Formononetin (BioDeep_00000398529)

Main id: BioDeep_00000000371

Secondary id: BioDeep_00000270229

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


Formononetin (Biochanin B)

化学式: C16H12O4 (268.0736)
中文名称: 刺芒柄花素, 芒柄花黄素, 芒柄花素
谱图信息: 最多检出来源 Homo sapiens(blood) 32.13%

分子结构信息

SMILES: COC1=CC=C(C=C1)C1=COC2=C(C=CC(O)=C2)C1=O
InChI: InChI=1/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3

描述信息

Annotation level-1
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.059
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.061
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].

同义名列表

8 个代谢物同义名

Formononetin (Biochanin B); Formononetin; Norberto Lopes; Biochanin B; Flavosil; Formononetol; Formononetin; Formononetin



数据库引用编号

97 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(4)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

644 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 BCL2, CASP3, CCND1, EGFR, ESR1, MAPK14, NOS2, NOS3, PIK3C3, PIK3CA, PPARG, PTGS2, RELA, STAT3, TP53, VEGFA
Peripheral membrane protein 2 ESR1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 BCL2, EGFR, HMOX1, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 14 BCL2, CASP3, CCND1, EGFR, ESR1, HMOX1, MAPK14, NOS2, NOS3, PPARG, RELA, STAT3, TP53, VEGFA
autophagosome 1 PIK3C3
cytosol 14 BCL2, CASP3, CCND1, ESR1, HMOX1, MAPK14, NOS2, NOS3, PIK3C3, PIK3CA, PPARG, RELA, STAT3, TP53
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 2 CCND1, TP53
nucleoplasm 11 CASP3, CCND1, ESR1, HMOX1, MAPK14, NOS2, NOS3, PPARG, RELA, STAT3, TP53
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 2 EGFR, ESR1
Cytoplasmic side 2 ESR1, HMOX1
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 2 EGFR, VEGFA
glutamatergic synapse 5 CASP3, EGFR, MAPK14, PIK3C3, RELA
Golgi apparatus 3 ESR1, NOS3, VEGFA
Golgi membrane 3 EGFR, INS, NOS3
neuronal cell body 1 CASP3
Cytoplasm, cytosol 1 NOS2
endosome 2 EGFR, PIK3C3
plasma membrane 6 EGFR, ESR1, NOS2, NOS3, PIK3CA, STAT3
Membrane 7 BCL2, EGFR, ESR1, HMOX1, PIK3C3, TP53, VEGFA
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 2 NOS3, PTGS2
extracellular exosome 2 BMP3, MMP9
endoplasmic reticulum 5 BCL2, HMOX1, PTGS2, TP53, VEGFA
extracellular space 6 BMP3, EGFR, HMOX1, INS, MMP9, VEGFA
perinuclear region of cytoplasm 6 EGFR, HMOX1, NOS2, NOS3, PIK3CA, PPARG
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, MAPK14, TP53
protein-containing complex 5 BCL2, EGFR, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 3 BMP3, INS, VEGFA
extracellular region 5 BMP3, INS, MAPK14, MMP9, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 4 ESR1, RELA, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CCND1, EGFR
Secreted, extracellular space, extracellular matrix 2 MMP9, VEGFA
nucleolus 1 TP53
midbody 1 PIK3C3
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
GABA-ergic synapse 1 PIK3C3
extracellular matrix 1 VEGFA
Peroxisome 2 NOS2, PIK3C3
intracellular vesicle 1 EGFR
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 MMP9
secretory granule 1 VEGFA
axoneme 1 PIK3C3
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 PIK3C3
receptor complex 2 EGFR, PPARG
neuron projection 1 PTGS2
chromatin 5 ESR1, PPARG, RELA, STAT3, TP53
phagocytic vesicle membrane 1 PIK3C3
cytoskeleton 1 NOS3
spindle pole 1 MAPK14
site of double-strand break 1 TP53
endosome lumen 1 INS
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 ESR1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 MAPK14, MMP9
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 MMP9
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic endosome 1 PIK3C3
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 2 ESR1, TP53
death-inducing signaling complex 1 CASP3
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
cortical cytoskeleton 1 NOS2
Autolysosome 1 PIK3C3
