fenthion (BioDeep_00000397584)
Main id: BioDeep_00000002429
代谢物信息卡片
fenthion
化学式: C10H15O3PS2 (278.02)
中文名称: 倍硫磷
谱图信息:
最多检出来源 Homo sapiens(not specific) 2.78%
分子结构信息
SMILES: CC1=C(C=CC(=C1)OP(=S)(OC)OC)SC
InChI: InChI=1S/C10H15O3PS2/c1-8-7-9(5-6-10(8)16-4)13-14(15,11-2)12-3/h5-7H,1-4H3
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals
CONFIDENCE standard compound; INTERNAL_ID 3155
CONFIDENCE standard compound; INTERNAL_ID 8480
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:34761
- KEGG: C14420
- KEGGdrug: D07950
- PubChem: 3346
- DrugBank: DB11412
- ChEMBL: CHEMBL1604375
- MeSH: Fenthion
- CAS: 55-38-9
- MoNA: AU315506
- MoNA: SM848001
- MoNA: AU315505
- MoNA: AU315504
- MoNA: AU315503
- MoNA: AU315502
- MoNA: AU315501
- PubChem: 17395420
- NIKKAJI: J2.314K
- RefMet: Fenthion
- KNApSAcK: 34761
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cuicui Ma, Dandan Wei, Pengling Liu, Keliang Fan, Luting Nie, Yu Song, Mian Wang, Lulu Wang, Qingqing Xu, Juan Wang, Jiayu Shi, Jintian Geng, Mengzhen Zhao, Zexin Jia, Changsheng Huan, Wenqian Huo, Chongjian Wang, Zhenxing Mao, Shan Huang, Xin Zeng. Pesticide Residues in Commonly Consumed Vegetables in Henan Province of China in 2020.
Frontiers in public health.
2022; 10(?):901485. doi:
10.3389/fpubh.2022.901485. [PMID: 35757605] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Faye V Andrews, Stephanie M Kim, Lariah Edwards, Jennifer J Schlezinger. Identifying adipogenic chemicals: Disparate effects in 3T3-L1, OP9 and primary mesenchymal multipotent cell models.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Sep; 67(?):104904. doi:
10.1016/j.tiv.2020.104904. [PMID: 32473317] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Orhan Baş, Soner Çankaya, Özgür Enginyurt, Ali Aslan, Hüseyin Avni Uydu, Ersan Odaci, Ali Yılmaz, Adem Demir, Tuba Gul. The effect of acute organophosphate intoxication on female rat hippocampus cornu ammonis region pyramidal neuron numbers, biochemistry and morphology.
Journal of chemical neuroanatomy.
2019 10; 100(?):101652. doi:
10.1016/j.jchemneu.2019.101652. [PMID: 31152871] - Jung-Ah Shin, Hoonho Cho, Dong-Woo Seo, Hee-Gon Jeong, Sung Chul Kim, Jeung-Hee Lee, Soon-Taek Hong, Ki-Teak Lee. Approach Study for Mass Balance of Pesticide Residues in Distillers' Stillage along with Distillate and Absence Verification of Pesticides in Distilled Spirits from Pilot-Scale of Distillation Column.
Molecules (Basel, Switzerland).
2019 Jul; 24(14):. doi:
10.3390/molecules24142572. [PMID: 31311184] - Yasemin Kaya, Orhan Bas, Hatice Hanci, Soner Cankaya, Ismail Nalbant, Ersan Odaci, Hüseyin Avni Uydu, Ali Aslan. Acute renal involvement in organophosphate poisoning: histological and immunochemical investigations.
Renal failure.
2018 Nov; 40(1):410-415. doi:
10.1080/0886022x.2018.1489289. [PMID: 30012025] - Christopher Didigwu Nwani, Peace Onas Somdare, Emmanuel Okechukwu Ogueji, Jacinta Chinedu Nwani, Juliana Adimonye Ukonze, Alfreda O Nwadinigwe. Genotoxicity assessment and oxidative stress responses in freshwater African catfish Clarias gariepinus exposed to fenthion formulations.
Drug and chemical toxicology.
