Pralidoxime (BioDeep_00001867978)
Main id: BioDeep_00000003476
PANOMIX_OTCML-2023
代谢物信息卡片
Pralidoxime
化学式: C7H9N2O+ (137.0715)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1=CC=CC=C1C=NO
InChI: InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1
描述信息
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002801 - Cholinesterase Reactivators
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
D020011 - Protective Agents > D000931 - Antidotes
D004793 - Enzyme Reactivators
同义名列表
2 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:8354
- KEGG: C07400
- PubChem: 135398747
- DrugBank: DB00733
- CAS: 25615-00-3
- CAS: 6735-59-7
- CAS: 94-63-3
- PubChem: 9604
- NIKKAJI: J232.003G
- KNApSAcK: 8354
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Brian S Backer, Edward C Meek, Matthew K Ross, Janice E Chambers. Pharmacokinetics of three novel pyridinium aldoxime acetylcholinesterase reactivators in female rats.
Toxicology and applied pharmacology.
2022 07; 446(?):116046. doi:
10.1016/j.taap.2022.116046. [PMID: 35550885] - Yan-Jye Shyong, Yadira Sepulveda, Arnold Garcia, Nathan M Samskey, Zoran Radic, Rakesh K Sit, K Barry Sharpless, Jeremiah D Momper, Palmer Taylor. Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures.
The Journal of pharmacology and experimental therapeutics.
2021 09; 378(3):315-321. doi:
10.1124/jpet.121.000715. [PMID: 34145064] - Jia-Ruei Yu, Yi-Chou Hou, Jen-Fen Fu, I-Kuan Wang, Ming-Jen Chan, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Huang-Yu Yang, Ching-Wei Hsu, Tzung-Hai Yen. Outcomes of elderly patients with organophosphate intoxication.
Scientific reports.
2021 06; 11(1):11615. doi:
10.1038/s41598-021-91230-2. [PMID: 34079035] - Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice.
The Journal of toxicological sciences.
2021; 46(6):289-301. doi:
10.2131/jts.46.289. [PMID: 34078836] - Daina N Buzyurova, Tatiana N Pashirova, Irina V Zueva, Evgenia A Burilova, Zukhra M Shaihutdinova, Ildar Kh Rizvanov, Vasily M Babaev, Konstantin A Petrov, Eliana B Souto. Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat.
Toxicology.
2020 11; 444(?):152578. doi:
10.1016/j.tox.2020.152578. [PMID: 32898602] - H-F Liu, C-H Ku, S-S Chang, C-M Chang, I-K Wang, H-Y Yang, C-H Weng, W-H Huang, C-W Hsu, T-H Yen. Outcome of patients with chlorpyrifos intoxication.
Human & experimental toxicology.
2020 Oct; 39(10):1291-1300. doi:
10.1177/0960327120920911. [PMID: 32336155] - Tamara Kranawetvogl, Dirk Steinritz, Horst Thiermann, Harald John. A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.
Drug testing and analysis.
2020 Jul; 12(7):938-947. doi:
10.1002/dta.2800. [PMID: 32267631] - Vendula Hepnarova, Lubica Muckova, Avi Ring, Jaroslav Pejchal, David Herman, Jan Misik, Martina Hrabinova, Daniel Jun, Ondrej Soukup. Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators.
Toxicology and applied pharmacology.
2019 11; 383(?):114776. doi:
10.1016/j.taap.2019.114776. [PMID: 31629733] - Amna Iqbal, Shahrukh Malik, Syed M Nurulain, Kamil Musilek, Kamil Kuca, Huba Kalasz, M Qaiser Fatmi. Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models.
Chemico-biological interactions.
2019 Sep; 310(?):108735. doi:
10.1016/j.cbi.2019.108735. [PMID: 31276662] - Alciene Almeida Siqueira, Alexandre Frinhani Cunha, Graziany Leite Moreira Marques, Igor Simões Assunção Felippe, Vitor Sampaio Minassa, Thallis Coelho da Silva Gramelich, Maria Aparecida Cicilini, Tamara Andrea Alarcon, Rita Gomes Wanderley Pires, Karla Nivea Sampaio, Vanessa Beijamini. Atropine counteracts the depressive-like behaviour elicited by acute exposure to commercial chlorpyrifos in rats.
Neurotoxicology and teratology.
