Pralidoxime (BioDeep_00000003476)
Secondary id: BioDeep_00000400260, BioDeep_00001867978
natural product human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
2-[(1E)-(hydroxyimino)methyl]-1-methylpyridin-1-ium
化学式: [C7H9N2O]+ (137.0715)
中文名称:
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 34.72%
分子结构信息
SMILES: CN1C=CC=CC1=C[NH+]=O
InChI: InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1
描述信息
Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002801 - Cholinesterase Reactivators
Acquisition and generation of the data is financially supported in part by CREST/JST.
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
D020011 - Protective Agents > D000931 - Antidotes
D004793 - Enzyme Reactivators
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:8354
- KEGG: C07400
- PubChem: 135398747
- PubChem: 5353894
- PubChem: 6789253
- HMDB: HMDB0014871
- DrugBank: DB00733
- Wikipedia: Pralidoxime
- chemspider: 5193737
- CAS: 25615-00-3
- CAS: 6735-59-7
- MoNA: PR100194
- MoNA: PS033103
- MoNA: PS033104
- MoNA: PS033105
- MoNA: PS033102
- MoNA: PR100195
- MoNA: PS033101
- PubChem: 9604
- NIKKAJI: J232.003G
- KNApSAcK: 8354
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Brian S Backer, Edward C Meek, Matthew K Ross, Janice E Chambers. Pharmacokinetics of three novel pyridinium aldoxime acetylcholinesterase reactivators in female rats.
Toxicology and applied pharmacology.
2022 07; 446(?):116046. doi:
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The Journal of pharmacology and experimental therapeutics.
2021 09; 378(3):315-321. doi:
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Scientific reports.
2021 06; 11(1):11615. doi:
10.1038/s41598-021-91230-2. [PMID: 34079035] - Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice.
The Journal of toxicological sciences.
2021; 46(6):289-301. doi:
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Toxicology.
2020 11; 444(?):152578. doi:
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Human & experimental toxicology.
2020 Oct; 39(10):1291-1300. doi:
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Drug testing and analysis.
2020 Jul; 12(7):938-947. doi:
10.1002/dta.2800. [PMID: 32267631] - Vendula Hepnarova, Lubica Muckova, Avi Ring, Jaroslav Pejchal, David Herman, Jan Misik, Martina Hrabinova, Daniel Jun, Ondrej Soukup. Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators.
Toxicology and applied pharmacology.
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Chemico-biological interactions.
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Neurotoxicology and teratology.
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ACS chemical neuroscience.
2018 12; 9(12):3007-3014. doi:
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Pediatric emergency care.
2018 Oct; 34(10):e184-e186. doi:
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Archives of toxicology.
2018 Feb; 92(2):745-757. doi:
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Human & experimental toxicology.
2017 Dec; 36(12):1270-1285. doi:
10.1177/0960327116685888. [PMID: 28078916] - Tatiana N Pashirova, Irina V Zueva, Konstantin A Petrov, Vasily M Babaev, Svetlana S Lukashenko, Ildar Kh Rizvanov, Eliana B Souto, Evgeny E Nikolsky, Lucia Ya Zakharova, Patrick Masson, Oleg G Sinyashin. Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity.
ACS applied materials & interfaces.
2017 May; 9(20):16922-16932. doi:
10.1021/acsami.7b04163. [PMID: 28504886] - André-Guilhem Calas, José Dias, Catherine Rousseau, Mélanie Arboléas, Mélanie Touvrey-Loiodice, Guillaume Mercey, Ludovic Jean, Pierre-Yves Renard, Florian Nachon. An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.
Chemico-biological interactions.
2017 Apr; 267(?):11-16. doi:
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The Turkish journal of pediatrics.
2017; 59(4):491-496. doi:
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Biomedical journal.
2016 Dec; 39(6):391-399. doi:
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Chemical research in toxicology.
2016 11; 29(11):1810-1817. doi:
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Journal of clinical apheresis.
2016 Oct; 31(5):467-9. doi:
10.1002/jca.21417. [PMID: 26273819] - Erin Gallagher, Il Minn, Janice E Chambers, Peter C Searson. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs).
