Formononetin (BioDeep_00000000371)

 

Secondary id: BioDeep_00000270229, BioDeep_00000398529

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one

化学式: C16H12O4 (268.0736)
中文名称: 芒柄花黄素, 刺芒柄花素, 芒柄花素, 7-羟基-4-甲氧基异黄酮
谱图信息: 最多检出来源 Viridiplantae(plant) 12.86%

分子结构信息

SMILES: c1(ccc2c(c1)occ(c2=O)c1ccc(cc1)OC)O
InChI: InChI=1/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3

描述信息

Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-).
Formononetin is under investigation in clinical trial NCT02174666 (Isoflavone Treatment for Postmenopausal Osteopenia.).
Formononetin is a natural product found in Pterocarpus indicus, Ardisia paniculata, and other organisms with data available.
See also: Astragalus propinquus root (part of); Trifolium pratense flower (part of).
Formononetin are abundant in vegetables. It is a phyto-oestrogen that is a polyphenolic non-steroidal plant compound with oestrogen-like biological activity (PMID: 16108819). It can be the source of considerable estrogenic activity (http://www.herbalchem.net/Intermediate.htm).
Widespread isoflavone found in soy beans (Glycine max), red clover (Trifolium pratense and chick peas (Cicer arietinum). Potential nutriceutical
A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8803; ORIGINAL_PRECURSOR_SCAN_NO 8802
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8826; ORIGINAL_PRECURSOR_SCAN_NO 8825
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4484; ORIGINAL_PRECURSOR_SCAN_NO 4480
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4474; ORIGINAL_PRECURSOR_SCAN_NO 4471
DATA_PROCESSING MERGING RMBmix ver. 0.2.7; CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4474; ORIGINAL_PRECURSOR_SCAN_NO 4470
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8863; ORIGINAL_PRECURSOR_SCAN_NO 8861
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4474; ORIGINAL_PRECURSOR_SCAN_NO 4470
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8847; ORIGINAL_PRECURSOR_SCAN_NO 8844
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8852; ORIGINAL_PRECURSOR_SCAN_NO 8851
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8822; ORIGINAL_PRECURSOR_SCAN_NO 8821
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4569; ORIGINAL_PRECURSOR_SCAN_NO 4566
CONFIDENCE standard compound; INTERNAL_ID 301; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4507; ORIGINAL_PRECURSOR_SCAN_NO 4504
Acquisition and generation of the data is financially supported in part by CREST/JST.
INTERNAL_ID 2291; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2291
IPB_RECORD: 481; CONFIDENCE confident structure
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].

同义名列表

57 个代谢物同义名

Formononetin, United States Pharmacopeia (USP) Reference Standard; 7-hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one(9CI); 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-; 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 7-Hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one; 7-hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one; 7-hydroxy-3-(4-methoxyphenyl)-1-benzopyran-4-one; 7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; FORMONONETIN (CONSTITUENT OF ASTRAGALUS) [DSC]; FORMONONETIN (CONSTITUENT OF RED CLOVER) [DSC]; 7-Hydroxy-3-(4-methoxyphenyl)-4-benzopyrone; 7-hydroxy-3-(4-methoxyphenyl)chromen-4-one; FORMONONETIN (CONSTITUENT OF ASTRAGALUS); FORMONONETIN (CONSTITUENT OF RED CLOVER); 7-Hydroxy-3-(4-methoxyphenyl)chromone; 7-hydroxy-4-methoxy-Isoflavone (8CI); Formononetin, analytical standard; Isoflavone, 7-hydroxy-4-methoxy-; 7-hydroxy-4-methoxy-isoflavone; 7-Hydroxy-4-methoxyisoflavone; formononetin, 4-(14)C-labeled; Formononetin, >=99.0\\% (TLC); Formononetin (Formononetol); Daidzein 4-methyl ether; FORMONONETIN [USP-RS]; FORMONONETIN (USP-RS); FORMONONETIN [INCI]; Formononetin (FOR); 4-O-methyldaidzein; FORMONONETIN [MI]; Spectrum4_001429; Spectrum2_000560; Spectrum5_000258; Formononetin,(S); Spectrum3_000660; NCIOpen2_005983; Oprea1_139748; formononetine; Oprea1_815287; DivK1c_006319; Formoononetin; KBio2_003421; Formononetol; KBio1_001263; Formononetin; Tox21_301848; KBio2_005989; NCI60_042081; KBio3_001519; KBio2_000853; Biochanin B; Neochanin; Mycotech; Flavosil; Myconate; Formononetin; Formononetin



