Glucosamine (BioDeep_00000001863)

 

Secondary id: BioDeep_00000400233, BioDeep_00000412599

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs Antibiotics BioNovoGene_Lab2019


代谢物信息卡片


(3R,4R,5S,6R)-3-Amino-6-(hydroxymethyl)oxane-2,4,5-triol

化学式: C6H13NO5 (179.0794)
中文名称: 2-氨基-2-脱氧-D-吡喃葡萄糖, D-氨基葡萄糖, D-(+)-葡萄糖胺 盐酸盐, 氨基葡萄糖, β-D-葡糖胺, 葡糖胺
谱图信息: 最多检出来源 Homo sapiens(blood) 28.98%

分子结构信息

SMILES: C(C1C(C(C(C(O1)O)N)O)O)O
InChI: InChI=1/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6u/m1/s1

描述信息

Glucosamine (C6H13NO5) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Glucosamine is part of the structure of two polysaccharides, chitosan and chitin. Glucosamine is one of the most abundant monosaccharides. Produced commercially by the hydrolysis of shellfish exoskeletons or, less commonly, by fermentation of a grain such as corn or wheat, glucosamine has many names depending on country. Although a common dietary supplement, there is little evidence that it is effective for relief of arthritis or pain, and is not an approved prescription drug. In the United States, glucosamine is not approved by the Food and Drug Administration for medical use in humans. Since glucosamine is classified as a dietary supplement, evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition. Nevertheless, glucosamine is a popular alternative medicine used by consumers for the treatment of osteoarthritis. Glucosamine is also extensively used in veterinary medicine as an unregulated but widely accepted supplement. Treatment with oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. However, there is little evidence that any clinical effect of glucosamine works this way. Its use as a therapy for osteoarthritis appears safe but there is conflicting evidence as to its effectiveness. Glucosamine is naturally present in the shells of shellfish, animal bones, bone marrow, and fungi. D-Glucosamine is made naturally in the form of glucosamine-6-phosphate, and is the biochemical precursor of all nitrogen-containing sugars. Specifically in humans, glucosamine-6-phosphate is synthesized from fructose 6-phosphate and glutamine by glutamine—fructose-6-phosphate transaminase as the first step of the hexosamine biosynthesis pathway. The end-product of this pathway is uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is then used for making glycosaminoglycans, proteoglycans, and glycolipids. As the formation of glucosamine-6-phosphate is the first step for the synthesis of these products, glucosamine may be important in regulating their production; however, the way that the hexosamine biosynthesis pathway is actually regulated, and whether this could be involved in contributing to human disease remains unclear.
Present in mucopolysaccharides and in polysaccharides found in bacteria, fungi, higher plants, invertebrates, vertebrates, antibiotics and UDP complexes. Obt. comly. by hydrol. of seashells [CCD]
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID G051
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

同义名列表

28 个代谢物同义名

(3R,4R,5S,6R)-3-Amino-6-(hydroxymethyl)oxane-2,4,5-triol; Fides ecopharma brand OF glucosamine sulfate; Rottapharm brand OF glucosamine sulfate; Opfermann brand OF glucosamine sulfate; (+)-2-Amino-2-deoxy-D-glucopyranose; D-(+)-Glucosamine hydrochloride; 2-Amino-2-deoxy-D-glucopyranose; 2-Amino-2-deoxyhexopyranose; 2-Deoxy-2-amino-D-glucose; 2-Amino-2-deoxy-D-glucose; 2-Deoxy-2-aminoglucose; 2-Amino-2-deoxyglucose; 2 Amino 2 deoxyglucose; Sulfate, glucosamine; Glucosamine sulfate; D-(+)-Glucosamine; 2-Aminoglucose; D-Glucosamine; Hespercorbin; Glucosamine; Chitosamine; Cosamin; Dona S; Xicil; Dona; Glucosamine; D-Glucosamine; beta-D-Glucosamine



数据库引用编号

39 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(8)

PlantCyc(0)

代谢反应

67 个相关的代谢反应过程信息。

Reactome(33)