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Hao-Tian Xu, Qi Zheng, Zong-Guang Tai, Wen-Cheng Jiang, Shao-Qiong Xie, Yue Luo, Xiao-Ya Fei, Ying Luo, Xin Ma, Le Kuai, Ying Zhang, Rui-Ping Wang, Bin Li, Quan-Gang Zhu, Jian-Kun Song. Formononetin attenuates psoriasiform inflammation by regulating interferon signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155412. doi: 10.1016/j.phymed.2024.155412. [PMID: 38579666]
  • Palash Mandal, David A Mortensen, André F Brito, Anna K Wallingford, Marta R M Lima, Nicholas D Warren, Richard G Smith. Water Stress Influences Phytoestrogen Levels in Red Clover (Trifolium pratense) but Not Kura Clover (T. ambiguum). Journal of agricultural and food chemistry. 2024 May; 72(18):10247-10256. doi: 10.1021/acs.jafc.4c00300. [PMID: 38683760]
  • Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua Wu. Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway. Brain research. 2024 Apr; 1829(?):148845. doi: 10.1016/j.brainres.2024.148845. [PMID: 38452845]
  • Haipeng Chen, Yanmei Lou, Senyi Lin, Xuanjing Tan, Yuting Zheng, Hong Yu, Ruidi Jiang, Yijie Wei, Huijie Huang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Jinjun Wu. Formononetin, a bioactive isoflavonoid constituent from Astragalus membranaceus (Fisch.) Bunge, ameliorates type 1 diabetes mellitus via activation of Keap1/Nrf2 signaling pathway: An integrated study supported by network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 Mar; 322(?):117576. doi: 10.1016/j.jep.2023.117576. [PMID: 38104880]
  • Ying He, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yazhou Zhang. Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice. BMC cardiovascular disorders. 2024 Feb; 24(1):121. doi: 10.1186/s12872-024-03774-6. [PMID: 38388385]
  • Jiabao Liao, Xuehua Xie, Ning Wang, Yuming Wang, Jie Zhao, Feng Chen, Fei Qu, Weibo Wen, Jing Miao, Huantian Cui. Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155285. doi: 10.1016/j.phymed.2023.155285. [PMID: 38185065]
  • Xiaomei Li, Xianhan Jiang, Runhao Zeng, Xiujuan Lai, Jing Wang, Hao Liu, Huihui Wu, Jiaxun He, Lian Liu, Zhiying Zhu, Jingpei Li, Xue Liang. Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8104. [PMID: 38191199]
  • Mi Li, Chengzhi Jiang, Jianting Chen, Junyan Wang. [Formononetin enhances the antitumor effect of H22 hepatoma transplanted mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Dec; 39(12):1063-1068. doi: . [PMID: 38140864]
  • Liang Zhang, Qian Wu, Yuying Huang, Jun Zheng, Sheng Guo, Li He. Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115799. doi: 10.1016/j.biopha.2023.115799. [PMID: 37922653]
  • Wen Jiang, Ting Hu, Chen Ye, Man Hu, Qingqing Yu, Lijuan Sun, Jichao Liang, Yong Chen. Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Nov; 182(?):114156. doi: 10.1016/j.fct.2023.114156. [PMID: 37944786]
  • Yu-Zhu Yang, Tao Wang, Qi-Lei Chen, Hu-Biao Chen, Qian-Song He, Ya-Zhou Zhang. Identification of the Metabolites of Both Formononetin in Rat Hepatic S9 and Ononin in Rat Urine Samples and Preliminary Network Pharmacology Evaluation of Their Main Metabolites. Molecules (Basel, Switzerland). 2023 Nov; 28(21):. doi: 10.3390/molecules28217451. [PMID: 37959870]
  • Zhijing Zhou, Peng Zhang. Formononetin ameliorates the LPS-induced inflammatory response and apoptosis of neuronal cells via NF-κB/NLRP3 signaling pathway. Functional & integrative genomics. 2023 Oct; 23(4):321. doi: 10.1007/s10142-023-01247-1. [PMID: 37847432]
  • Chun Li, Yuxin Xie, Shaoyu Hu, Hong Yu, Yunke Xu, Hongping Shen, Yuan Yuan, Long Gu, Bangming Pu. Identification of formononetin as the active compound of CR-SR in hepatocellular carcinoma treatment: An integrated approach combining network pharmacology and weighted gene co-expression networks. Chemical biology & drug design. 2023 Oct; ?(?):. doi: 10.1111/cbdd.14363. [PMID: 37793997]
  • Zi-Wen Zhou, Xue-Yan Zhu, Shu-Ying Li, Si-En Lin, Yu-Han Zhu, Kunmei Ji, Jia-Jie Chen. Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions. Molecules (Basel, Switzerland). 2023 Jul; 28(13):. doi: 10.3390/molecules28135271. [PMID: 37446928]