数据库引用编号

69 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(4)

代谢反应

55 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(7)

WikiPathways(0)

Plant Reactome(5)

INOH(0)

PlantCyc(43)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

647 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 BCL2, CASP3, CCND1, EGFR, ESR1, MAPK14, NOS2, NOS3, PIK3C3, PIK3CA, PPARG, PTGS2, RELA, STAT3, TP53, VEGFA
Peripheral membrane protein 2 ESR1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 BCL2, EGFR, HMOX1, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 14 BCL2, CASP3, CCND1, EGFR, ESR1, HMOX1, MAPK14, NOS2, NOS3, PPARG, RELA, STAT3, TP53, VEGFA
autophagosome 1 PIK3C3
cytosol 14 BCL2, CASP3, CCND1, ESR1, HMOX1, MAPK14, NOS2, NOS3, PIK3C3, PIK3CA, PPARG, RELA, STAT3, TP53
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 2 CCND1, TP53
nucleoplasm 11 CASP3, CCND1, ESR1, HMOX1, MAPK14, NOS2, NOS3, PPARG, RELA, STAT3, TP53
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 2 EGFR, ESR1
Cytoplasmic side 2 ESR1, HMOX1
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 2 EGFR, VEGFA
glutamatergic synapse 5 CASP3, EGFR, MAPK14, PIK3C3, RELA
Golgi apparatus 3 ESR1, NOS3, VEGFA
Golgi membrane 3 EGFR, INS, NOS3
neuronal cell body 1 CASP3
Cytoplasm, cytosol 1 NOS2
endosome 2 EGFR, PIK3C3
plasma membrane 6 EGFR, ESR1, NOS2, NOS3, PIK3CA, STAT3
Membrane 7 BCL2, EGFR, ESR1, HMOX1, PIK3C3, TP53, VEGFA
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 2 NOS3, PTGS2
extracellular exosome 2 BMP3, MMP9
endoplasmic reticulum 5 BCL2, HMOX1, PTGS2, TP53, VEGFA
extracellular space 6 BMP3, EGFR, HMOX1, INS, MMP9, VEGFA
perinuclear region of cytoplasm 6 EGFR, HMOX1, NOS2, NOS3, PIK3CA, PPARG
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, MAPK14, TP53
protein-containing complex 5 BCL2, EGFR, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 3 BMP3, INS, VEGFA
extracellular region 5 BMP3, INS, MAPK14, MMP9, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 4 ESR1, RELA, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CCND1, EGFR
Secreted, extracellular space, extracellular matrix 2 MMP9, VEGFA
nucleolus 1 TP53
midbody 1 PIK3C3
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
GABA-ergic synapse 1 PIK3C3
extracellular matrix 1 VEGFA
Peroxisome 2 NOS2, PIK3C3
intracellular vesicle 1 EGFR
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 MMP9
secretory granule 1 VEGFA
axoneme 1 PIK3C3
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 PIK3C3
receptor complex 2 EGFR, PPARG
neuron projection 1 PTGS2
chromatin 5 ESR1, PPARG, RELA, STAT3, TP53
phagocytic vesicle membrane 1 PIK3C3
cytoskeleton 1 NOS3
spindle pole 1 MAPK14
site of double-strand break 1 TP53
endosome lumen 1 INS
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 ESR1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 MAPK14, MMP9
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 MMP9
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic endosome 1 PIK3C3
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 2 ESR1, TP53
death-inducing signaling complex 1 CASP3
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
cortical cytoskeleton 1 NOS2