Fluids and barriers of the CNS.
2016 Jul; 13(1):10. doi:
10.1186/s12987-016-0035-0. [PMID: 27396356] - Nabeel I Uwaydah, Stephen L Hoskins, Stephen P Bruttig, Henry Farrar, Nick C Copper, Donald J Deyo, Michael A Dubick, George C Kramer. Intramuscular versus Intraosseous Delivery of Nerve Agent Antidote Pralidoxime Chloride in Swine.
Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors.
2016 Jul; 20(4):485-92. doi:
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European journal of drug metabolism and pharmacokinetics.
2016 Jun; 41(3):219-30. doi:
10.1007/s13318-014-0250-5. [PMID: 25547639] - Janice E Chambers, Edward C Meek, Joshua P Bennett, W Shane Bennett, Howard W Chambers, C Andrew Leach, Ronald B Pringle, Robert W Wills. Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.
Toxicology.
2016 Jan; 339(?):51-57. doi:
10.1016/j.tox.2015.12.001. [PMID: 26705700] - Bo Zhao, Lanju Yang, Lei Xiao, Baoquan Sun, Xianbao Zou, Dongmei Gao, Xiandong Jian. [The influence of sodium bicarbonate combined with ulinastatin on cholinesterase activity for patients with acute phoxim pesticide poisoning].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2016 Jan; 34(1):53-5. doi:
10.3760/cma.j.issn.1001-9391.2016.01.015. [PMID: 27014821] - Sahajal Dhooria, Digambar Behera, Ritesh Agarwal. Amitraz: a mimicker of organophosphate poisoning.
BMJ case reports.
2015 Oct; 2015(?):. doi:
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Cellular and molecular biology (Noisy-le-Grand, France).
2014 Oct; 60(3):53-9. doi:
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The American journal of emergency medicine.
2014 Jul; 32(7):693-6. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):274-83. doi:
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Arhiv za higijenu rada i toksikologiju.
2013 Jun; 64(2):87-91. doi:
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Clinical toxicology (Philadelphia, Pa.).
2013 Jun; 51(5):402-8. doi:
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British journal of clinical pharmacology.
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Chemico-biological interactions.
2013 Mar; 203(1):129-34. doi:
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Human & experimental toxicology.
2013 Jan; 32(1):45-52. doi:
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Clinical toxicology (Philadelphia, Pa.).
2013 Jan; 51(1):35-40. doi:
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Basic & clinical pharmacology & toxicology.
2012 Dec; 111(6):362-70. doi:
10.1111/j.1742-7843.2012.00912.x. [PMID: 22703537] - Douglas B Murray, Michael Eddleston, Simon Thomas, Robert D Jefferson, Adrian Thompson, Mick Dunn, Daniel S Vidler, R Eddie Clutton, Peter G Blain. Rapid and complete bioavailability of antidotes for organophosphorus nerve agent and cyanide poisoning in minipigs after intraosseous administration.
Annals of emergency medicine.
2012 Oct; 60(4):424-30. doi:
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European journal of radiology.
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10.1016/j.ejrad.2011.04.051. [PMID: 21596500] - Harald John, Marc-Michael Blum. Review of UV spectroscopic, chromatographic, and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM).
Drug testing and analysis.
2012 Mar; 4(3-4):179-93. doi:
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Interdisciplinary toxicology.
2012 Mar; 5(1):1-8. doi:
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Drug testing and analysis.
2012 Mar; 4(3-4):169-78. doi:
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Neurotoxicology.
2011 Dec; 32(6):888-95. doi:
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The Medical journal of Malaysia.
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2011 Jun; 27(5):417-29. doi:
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Critical care medicine.
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Critical care medicine.
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Clinical toxicology (Philadelphia, Pa.).
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JNMA; journal of the Nepal Medical Association.
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Chemico-biological interactions.
2010 Sep; 187(1-3):191-8. doi:
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Chemico-biological interactions.
2010 Sep; 187(1-3):199-206. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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The American journal of emergency medicine.
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