  • Tanvi Dayanand Pingale, Girdhari Lal Gupta. Acute & sub-acute toxicity study reveals no dentrimental effect of formononetin in mice upon repeated i.p. dosing. Toxicology mechanisms and methods. 2023 Jul; ?(?):1-17. doi: 10.1080/15376516.2023.2234026. [PMID: 37415263]
  • Chunhua Zhang, Lingyun Hu, Yun Xie, Jing Wen, Yadi Chen. [Formononetin improves cognitive behavior in aging rats with chronic unpredictable mild in hippocampal tissue stress by blocking the NF-κB pathway and inhibiting the release of inflammatory factors]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Jul; 39(7):610-616. doi: . [PMID: 37403720]
  • Xin Yu, Binkui Yang, Bin Chen, Qi Wu, Zhengrong Ren, Dongsheng Wang, Tao Yuan, Hao Ding, Chao Ding, Yang Liu, Lei Zhang, Zhongyang Sun, Jianning Zhao. Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-κB and MAPK signaling. Cellular signalling. 2023 Jun; 106(?):110651. doi: 10.1016/j.cellsig.2023.110651. [PMID: 36894124]
  • Lan-Fang Zhang, Xiao-Yan Zhang, Ai-Cheng Wang, Yi-Jia Feng, Xiao-Ming Qi, Yuan-Lin Zhang, Qing-Fang Li, Yuan-Biao Qiao, Qing-Shan Li. Bidirectional crosstalk of the cAMP/ROS-dependent signaling pathways in inflammatory macrophage: An activation of formononetin. Toxicology and applied pharmacology. 2023 Jun; ?(?):116571. doi: 10.1016/j.taap.2023.116571. [PMID: 37269934]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Gereltsetseg Enkhbat, Kevin J Foster, Phillip G H Nichols, William Erskine, Yoshiaki Inukai, Megan H Ryan. Leaf formononetin content of Trifolium subterraneum increases in response to waterlogging but its proportion of total isoflavones is little changed. Functional plant biology : FPB. 2023 May; ?(?):. doi: 10.1071/fp22151. [PMID: 37142401]
  • Bingwen Zhu, Yufang Ni, Yi Gong, Xiaoshuang Kang, Huaiying Guo, Xiaoheng Liu, Jianchun Li, Li Wang. Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling. Life sciences. 2023 Feb; 315(?):121331. doi: 10.1016/j.lfs.2022.121331. [PMID: 36586573]
  • Sandra Yu, Francesco Caruso, Stuart Belli, Miriam Rossi. Scavenging of Superoxide in Aprotic Solvents of Four Isoflavones That Mimic Superoxide Dismutase. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043815. [PMID: 36835226]
  • Faryal Rubab, Hira Ijaz, Shah Hussain, Ans Munir, Stefan Stuppner, Thomas Jakschitz, Günther K Bonn, Saiqa Ishtiaq. Gastroprotective effects of Caragana ambigua stocks on ethanol-induced gastric ulcer in rats supported by LC-MS/MS characterization of formononetin and biochanin A. Journal of the science of food and agriculture. 2022 Dec; 102(15):7030-7038. doi: 10.1002/jsfa.12064. [PMID: 35689485]
  • Jia-Yu Li, Jin-Xin Wang, Qiu-Hao Li, Xiao-Feng Li, Jun-Ping Xiao, Shan-Shan Li, Xiu-Ping Shen, Wei-Dong Zhang, Yun-Heng Shen. Natural borneol enhances the anti-cerebral ischaemia efficacy of formononetin in MCAO/R rats by promoting its delivery in the brain. The Journal of pharmacy and pharmacology. 2022 Nov; 74(11):1598-1608. doi: 10.1093/jpp/rgac070. [PMID: 36106815]
  • Xinru Zhang-Peng, Hong Wei, Jing Ma, Yuanyuan Li, Yan Chen, Fang Cui, Fangdi Hu, Yongling Du. Molecularly imprinted flexible sensor based on nitrogen-doped graphene for selective determination of formononetin. Journal of pharmaceutical and biomedical analysis. 2022 Aug; 217(?):114805. doi: 10.1016/j.jpba.2022.114805. [PMID: 35580480]
  • Changjing Zhang, Leilei Zhu, Shuaifei Lu, Mengyuan Li, Ming Bai, Yucheng Li, Erping Xu. The antidepressant-like effect of formononetin on chronic corticosterone-treated mice. Brain research. 2022 05; 1783(?):147844. doi: 10.1016/j.brainres.2022.147844. [PMID: 35218705]
  • Li Yu, Yangyang Zhang, Qianqian Chen, Yu He, Huifen Zhou, Haitong Wan, Jiehong Yang. Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2/STAT3 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May; 149(?):112836. doi: 10.1016/j.biopha.2022.112836. [PMID: 35339827]