Autolysosome 1 PIK3C3
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Hao-Tian Xu, Qi Zheng, Zong-Guang Tai, Wen-Cheng Jiang, Shao-Qiong Xie, Yue Luo, Xiao-Ya Fei, Ying Luo, Xin Ma, Le Kuai, Ying Zhang, Rui-Ping Wang, Bin Li, Quan-Gang Zhu, Jian-Kun Song. Formononetin attenuates psoriasiform inflammation by regulating interferon signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155412. doi: 10.1016/j.phymed.2024.155412. [PMID: 38579666]
  • Palash Mandal, David A Mortensen, André F Brito, Anna K Wallingford, Marta R M Lima, Nicholas D Warren, Richard G Smith. Water Stress Influences Phytoestrogen Levels in Red Clover (Trifolium pratense) but Not Kura Clover (T. ambiguum). Journal of agricultural and food chemistry. 2024 May; 72(18):10247-10256. doi: 10.1021/acs.jafc.4c00300. [PMID: 38683760]
  • Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua Wu. Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway. Brain research. 2024 Apr; 1829(?):148845. doi: 10.1016/j.brainres.2024.148845. [PMID: 38452845]
  • Haipeng Chen, Yanmei Lou, Senyi Lin, Xuanjing Tan, Yuting Zheng, Hong Yu, Ruidi Jiang, Yijie Wei, Huijie Huang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Jinjun Wu. Formononetin, a bioactive isoflavonoid constituent from Astragalus membranaceus (Fisch.) Bunge, ameliorates type 1 diabetes mellitus via activation of Keap1/Nrf2 signaling pathway: An integrated study supported by network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 Mar; 322(?):117576. doi: 10.1016/j.jep.2023.117576. [PMID: 38104880]
  • Ying He, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yazhou Zhang. Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice. BMC cardiovascular disorders. 2024 Feb; 24(1):121. doi: 10.1186/s12872-024-03774-6. [PMID: 38388385]
  • Jiabao Liao, Xuehua Xie, Ning Wang, Yuming Wang, Jie Zhao, Feng Chen, Fei Qu, Weibo Wen, Jing Miao, Huantian Cui. Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155285. doi: 10.1016/j.phymed.2023.155285. [PMID: 38185065]
  • Xiaomei Li, Xianhan Jiang, Runhao Zeng, Xiujuan Lai, Jing Wang, Hao Liu, Huihui Wu, Jiaxun He, Lian Liu, Zhiying Zhu, Jingpei Li, Xue Liang. Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8104. [PMID: 38191199]
  • Mi Li, Chengzhi Jiang, Jianting Chen, Junyan Wang. [Formononetin enhances the antitumor effect of H22 hepatoma transplanted mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Dec; 39(12):1063-1068. doi: . [PMID: 38140864]
  • Liang Zhang, Qian Wu, Yuying Huang, Jun Zheng, Sheng Guo, Li He. Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115799. doi: 10.1016/j.biopha.2023.115799. [PMID: 37922653]
  • Wen Jiang, Ting Hu, Chen Ye, Man Hu, Qingqing Yu, Lijuan Sun, Jichao Liang, Yong Chen. Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Nov; 182(?):114156. doi: 10.1016/j.fct.2023.114156. [PMID: 37944786]
  • Yu-Zhu Yang, Tao Wang, Qi-Lei Chen, Hu-Biao Chen, Qian-Song He, Ya-Zhou Zhang. Identification of the Metabolites of Both Formononetin in Rat Hepatic S9 and Ononin in Rat Urine Samples and Preliminary Network Pharmacology Evaluation of Their Main Metabolites. Molecules (Basel, Switzerland). 2023 Nov; 28(21):. doi: 10.3390/molecules28217451. [PMID: 37959870]