2019 Jan; 71(?):6-15. doi:
10.1016/j.ntt.2018.11.002. [PMID: 30458229] - Kiel D Neumann, Joseph E Blecha, Thomas R Hayes, Tony Huynh, Chih-Kai Chao, Nicolas Guilloteau, Kurt R Zinn, Henry F VanBrocklin, Charles M Thompson, John M Gerdes. Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication.
ACS chemical neuroscience.
2018 12; 9(12):3007-3014. doi:
10.1021/acschemneuro.8b00212. [PMID: 30071719] - Eylem Ulaş Saz, Ali Yurtseven, Mehmet Arda Kilinç, Ferhat Sari, Hasan Ağin. The First Use of Pralidoxime in a Child With Rivastigmine Poisoning.
Pediatric emergency care.
2018 Oct; 34(10):e184-e186. doi:
10.1097/pec.0000000000001086. [PMID: 28328690] - Evica Antonijevic, Jelena Kotur-Stevuljevic, Kamil Musilek, Andrea Kosvancova, Kamil Kuca, Danijela Djukic-Cosic, Vesna Spasojevic-Kalimanovska, Biljana Antonijevic. Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain.
Archives of toxicology.
2018 Feb; 92(2):745-757. doi:
10.1007/s00204-017-2101-z. [PMID: 29098328] - P Kumar, D Swami, D P Nagar, K P Singh, J Acharya, H N Karade, R Yadav. In vivo protection studies of bis-quaternary 2-(hydroxyimino)- N-(pyridin-3-yl) acetamide derivatives (HNK oximes) against tabun and soman poisoning in Swiss albino mice.
Human & experimental toxicology.
2017 Dec; 36(12):1270-1285. doi:
10.1177/0960327116685888. [PMID: 28078916] - Tatiana N Pashirova, Irina V Zueva, Konstantin A Petrov, Vasily M Babaev, Svetlana S Lukashenko, Ildar Kh Rizvanov, Eliana B Souto, Evgeny E Nikolsky, Lucia Ya Zakharova, Patrick Masson, Oleg G Sinyashin. Nanoparticle-Delivered 2-PAM for Rat Brain Protection against Paraoxon Central Toxicity.
ACS applied materials & interfaces.
2017 May; 9(20):16922-16932. doi:
10.1021/acsami.7b04163. [PMID: 28504886] - André-Guilhem Calas, José Dias, Catherine Rousseau, Mélanie Arboléas, Mélanie Touvrey-Loiodice, Guillaume Mercey, Ludovic Jean, Pierre-Yves Renard, Florian Nachon. An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.
Chemico-biological interactions.
2017 Apr; 267(?):11-16. doi:
10.1016/j.cbi.2016.03.009. [PMID: 26972668] - Ufuk Yükselmiş, Mustafa Özçetin, Yakup Çağ, Dinçer Yıldızdaş, Hayri Levent Yılmaz. The role of plasmapheresis in organophosphate poisoning: Case reports of three pediatric patients.
The Turkish journal of pediatrics.
2017; 59(4):491-496. doi:
10.24953/turkjped.2017.04.020. [PMID: 29624234] - Chih-Chuan Lin, Dong-Zong Hung, Hsien-Yi Chen, Kuang-Hung Hsu. The effectiveness of patient-tailored treatment for acute organophosphate poisoning.
Biomedical journal.
2016 Dec; 39(6):391-399. doi:
10.1016/j.bj.2016.11.001. [PMID: 28043418] - Chih-Kai Chao, S Kaleem Ahmed, John M Gerdes, Charles M Thompson. Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases.
Chemical research in toxicology.
2016 11; 29(11):1810-1817. doi:
10.1021/acs.chemrestox.6b00160. [PMID: 27551891] - Osman Yesilbas, Hasan S Kihtir, Mohammad Altiti, Mey Talip Petmezci, Seda Balkaya, Burcu Bursal Duramaz, Melike Ersoy, Esra Sevketoglu. Acute severe organophosphate poisoning in a child who was successfully treated with therapeutic plasma exchange, high-volume hemodiafiltration, and lipid infusion.
Journal of clinical apheresis.
2016 Oct; 31(5):467-9. doi:
10.1002/jca.21417. [PMID: 26273819] - Erin Gallagher, Il Minn, Janice E Chambers, Peter C Searson. In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs).
Fluids and barriers of the CNS.
2016 Jul; 13(1):10. doi:
10.1186/s12987-016-0035-0. [PMID: 27396356] - Nabeel I Uwaydah, Stephen L Hoskins, Stephen P Bruttig, Henry Farrar, Nick C Copper, Donald J Deyo, Michael A Dubick, George C Kramer. Intramuscular versus Intraosseous Delivery of Nerve Agent Antidote Pralidoxime Chloride in Swine.
Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors.
2016 Jul; 20(4):485-92. doi:
10.3109/10903127.2014.942479. [PMID: 27158860] - Subham Banerjee, Pronobesh Chattopadhyay, Animesh Ghosh, Aseem Bhatnagar, Vijay Veer. Pharmacokinetic and biodistribution study of eserine and pralidoxime chloride in rabbits following a single application of a transdermal patch.
European journal of drug metabolism and pharmacokinetics.
2016 Jun; 41(3):219-30. doi:
10.1007/s13318-014-0250-5. [PMID: 25547639] - Janice E Chambers, Edward C Meek, Joshua P Bennett, W Shane Bennett, Howard W Chambers, C Andrew Leach, Ronald B Pringle, Robert W Wills. Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.
Toxicology.
2016 Jan; 339(?):51-57. doi:
10.1016/j.tox.2015.12.001. [PMID: 26705700] - Bo Zhao, Lanju Yang, Lei Xiao, Baoquan Sun, Xianbao Zou, Dongmei Gao, Xiandong Jian. [The influence of sodium bicarbonate combined with ulinastatin on cholinesterase activity for patients with acute phoxim pesticide poisoning].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2016 Jan; 34(1):53-5. doi:
10.3760/cma.j.issn.1001-9391.2016.01.015. [PMID: 27014821] - Sahajal Dhooria, Digambar Behera, Ritesh Agarwal. Amitraz: a mimicker of organophosphate poisoning.
BMJ case reports.
2015 Oct; 2015(?):. doi:
10.1136/bcr-2015-210296. [PMID: 26430228] - P Kumar, D Swami, H N Karade, J Acharya, P C Jatav, A Kumar, M K Meena. In vivo protection of diisopropylphosphorofluoridate (DFP) poisoning by three bis-quaternary 2 -(hydroxyimino) -N -(pyridin-3-yl) acetamide derivatives in Swiss mice.
Cellular and molecular biology (Noisy-le-Grand, France).
2014 Oct; 60(3):53-9. doi:
. [PMID: 25346249] - Duk Hee Lee, Koo Young Jung, Yoon Hee Choi, Young Jin Cheon. Body mass index as a prognostic factor in organophosphate-poisoned patients.
The American journal of emergency medicine.
2014 Jul; 32(7):693-6. doi:
10.1016/j.ajem.2014.04.030. [PMID: 24856742] - Lisa A Konickx, Franz Worek, Shaluka Jayamanne, Horst Thiermann, Nicholas A Buckley, Michael Eddleston. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Dec; 136(2):274-83. doi:
10.1093/toxsci/kft217. [PMID: 24052565] - Slavica Vučinić, Milica Zlatković, Biljana Antonijević, Marijana Ćurčić, Bogdan Bošković. Fresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoning.
Arhiv za higijenu rada i toksikologiju.
2013 Jun; 64(2):87-91. doi:
10.2478/10004-1254-64-2013-2378. [PMID: 23819936] - C H Chaou, C C Lin, H Y Chen, C H Lee, T H H Chen. Chlorpyrifos is associated with slower serum cholinesterase recovery in acute organophosphate-poisoned patients.
Clinical toxicology (Philadelphia, Pa.).
2013 Jun; 51(5):402-8. doi:
10.3109/15563650.2013.782035. [PMID: 23590812] - Michael Eddleston. Applied clinical pharmacology and public health in rural Asia--preventing deaths from organophosphorus pesticide and yellow oleander poisoning.
British journal of clinical pharmacology.
2013 May; 75(5):1175-88. doi:
10.1111/j.1365-2125.2012.04449.x. [PMID: 22943579] - Jayendra B Bhonsle, Robert Causey, Benjamin L Oyler, Cecilia Bartolucci, Doriano Lamba, Alessandro Pesaresi, Nanaji K Bhamare, Iswarduth Soojhawon, Gregory E Garcia. Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model.
Chemico-biological interactions.
2013 Mar; 203(1):129-34. doi:
10.1016/j.cbi.2012.09.012. [PMID: 23073172] - A Bayir, H Kara, O Köylü, R Kocabas, A Ak. The effects of ubiquinone (CoQ10) on heart tissue in cardiac toxicity related to organophosphate poisoning.
Human & experimental toxicology.