2017 Jul; 40(3):273-280. doi:
10.1080/01480545.2016.1209772. [PMID: 27460958] - Christopher Didigwu Nwani, Peace Onas Somdare, Juliana Adimonye Ukonze, Vincent Chikwendu Ejere, Alfreda O Nwadinigwe, Jacinta Chinedu Nwani, Gregory Ejike Odo, Ogechi Nnabuchi Ugbor. Subchronic Exposure to Fenthion Induces Hematological Changes in Liver Tissue of African Catfish Clarias gariepinus.
Journal of aquatic animal health.
2016 12; 28(4):229-234. doi:
10.1080/08997659.2016.1194907. [PMID: 27764572] - Idriss Bakas, Najwa Ben Oujji, Georges Istamboulié, Sergey Piletsky, Elena Piletska, Elhabib Ait-Addi, Ihya Ait-Ichou, Thierry Noguer, Régis Rouillon. Molecularly imprinted polymer cartridges coupled to high performance liquid chromatography (HPLC-UV) for simple and rapid analysis of fenthion in olive oil.
Talanta.
2014 Jul; 125(?):313-8. doi:
10.1016/j.talanta.2014.03.020. [PMID: 24840449] - Nevin Üner, Petek Piner, Özge Temiz. Piperonyl butoxide increases oxidative toxicity of fenthion in the brain of Oreochromis niloticus.
Journal of biochemical and molecular toxicology.
2014 Feb; 28(2):84-90. doi:
10.1002/jbt.21539. [PMID: 24497177] - Mediha Sefi, Afef Troudi, Fatma B Hamida, Nejla Soudani, Tahia Boudawara, Najiba Zeghal. Protective effects of Artemisia campestris upon fenthion-induced nephrotoxicity in adult rats and their progeny.
General physiology and biophysics.
2013 Dec; 32(4):577-88. doi:
10.4149/gpb_2013047. [PMID: 23940090] - Lisa A Konickx, Franz Worek, Shaluka Jayamanne, Horst Thiermann, Nicholas A Buckley, Michael Eddleston. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):274-83. doi:
10.1093/toxsci/kft217. [PMID: 24052565] - Ahmet Kanter, Ismail Celik. Acute effects of fenthion on certain oxidative stress biomarkers in various tissues of frogs (Rana ridibunda).
Toxicology and industrial health.
2012 May; 28(4):369-76. doi:
10.1177/0748233711412426. [PMID: 21859772] - Youmie Park, A-Rang Im, Yoo Na Hong, Chong-Kook Kim, Yeong Shik Kim. Detection of malathion, fenthion and methidathion by using heparin-reduced gold nanoparticles.
Journal of nanoscience and nanotechnology.
2011 Sep; 11(9):7570-8. doi:
10.1166/jnn.2011.5123. [PMID: 22097460] - Yusuf Sevgiler, Nevin Uner. Tissue-specific effects of fenthion on glutathione metabolism modulated by NAC and BSO in Oreochromis niloticus.
Drug and chemical toxicology.
2010 Oct; 33(4):348-56. doi:
10.3109/01480541003734048. [PMID: 20550428] - Nevin Uner, Yusuf Sevgiler, Petek Piner. Tissue-specific in vivo inhibition of cholinesterases by the organophosphate fenthion in Oreochromis niloticus.
Environmental toxicology.
2010 Aug; 25(4):391-9. doi:
10.1002/tox.20514. [PMID: 19479785] - Lalit Mohan, Preeti Sharma, C N Srivastava. Combination larvicidal action of Solanum xanthocarpum extract and certain synthetic insecticides against filarial vector, Culex quinquefasciatus (SAY).
The Southeast Asian journal of tropical medicine and public health.
2010 Mar; 41(2):311-9. doi:
. [PMID: 20578513] - Mustafa Cemek, Mehmet Emin Büyükokuroğlu, Yusuf Yürümez, Yücel Yavuz, Adem Aslan, Ahmet Büyükben, Fatih Aymelek. Tissue trace and major element levels in organophosphate insecticide fenthion (Lebaycid) toxicity in rats: prophylactic and therapeutic effect of exogenous melatonin.
Ecotoxicology and environmental safety.