  • Zhijing Zhou, Peng Zhang. Formononetin ameliorates the LPS-induced inflammatory response and apoptosis of neuronal cells via NF-κB/NLRP3 signaling pathway. Functional & integrative genomics. 2023 Oct; 23(4):321. doi: 10.1007/s10142-023-01247-1. [PMID: 37847432]
  • Chun Li, Yuxin Xie, Shaoyu Hu, Hong Yu, Yunke Xu, Hongping Shen, Yuan Yuan, Long Gu, Bangming Pu. Identification of formononetin as the active compound of CR-SR in hepatocellular carcinoma treatment: An integrated approach combining network pharmacology and weighted gene co-expression networks. Chemical biology & drug design. 2023 Oct; ?(?):. doi: 10.1111/cbdd.14363. [PMID: 37793997]
  • Zi-Wen Zhou, Xue-Yan Zhu, Shu-Ying Li, Si-En Lin, Yu-Han Zhu, Kunmei Ji, Jia-Jie Chen. Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions. Molecules (Basel, Switzerland). 2023 Jul; 28(13):. doi: 10.3390/molecules28135271. [PMID: 37446928]
  • Tanvi Dayanand Pingale, Girdhari Lal Gupta. Acute & sub-acute toxicity study reveals no dentrimental effect of formononetin in mice upon repeated i.p. dosing. Toxicology mechanisms and methods. 2023 Jul; ?(?):1-17. doi: 10.1080/15376516.2023.2234026. [PMID: 37415263]
  • Chunhua Zhang, Lingyun Hu, Yun Xie, Jing Wen, Yadi Chen. [Formononetin improves cognitive behavior in aging rats with chronic unpredictable mild in hippocampal tissue stress by blocking the NF-κB pathway and inhibiting the release of inflammatory factors]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Jul; 39(7):610-616. doi: . [PMID: 37403720]
  • Xin Yu, Binkui Yang, Bin Chen, Qi Wu, Zhengrong Ren, Dongsheng Wang, Tao Yuan, Hao Ding, Chao Ding, Yang Liu, Lei Zhang, Zhongyang Sun, Jianning Zhao. Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-κB and MAPK signaling. Cellular signalling. 2023 Jun; 106(?):110651. doi: 10.1016/j.cellsig.2023.110651. [PMID: 36894124]
  • Lan-Fang Zhang, Xiao-Yan Zhang, Ai-Cheng Wang, Yi-Jia Feng, Xiao-Ming Qi, Yuan-Lin Zhang, Qing-Fang Li, Yuan-Biao Qiao, Qing-Shan Li. Bidirectional crosstalk of the cAMP/ROS-dependent signaling pathways in inflammatory macrophage: An activation of formononetin. Toxicology and applied pharmacology. 2023 Jun; ?(?):116571. doi: 10.1016/j.taap.2023.116571. [PMID: 37269934]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Gereltsetseg Enkhbat, Kevin J Foster, Phillip G H Nichols, William Erskine, Yoshiaki Inukai, Megan H Ryan. Leaf formononetin content of Trifolium subterraneum increases in response to waterlogging but its proportion of total isoflavones is little changed. Functional plant biology : FPB. 2023 May; ?(?):. doi: 10.1071/fp22151. [PMID: 37142401]
  • Bingwen Zhu, Yufang Ni, Yi Gong, Xiaoshuang Kang, Huaiying Guo, Xiaoheng Liu, Jianchun Li, Li Wang. Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling. Life sciences. 2023 Feb; 315(?):121331. doi: 10.1016/j.lfs.2022.121331. [PMID: 36586573]
  • Sandra Yu, Francesco Caruso, Stuart Belli, Miriam Rossi. Scavenging of Superoxide in Aprotic Solvents of Four Isoflavones That Mimic Superoxide Dismutase. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043815. [PMID: 36835226]
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