2013 Jan; 32(1):45-52. doi:
10.1177/0960327112455070. [PMID: 23060413] - A Basher, S H Rahman, A Ghose, S M Arif, M A Faiz, A H Dawson. Phase II study of magnesium sulfate in acute organophosphate pesticide poisoning.
Clinical toxicology (Philadelphia, Pa.).
2013 Jan; 51(1):35-40. doi:
10.3109/15563650.2012.757318. [PMID: 23311540] - Thiago Henrique Lugokenski, Priscila Gubert, Diones Caeran Bueno, Pablo Andrei Nogara, Rogério de Aquino Saraiva, Rômulo Pillon Barcelos, Vanessa Santana Carratu, Leandro Bresolin, Nilda Berenice de Vargas Barbosa, Maria Ester Pereira, João Batista Teixeira da Rocha, Félix Alexandre Antunes Soares. Effect of different oximes on rat and human cholinesterases inhibited by methamidophos: a comparative in vitro and in silico study.
Basic & clinical pharmacology & toxicology.
2012 Dec; 111(6):362-70. doi:
10.1111/j.1742-7843.2012.00912.x. [PMID: 22703537] - Douglas B Murray, Michael Eddleston, Simon Thomas, Robert D Jefferson, Adrian Thompson, Mick Dunn, Daniel S Vidler, R Eddie Clutton, Peter G Blain. Rapid and complete bioavailability of antidotes for organophosphorus nerve agent and cyanide poisoning in minipigs after intraosseous administration.
Annals of emergency medicine.
2012 Oct; 60(4):424-30. doi:
10.1016/j.annemergmed.2012.05.013. [PMID: 22738685] - Yonghua Xu, Wenli Cai, Janne Nappi, Hiro Yoshida. Fecal-tagging CT colonography with structure-analysis electronic cleansing for detection of colorectal flat lesions.
European journal of radiology.
2012 Aug; 81(8):1712-6. doi:
10.1016/j.ejrad.2011.04.051. [PMID: 21596500] - Harald John, Marc-Michael Blum. Review of UV spectroscopic, chromatographic, and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM).
Drug testing and analysis.
2012 Mar; 4(3-4):179-93. doi:
10.1002/dta.327. [PMID: 21953823] - Preeti Yadav, Sunil E Jadhav, Vinesh Kumar, Kirtee K Kaul, Satish C Pant, Swaran J S Flora. Protective efficacy of 2-PAMCl, atropine and curcumin against dichlorvos induced toxicity in rats.
Interdisciplinary toxicology.
2012 Mar; 5(1):1-8. doi:
10.2478/v10102-012-0001-x. [PMID: 22783142] - Harald John, Michael Eddleston, R Eddie Clutton, Franz Worek, Horst Thiermann. Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig.
Drug testing and analysis.
2012 Mar; 4(3-4):169-78. doi:
10.1002/dta.340. [PMID: 22102522] - Alessandra Antunes dos Santos, Danúbia Bonfanti dos Santos, Renata Pietsch Ribeiro, Dirleise Colle, Kaite Cristiane Peres, Júlia Hermes, Anderson Machado Barbosa, Alcir Luiz Dafré, Andreza Fabro de Bem, Kamil Kuca, Marcelo Farina. Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice.
Neurotoxicology.
2011 Dec; 32(6):888-95. doi:
10.1016/j.neuro.2011.05.008. [PMID: 21723318] - Michael D Costa, Mayara L Freitas, Félix Alexandre Antunes Soares, Vanessa Santana Carratu, Ricardo Brandão. Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study.
Toxicology in vitro : an international journal published in association with BIBRA.
2011 Dec; 25(8):2120-3. doi:
10.1016/j.tiv.2011.09.018. [PMID: 21983245] - S Pazooki, H Solhi, H R Khoddami Vishteh, S Shadnia, M J Bahram Beigi. Effectiveness of fresh frozen plasma as supplementary treatment in organophosphate poisoning.
The Medical journal of Malaysia.
2011 Oct; 66(4):342-5. doi:
NULL. [PMID: 22299554] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Hamidreza Mohammadi, Gholamreza Karimi, Seyed Mahdi Rezayat, Ahmad Reza Dehpour, Hoda Shafiee, Shekoufeh Nikfar, Maryam Baeeri, Omid Sabzevari, Mohammad Abdollahi. Benefit of nanocarrier of magnetic magnesium in rat malathion-induced toxicity and cardiac failure using non-invasive monitoring of electrocardiogram and blood pressure.
Toxicology and industrial health.