2010 Feb; 73(2):206-12. doi:
10.1016/j.ecoenv.2009.09.008. [PMID: 19800688] - Nevin Uner, Yusuf Sevgiler, Hülya Durmaz, Petek Piner, Emine Cinkiloğlu. N-Acetylcysteine provides dose-dependent protection against fenthion toxicity in the brain of Cyprinus carpio L.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2009 Jul; 150(1):33-8. doi:
10.1016/j.cbpc.2009.02.001. [PMID: 19444991] - T Galeano Díaz, A Guiberteau Cabanillas, M D López Soto, J M Ortiz. Determination of fenthion and fenthion-sulfoxide, in olive oil and in river water, by square-wave adsorptive-stripping voltammetry.
Talanta.
2008 Aug; 76(4):809-14. doi:
10.1016/j.talanta.2008.04.037. [PMID: 18656663] - Elpiniki G Amvrazi, Triantafyllos A Albanis. Multiclass pesticide determination in olives and their processing factors in olive oil: comparison of different olive oil extraction systems.
Journal of agricultural and food chemistry.
2008 Jul; 56(14):5700-9. doi:
10.1021/jf703783u. [PMID: 18558709] - Indu Bala, Monica Pratap, Dhiraj Nakra, T Ramprabhu. Prolonged cholinergic crisis and compartment syndrome following subcutaneous injection of an organophosphate compound for suicide attempt.
Journal of forensic and legal medicine.
2008 May; 15(4):256-8. doi:
10.1016/j.jflm.2007.07.008. [PMID: 18423360] - Nevin Uner, Yusuf Sevgiler, Petek Piner, Hülya Durmaz. Modulation of fenthion-induced oxidative effects by BSO in the liver of Cyprinus carpio L.
Drug and chemical toxicology.
2008; 31(3):353-69. doi:
10.1080/01480540802171233. [PMID: 18622870] - Petek Piner, Yusuf Sevgiler, Nevin Uner. In vivo effects of fenthion on oxidative processes by the modulation of glutathione metabolism in the brain of Oreochromis niloticus.
Environmental toxicology.
2007 Dec; 22(6):605-12. doi:
10.1002/tox.20286. [PMID: 18000850] - Qi Zhang, Laibao Wang, Ki Chang Ahn, Qin Sun, Baishi Hu, Jie Wang, Fengquan Liu. Hapten heterology for a specific and sensitive indirect enzyme-linked immunosorbent assay for organophosphorus insecticide fenthion.
Analytica chimica acta.
2007 Jul; 596(2):303-11. doi:
10.1016/j.aca.2007.06.009. [PMID: 17631111] - Bokhee Kim, Eun Yong Park, Yong Tae Lee, Jung Hun Lee, Sang Hee Lee. Development of homogeneous enzyme immunoassay for the organophosphorus insecticide fenthion.
Journal of microbiology and biotechnology.
2007 Jun; 17(6):1002-9. doi:
NULL. [PMID: 18050919] - Yusuf Yurumez, Ibrahim Ikizceli, Erdogan Mutevelli Sozuer, Isin Soyuer, Yucel Yavuz, Levent Avsarogullari, Polat Durukan. Effect of interleukin-10 on tissue damage caused by organophosphate poisoning.
Basic & clinical pharmacology & toxicology.
2007 May; 100(5):323-7. doi:
10.1111/j.1742-7843.2007.00049.x. [PMID: 17448118] - Yusuf Yurumez, Mustafa Cemek, Yucel Yavuz, Yavuz Osman Birdane, Mehmet Emin Buyukokuroglu. Beneficial effect of N-acetylcysteine against organophosphate toxicity in mice.
Biological & pharmaceutical bulletin.
2007 Mar; 30(3):490-4. doi:
10.1248/bpb.30.490. [PMID: 17329844] - Sara C Cunha, José O Fernandes, M Beatriz, P P Oliveira. Comparison of matrix solid-phase dispersion and liquid-liquid extraction for the chromatographic determination of fenthion and its metabolites in olives and olive oils.
Food additives and contaminants.
2007 Feb; 24(2):156-64. doi:
10.1080/02652030600970374. [PMID: 17364916] - John W Edwards, Su-Gil Lee, Linda M Heath, Dino L Pisaniello. Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia.