  • Jing Ying Wang, Ming Wen Jiang, Ming Yue Li, Zhi Hong Zhang, Yue Xing, MyongHak Ri, Cheng Hua Jin, Guang Hua Xu, Lian Xun Piao, Hong Lan Jin, Juan Ma, Yong Jin, Hong Xiang Zuo, Xuejun Jin. Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation. The Journal of nutritional biochemistry. 2022 02; 100(?):108899. doi: 10.1016/j.jnutbio.2021.108899. [PMID: 34748924]
  • Lanjie Yi, Yan Lu, Shun Yu, Qian Cheng, Lanjuan Yi. Formononetin inhibits inflammation and promotes gastric mucosal angiogenesis in gastric ulcer rats through regulating NF-κB signaling pathway. Journal of receptor and signal transduction research. 2022 Feb; 42(1):16-22. doi: 10.1080/10799893.2020.1837873. [PMID: 33100111]
  • Zhongxiao Zhou, Haimeng Zhou, Xin Zou, Xiaowei Wang, Mengjun Yan. Formononetin regulates endothelial nitric oxide synthase to protect vascular endothelium in deep vein thrombosis rats. International journal of immunopathology and pharmacology. 2022 Jan; 36(?):3946320221111117. doi: 10.1177/03946320221111117. [PMID: 35731855]
  • Mahrukh Naudhani, Kiran Thakur, Zhi-Jing Ni, Jian-Guo Zhang, Zhao-Jun Wei. Formononetin reshapes the gut microbiota, prevents progression of obesity and improves host metabolism. Food & function. 2021 Dec; 12(24):12303-12324. doi: 10.1039/d1fo02942h. [PMID: 34821251]
  • Juanjuan Huang, Xianfeng Chen, Aihua Xie. Formononetin ameliorates IL‑13‑induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway. Molecular medicine reports. 2021 Dec; 24(6):. doi: 10.3892/mmr.2021.12472. [PMID: 34590155]
  • Baohua Zhang, Zhongwei Hao, Wenli Zhou, Shan Zhang, Mingyan Sun, Honglei Li, Naijing Hou, Cui Jing, Mingxing Zhao. Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation. Bioengineered. 2021 12; 12(1):4887-4898. doi: 10.1080/21655979.2021.1959493. [PMID: 34369277]
  • Shaza H Aly, Ahmed M Elissawy, Ahmed M Fayez, Omayma A Eldahshan, Mohamed A Elshanawany, Abdel Nasser B Singab. Neuroprotective effects of Sophora secundiflora, Sophora tomentosa leaves and formononetin on scopolamine-induced dementia. Natural product research. 2021 Dec; 35(24):5848-5852. doi: 10.1080/14786419.2020.1795853. [PMID: 32696670]
  • Zhanding Cui, Qian Wang, Dengliang Li, Shihui Zhao, Qian Zhang, Yuxin Tan, Qianwen Gong, Ting Liu, Jiang Shao, Shuang Zhang, Hailong Huang, Junzheng Wang, Zhihua Pei, Hao Dong, Kai Wang, Guixue Hu, Zhiyong Li. Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro. Archives of virology. 2021 Sep; 166(9):2443-2450. doi: 10.1007/s00705-021-05107-w. [PMID: 34173062]
  • Jingjing Wu, Wen Xu, Lina Ma, Jiayu Sheng, Meina Ye, Hao Chen, Yuzhu Zhang, Bing Wang, Mingjuan Liao, Tian Meng, Yue Zhou, Hongfeng Chen. Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer. Aging. 2021 07; 13(14):18191-18222. doi: 10.18632/aging.203156. [PMID: 34289449]
  • Young-A Lee, Yu-Jeong Kim, Ju Sung Lee, Sanghyun Lee, Yukiori Goto. Imbalance between dopamine and serotonin caused by neonatal habenula lesion. Behavioural brain research. 2021 07; 409(?):113316. doi: 10.1016/j.bbr.2021.113316. [PMID: 33901435]
  • Ling Li, Xiao-Jie Jin, Jia-Wei Li, Cheng-Hao Li, Shuang-Yan Zhou, Jun-Jie Li, Cai-Qin Feng, Dong-Ling Liu, Yong-Qi Liu. Systematic insight into the active constituents and mechanism of Guiqi Baizhu for the treatment of gastric cancer. Cancer science. 2021 May; 112(5):1772-1784. doi: 10.1111/cas.14851. [PMID: 33682294]
  • Randy D Dinkins, Julie Hancock, Brenda L Coe, John B May, Jack P Goodman, William T Bass, Jinge Liu, Yinglun Fan, Qiaolin Zheng, Hongyan Zhu. Isoflavone levels, nodulation and gene expression profiles of a CRISPR/Cas9 deletion mutant in the isoflavone synthase gene of red clover. Plant cell reports. 2021 Mar; 40(3):517-528. doi: 10.1007/s00299-020-02647-4. [PMID: 33389047]
  • Weiyuan Yuan, Yanyan Chen, Yijing Zhou, Kaifan Bao, Xuerui Yu, Yifan Xu, Yuheng Zhang, Jie Zheng, Guorong Jiang, Min Hong. Formononetin attenuates atopic dermatitis by upregulating A20 expression via activation of G protein-coupled estrogen receptor. Journal of ethnopharmacology. 2021 Feb; 266(?):113397. doi: 10.1016/j.jep.2020.113397. [PMID: 32971159]
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