2011 Jun; 27(5):417-29. doi:
10.1177/0748233710387634. [PMID: 21310777] - Maya Kayouka, Pascal Houzé, Frederic J Baud, Salvatore Cisternino, Marcel Debray, Patricia Risède, Alfred H Schinkel, Jean-Michel Warnet. Does modulation of organic cation transporters improve pralidoxime activity in an animal model of organophosphate poisoning?.
Critical care medicine.
2011 Apr; 39(4):803-11. doi:
10.1097/ccm.0b013e318206d52f. [PMID: 21242797] - Na-Na Wang, Li Yuan, Heng Dai, Zhen-Kun Han, Min Zhao. Effect of PON1 on dichlorvos toxicokinetics.
Emergency medicine journal : EMJ.
2011 Apr; 28(4):313-5. doi:
10.1136/emj.2009.088500. [PMID: 20581384] - Michael Eddleston, Nicholas A Buckley. A strategy for changing plasma pralidoxime kinetics and, perhaps, effect in organophosphorus insecticide poisoning.
Critical care medicine.
2011 Apr; 39(4):908-9. doi:
10.1097/ccm.0b013e31820a839b. [PMID: 21613850] - Alexis Soummer, Bruno Megarbane, Filippo Boroli, Charlotte Arbelot, Mohamed Saleh, Christian Moesch, Emmanuel Fournier, Jean-Jacques Rouby. Severe and prolonged neurologic toxicity following subcutaneous chlorpyrifos self-administration: a case report.
Clinical toxicology (Philadelphia, Pa.).
2011 Feb; 49(2):124-7. doi:
10.3109/15563650.2011.552066. [PMID: 21370952] - N R Simkhada, K K Kafle, P N Prasad. Pralidoxime in organophosphorus poisoning.
JNMA; journal of the Nepal Medical Association.
2010 Oct; 50(180):300-2. doi:
10.31729/jnma.62. [PMID: 22049895] - James C Demar, Edward D Clarkson, Ruthie H Ratcliffe, Amy J Campbell, Sonia G Thangavelu, Christine A Herdman, Haim Leader, Susan M Schulz, Elizabeth Marek, Marie A Medynets, Therese C Ku, Sarah A Evans, Farhat A Khan, Roberta R Owens, Madhusoodana P Nambiar, Richard K Gordon. Pro-2-PAM therapy for central and peripheral cholinesterases.
Chemico-biological interactions.
2010 Sep; 187(1-3):191-8. doi:
10.1016/j.cbi.2010.02.015. [PMID: 20156430] - Gregory E Garcia, Amy J Campbell, John Olson, Deborah Moorad-Doctor, Venee I Morthole. Novel oximes as blood-brain barrier penetrating cholinesterase reactivators.
Chemico-biological interactions.
2010 Sep; 187(1-3):199-206. doi:
10.1016/j.cbi.2010.02.033. [PMID: 20227398] - Pascal Houzé, Donald E Mager, Patricia Risède, Frédéric J Baud. Pharmacokinetics and toxicodynamics of pralidoxime effects on paraoxon-induced respiratory toxicity.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Aug; 116(2):660-72. doi:
10.1093/toxsci/kfq152. [PMID: 20498006] - Sara Bohnert, Cory Vair, John Mikler. Development and validation of a sensitive HPLC method for the quantification of HI-6 in guinea pig plasma and evaluated in domestic swine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 May; 878(17-18):1407-13. doi:
10.1016/j.jchromb.2010.03.018. [PMID: 20395179] - Hsien-Yi Chen, Warren Wei-Jen Wang, Chung-Hsien Chaou, Chih-Chuan Lin. Prognostic value of serial serum cholinesterase activities in organophosphate poisoned patients.
The American journal of emergency medicine.
2009 Nov; 27(9):1034-9. doi:
10.1016/j.ajem.2008.07.006. [PMID: 19931747] - Maya Kayouka, Pascal Houzé, Marcel Debray, Frederic J Baud. Acute renal failure enhances the antidotal activity of pralidoxime towards paraoxon-induced respiratory toxicity.
Toxicology letters.
2009 Aug; 189(1):48-56. doi:
10.1016/j.toxlet.2009.04.020. [PMID: 19406220] - C Abbara, J M Rousseau, A Turcant, G Lallement, E Comets, I Bardot, P Clair, B Diquet. Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers.
British journal of pharmacology.