Environmental research.
2007 Jan; 103(1):38-45. doi:
10.1016/j.envres.2006.06.001. [PMID: 16914134] - I Ikizceli, Y Yurumez, L Avsaroğullari, C Kucuk, E M Sozuer, I Soyuer, Y Yavuz, S Muhtaroglu. Effect of interleukin-10 on pancreatic damage caused by organophosphate poisoning.
Regulatory toxicology and pharmacology : RTP.
2005 Aug; 42(3):260-4. doi:
10.1016/j.yrtph.2005.04.008. [PMID: 16005131] - A M Tsatsakis, I N Tsakiris, M N Tzatzarakis, Z B Agourakis, M Tutudaki, A K Alegakis. Three-year study of fenthion and dimethoate pesticides in olive oil from organic and conventional cultivation.
Food additives and contaminants.
2003 Jun; 20(6):553-9. doi:
10.1080/0265203031000070786. [PMID: 12881128] - A M Tsatsakis, G K Bertsias, V Liakou, I N Mammas, I Stiakakis, G N Tzanakakis. Severe fenthion intoxications due to ingestion and inhalation with survival outcome.
Human & experimental toxicology.
2002 Jan; 21(1):49-54. doi:
10.1191/0960327102ht232cr. [PMID: 12046724] - P T Guichon, G K Jim, C W Booker, O C Schunicht, B K Wildman, J R Brown. Relative cost-effectiveness of treatment of feedlot calves with ivermectin versus treatment with a combination of fenbendazole, permethrin, and fenthion.
Journal of the American Veterinary Medical Association.
2000 Jun; 216(12):1965-9. doi:
10.2460/javma.2000.216.1965. [PMID: 10863598] - S M Tuler, J M Bowen. Chronic fenthion toxicity in laying hens.
Veterinary and human toxicology.
1999 Oct; 41(5):302-7. doi:
. [PMID: 10509433] - G P Molinari, S Cavanna, L Fornara. Determination of fenthion and its oxidative metabolites in olives and olive oil: errors caused by matrix effects.
Food additives and contaminants.
1998 Aug; 15(6):661-70. doi:
10.1080/02652039809374695. [PMID: 10209576] - S Cavanna, G P Molinari. Residues of fenthion and trichloron in olives and olive oil after olive tree treatments.
Food additives and contaminants.
1998 Jul; 15(5):518-27. doi:
10.1080/02652039809374676. [PMID: 9829035] - K Sakaguchi, F Akahori, M Shirai, T Masaoka, K Arishima, G Kounenis. Effect of combined fenthion and cimetidine use in rats on lethality, blood cholinesterase activities, and serum cholinesterase isoenzymes.
Veterinary and human toxicology.
1998 Apr; 40(2):77-82. doi:
. [PMID: 9554058] - K Sakaguchi, M Nagayama, T Masaoka, A Nishimura, K Kageyama, M Shirai, F Akahori. Effects of fenthion, isoxathion, dichlorvos and propaphos on the serum cholinesterase isoenzyme patterns of dogs.
Veterinary and human toxicology.
1997 Feb; 39(1):1-5. doi:
. [PMID: 9004458] - Y Jia, Y T Loh, J Zhou, G B Martin. Alleles of Pto and Fen occur in bacterial speck-susceptible and fenthion-insensitive tomato cultivars and encode active protein kinases.
The Plant cell.
1997 Jan; 9(1):61-73. doi:
10.1105/tpc.9.1.61. [PMID: 9014365] - D Bagchi, G Bhattacharya, S J Stohs. In vitro and in vivo induction of heat shock (stress) protein (Hsp) gene expression by selected pesticides.
Toxicology.
1996 Aug; 112(1):57-68. doi:
10.1016/0300-483x(96)03350-1. [PMID: 8792849] - M Nagayama, F Akahori, H Chiwata, M Shirai, M Motoya, T Masaoka, K Sakaguchi. Effects of selected organophosphate insecticides on serum cholinesterase isoenzyme patterns in the rat.
Veterinary and human toxicology.
1996 Jun; 38(3):196-9. doi:
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Veterinary and human toxicology.
1996 Apr; 38(2):101-7. doi:
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Toxicology.