BioCyc(15)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(18)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKT1, APOE, HSPA5, MTOR, OGT, PIK3CA, PTGS2, TLR4, XBP1
Peripheral membrane protein 3 MTOR, PTGS2, XBP1
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 HSPA5, MTOR, PTGS2, XBP1
Mitochondrion membrane 1 OGT
Nucleus 7 AKT1, APOE, HSPA5, MTOR, OGA, OGT, XBP1
cytosol 11 AKT1, GFPT1, HSPA5, MTOR, OGA, OGT, PIK3CA, PRKCQ, SLC2A1, SLC2A4, XBP1
dendrite 2 APOE, MTOR
mitochondrial membrane 1 OGT
phagocytic vesicle 1 MTOR
trans-Golgi network 1 SLC2A4
nucleoplasm 4 AKT1, MTOR, OGT, XBP1
RNA polymerase II transcription regulator complex 1 XBP1
Cell membrane 7 AKT1, ITGAM, OGT, SLC2A1, SLC2A4, TLR4, TNF
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 2 SLC2A1, SLC2A4
Golgi apparatus membrane 1 MTOR
Synapse 1 ACAN
cell cortex 1 AKT1
cell surface 4 HSPA5, ITGAM, TLR4, TNF
glutamatergic synapse 4 ACAN, AKT1, APOE, OGT
Golgi apparatus 1 APOE
Golgi membrane 3 INS, MTOR, SLC2A1
lysosomal membrane 1 MTOR
neuronal cell body 2 APOE, TNF
postsynapse 1 AKT1
sarcolemma 2 SLC2A1, SLC2A4
Lysosome 1 MTOR
Presynapse 2 SLC2A1, SLC2A4
plasma membrane 12 AKT1, APOE, HSPA5, IFNLR1, ITGAM, OGT, PIK3CA, PRKCQ, SLC2A1, SLC2A4, TLR4, TNF
Membrane 12 AKT1, APOE, HSPA5, IFNLR1, ITGAM, MTOR, OGA, OGT, SLC2A1, SLC2A4, TLR4, XBP1
apical plasma membrane 1 SLC2A1
basolateral plasma membrane 1 SLC2A1
caveola 2 PTGS2, SLC2A1
extracellular exosome 6 APOE, GFPT1, HSPA5, ITGAM, SLC2A1, SLC2A4
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 APOE, HSPA5, PTGS2, XBP1
extracellular space 6 ACAN, APOE, IL10, INS, ITGAM, TNF
lysosomal lumen 1 ACAN
perinuclear region of cytoplasm 3 PIK3CA, SLC2A4, TLR4
intercalated disc 2 PIK3CA, SLC2A1
mitochondrion 1 HSPA5
protein-containing complex 4 AKT1, HSPA5, OGT, PTGS2
intracellular membrane-bounded organelle 1 HSPA5
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 IFNLR1, ITGAM, TLR4
Secreted 3 APOE, IL10, INS
extracellular region 5 ACAN, APOE, IL10, INS, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
centriolar satellite 1 PRKCQ
photoreceptor inner segment 1 SLC2A1
external side of plasma membrane 4 ITGAM, SLC2A4, TLR4, TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 2 ACAN, APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 2 APOE, SLC2A4
very-low-density lipoprotein particle 1 APOE
T-tubule 1 SLC2A4
Z disc 1 SLC2A1
microtubule cytoskeleton 1 AKT1
midbody 2 HSPA5, SLC2A1
Early endosome 2 APOE, TLR4
cell-cell junction 1 AKT1
clathrin-coated pit 1 SLC2A4
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TNF, XBP1
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 3 ITGAM, SLC2A4, TNF
focal adhesion 1 HSPA5
spindle 1 AKT1
GABA-ergic synapse 1 ACAN
extracellular matrix 1 APOE
basement membrane 1 ACAN
sarcoplasmic reticulum 1 SLC2A4
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ACAN, APOE
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
cell projection 1 OGT
phagocytic cup 2 TLR4, TNF
[Isoform 3]: Nucleus 1 OGA
Secreted, extracellular space 1 APOE
[Isoform 2]: Mitochondrion 1 OGT
blood microparticle 2 APOE, SLC2A1
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, SLC2A4
endosome lumen 1 INS
NSL complex 1 OGT
female germ cell nucleus 1 SLC2A1
Cytoplasmic vesicle membrane 1 SLC2A4
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
Melanosome 3 APOE, HSPA5, SLC2A1
[Isoform 1]: Cytoplasm 1 OGA
[Isoform 3]: Cytoplasm 1 OGT
[Isoform 4]: Cytoplasm 1 OGT
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
lipopolysaccharide receptor complex 1 TLR4
plasma membrane raft 1 ITGAM
secretory granule lumen 1 INS
