Methylnissolin (BioDeep_00000270189)

Main id: BioDeep_00000011693

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-Hydroxy-9,10-Dimethoxypterocarpan

化学式: C17H16O5 (300.0998)
中文名称: 美迪紫檀素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(ccc2c(c1)OC[C@H]1[C@@H]2Oc2c1ccc(c2OC)OC)O
InChI: InChI=1S/C17H16O5/c1-19-13-6-5-10-12-8-21-14-7-9(18)3-4-11(14)15(12)22-16(10)17(13)20-2/h3-7,12,15,18H,8H2,1-2H3/t12-,15-/m0/s1

描述信息

Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].

同义名列表

3 个代谢物同义名

Astrapterocarpan; Methylnissolin; 3-Hydroxy-9,10-Dimethoxypterocarpan



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ALOX5, BCL2, CASP3, CDC42, EGFR, MAPK1, MAPK14, NQO1, PIK3CA, PPARG, PTGS2, TACC3
Peripheral membrane protein 3 ACHE, ALOX5, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 5 BCL2, CDC42, EGFR, HMOX1, PTGS2
Nucleus 11 ACHE, BCL2, CASP3, CEBPA, EGFR, GABPA, HMOX1, MAPK1, MAPK14, NQO1, PPARG
cytosol 11 ALOX5, BCL2, CASP3, CDC42, HMOX1, MAPK1, MAPK14, NQO1, PIK3CA, PPARG, TACC3
dendrite 1 NQO1
phagocytic vesicle 1 CDC42
centrosome 2 CDC42, MAPK1
nucleoplasm 8 ALOX5, CASP3, CEBPA, GABPA, HMOX1, MAPK1, MAPK14, PPARG
RNA polymerase II transcription regulator complex 2 CEBPA, PPARG
Cell membrane 4 ACHE, CDC42, EGFR, TNF
Lipid-anchor 1 CDC42
Cytoplasmic side 2 CDC42, HMOX1
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Synapse 3 ACHE, MAPK1, NQO1
cell junction 1 EGFR
cell surface 3 ACHE, EGFR, TNF
glutamatergic synapse 4 CASP3, CDC42, EGFR, MAPK14
Golgi apparatus 2 ACHE, MAPK1
Golgi membrane 2 CDC42, EGFR
neuromuscular junction 1 ACHE
neuronal cell body 4 CASP3, CDC42, NQO1, TNF
Cytoplasm, cytosol 2 ALOX5, NQO1
endosome 1 EGFR
plasma membrane 6 ACHE, CDC42, EGFR, MAPK1, PIK3CA, TNF
Membrane 6 ACHE, BCL2, CDC42, EGFR, HMOX1, NQO1
apical plasma membrane 1 EGFR
axon 1 CCK
basolateral plasma membrane 1 EGFR
caveola 2 MAPK1, PTGS2
extracellular exosome 1 CDC42
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 8 ACHE, ALOX5, CCK, CCL2, EGFR, HMOX1, IL6, TNF
perinuclear region of cytoplasm 6 ACHE, ALOX5, EGFR, HMOX1, PIK3CA, PPARG
Schaffer collateral - CA1 synapse 1 CDC42
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, MAPK1, MAPK14
protein-containing complex 4 BCL2, CDC42, EGFR, PTGS2
intracellular membrane-bounded organelle 3 CEBPA, PPARG, TACC3
Microsome membrane 1 PTGS2
filopodium 1 CDC42
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 4 ACHE, CCK, CCL2, IL6
extracellular region 8 ACHE, ALOX5, CCK, CCL2, IL6, MAPK1, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Extracellular side 1 ACHE
transcription regulator complex 1 CEBPA
centriolar satellite 1 TACC3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 CDC42, MAPK1, TACC3
Nucleus membrane 2 ALOX5, BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 ALOX5, BCL2, EGFR
external side of plasma membrane 1 TNF
dendritic spine 1 CDC42
nucleolus 1 CEBPA
midbody 1 CDC42
Early endosome 1 MAPK1
apical part of cell 1 CDC42
cell-cell junction 1 CDC42
recycling endosome 1 TNF
spindle midzone 1 CDC42
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 TACC3
Cytoplasm, cytoskeleton, spindle 3 CDC42, MAPK1, TACC3
focal adhesion 3 CDC42, EGFR, MAPK1
spindle 1 MAPK1
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
secretory granule 1 CDC42
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK1
receptor complex 2 EGFR, PPARG
neuron projection 2 CDC42, PTGS2
chromatin 3 CEBPA, GABPA, PPARG
phagocytic cup 1 TNF
mitotic spindle 3 CDC42, MAPK1, TACC3
cytoskeleton 1 MAPK1
cytoplasmic ribonucleoprotein granule 1 CDC42
spindle pole 2 MAPK14, TACC3
Lipid-anchor, GPI-anchor 1 ACHE
Cytoplasm, cytoskeleton, spindle pole 1 TACC3
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Membrane, caveola 1 MAPK1
leading edge membrane 1 CDC42
Cell projection, dendrite 1 CDC42
side of membrane 1 ACHE
myelin sheath 1 BCL2
pseudopodium 1 MAPK1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 3 ALOX5, MAPK1, MAPK14
secretory granule lumen 2 ALOX5, MAPK14
endoplasmic reticulum lumen 3 IL6, MAPK1, PTGS2
nuclear matrix 1 ALOX5
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 MAPK1
Single-pass type IV membrane protein 1 HMOX1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
clathrin-coated endocytic vesicle membrane 1 EGFR
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
Nucleus intermembrane space 1 ALOX5
BAD-BCL-2 complex 1 BCL2
C/EBP complex 1 CEBPA
CHOP-C/EBP complex 1 CEBPA
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform 4]: Nucleus, nucleolus 1 CEBPA
Golgi transport complex 1 CDC42
storage vacuole 1 CDC42
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Chelliah Selvam, Brian C Jordan, Sandhya Prakash, Daniel Mutisya, Ramasamy Thilagavathi. Pterocarpan scaffold: A natural lead molecule with diverse pharmacological properties. European journal of medicinal chemistry. 2017 Mar; 128(?):219-236. doi: 10.1016/j.ejmech.2017.01.023. [PMID: 28189086]