2009 Aug; 157(8):1390-7. doi:
10.1111/j.1476-5381.2009.00330.x. [PMID: 19681868] - Michael Eddleston, Peter Eyer, Franz Worek, Edmund Juszczak, Nicola Alder, Fahim Mohamed, Lalith Senarathna, Ariyasena Hittarage, Shifa Azher, K Jeganathan, Shaluka Jayamanne, Ludwig von Meyer, Andrew H Dawson, Mohamed Hussain Rezvi Sheriff, Nick A Buckley. Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial.
PLoS medicine.
2009 Jun; 6(6):e1000104. doi:
10.1371/journal.pmed.1000104. [PMID: 19564902] - Arthur Chang, M Angela Montesano, Dana Barr, Jerry Thomas, Robert Geller. Urinary elimination kinetics of acephate and its metabolite, methamidophos, in urine after acute ingestion.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2009 Jun; 5(2):68-72. doi:
10.1007/bf03161090. [PMID: 19415590] - N Aurbek, H Thiermann, F Eyer, P Eyer, F Worek. Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Toxicology.
2009 May; 259(3):133-9. doi:
10.1016/j.tox.2009.02.014. [PMID: 19428953] - Huba Kalász, Eva Szöko, Tamás Tábi, Georg A Petroianu, Dietrich E Lorke, Abdulrab Omar, Salem Alafifi, Almerri Jasem, Kornélia Tekes. Analysis of pralidoxime in serum, brain and CSF of rats.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2009 May; 5(3):237-41. doi:
10.2174/157340609788185882. [PMID: 19442213] - Ataman Kose, Nurullah Gunay, Cuma Yildirim, Mehmet Tarakcioglu, Ibrahim Sari, Abdullah T Demiryurek. Cardiac damage in acute organophosphate poisoning in rats: effects of atropine and pralidoxime.
The American journal of emergency medicine.
2009 Feb; 27(2):169-75. doi:
10.1016/j.ajem.2008.01.016. [PMID: 19371524] - Maya Kayouka, Pascal Houzé, Patricia Risède, Marcel Debray, Frederic J Baud. Acute renal failure alters the kinetics of pralidoxime in rats.
Toxicology letters.
2009 Jan; 184(1):61-6. doi:
10.1016/j.toxlet.2008.10.022. [PMID: 19026730] - Chadi Abbara, Isabelle Bardot, Annie Cailleux, Guy Lallement, Anne Le Bouil, Alain Turcant, Pascal Clair, Bertrand Diquet. High-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of diazepam, atropine and pralidoxime in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Oct; 874(1-2):42-50. doi:
10.1016/j.jchromb.2008.08.027. [PMID: 18805073] - Andrés Maximiliano Attademo, Paola M Peltzer, Rafael C Lajmanovich, Mariana Cabagna, Gabriela Fiorenza. Plasma B-esterase and glutathione S-transferase activity in the toad Chaunus schneideri (Amphibia, Anura) inhabiting rice agroecosystems of Argentina.
Ecotoxicology (London, England).
2007 Nov; 16(8):533-9. doi:
10.1007/s10646-007-0154-0. [PMID: 17701347] - G A Petroianu, D E Lorke, M Y Hasan, A Adem, R Sheen, S M Nurulain, H Kalasz. Paraoxon has only a minimal effect on pralidoxime brain concentration in rats.
Journal of applied toxicology : JAT.
2007 Jul; 27(4):350-7. doi:
10.1002/jat.1213. [PMID: 17265425] - Surjit Singh, Udaybhan Bhardwaj, Suresh K Verma, Ashish Bhalla, Kirandip Gill. Hyperamylasemia and acute pancreatitis following anticholinesterase poisoning.
Human & experimental toxicology.
2007 Jun; 26(6):467-71. doi:
10.1177/0960327107076814. [PMID: 17698941] - Tzeng-Jih Lin, Donald-D Jiang, Hon-Man Chan, Dong-Zong Hung, Hong-Ping Li. Prognostic factors of organophosphate poisoning between the death and survival groups.
The Kaohsiung journal of medical sciences.
2007 Apr; 23(4):176-82. doi:
10.1016/s1607-551x(09)70394-8. [PMID: 17395565] - I M Abdullat, A H Battah, K A Hadidi. The use of serial measurement of plasma cholinesterase in the management of acute poisoning with organophosphates and carbamates.
Forensic science international.