Golgi lumen 2 ACAN, INS
endoplasmic reticulum lumen 4 APOE, HSPA5, INS, PTGS2
cortical actin cytoskeleton 1 SLC2A1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
perineuronal net 1 ACAN
aggresome 1 PRKCQ
vesicle membrane 1 SLC2A4
clathrin-coated endocytic vesicle membrane 1 APOE
endoplasmic reticulum-Golgi intermediate compartment 1 HSPA5
[Isoform 2]: Nucleus 1 XBP1
[Isoform 1]: Nucleus 1 XBP1
synaptic cleft 1 APOE
histone acetyltransferase complex 1 OGT
protein N-acetylglucosaminyltransferase complex 1 OGT
Sin3-type complex 1 OGT
female pronucleus 1 SLC2A1
Cytoplasmic vesicle, phagosome 1 MTOR
integrin complex 1 ITGAM
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
integrin alphaM-beta2 complex 1 ITGAM
endoplasmic reticulum chaperone complex 1 HSPA5
glucose transporter complex 1 SLC2A1
insulin-responsive compartment 1 SLC2A4
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm 1 XBP1
perisynaptic extracellular matrix 1 ACAN
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yuan Zhang, Line A Borch, Niklas H Fischer, Morten Meldal. Hydrodynamic Control of Alzheimer Aβ Fibrillation with Glucosaminic Acid Containing Click-Cyclized β-Bodies. Journal of the American Chemical Society. 2024 Jan; 146(4):2654-2662. doi: 10.1021/jacs.3c12118. [PMID: 38126710]
  • Mazlyzam Abdul Latif, Asrul Mustafa, Lee Chee Keong, Asmah Hamid. Chromolaena odorata layered-nitrile rubber polymer transdermal patch enhanced wound healing in vivo. PloS one. 2024; 19(3):e0295381. doi: 10.1371/journal.pone.0295381. [PMID: 38466676]
  • Sang-Min Kim, Dong Yeol Kim, Jiwon Park, Young-Ah Moon, Inn-Oc Han. Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway. BMB reports. 2023 Nov; ?(?):. doi: . [PMID: 37964636]
  • Akshayaa Venkataraghavan, Julian G Schwerdt, Stephen D Tyerman, Maria Hrmova. Barley Nodulin 26-like Intrinsic Protein permeates water, metalloids, saccharides, and ion pairs due to structural plasticity and diversification. The Journal of biological chemistry. 2023 Oct; ?(?):105410. doi: 10.1016/j.jbc.2023.105410. [PMID: 37913906]
  • Yi Zou, Zongkai Liu, Wenjia Liu, Zhaidong Liu. Current knowledge and potential intervention of hexosamine biosynthesis pathway in lung cancer. World journal of surgical oncology. 2023 Oct; 21(1):334. doi: 10.1186/s12957-023-03226-z. [PMID: 37880766]
  • Feng Li, Zhengyan Zhang, Yan Bai, Qishi Che, Hua Cao, Jiao Guo, Zhengquan Su. Glucosamine Improves Non-Alcoholic Fatty Liver Disease Induced by High-Fat and High-Sugar Diet through Regulating Intestinal Barrier Function, Liver Inflammation, and Lipid Metabolism. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196918. [PMID: 37836761]
  • Yihao Liu, Zhen Qin, Chunling Wang, Zhengqiang Jiang. N-acetyl-d-glucosamine-based oligosaccharides from chitin: Enzymatic production, characterization and biological activities. Carbohydrate polymers. 2023 Sep; 315(?):121019. doi: 10.1016/j.carbpol.2023.121019. [PMID: 37230627]
  • Zeqi Li, Bo Fu, Aili Wei, Yanchen Wu, Ming Huang, Enhao Zhang, Bo Cui, Bo Wang, Hui Peng. d-Glucosamine induces circadian phase delay by promoting BMAL1 degradation through AMPK/mTOR pathway. Life sciences. 2023 Jul; 325(?):121765. doi: 10.1016/j.lfs.2023.121765. [PMID: 37169147]
  • Giorgia Della Rocca, Carlo Schievano, Alessandra Di Salvo, Maria Beatrice Conti, Maria Federica Della Valle. Palmitoyl-glucosamine co-micronized with curcumin for maintenance of meloxicam-induced pain relief in dogs with osteoarthritis pain. BMC veterinary research. 2023 Feb; 19(1):37. doi: 10.1186/s12917-023-03594-4. [PMID: 36747264]
