTT, SLC13A3
Lipid-anchor 1 GLUL
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 8 ABCC3, ATP2B1, HTT, SLC13A2, SLC13A3, SLC22A6, SLC25A10, SLC25A11
Synapse 2 ATP2B1, HTT
cell surface 1 CD2
glutamatergic synapse 1 ATP2B1
Golgi apparatus 2 CD2, HTT
Golgi membrane 1 INS
mitochondrial inner membrane 2 SLC25A10, SLC25A11
neuronal cell body 1 SRR
presynaptic membrane 2 ATP2B1, HTT
Cytoplasm, cytosol 1 GLUL
plasma membrane 9 ABCC3, ATP2B1, CD2, GLUL, HTT, SLC13A2, SLC13A3, SLC22A6, SLC25A11
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ABCC3, ATP2B1, CAT, SLC13A2, SLC13A3, SLC22A6, SLC25A10, SLC25A11
apical plasma membrane 1 SLC13A2
axon 1 HTT
basolateral plasma membrane 4 ABCC3, ATP2B1, SLC13A3, SLC22A6
caveola 1 SLC22A6
extracellular exosome 7 ATP2B1, CAT, FH, GLUL, SLC13A2, SLC13A3, SLC22A6
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 GLUL, HSD17B6, HTT
extracellular space 2 IL6, INS
perinuclear region of cytoplasm 1 HTT
mitochondrion 8 ACSF3, CAT, FH, GLUL, MLYCD, PC, SLC25A10, SLC25A11
protein-containing complex 4 CAT, CD2, HTT, SLC22A6
intracellular membrane-bounded organelle 3 ATP2B1, CAT, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 CD2
Secreted 2 IL6, INS
extracellular region 4 CAT, CD2, IL6, INS
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 2 MLYCD, PC
mitochondrial matrix 5 ACSF3, CAT, FH, MLYCD, PC
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 CD2
Early endosome 1 HTT
apical part of cell 1 SRR
cell-cell junction 1 CD2
postsynaptic membrane 1 HTT
Apical cell membrane 1 SLC13A2
Mitochondrion inner membrane 1 SLC25A11
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
focal adhesion 2 CAT, HTT
Peroxisome 2 CAT, MLYCD
Peroxisome matrix 2 CAT, MLYCD
peroxisomal matrix 2 CAT, MLYCD
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
cell projection 1 ATP2B1
Chromosome 1 FH
centriole 1 HTT
Basolateral cell membrane 3 ABCC3, ATP2B1, SLC22A6
site of double-strand break 1 FH
Endomembrane system 1 HTT
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 HTT
Presynaptic cell membrane 1 ATP2B1
cell body 1 GLUL
basal plasma membrane 2 ABCC3, SLC22A6
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
Basal cell membrane 2 ABCC3, SLC22A6
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
glial cell projection 1 GLUL
catalase complex 1 CAT
inclusion body 1 HTT
interleukin-6 receptor complex 1 IL6
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
photoreceptor ribbon synapse 1 ATP2B1
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT


文献列表

  • Shubo Zhang, Wenfang Gao, Lina Xie, Guogang Zhang, Zimin Wei, Jie Li, Caihong Song, Mingkai Chang. Malonic acid shapes bacterial community dynamics in compost to promote carbon sequestration and humic substance synthesis. Chemosphere. 2024 Feb; 350(?):141092. doi: 10.1016/j.chemosphere.2023.141092. [PMID: 38169202]
  • Milica N Dimitrijević Stojanović, Andjela A Franich, Milena M Jurišević, Nevena M Gajović, Nebojša N Arsenijević, Ivan P Jovanović, Bojan S Stojanović, Slobodanka Lj Mitrović, Jakob Kljun, Snežana Rajković, Marija D Živković. Platinum(II) complexes with malonic acids: Synthesis, characterization, in vitro and in vivo antitumor activity and interactions with biomolecules. Journal of inorganic biochemistry. 2022 06; 231(?):111773. doi: 10.1016/j.jinorgbio.2022.111773. [PMID: 35279446]
  • Sarah Snanoudj, Stéphanie Torre, Bénédicte Sudrié-Arnaud, Lenaig Abily-Donval, Alice Goldenberg, Gajja S Salomons, Stéphane Marret, Soumeya Bekri, Abdellah Tebani. Heterogenous Clinical Landscape in a Consanguineous Malonic Aciduria Family. International journal of molecular sciences. 2021 Nov; 22(23):. doi: 10.3390/ijms222312633. [PMID: 34884438]
  • Randy J Chandler, Leah E Venturoni, Jing Liao, Brandon T Hubbard, Jessica L Schneller, Victoria Hoffmann, Susana Gordo, Shengwen Zang, Chih-Wei Ko, Nelson Chau, Kyle Chiang, Mark A Kay, Adi Barzel, Charles P Venditti. Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia. Hepatology (Baltimore, Md.). 2021 06; 73(6):2223-2237. doi: 10.1002/hep.31570. [PMID: 32976669]
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  • S S Efimova, D A Khaleneva, E V Litasova, L B Piotrovskiy, O S Ostroumova. The mechanisms of action of water-soluble aminohexanoic and malonic adducts of fullerene C60 with hexamethonium on model lipid membranes. Biochimica et biophysica acta. Biomembranes. 2020 11; 1862(11):183433. doi: 10.1016/j.bbamem.2020.183433. [PMID: 32763244]
  • Seung Hoon Lee, Jung Min Ko, Mi-Kyoung Song, Junghan Song, Kyung Sun Park. A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy. Molecular genetics & genomic medicine. 2020 09; 8(9):e1379. doi: 10.1002/mgg3.1379. [PMID: 32602666]
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