1995 Dec; 104(1-3):129-40. doi:
10.1016/0300-483x(95)03156-a. [PMID: 8560491] - Y T Loh, G B Martin. The Pto bacterial resistance gene and the Fen insecticide sensitivity gene encode functional protein kinases with serine/threonine specificity.
Plant physiology.
1995 Aug; 108(4):1735-9. doi:
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Human & experimental toxicology.
1995 Jul; 14(7):600-4. doi:
10.1177/096032719501400708. [PMID: 7576821] - Y T Loh, G B Martin. The disease-resistance gene Pto and the fenthion-sensitivity gene fen encode closely related functional protein kinases.
Proceedings of the National Academy of Sciences of the United States of America.
1995 May; 92(10):4181-4. doi:
10.1073/pnas.92.10.4181. [PMID: 7753781] - C M Rommens, J M Salmeron, D C Baulcombe, B J Staskawicz. Use of a gene expression system based on potato virus X to rapidly identify and characterize a tomato Pto homolog that controls fenthion sensitivity.
The Plant cell.
1995 Mar; 7(3):249-57. doi:
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The Plant cell.
1994 Nov; 6(11):1543-52. doi:
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Electromyography and clinical neurophysiology.
1994 Jun; 34(4):197-203. doi:
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Toxicology letters.
1994 Apr; 71(2):139-50. doi:
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The Plant cell.
1994 Apr; 6(4):511-20. doi:
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Journal of toxicology. Clinical toxicology.
1994; 32(1):61-8. doi:
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Molecular & general genetics : MGG.
1993 May; 239(1-2):17-27. doi:
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Critical care medicine.
1992 Jul; 20(7):1062-4. doi:
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Investigacion clinica.
1992; 33(3):89-94. doi:
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Poultry science.
1991 Jul; 70(7):1633-6. doi:
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Klinische Wochenschrift.
1991 Feb; 69(4):177-83. doi:
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Biomedical and environmental sciences : BES.
1990 Sep; 3(3):262-75. doi:
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Nippon Ganka Gakkai zasshi.
1990 Aug; 94(8):723-30. doi:
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Journal of chromatography.
1990 May; 508(1):199-202. doi:
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Journal of toxicology and environmental health.
1989; 27(2):209-23. doi:
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Fundamental and applied toxicology : official journal of the Society of Toxicology.
1988 Jul; 11(1):155-68. doi:
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Veterinary and human toxicology.
1988 Jun; 30(3):229-34. doi:
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Archives of toxicology.
1988; 61(6):496-500. doi:
10.1007/bf00293697. [PMID: 3190448] - T Miyaoka, S Tsuda, Y Shirasu. Mechanism of potentiation of BPMC toxicity by fenthion pretreatment in mice.
Journal of pharmacobio-dynamics.
1986 Sep; 9(9):697-703. doi:
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Human toxicology.
1985 Mar; 4(2):135-45. doi:
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Toxicology letters.
1985 Feb; 24(2-3):187-93. doi:
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Fundamental and applied toxicology : official journal of the Society of Toxicology.
1984 Oct; 4(5):802-7. doi:
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American journal of veterinary research.
1984 Oct; 45(10):2167-9. doi:
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Veterinary and human toxicology.
1984 Apr; 26(2):112-7. doi:
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Environmental research.
1983 Apr; 30(2):453-65. doi:
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Critical care medicine.
1982 Aug; 10(8):550-1. doi:
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Journal of toxicology. Clinical toxicology.
1982 Jul; 19(5):425-32. doi:
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Comparative biochemistry and physiology. C: Comparative pharmacology.
1982; 73(1):101-7. doi:
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Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.
1981; 36(?):227-33. doi:
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Zentralblatt fur Veterinarmedizin. Reihe A.
1980 Feb; 27(1):54-64. doi:
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1979 Dec; 26(10):822-34. doi:
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1979 Oct; 22(4):48-52. doi:
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Journal of the American Veterinary Medical Association.
1977 Apr; 170(8):812-4. doi:
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Toxicology and applied pharmacology.
1973 Sep; 26(1):29-38. doi:
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1972 Jun; 55(6):777-82. doi:
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