  • Yingde Xu, Liangjie Sun, Xiaodan Gao, Jingkuan Wang. Contrasting response of fungal versus bacterial residue accumulation within soil aggregates to long-term fertilization. Scientific reports. 2022 10; 12(1):17834. doi: 10.1038/s41598-022-22064-9. [PMID: 36284223]
  • G Zhou, M W Zhao, Y P Cao, J H Lin, W G Wang, A Guo, H Tian. [A multicenter cross-sectional study of quality of life and nonsurgical treatment in patients with knee osteoarthritis]. Zhonghua yi xue za zhi. 2022 Sep; 102(35):2799-2805. doi: 10.3760/cma.j.cn112137-20220406-00719. [PMID: 36124353]
  • Ying Chen, Xiaoming Liao, Pei Jing, Liangkui Hu, Zengqiu Yang, Yongchao Yao, Chunyan Liao, Shiyong Zhang. Linoleic Acid-Glucosamine Hybrid for Endogenous Iron-Activated Ferroptosis Therapy in High-Grade Serous Ovarian Cancer. Molecular pharmaceutics. 2022 09; 19(9):3187-3198. doi: 10.1021/acs.molpharmaceut.2c00333. [PMID: 35939328]
  • Kun Gao, Yukun Qin, Linsong Wang, Xin Li, Song Liu, Ronge Xing, HuaHua Yu, Xiaolin Chen, Pengcheng Li. Design, Synthesis, and Antifungal Activities of Hymexazol Glycosides Based on a Biomimetic Strategy. Journal of agricultural and food chemistry. 2022 Aug; 70(30):9520-9535. doi: 10.1021/acs.jafc.2c02507. [PMID: 35877994]
  • Jing Chen, Li-Na Huo, Yuan Gao, Yun-Li Zhang, Ye Chen. Two new N-acetyl-ᴅ-glucosamine derivatives from the medical algae-derived endophytic fungus Penicillium chrysogenum. Natural product research. 2022 Aug; 36(15):3988-3991. doi: 10.1080/14786419.2021.1889543. [PMID: 33957817]
  • Venkanna Babu Mullapudi, Kendall C Craig, Zhongwu Guo. Design and Synthesis of a Doubly Functionalized Core Structure of a Glycosylphosphatidylinositol Anchor Containing Photoreactive and Clickable Functional Groups. The Journal of organic chemistry. 2022 07; 87(14):9419-9425. doi: 10.1021/acs.joc.2c00901. [PMID: 35766889]
  • Bojian Chen, Lei Fang, Liangzhuo Lin, Yang Lv, Zexin Huang, Xiaodong Lin, Xin Wang. Aerobic exercise combined with glucosamine hydrochloride capsules inhibited the apoptosis of chondrocytes in rabbit knee osteoarthritis by affecting TRPV5 expression. Gene. 2022 Jul; 830(?):146465. doi: 10.1016/j.gene.2022.146465. [PMID: 35427733]
  • Alexandre de Fátima Cobre, Monica Surek, Dile Pontarolo Stremel, Mariana Millan Fachi, Helena Hiemisch Lobo Borba, Fernanda Stumpf Tonin, Roberto Pontarolo. Diagnosis and prognosis of COVID-19 employing analysis of patients' plasma and serum via LC-MS and machine learning. Computers in biology and medicine. 2022 Jul; 146(?):105659. doi: 10.1016/j.compbiomed.2022.105659. [PMID: 35751188]
  • Yanmin Gao, Yanli Ma, Di Xie, Hua Jiang. ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model. International immunopharmacology. 2022 Jun; 107(?):108711. doi: 10.1016/j.intimp.2022.108711. [PMID: 35338958]
  • Janeala J Morsby, Bradley D Smith. Advances in Optical Sensors of N-Acetyl-β-d-hexosaminidase (N-Acetyl-β-d-glucosaminidase). Bioconjugate chemistry. 2022 04; 33(4):544-554. doi: 10.1021/acs.bioconjchem.2c00057. [PMID: 35302753]
  • Peipei Han, Yingying Wei, Shu Jiang, Yi Chen, Feng Xu, Hongfei Wang, Xingfeng Shao. N-Acetyl-d-glucosamine Inhibition of Hexokinase Results in Downregulation of the Phenylpropanoid Metabolic Pathway and Decreased Resistance to Brown Rot in Peach Fruit. Journal of agricultural and food chemistry. 2022 Mar; 70(12):3917-3928. doi: 10.1021/acs.jafc.1c06573. [PMID: 35298175]
  • Salim Cerig, Fatime Geyikoglu. Oxidative stress and cyto-genotoxicity induced by poly-d-glucosamine in human blood cells in vitro. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2022 Jan; 77(1-2):43-55. doi: 10.1515/znc-2021-0080. [PMID: 34036758]