2006 Oct; 162(1-3):126-30. doi:
10.1016/j.forsciint.2006.06.074. [PMID: 16890390] - Pascal Houzé, Hafedh Thabet, Alexandre Delfour, Lucile Larrouy, Thierry Le Bricon, Frédéric J Baud. Quantification of pralidoxime methylsulfate (Contrathion) in human urine by capillary zone electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Nov; 826(1-2):63-8. doi:
10.1016/j.jchromb.2005.08.007. [PMID: 16157515] - Ahmed A Kamha, Ibrahim Y M Al Omary, Hisham A Zalabany, Yolande Hanssens, Fathia S Adheir. Organophosphate poisoning in pregnancy: a case report.
Basic & clinical pharmacology & toxicology.
2005 May; 96(5):397-8. doi:
10.1111/j.1742-7843.2005.pto_09.x. [PMID: 15853933] - Salim Satar, Deniz Satar, Sinan Kirim, Hülya Leventerler. Effects of acute organophosphate poisoning on thyroid hormones in rats.
American journal of therapeutics.
2005 May; 12(3):238-42. doi:
. [PMID: 15891268] - Zhaohui Fu, Xuexiang Huang, Hongrui Xiao, Jinxiang Huang. [Determination of pralidoxime chloride in rat plasma by high performance liquid chromatography].
Wei sheng yan jiu = Journal of hygiene research.
2005 Mar; 34(2):255-6. doi:
NULL. [PMID: 15952678] - Pascal Houzé, Stephen W Borron, François Scherninski, Bernard Bousquet, Bernard Gourmel, Frédéric Baud. Measurement of serum pralidoxime methylsulfate (Contrathion) by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jan; 814(1):149-54. doi:
10.1016/j.jchromb.2004.10.017. [PMID: 15607719] - Salim Satar, Deniz Satar, Ufuk Ozgu Mete, Jeffrey R Suchard, Metin Topal, Mehmet Kaya. Ultrastructural effects of acute organophosphate poisoning on rat kidney.
Renal failure.
2005; 27(5):623-7. doi:
10.1080/08860220500200536. [PMID: 16153004] - Juan C Sánchez-Hernández, R Carbonell, A Henríquez Pérez, M Montealegre, L Gómez. Inhibition of plasma butyrylcholinesterase activity in the lizard Gallotia galloti palmae by pesticides: a field study.
Environmental pollution (Barking, Essex : 1987).
2004 Dec; 132(3):479-88. doi:
10.1016/j.envpol.2004.05.008. [PMID: 15325464] - Salim Satar, Deniz Satar, Ozgul Tap, Zikret Koseoglu, Mehmet Kaya. Ultrastructural changes in rat liver treated with pralidoxime following acute organophosphate poisoning.
The Mount Sinai journal of medicine, New York.
2004 Nov; 71(6):405-10. doi:
. [PMID: 15592660] - Georg A Petroianu, Anke Missler, Katia Zuleger, Caroline Thyes, Vanessa Ewald, Wolfgang H Maleck. Enzyme reactivator treatment in organophosphate exposure: clinical relevance of thiocholinesteratic activity of pralidoxime.
Journal of applied toxicology : JAT.
2004 Nov; 24(6):429-35. doi:
10.1002/jat.995. [PMID: 15551381] - Muhammet Güven, Murat Sungur, Bülent Eser. The effect of plasmapheresis on plasma cholinesterase levels in a patient with organophosphate poisoning.
Human & experimental toxicology.
2004 Jul; 23(7):365-8. doi:
10.1191/0960327104ht462cr. [PMID: 15311856] - Yasuhisa Fujino, Yoshihiro Inoue, Makoto Onodera, Kazutomo Endo, Shigeatsu Endo, Hideki Nakayama, Yuji Fujita. [Three cases of organophosphate poisoning treated with pralidoxime iodide and whole-bowel irrigation].
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology.
2004 Jul; 17(3):273-7. doi:
NULL. [PMID: 15495687] - Muhammet Güven, Murat Sungur, Bülent Eser, Ismail Sari, Fevzi Altuntaş. The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning.
Journal of toxicology. Clinical toxicology.
2004; 42(5):617-23. doi:
10.1081/clt-200026967. [PMID: 15462154] - L Taysse, J-H Calvet, J Buée, D Christin, S Delamanche, P Breton. Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
Toxicology.
2003 Jun; 188(2-3):197-209. doi:
10.1016/s0300-483x(03)00086-6. [PMID: 12767691] - Moreno Agostini, Andrea Bianchin. Acute renal failure from organophospate poisoning: a case of success with haemofiltration.
Human & experimental toxicology.
2003 Mar; 22(3):165-7. doi:
10.1191/0960327103ht343cr. [PMID: 12723899] - Juan C Sanchez-Hernandez. Evaluating reptile exposure to cholinesterase-inhibiting agrochemicals by serum butyrylcholinesterase activity.
Environmental toxicology and chemistry.
2003 Feb; 22(2):296-301. doi:
10.1002/etc.5620220209. [PMID: 12558160] - Juan C Sanchez-Hernandez, Beatriz Moreno Sanchez. Lizard cholinesterases as biomarkers of pesticide exposure: enzymological characterization.
Environmental toxicology and chemistry.
2002 Nov; 21(11):2319-25. doi:
10.1002/etc.5620211109. [PMID: 12389909] - R P Santos, M J Cavaliere, F R Puga, E S Narciso, J R Pelegrino, E E Calore. Protective effect of early and late administration of pralidoxime against organophosphate muscle necrosis.
Ecotoxicology and environmental safety.
2002 Sep; 53(1):48-51. doi:
10.1006/eesa.2001.2138. [PMID: 12481856] - A M Tsatsakis, G K Bertsias, V Liakou, I N Mammas, I Stiakakis, G N Tzanakakis. Severe fenthion intoxications due to ingestion and inhalation with survival outcome.
Human & experimental toxicology.
2002 Jan; 21(1):49-54. doi:
10.1191/0960327102ht232cr. [PMID: 12046724] - A Tracqui, F Flesch, P Sauder, J S Raul, A Géraut, B Ludes, A Jaeger. Repeated measurements of aldicarb in blood and urine in a case of nonfatal poisoning.
Human & experimental toxicology.
2001 Dec; 20(12):657-60. doi:
10.1191/096032701718890612. [PMID: 11936581] - A K Srivastava, J K Malik. Intramuscular kinetics and dosage regimens for pralidoxime in buffalo calves (Bubalus bubalis).
Veterinary research communications.
2001 May; 25(4):301-9. doi:
10.1023/a:1010630709407. [PMID: 11432431] - G Petroianu, C Roth, U Beha, J Fisher, W Bergler, R Rüfer. Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection.
Journal of applied toxicology : JAT.
2001 Jan; 21(1):7-13. doi:
10.1002/jat.726. [PMID: 11180275] - S Mittra, S S Peshin, S B Lall. Cholinesterase inhibition by aluminium phosphide poisoning in rats and effects of atropine and pralidoxime chloride.
Acta pharmacologica Sinica.
2001 Jan; 22(1):37-9. doi:
NULL. [PMID: 11730559] - C Ragoucy-Sengler, A Tracqui, A Chavonnet, J B Daijardin, M Simonetti, P Kintz, B Pileire. Aldicarb poisoning.
Human & experimental toxicology.
2000 Dec; 19(12):657-62. doi:
10.1191/096032700672133218. [PMID: 11291736] - G Lallement, F Renault, D Baubichon, M Peoc'h, M F Burckhart, M Galonnier, D Clarençon, N Jourdil. Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics.
Archives of toxicology.
2000 Oct; 74(8):480-6. doi:
10.1007/s002040000146. [PMID: 11097386] - F Worek, P Eyer, D Kiderlen, H Thiermann, L Szinicz. Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase.
Archives of toxicology.
2000 Mar; 74(1):21-6. doi:
10.1007/s002040050647. [PMID: 10817663] - D L Sudakin, M E Mullins, B Z Horowitz, V Abshier, L Letzig. Intermediate syndrome after malathion ingestion despite continuous infusion of pralidoxime.
Journal of toxicology. Clinical toxicology.
2000; 38(1):47-50. doi:
10.1081/clt-100100915. [PMID: 10696924] - M E Hansen, B W Wilson. Oxime reactivation of RBC acetylcholinesterases for biomonitoring.
Archives of environmental contamination and toxicology.
1999 Oct; 37(3):283-9. doi:
10.1007/s002449900516. [PMID: 10473783] - Gagandeep, G Avasthi. PAM responsive Gullian Barre like syndrome with low serum cholinesterase.
The Journal of the Association of Physicians of India.
1998 Feb; 46(2):244-5. doi:
NULL. [PMID: 11273132] - M J Cavaliere, F R Puga, E E Calore, N M Calore, J R Pelegrino, A R da Rosa, R Weg. Protective effect of pralidoxime on muscle fiber necrosis induced by organophosphate compounds.
Journal of toxicology. Clinical toxicology.
1998; 36(4):295-300. doi:
10.3109/15563659809028024. [PMID: 9711194]