  • Rebecca A Bova, Angela Melton-Celsa. Shiga toxin (Stx) type 2-induced increase in O-linked N-acetyl glucosamine protein modification: a new therapeutic target?. EMBO molecular medicine. 2022 01; 14(1):e15389. doi: 10.15252/emmm.202115389. [PMID: 34935281]
  • Leire Pedrosa, Carles Foguet, Helena Oliveres, Iván Archilla, Marta García de Herreros, Adela Rodríguez, Antonio Postigo, Daniel Benítez-Ribas, Jordi Camps, Miriam Cuatrecasas, Antoni Castells, Aleix Prat, Timothy M Thomson, Joan Maurel, Marta Cascante. A novel gene signature unveils three distinct immune-metabolic rewiring patterns conserved across diverse tumor types and associated with outcomes. Frontiers in immunology. 2022; 13(?):926304. doi: 10.3389/fimmu.2022.926304. [PMID: 36119118]
  • Nuria Carrillo, May C Malicdan, Petcharat Leoyklang, Joseph A Shrader, Galen Joe, Christina Slota, John Perreault, John D Heiss, Bradley Class, Chia-Ying Liu, Kennan Bradley, Colleen Jodarski, Carla Ciccone, Claire Driscoll, Rebecca Parks, Scott Van Wart, Levent Bayman, Christopher S Coffey, Melanie Quintana, Scott M Berry, Marjan Huizing, William A Gahl. Safety and efficacy of N-acetylmannosamine (ManNAc) in patients with GNE myopathy: an open-label phase 2 study. Genetics in medicine : official journal of the American College of Medical Genetics. 2021 11; 23(11):2067-2075. doi: 10.1038/s41436-021-01259-x. [PMID: 34257421]
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  • Congcong Zhang, Yongjie Niu, Zhixian Wang, Xin Xu, Yan Li, Lifang Ma, Jiayi Wang, Yongchun Yu. Corosolic acid inhibits cancer progression by decreasing the level of CDK19-mediated O-GlcNAcylation in liver cancer cells. Cell death & disease. 2021 09; 12(10):889. doi: 10.1038/s41419-021-04164-y. [PMID: 34588426]
  • Laura Morelli, Luigi Lay, Darielys Santana-Mederos, Yury Valdes-Balbin, Vicente Verez Bencomo, Angela van Diepen, Cornelis H Hokke, Fabrizio Chiodo, Federica Compostella. Glycan Array Evaluation of Synthetic Epitopes between the Capsular Polysaccharides from Streptococcus pneumoniae 19F and 19A. ACS chemical biology. 2021 09; 16(9):1671-1679. doi: 10.1021/acschembio.1c00347. [PMID: 34469105]
  • Fabio A Facchini, Alberto Minotti, Andrea Luraghi, Alessio Romerio, Nicole Gotri, Alejandra Matamoros-Recio, Andrea Iannucci, Charys Palmer, Guanbo Wang, Rebecca Ingram, Sonsoles Martin-Santamaria, Grisha Pirianov, Marco De Andrea, Miguel A Valvano, Francesco Peri. Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity. Journal of medicinal chemistry. 2021 08; 64(16):12261-12272. doi: 10.1021/acs.jmedchem.1c00896. [PMID: 34382796]
  • Seyedeh Fatemeh Mirpoor, Odile Francesca Restaino, Chiara Schiraldi, Concetta Valeria L Giosafatto, Francesco Ruffo, Raffaele Porta. Lignin/Carbohydrate Complex Isolated from Posidonia oceanica Sea Balls (Egagropili): Characterization and Antioxidant Reinforcement of Protein-Based Films. International journal of molecular sciences. 2021 Aug; 22(17):. doi: 10.3390/ijms22179147. [PMID: 34502058]
  • Speranta Avram, Ana Maria Udrea, Diana Camelia Nuta, Carmen Limban, Adrian Cosmin Balea, Miron Teodor Caproiu, Florea Dumitrascu, Cătălin Buiu, Alexandra Teodora Bordei. Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144160. [PMID: 34299440]
  • Jessica M Moon, Peter Finnegan, Richard A Stecker, Hanna Lee, Kayla M Ratliff, Ralf Jäger, Martin Purpura, Carolyn M Slupsky, Maria L Marco, Craig J Wissent, Jason Theodosakis, Chad M Kerksick. Impact of Glucosamine Supplementation on Gut Health. Nutrients. 2021 Jun; 13(7):. doi: 10.3390/nu13072180. [PMID: 34202877]
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